检索结果-南通市图书馆

Journal of Advanced Ceramics 2020年第6期9卷 726-738页

作者： Hao WANG Fuming ZHOU jianming guo Yuanyuan ZHANG Hui YANG Qilong ZHANG School of Materials Science and Engineering State Key Laboratory of Silicon MaterialsZhejiang UniversityHangzhou 310027China Jiaxing Glead Electronics Co. Ltd.Jiaxing 314003China

Polymer-ceramic composites are widely applied in microwave substrate materials due to the excellent dielectric properties and simple preparation process ***-based(PTFE)composites filled with Zn_(0.5)Ti_(0.5)NbO_(4)(ZTN)ceramic particles were fabricated by *** particles were modified by C_(14)H_(19)F_(13)O_(3)Si to enhance the interface compatibility between PTFE and ZTN powders,which was characterized by X-ray photoelectron spectroscopy(XPS)and contact *** surface characteristic of particles transformed into hydrophobicity and tight microstructure as well as better dielectric properties were obtained after the surface *** microstructure,dielectric,thermal,mechanical properties,and water absorption of the composites concerning ZTN content were *** ZTN/PTFE composites with 50 vol% ZTN particles exhibit excellent dielectric properties with a high dielectric constant of 8.3,an extremely low dielectric loss of 0.00055 at 7 GHz,and a stable temperature coefficient of the dielectric constant of-12.2 ppm/℃.All the properties show modified ZTN particles filled PTFE composite is the potential material for microwave substrate application.

关键词： composites dielectric properties niobium substrate

Abelmoschus manihot polysaccharide fortifies intestinal mucus barrier to alleviate intestinal inflammation by modulating Akkermansia muciniphila abundance

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第9期14卷 3901-3915页

作者： Yumeng Wang Chengxi Li Jianping Li Shu Zhang Qinyu Zhang Jinao Duan jianming guo Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization Nanjing University of Chinese MedicineNanjing 210023China Jiangsu Key Laboratory for High Technology Research of TCM Formulae Nanjing University of Chinese MedicineNanjing 210023China

The intestinal mucus barrier is an important line of defense against gut *** to this barrier brings bacteria into close contact with the epithelium,leading to intestinal ***,its restoration is a promising strategy for alleviating intestinal *** study showed that Abelmoschus manihot polysaccharide(AMP)fortifies the intestinal mucus barrier by increasing mucus production,which plays a crucial role in the AMP-mediated amelioration of ***-10-deficient mouse models demonstrated that the effect of AMP on mucus production is dependent on ***,bacterial depletion and replenishment confirmed that the effects of AMP on IL-10 secretion and mucus production were mediated by Akkermansia *** findings suggest that plant polysaccharides fortify the intestinal mucus barrier by maintaining homeostasis in the gut *** demonstrates that targeting mucus barrier is a promising strategy for treating intestinal inflammation.

关键词： Plant polysaccharide Abelmoschus manihot Intestinal inflammation Mucus barrier Interleukin 10 Gut microbiota A.muciniphila Mucin 2

Advances in the study of mitophagy in osteoarthritis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第3期25卷 197-211页

作者： Hong CAO Xuchang ZHOU Bowen XU Han HU jianming guo Miao WANG Nan LI Jun ZOU Department of Sport Rehabilitation Shanghai University of SportShanghai 200438China National Key Laboratory of Immunity and Inflammation Naval Medical UniversityShanghai 200433China School of Sport Medicine and Rehabilitation Beijing Sport UniversityBeijing 100084China

Osteoarthritis(OA),characterized by cartilage degeneration,synovial inflammation,and subchondral bone remodeling,is among the most common musculoskeletal disorders globally in people over 60 years of *** initiation and progression of OA involves the abnormal metabolism of chondrocytes as an important pathogenic *** degeneration features mitochondrial dysfunction as one of the important causative factors of abnormal chondrocyte ***,maintaining mitochondrial homeostasis is an important strategy to mitigate *** is a vital process for autophagosomes to target,engulf,and remove damaged and dysfunctional mitochondria,thereby maintaining mitochondrial *** studies have revealed a strong association between mitophagy and OA,suggesting that the regulation of mitophagy may be a novel therapeutic direction for *** reviewing the literature on mitophagy and OA published in recent years,this paper elaborates the potential mechanism of mitophagy regulating OA,thus providing a theoretical basis for studies related to mitophagy to develop new treatment options for OA.

