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基于MaxEnt模型的广东省红豆属植物潜在适生区研究

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广西科学 2024年第1期31卷 149-166页

作者：姜垒胡喻华吴玉芬梁键明蒋庆莲张铭谭淦何春梅韦霄施诗唐光大华南农业大学林学与风景园林学院广东广州510642 广东省林业科学研究院广东广州510520 广东省林业调查规划院广东广州510520 广西壮族自治区中国科学院广西植物研究所广西桂林541006

为了解气候变化情景下广东省红豆属(Ormosia)潜在适生区的变化,探究影响红豆属植物潜在适生区的主导环境因子,本研究基于MaxEnt模型和ArcGIS 10.8软件,利用17种红豆属植物的分布数据及22个环境变量数据,结合未来共享社会经济路径(SSP126... 详细信息

为了解气候变化情景下广东省红豆属(Ormosia)潜在适生区的变化,探究影响红豆属植物潜在适生区的主导环境因子,本研究基于MaxEnt模型和ArcGIS 10.8软件,利用17种红豆属植物的分布数据及22个环境变量数据,结合未来共享社会经济路径(SSP126、SSP585)的气候情景,分别预测红豆属植物在当前和未来气候场景下的潜在适生区分布情况。结果表明:(1)适生区预测模型的评价效果良好,受试者工作特征曲线(Receiver Operating Characteristic curve,ROC曲线)下面积(AUC平均值)均为0.8-1.0。(2)在当前气候情景下,大面积(占广东省面积的40%-100%)适生的红豆属植物有茸荚红豆(Ormosia pachycarpa)等3种;中等面积(占20%-40%)适生的有薄毛茸荚红豆(*** ***)等6种;小面积(占5%-20%)适生的有韧荚红豆(***)等4种;极小面积(占0%-5%)适生的有凹叶红豆(***)等4种。其中面积占比最大的是茸荚红豆,总适生面积为15.2288×10^(4) km^(2)(占84.75%);面积占比最小的是博罗红豆(***),总适生面积为0.0337×10^(4) km^(2)(占0.19%)。(3)降水和海拔对红豆属植物的分布起主导作用:12种红豆属植物适生区的主导环境因子为气候因子(9个降水因子,3个温度因子),剩余5种的主导环境因子是高程海拔因子(5个海拔因子)。(4)在未来(SSP126、SSP585)的气候情景下,潜在适生区面积增加的红豆属植物有凹叶红豆等4种,增加幅度为0.79%-42.43%;面积减小的红豆属植物有博罗红豆等13种,减少幅度为1.30%-78.56%。气候变暖对红豆属的潜在分布区具有一定的消极影响,17种红豆属植物中有13种的适生区面积将减少,特别是几个狭域分布的物种:博罗红豆、锈枝红豆(***)、小叶红豆(***)、紫花红豆(***)和亮毛红豆(***),它们应是红豆属就地保护和迁地保护优先考虑的类群。

关键词：红豆属气候变化 MaxEnt模型潜在适生区主导因子广东省

Genetic Analysis of Structural Styles in the Makran Accretionary Wedge–Insight from Physical Simulations

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Journal of Ocean University of China 2024年第1期23卷 157-172页

作者： SHAO Longfei YU Fusheng GONG jianming LIAO Jing YU Zhifeng TANG liang CHEN Jiangong WANG Yuefeng NENG Yuan School of Earth Sciences China University of PetroleumBeijing 102249China State Key Laboratory of Petroleum Resources and Processing China University of PetroleumBeijing 102249China Qingdao Institute of Marine Geology China Geological SurveyQingdao 266071China China University of Petroleum–Beijing at Karamay Karamay 834000China

The Makran accretionary wedge has the smallest subduction angle among any accretionary prism in the world. The factors controlling the spacing and morphological development of its deep thrust faults, as well as the formation mechanism of shallow normal faults, remain unclear. Meanwhile, the factors affecting the continuity of plane faults must be comprehensively discussed. Clarifying the development characteristics and deformation mechanisms of the Makran accretionary wedge is crucial to effectively guide the exploration of gas hydrate deposits in the area. This study aims to interpret seismic data to identify typical structures in the Makran accretionary wedge, including deep imbricate thrust faults, shallow and small normal faults, wedge-shaped piggyback basins, mud diapirs with fuzzy and disorderly characteristics of reflection, décollements with a northward tilt of 1° – 2°, and large seamounts. Physical simulation-based experiments are performed to comprehensively analyze the results of the plane, section, and slices of the wedge. Results reveal that the distances between and shapes of thrust faults in the deep parts of the Makran accretionary wedge are controlled by the bottom décollement. The uplift of the thrust fault-related folds and the upwelling of the mud diapirs primarily contribute to the formation of small normal faults in the shallow part of the area. The mud diapirs originate from plastic material at the bottom, while those that have developed in the area near the trench are larger. Seamounts and mud diapirs break the continuity of fault plane distribution.

