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Light(Science & Applications) 2020年第1期9卷 450-465页

作者： Yanfeng Dai Xiang Yu jianshuang wei Fanxin Zeng Yiran Li Xiaoquan Yang Qingming Luo Zhihong Zhang Britton Chance Center and MOE Key Laboratory for Biomedical Photonics School of Engineering SciencesWuhan National Laboratory for Optoelectronics–Huazhong University of Science and TechnologyWuhanHubei 430074China School of Biomedical Engineering Hainan UniversityHaikouHainan 570228China

Detection of sentinel lymph nodes(SLNs)is critical to guide the treatment of breast ***,distinguishing metastatic SLNs from normal and inflamed lymph nodes(LNs)during surgical resection remains a ***,we report a CD44 and scavenger receptor class B1 dual-targeting hyaluronic acid nanoparticle(5K-HA-HPPS)loaded with the near-infra-red fluorescent dye DiR-BOA for SLN imaging in breast *** small sized(~40 nm)self-assembled 5K-HA-HPPSs accumulated rapidly in the SLNs after intradermal *** with normal popliteal LNs(N-LN),there were ~3.2-fold and ~2.4-fold increases in fluorescence intensity in tumour metastatic SLNs(T-MLN)and inflamed LNs(Inf-LN),respectively,6 h after nanoparticle *** importantly,photoacoustic microscopy(PAM)of 5KHA-HPPS showed a significantly distinct distribution in T-MLN compared with N-LN and *** were mainly distributed at the centre of T-MLN but at the periphery of N-LN and *** ratio of PA intensity(R)at the centre of the LNs compared with that at the periphery was 5.93±0.75 for T-MLNs of the 5K-HA-HPPS group,which was much higher than that for the Inf-LNs(R=0.2±0.07)and N-LNs(R=0.45±0.09).These results suggest that 5K-HA-HPPS injection combined with PAM provides a powerful tool for distinguishing metastatic SLNs from pLNs and inflamed LNs,thus guiding the removal of SLNs during breast cancer surgery.

关键词： breast injection cancer

Bessel-Beam Photoacoustic Microscopical Simulation Platform Based on k-Wave

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Optics and Photonics Journal 2020年第6期10卷 111-116页

作者： Xianlin Song jianshuang wei School of Information Engineering Nanchang University Nanchang China Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan China

We developed a Bessel-beam photoacoustic microscopical simulation platform by using the k-Wave: MATLAB toolbox. The simulation platform uses the ring slit method to generate Bessel beam. By controlling the inner and outer radius of the ring slit, the depth-of-field (DoF) of Bessel beam can be controlled. And the large volumetric image is obtained by point scanning. The simulation experiments on blood vessels were carried out to demonstrate the feasibility of the simulation platform. This simulation work can be used as an auxiliary tool for the research of Bessel-beam photoacoustic microscopy.

关键词： k-Wave Bessel Beam Photoacoustic Microscope

Simulation Platform of Multi-Pulse Photoacoustic Microscopy Based on K-Space Pseudospectral Method

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Journal of Applied Mathematics and Physics 2020年第11期8卷 2540-2548页

作者： Xianlin Song jianshuang wei Jianmin Xiong Lingfang Song School of Information Engineering Nanchang University Nanchang China Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology Wuhan China Moe Key Laboratory of Biomedical Photonics of Ministry of Education Department of Biomedical Engineering Huazhong University of Science and Technology Wuhan China Nanchang Normal University Nanchang China

Photoacoustic imaging has emerged in the past decades. Compared with the traditional medical imaging mode, it has better imaging performance and has great development potential in the field of biological imaging. In traditional photoacoustic microscopy, a single laser pulse is generally used to irradiate the sample to produce photoacoustic signal. And sig-nal-to-noise ratio (SNR) is a very important indicator for photoacoustic im-aging. In order to obtain the image with high SNR, multiple acquisition or increasing laser pulse energy is usually adopted. The former will lead to slower imaging speed, and the latter will lead to photobleaching or pho-totoxicity. Here, we propose multi-pulse photoacoustic microscopy, the photoacoustic signals were stimulated sequentially using multiple laser pulses in each A line data acquisition. In order to verify the feasibility of this method, a multi-pulse photoacoustic imaging simulation platform is established using k-Wave toolbox. The performance of multi-pulse photo-acoustic imaging is verified through the three scanning modes of photoa-coustic microscopy A-scan, B-scan, and C-scan. The results indicate that the SNR is proportion to the number of laser pulses used, high SNR can be achieved by low-energy laser pulse. This work will help to expand the ap-plication of photoacoustic imaging.