关键词： Mitophagy Osteoarthritis Chondrocyte Mitochondria Apoptosis

Advances in the study of protein folding and endoplasmic reticulum-associated degradation in mammal cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第3期25卷 212-232页

作者： Hong CAO Xuchang ZHOU Bowen XU Han HU jianming guo Yuwei MA Miao WANG Nan LI Jun ZOU Department of Sport Rehabilitation Shanghai University of SportShanghai 200438China National Key Laboratory of Immunity and Inflammation Naval Medical UniversityShanghai 200433China

The endoplasmic reticulum is a key site for protein production and quality *** than one-third of proteins are synthesized and folded into the correct three-dimensional conformation in the endoplasmic ***,during protein folding,unfolded and/or misfolded proteins are prone to occur,which may lead to endoplasmic reticulum *** can monitor the quality of the proteins produced by endoplasmic reticulum quality control(ERQC)and endoplasmic reticulum-associated degradation(ERAD),which maintain endoplasmic reticulum protein homeostasis by degrading abnormally folded *** underlying mechanisms of protein folding and ERAD in mammals have not yet been fully ***,this paper reviews the process and function of protein folding and ERAD in mammalian cells,in order to help clinicians better understand the mechanism of ERAD and to provide a scientific reference for the treatment of diseases caused by abnormal ERAD.

关键词： Endoplasmic reticulum-associated degradation(ERAD) Protein folding Ubiquitination Retrotranslocation

An Efficient Probe for Bacterial Nitroreductase Imaging and Detection Based on NanoLuc-Furimazine Bioluminescent Pair

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2024年第12期42卷 1373-1380页

作者： Ximeng Shi Yumeng Wang Jiaoyang Yu Yating Yang Zecheng Jin Hanghang Wang Dalei Wu Wei Chen jianming guo Yinan Zhang Jiangsu Key LaboratoryforFunctional Substances of Chinese Medicine School of PharmacyNanjing Universityof Chinese MedicineNanjingJiangsu210023China Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization School of PharmacyNanjing University of ChineseMedicineNanjingJiangsu210023China Clinical Research Center the Second Hospital of NanjingAffiliated Hospital to Nanjing University of Chinese MedicineNanjingJiangsu210003China Key Laboratory of Resources Biology and Biotechnology in Western China Ministry of EducationCollege of Life SciencesNorthwestUniversityXi'anShaanxi710069China Helmholtz International Lab State Key Laboratoryof Microbial TechnologyShandong UniversityQingdaoShandong 266237China

Comprehensive SummaryThe detection of critical endogenous species, such as bacteria in microenvironments in the body, requires better imaging tools for visualization and monitoring of biological events. Bioluminescence imaging is the most popular strategy for obtaining real-time in living cells and organisms. Herein, we introduced a nitroaryl group on the C-3 position and a hydroxy group at the C-6 phenyl ring on furimazine to report the first bioluminescent probe (7) based on NanoLuc-furimazine bioluminescent pair for the detection of nitroreductase in bacteria. The probe, which possessed up to 560-fold intensity increase with a low detection limit of 16 ng/mL of nitroreductase, has the most efficient uncage efficiency in comparison with other bioluminescent congeners, thus enabling highly selective and sensitive visualization of NTR activity in a panel of clinical priority pathogens. Additionally, imaging of the recombinant strain as well as the NTR from mouse feces indicated the potential of this probe in the application of different mouse disease models.

关键词： Nitroreductase NanoLuc-furimazine Biosensors Analytical methods Luminescence Imaging agents

Immunogenicity of mucosal COVID-19 vaccine candidates based on the highly attenuated vesicular stomatitis virus vector(VSV_(MT))in golden syrian hamster

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2023年第12期13卷 4856-4874页

作者： Yong Ke En Zhang jianming guo Xiaoxiao Zhang Lei Wang Duo Chen Xinkui Fang Jianwei Zhu Feng Li Tao Sun Baohong Zhang Engineering Research Center of Cell&Therapeutic Antibody Ministry of EducationSchool of PharmacyShanghai Jiao Tong UniversityShanghai 200240China School of Agriculture and Biology Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Municipal Veterinary Key Laboratory Shanghai 200240China Shanghai Public Health Clinical Center Fudan UniveristyShanghai 201508China