关键词： Makran accretionary wedge structural styles faults distribution physical simulation

Corrosion Evolution of High-Strength Aluminum Alloys in the Simulated Service Environment of Amphibious Aircraft in the Presence of Chloride and Bisulfite

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Acta Metallurgica Sinica(English Letters) 2021年第12期34卷 1679-1694页

作者： Feng Ge Lin Fan jianming liang Kun Pang Han Li Xin Wang Zhongyu Cui School of Materials Science and Engineering Ocean University of ChinaQingdao 266100China State Key Laboratory for Marine Corrosion and Protection Luoyang Ship Material Research Institute(LSMRI)Qingdao 266237China

The corrosion evolution of 2024-T351 and 7075-T651 aluminum alloys in the thin electrolyte layer(TEL)and wet-dry alternating cycle(WDAC)environment is studied in this *** results show that in the TEL environment,the competitive effect between H+that accelerates corrosion reactions and deposition of aluminum sulfate that impedes corrosion attacks exists during the corrosion *** difference is that with increasing HSO_(3)^(-),subsurface intergranular corrosion on 2024-T351 is promoted to form exfoliation corrosion eventually and the degree of exfoliation corrosion begins to decrease because the blocking effect of aluminum sulfate exceeds the expediting effect of H+.For 7075-T651,the corrosion area and the corrosion diameter decrease gradually,which is attributed to the HSO_(3)^(-)-enhanced deposition of corrosion products and their blocking *** the WDAC environment,the corrosion processes of 2024-T351 and 7075-T651 are the acidic dissolution of the matrix during the soaking *** the HSO_(3)^(-)concentration is high enough(0.1 M),the inhibiting effect of aluminum sulfate becomes the dominant factor.

关键词： High-strength aluminum alloy Atmospheric corrosion HSO_(3)^(-) Intergranular corrosion Exfoliation corrosion

Winter wheat mapping using a random forest classifier combined with multi-temporal and multi-sensor data

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International Journal of Digital Earth 2018年第8期11卷 783-802页

作者： Jiantao Liu Quanlong Feng Jianhua Gong Jieping Zhou jianming liang Yi Li State Key Laboratory of Remote Sensing Science Institute of Remote Sensing and Digital EarthChinese Academy of SciencesBeijingPeople’s Republic of China University of Chinese Academy of Sciences BeijingPeople’s Republic of China Beijing Piesat Information Technology Co. Ltd.BeijingPeople’s Republic of China Zhejiang-CAS Application Center for Geoinformatics JiashanPeople’s Republic of China School of Life Sciences Arizona State UniversityTempeAZUSA

Wheat is a major staple food crop in *** and cost-effective wheat mapping is exceedingly critical for food production management,food security warnings,and food trade policy-making in *** reduce confusion between wheat and non-wheat crops for accurate growth stage wheat mapping,we present a novel approach that combines a random forest(RF)classifier with multi-sensor and multi-temporal image *** study aims to(1)determine whether an RF combined with multi-sensor and multi-temporal imagery can achieve accurate winter wheat mapping,(2)to find out whether the proposed approach can provide improved performance over the traditional classifiers,and(3)examine the feasibility of deriving reliable estimates of winter wheat-growing areas from medium-resolution remotely sensed *** wheat mapping experiments were conducted in Boxing *** experimental results suggest that the proposed method can achieve good performance,with an overall accuracy of 92.9%and a kappa coefficient(κ)of *** winter wheat acreage was estimated at 33,895.71 ha with a relative error of only 9.3%.The effectiveness and feasibility of the proposed approach has been evaluated through comparison with other image classification *** conclude that the proposed approach can provide accurate delineation of winter wheat areas.

