In situ construction of ligand nano-network to integrin αvβ3 for angiogenesis inhibition

作     者：Ziming Chen Kuo Zhang Jiaqi Fan Yu Fan Chao Yang Wen Tian Yuan Li Wenliang Li Jingping Zhang Hao Wang Lei Wang Ziming Chen;Kuo Zhang;Jiaqi Fan;Yu Fan;Chao Yang;Wen Tian;Yuan Li;Wenliang Li;Jingping Zhang;Hao Wang;Lei Wang

作者机构：Faculty of ChemistryNortheast Normal UniversityChangchun 130024China CAS Center for Excellence in NanoscienceCAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing 100190China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2020年第31卷第12期

页      面：3107-3112页

核心收录：

学科分类：07[理学] 08[工学] 070205[理学-凝聚态物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 0702[理学-物理学] 

基　　金：the National Natural Science Foundation of China(Nos.51890891,51725302,21807020,51573031 and 51573032) Science Fund for Creative Research Groups of the National Natural Science Foundation of China(No.11621505) CAS Interdisciplinary Innovation Team,Jilin Province Key Laboratory of Organic Functional Molecular Design and Synthesis(No.130028911) Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety,CAS(No.NSKF201807) 

主　　题：Self-assembly Integrinαvβ3 Peptide Anti-angiogenesis Tumor 

摘      要：Angiogenesis occurs during the process of tumor growth,invasion and metastasis,and is essential for the survival of solid *** an integrin significantly ove rexpressed in human tumor vascular endothelial cells,αvβ3 is a suitable targeting site for anti-angiogenesis of *** designed and prepared a selfassembling peptide(SAP)with the ability to targeting αvβ3 and *** formed nanoparticles in solution and transformed into nanofibrous network once specifically binding to integrin αvβ3 on the surface of human umbilical vein endothelial cells(HUVECs).The SAP network stably anchored on HUVECs over 24h,which consequently resulted in high-efficient inhibition of *** vitro anti-angiogenesis experiment displayed that the inhibition rate of tube-formation reached 94.9%.In vivo anti-angiogenesis array based on chick chorioallantoic membrane(CAM)model exhibited that the SAP had an inhibition rate up to 63.1%.These results indicated the outstanding anti-angiogenic ability of SAP,potentially for tumor therapy.