Simulation Platform of Multi-Pulse Photoacoustic Microscopy Based on K-Space Pseudospectral Method
作者单位：School of Information EngineeringNanchang University Britton Chance Center for Biomedical PhotonicsWuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology Moe Key Laboratory of Biomedical Photonics of Ministry of EducationDepartment of Biomedical EngineeringHuazhong University of Science and Technology Nanchang Normal University
会议日期：2021年
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1002[医学-临床医学] 07[理学] 08[工学] 082403[工学-水声工程] 1010[医学-医学技术（可授医学、理学学位）] 070206[理学-声学] 0824[工学-船舶与海洋工程] 10[医学] 0702[理学-物理学]
关 键 词：Photoacoustic Microscopy Multiple Laser Pulses Signal-to-Noise Ratio K-Wave
摘 要：Photoacoustic imaging has emerged in the past decades. Compared with the traditional medical imaging mode, it has better imaging performance and has great development potential in the field of biological imaging. In traditional photoacoustic microscopy, a single laser pulse is generally used to irradiate the sample to produce photoacoustic signal. And signal-to-noise ratio（SNR） is a very important indicator for photoacoustic imaging. In order to obtain the image with high SNR, multiple acquisition or increasing laser pulse energy is usually adopted. The former will lead to slower imaging speed, and the latter will lead to photobleaching or phototoxicity. Here, we propose multi-pulse photoacoustic microscopy, the photoacoustic signals were stimulated sequentially using multiple laser pulses in each A line data acquisition. In order to verify the feasibility of this method, a multi-pulse photoacoustic imaging simulation platform is established using k-Wave toolbox. The performance of multi-pulse photoacoustic imaging is verified through the three scanning modes of photoacoustic microscopy A-scan, B-scan, and C-scan. The results indicate that the SNR is proportion to the number of laser pulses used, high SNR can be achieved by low-energy laser pulse. This work will help to expand the application of photoacoustic imaging.