关键词： Winter wheat random forest phenology Landsat-8 GF-1

A novel tumor-targeting treatment strategy uses energy restriction via co-delivery of albendazole and nanosilver

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Nano Research 2018年第9期11卷 4507-4523页

作者： jianming liang Ruixiang Li Yuwei He Chengli Ling Qi Wang Yongzhuo Huang Jing Qin Weigen Lu Jianxin Wang Department of Pharmaceutics School of Pharmacy Fudan University & Key Laboratory of Smart Drug Delivery Ministry of Education Shanghai 201203 China Institute of Clinical Pharmacology Guangzhou University of Traditional Chinese Medicine Guangzhou 510006 China Shanghai Institute of Materia Medica Chinese Academy of Sciences 501 Haike Rd. Shanghai201203 China Shanghailnstitute of Pharmaceuticallndustry China State Institute of Pharmaceutical Industry 285 Gebaini Rd. Shanghai201203 China School of Pharmacy Chengdu University of Traditional Chinese Medicine No 1166 Liu TaiAvenue Wenjiang District Chengdu 610072 China

Although nanotechnology has been rapidly developed and applied in tumor targeting, the outcome of chemotherapy remains greatly restricted by the toxicity of cytotoxic drugs in normal tissues and cells. Therefore, the development of alternative delivery systems, with few side effects in normal cells, has attracted increasing attention. Energy restriction is a novel and promising approach to cancer treatment, which can restrict tumor growth via inhibition of cellular energy metabolism. In this study, a novel tumor targeting system, based on folate-conjugated bovine serum albumin （BSA）, was developed to co-deliver albendazole and nanosilver simultaneously, to restrain the energy metabolism of tumor cells. This nanosystem showed stronger anti-tumor efficacy than those using nanoparticles without folic acid modification, nanosilver, or albendazole, both in vitro and in vivo. This nanosystem depleted cellular ATP via direct inhibition of glycolytic enzymes and mitochondrial damage, resulting in inhibition of proliferation, cell-cycle arrest, and apoptosis of tumor cells. The enhanced anti-tumor activity contributed to the tumor-targeting ability of this system, resulting in specific energy inhibition in tumor cells. Toxicity evaluation was performed to confirm the safety of this system. This nanosystem provides an efficient and safe strate~ for tumor therapy.

关键词： albendazole nano silver co-delivery tumor targeting energy metabolism

Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid arthritis

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Nano Research 2018年第11期11卷 6086-6101页

作者： Yuwei He Ruixiang Li jianming liang Ying Zhu Shuya Zhang Zicong Zheng Jing Qin Zhiqing Pang Jianxin Wang Department of Pharmaceutics School of Pharmacy Fudan University & Key Laboratory of Smart Drug Delivery Ministry of Education Shanghai 201203 China Institute of Clinical Pharmacology Guangzhou University of Traditional Chinese Medicine Guangzhou 510006 China

The effective drug treatment of rheumatoid arthritis (RA) is hindered by poor delivery efficiency to the diseased site and the serious side effects caused by wide-spread drug distribution. Traditional drug-targeting strategies, such as ligand modification, are complex, laborious, and inefficient. Inspired by the intrinsic relationship between platelets and RA, platelet-mimetic nanoparticles (PNPs) were developed for targeted drug delivery in RA. Through platelet receptor-mediated adhesion, an intact platelet membrane was coated onto poly (lactic-co-glycolic acid) nanoparticles, endowing the resulting PNPs with various functional receptors. By coating with platelet membranes, the nanoparticles were stabilized and had a better circulation profile, providing a benefit for passive targeting. In vitro binding of PNPs to inflamed endothelium, and in vivo accumulation in joints of a collagen-induced arthritis (CIA) mouse model of RA were significantly improved via P-selectin and GVPI recognition, indicating that the PNPs could effectively target to RA tissues through multiple mechanisms, similar to natural platelets. Moreover, FK506, a model drug, was loaded into the PNPs and used to treat RA. Pharmacodynamic studies demonstrated that the FK506-PNPs had a notable anti-arthritic effect in CIA mice. This study provides a new biomimetic targeting strategy with great potential for the treatment of RA.

关键词： biomimetic nanoparticles platelet membrane rheumatoid arthritis targeted drug delivery

Logical Framework for Deepening International Energy Cooperation from the Perspective of Project Practice

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China Oil & Gas 2024年第3期31卷 36-41页

作者： Cong Wei liang Dong Li Longfei Wang jianming CNOOC Energy Economics Institute Global Energy Interconnection Development and Cooperation Organization 不详

Energy cooperation is a key area in the joint construction of the Belt and Road *** deepen international energy cooperation,it is advisable to place greater emphasis on whole life cycle and systematic planning in project collaboration,government-led initiatives with businesses playing a central role,alongside coordination with non-governmental international institutions,and comprehensive integration of resources.