关键词： Photoacoustic Microscopy Multiple Laser Pulses Signal-to-Noise Ratio K-Wave

Simulation Platform of Multi-Pulse Photoacoustic Microscopy Based on K-Space Pseudospectral Method

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Simulation Platform of Multi-Pulse Photoacoustic Microscopy ...

基于COMSOL的乳腺癌光热成像的可视化研究

作者： Xianlin Song jianshuang wei Jianmin Xiong Lingfang Song School of Information Engineering Nanchang University Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology Moe Key Laboratory of Biomedical Photonics of Ministry of Education Department of Biomedical EngineeringHuazhong University of Science and Technology Nanchang Normal University

Photoacoustic imaging has emerged in the past decades. Compared with the traditional medical imaging mode, it has better imaging performance and has great development potential in the field of biological imaging. In traditional photoacoustic microscopy, a single laser pulse is generally used to irradiate the sample to produce photoacoustic signal. And signal-to-noise ratio（SNR） is a very important indicator for photoacoustic imaging. In order to obtain the image with high SNR, multiple acquisition or increasing laser pulse energy is usually adopted. The former will lead to slower imaging speed, and the latter will lead to photobleaching or phototoxicity. Here, we propose multi-pulse photoacoustic microscopy, the photoacoustic signals were stimulated sequentially using multiple laser pulses in each A line data acquisition. In order to verify the feasibility of this method, a multi-pulse photoacoustic imaging simulation platform is established using k-Wave toolbox. The performance of multi-pulse photoacoustic imaging is verified through the three scanning modes of photoacoustic microscopy A-scan, B-scan, and C-scan. The results indicate that the SNR is proportion to the number of laser pulses used, high SNR can be achieved by low-energy laser pulse. This work will help to expand the application of photoacoustic imaging.

关键词： Photoacoustic Microscopy Multiple Laser Pulses Signal-to-Noise Ratio K-Wave

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华中科技大学学报（自然科学版） 2022年第5期50卷 84-88页

作者：宋贤林李昱黎魏剑霜赖叶平南昌大学信息工程学院江西南昌330031 南昌大学高等研究院江西南昌330031 华中科技大学武汉光电国家研究中心湖北武汉430074

利用有限元模拟软件COMSOL Multiphysics设计了乳腺癌光热成像可视化模型,该模型研究了光在乳腺癌患者乳房中的传播和热传递情况.首先构建了乳房的简化模型并进行网格划分,随后对COMSOL中系数形式偏微分方程和生物传热模块进行耦合.将... 详细信息

利用有限元模拟软件COMSOL Multiphysics设计了乳腺癌光热成像可视化模型,该模型研究了光在乳腺癌患者乳房中的传播和热传递情况.首先构建了乳房的简化模型并进行网格划分,随后对COMSOL中系数形式偏微分方程和生物传热模块进行耦合.将系数形式偏微分方程简化近似为亥姆霍兹方程,对光在乳房及肿瘤中的传播进行可视化模拟,生物传热模块对光能量吸收导致的温度变化进行可视化.仿真结果表明:肿瘤处剩余光能量约为周围乳房组织剩余光能量的1.524%.肿瘤吸收的更多光能量导致其温度显著高于周围乳房组织的温度,温度差约为0.06 K.肿瘤中心的温度低于肿瘤边缘的温度,同时肿瘤靠近光源一侧的温度高于远离光源一侧的温度.该研究有助于理解光在人体乳房和乳腺肿瘤中的传播及相互作用,对乳腺癌的光热治疗有一定指导意义.

