Anlotinib-induced sick sinus syndrome:Two case reports

作     者：Cheng-Feng Fu Li-Fen Yang Lei Tian Song Deng Qi Zhang Biao Yao 

作者机构：Department of OncologyTongren People’s HospitalTongren 554300Guizhou ProvinceChina Department of OncologyGuizhou Provincial People’s HospitalGuiyang 550000Guizhou ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志（英文）)

年 卷 期：2025年第13卷第6期

页      面：30-34页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：Lung cancer Anlotinib Sick sinus syndrome Cardiac pacemaker Adverse drug reaction Case report 

摘      要：BACKGROUND This manuscript describes the first known cases of sick sinus syndrome(SSS)associated with the use of anlotinib in non-small cell lung cancer patients,highlighting the need for increased vigilance and cardiac *** SUMMARY Two patients with non-small cell lung cancer developed SSS after 15 months and 5 months of anlotinib treatment,respectively,presenting with syncope and *** confirmed SSS,and different treatment approaches were taken for each *** patient received a dual-chamber permanent pacemaker,while the other discontinued the medication and experienced symptom *** Anlotinib can induce SSS,suggesting that cardiac monitoring is crucial during anlotinib *** management strategies are necessary for affected individuals.