关键词： cooperation coordination comprehensive

Menthol-modified casein nanoparticles loading 10-hydroxycamptothecin for glioma targeting therapy

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Acta Pharmaceutica Sinica B 2019年第4期9卷 843-857页

作者： Caifang Gao jianming liang Ying Zhu Chengli Ling Zhekang Cheng Ruixiang Li Jing Qin Weigen Lu Jianxin Wang Department of Pharmaceutics School of PharmacyFudan University&Key Laboratory of Smart Drug DeliveryMinistry of EducationShanghai 201203China Shanghai Institute of Pharmaceutical Industry China State Institute of Pharmaceutical IndustryShanghai 201203China Guangzhou University of Chinese Medicine Guangzhou 510006China School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China School of Pharmacy Minzu University of ChinaBeijing 100081China

Chemotherapy outcomes for the treatment of glioma remains unsatisfactory due to the inefficient drug transport across the blood–brain barrier(BBB) and insufficient drug accumulation in the tumor region. Although many approaches, including various nanosystems, have been developed to promote the distribution of chemotherapeutics in the brain tumor, the delivery efficiency and the possible damage to the normal brain function still greatly restrict the clinical application of the ***, it is urgent and necessary to discover more safe and effective BBB penetration and gliomatargeting strategies. In the present study, menthol, one of the strongest BBB penetration enhancers screened from traditional Chinese medicine, was conjugated to casein, a natural food protein with brain targeting capability. Then the conjugate self-assembled into the nanoparticles to load anti-cancer *** nanoparticles were characterized to have appropriate size, spheroid shape and high loading drug capacity. Tumor spheroid penetration experiments demonstrated that penetration ability of mentholmodified casein nanoparticles(M-CA-NP) into the tumor were much deeper than that of unmodified nanoparticles. In vivo imaging further verified that M-CA-NPs exhibited higher brain tumor distribution than unmodified nanoparticles. The median survival time of glioma-bearing mice treated with HCPT-MCA-NPs was significantly prolonged than those treated with free HCPT or HCPT-CA-NPs. HE staining ofthe organs indicated the safety of the nanoparticles. Therefore, the study combined the advantages of traditional Chinese medicine strategy with modern delivery technology for brain targeting, and provide a safe and effective approach for glioma therapy.

关键词： Glioma Casein Menthol Nanoparticles Brain targeting Blood–brain barrier 10-Hydroxycamptothecin

One Stone Four Birds:A Novel Liposomal Delivery System Multi-functionalized with Ginsenoside Rh2 for Tumor Targeting Therapy

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Nano-Micro Letters 2020年第10期12卷 69-86页

作者： Chao Hong jianming liang Jiaxuan Xia Ying Zhu Yizhen Guo Anni Wang Chunyi Lu Hongwei Ren Chen Chen Shiyi Li Dan Wang Huaxing Zhan Jianxin Wang Department of Pharmaceutics School of PharmacyFudan University&Key Laboratory of Smart Drug DeliveryMinistry of EducationShanghai 201203People’s Republic of China Institute of Tropical Medicine Guangzhou University of Chinese MedicineGuangzhou 510006People’s Republic of China Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhou 510006People’s Republic of China School of Pharmacy Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Shanghai Ginposome Pharmatech Co. LtdShanghai 201600People’s Republic of China Institute of Integrated Chinese and Western Medicine Fudan UniversityShanghai 200040People’s Republic of China

Liposomes hold great potential in anti-cancer drug delivery and the targeting treatment of ***,the clinical therapeutic efficacy of liposomes is still limited by the complexity of tumor microenvironment(TME)and the insufficient accumulation in tumor ***,the application of cholesterol and polyethylene glycol(PEG),which are usually used to prolong the blood circulation and stabilize the structure of liposomes respectively,has been questioned due to various ***,we developed a ginsenoside Rh2-based multifunctional liposome system(Rh2-lipo)to effectively address these challenges once for *** with the conventional’wooden’liposomes,Rh2-lipo is a much more brilliant carrier with multiple *** Rh2-lipo,both cholesterol and PEG were substituted by Rh2,which works as membrane stabilizer,long-circulating stealther,active targeting ligand,and chemotherapy adjuvant at the same ***,Rh2 could keep the stability of liposomes and avoid the shortcomings caused by ***,Rh2-lipo showed a specifically prolonged circulation behavior in the ***,the accumulation of the liposomes in the tumor was significantly enhanced by the interaction of glucose transporter of tumor cells with ***,Rh2-lipo could remodel the structure and reverse the immunosuppressive environment in *** tested in a 4T1 breast carcinoma xenograft model,the paclitaxel-loaded Rh2-lipo realized high efficient tumor growth ***,Rh2-lipo not only innovatively challenges the position of cholesterol as a liposome component,but also provides another innovative potential system with multiple functions for anti-cancer drug delivery.

关键词： Ginsenoside Rh2 Liposomes Cholesterol Multifunction Tumor targeting