关键词：光热成像乳腺癌 COMSOL 光沉积热传递可视化

Glycnsisitin A:A promising bicyclic peptide against heart failure that facilitates TFRCmediated uptake of iron in cardiomyocytes

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3125-3139页

作者： Jichao Zhou Yuanyuan Liu Xiaoli wei Meng Yuan Xu Zhang Lingfeng Qin Bing Cui Pingping Li Jing Zhang Ziming Feng jianshuang Jiang Xiang Yuan Ruibing Xu Zhimeng Zhang Peicheng Zhang Xiaowei Zhang Yanan Yang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Zhigancao decoction is a traditional prescription for treating irregular pulse and palpitations in *** the monarch drug of Zhigancao decoction,the bioactive molecules of licorice against heart diseases remain *** established the HRESIMS-guided method leading to the isolation of three novel bicyclic peptides,glycnsisitins A-C(1-3),with distinctive C-C and C-O-C side-chain-toside-chain linkages from the roots of Glycyrrhiza uralensis(Licorice).Glycnsisitin A demonstrated stronger cardioprotective activity than glycnsisitins B and C in an in vitro model of doxorubicin(DOX)-induced cardiomyocyte *** A treatment not only reduced the mortality of heart failure(HF)mice in a dose-dependent manner but also significantly attenuated DOX-induced cardiac dysfunction and myocardial *** set enrichment analysis(GSEA)of the differentially expressed genes indicated that the cardioprotective effect of glycnsisitin A was mainly attributed to its ability to maintain iron homeostasis in the ***,glycnsisitin A interacted with transferrin and facilitated its binding to the transferrin receptor(TFRC),which caused increased uptake of iron in *** findings highlight the key role of bicyclic peptides as bioactive molecules of Zhigancao decoction for the treatment of HF,and glycnsisitin A constitutes a promising therapeutic agent for the treatment of HF.

关键词： Glycyrrhiza uralensis Bicyclic peptides Myocardial energy metabolism Iron homeostasis TFRC

Visualization of Interaction of Laser Pulse-Gastric Tumor by COMSOL Based on Finite Element Analysis

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Visualization of Interaction of Laser Pulse-Gastric Tumor by...

Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activities

作者： Xianlin Song Ao Teng jianshuang wei Hao Chen Yang Zhao Jianheng Chen Fangwei Liu Qianxiang Wan Guoning Huang Lingfang Song Aojie Zhao Bo Li Zihao Li Qiming He Jinhong Zhang School of Information Engineering Nanchang University Institute for Advanced Study Nanchang University Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology Moe Key Laboratory of Biomedical Photonics of Ministry of Education Department of Biomedical EngineeringHuazhong University of Science and Technology School of Software Nanchang University Nanchang Normal University

Photoacoustic imaging is an emerging technology based on the photoacoustic effect that has developed rapidly in recent years. It combines the high contrast of optical imaging and the high penetration and high resolution of acoustic imaging. As a non-destructive biological tissue imaging technology, photoacoustic imaging has important application value in the field of biomedicine. With its high efficiency bioimaging capabilities and excellent biosafety performance, it has been favored by researchers. The visualization of photoacoustic imaging has great research significance in the early diagnosis of some diseases, especially tumors. In photoacoustic imaging, light transmission and thermal effects are important processes. This article is based on COMSOL software and uses finite element analysis to construct a physical model for simulation. Through laser pulses into the stomach tissue containing tumor, the physical process of light transmission and biological heat transfer was studied, and a photothermal model composed of two physical fields was built, and finally a series of visualization graphics were obtained. This work has certain theoretical guiding significance for further promoting the application of photoacoustic imaging in the field of biomedicine.

关键词： Photoacoustic Imaging Finite Element Analysis Gastric Tumor Biological Heat Transfer

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Acta Pharmaceutica Sinica B 2017年第4期7卷 491-495页

作者： Yanan Yang Yawen An wei Wang Ning Du Jinghua Zhang Ziming Feng jianshuang Jiang Peicheng Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Beijing Centre for Physical and Chemical Analysis Beijing 100089China

Two new compounds, named lyciumlignan D(1) and lyciumphenyl propanoid A(2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic data(UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds 3–9 were isolated from this genus for the first time. In the in vitro assay, compounds 3, 6, and 7 exhibited stronger anti-inflammatory effects than the positive control curcumin at a concentration of 10 μmol/L.

关键词： Lycium chinense Lyciumlignan D Lyciumphenyl propanoid A Structure elucidation Anti-inflammatory effect

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从特色田园乡村实践探讨我国乡村振兴的路径

城市规划 2020年第11期44卷 97-105页

作者：张伟徐宁胡剑双江苏省规划设计集团有限公司党委江苏省城镇与乡村规划设计院

文章回顾了新世纪以来中国乡村发展的顶层政策设计,以及乡村规划建设的实践历程,认为乡村振兴战略的提出正是基于新时代城镇化与城乡关系发展的必然结果。同时,基于乡村发展的困境是一个全球城镇化、现代化发展面临的共性问题,通过对国... 详细信息

文章回顾了新世纪以来中国乡村发展的顶层政策设计,以及乡村规划建设的实践历程,认为乡村振兴战略的提出正是基于新时代城镇化与城乡关系发展的必然结果。同时,基于乡村发展的困境是一个全球城镇化、现代化发展面临的共性问题,通过对国际乡村发展的实践经验认识,提出了可供中国乡村发展借鉴的经验。江苏省正是基于国家乡村振兴战略的大背景,提出开展特色田园乡村建设实践,在乡村环境改善、人居品质提升、集体资产增值和农民家庭增收等方面取得了突出成效,并且在组织模式、发展模式、设计模式和建设模式形成较为全面系统的一整套做法。文章还通过江苏特色田园乡村建设的过程,梳理出在推进乡村振兴中,应积极引导城乡要素流动,促进城乡互动,推动由点及面,走向区域一体化,充分发挥各类主体作用,推动协同共享,建设高质量品质社区,实现治理有效等经验,为探索中国乡村振兴路径提供“江苏经验”,以期为全国其他地区推进乡村振兴提供借鉴。

关键词：乡村振兴特色田园乡村实践路径

系统参数标定过程对多边坐标测量系统测量不确定度的影响

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仪器仪表学报 2020年第11期41卷 50-57页

作者：孙威缪东晶李建双姚燕钟文中国计量大学计量测试工程学院杭州310018 中国计量科学研究院北京100029

坐标测量结果的不确定度评定是多边坐标测量系统待解决的关键问题之一。实际应用中,系统通常需标定系统参数后再进行测量,因此系统参数标定过程会对测量结果产生重要影响,但目前还缺乏相关研究。为了对其准确评定,建立了多边坐标测量模... 详细信息

坐标测量结果的不确定度评定是多边坐标测量系统待解决的关键问题之一。实际应用中,系统通常需标定系统参数后再进行测量,因此系统参数标定过程会对测量结果产生重要影响,但目前还缺乏相关研究。为了对其准确评定,建立了多边坐标测量模型,分析了测量不确定度的空间分布特性,重点研究了系统参数标定的影响并评定了整体测量不确定度。结果表明,目标点的x坐标、y坐标、z坐标测量不确定度分别优于0.004 0 mm、0.003 8 mm、0.005 3 mm,且测量不确定度的空间分布呈现径向、轴向不同的特点。进行了坐标测量精度验证实验,结果表明,两目标点间测距量不确定度优于0.005 3 mm,各组En值均小于1,验证了评定结果的准确性。研究了各不确定度分量对总体测量不确定度的影响,其不确定性主要来源是反射镜的光学中心偏差以及系统参数标定不确定度,表明系统参数标定过程对多边坐标测量系统测量不确定度的影响不容忽视。

关键词：系统参数标定多边法坐标测量不确定度评定