COVID-19 is caused by coronavirus *** systemic vaccines generally pro-vide limited protection against viral replication and shedding within the *** VSV(rVSV)is an effective vector which inducing potent and comprehensive ***,there are two clinical trials investigating COVID-19vaccines based on VSV *** vaccines were developed with spike protein of WA1 which administrated *** intranasal route is ideal for activating mucosal immunity with VSV vector,safety is of ***,a highly attenuated rVSV with three amino acids mutations in matrix protein(VSV_(MT))was developed to construct safe mucosal vaccines against multiple SARS-CoV-2 variants of *** demonstrated that spike protein mutant lacking 21 amino acids in its cytoplasmic domain could rescue rVSV ***_(MT) indicated improved safeness compared with wild-type VSV as the vector encoding SARS-CoV-2 spike *** a single-dosed intranasal inoculation of rVSV_(ΔGMT)-S_(Δ21),potent SARS-CoV-2specific neutraliza-tion antibodies could be stimulated in animals,particularly in term of mucosal and cellular ***,the chimeric VSV encoding S_(Δ21) of Delta-variant can induce more potent immune responses compared with those encoding S_(Δ21) of Omicron-or ***_(MT) is a promising platform to develop a mucosal vaccine for countering COVID-19.

关键词： COVID-19 Vesicular stomatitisvirus Matrix protein mutant Mucosal Vaccine Spike protein Variants of concerns Intranasal inoculation Cellular immunity

可溶性ACE2水平与支原体肺炎病儿心肌损伤间关系的初步探讨

在线全文

学校读者我要写书评

暂无评论

安徽医药 2025年第1期29卷 118-122页

作者：郭建明刘春燕刘飞飞栗晓芳马俊帅马科中国人民解放军陆军第八十一集团军医院检验病理科河北张家口075000 任丘市人民医院急诊科河北沧州062550 河北北方学院附属第一医院检验科河北张家口075000

目的分析可溶性血管紧张素转换酶2(sACE2)水平与肺炎支原体肺炎(MPP)病儿心肌损伤的关系。方法收集2021年2月至2022年11月中国人民解放军陆军第八十一集团军医院收治的MPP病儿108例,根据病情严重程度分为重症MPP组30例和轻症MPP组78例,... 详细信息

目的分析可溶性血管紧张素转换酶2(sACE2)水平与肺炎支原体肺炎(MPP)病儿心肌损伤的关系。方法收集2021年2月至2022年11月中国人民解放军陆军第八十一集团军医院收治的MPP病儿108例,根据病情严重程度分为重症MPP组30例和轻症MPP组78例,选取同期健康体检儿童50例为对照组;根据MPP病儿是否发生心肌损伤分为发生组23例和未发生组85例。酶联免疫吸附测定检测血清sACE2水平;收集MPP病儿临床病历资料及生化指标水平,并进行组间比较;Pearson法分析sACE2与生化指标的相关性;logistic回归分析MPP病儿发生心肌损伤的影响因素;ROC曲线分析sACE2水平对MPP病儿发生心肌损伤的预测价值。结果重症MPP组、轻症MPP组、对照组儿童血清sACE2水平[(56.19±6.13)U/L、(42.36±6.02)U/L、(28.15±5.97)U/L]依次降低,心肌损伤发生组MPP病儿血清sACE2水平高于未发生组(P<0.05);发生组和未发生组MPP病儿发热程度、肺炎支原体(MP)抗体滴度、发热持续时间、大环内酯类药物使用时间、咳嗽性质、其他肺外并发症、胸片表现、心电图异常、C反应蛋白(CRP)、乳酸脱氢酶(LDH)、肌酸激酶同工酶(CK-MB)、磷酸肌酸激酶(CK)、红细胞分布宽度(RDW)、心肌肌钙蛋白(cTnI)、N-末端脑钠肽前体(NT-proBNP)、血小板计数(PLT)比较差异有统计学意义(P<0.05);sACE2水平与LDH、NT-proBNP、cTnI、CK、RDW、CRP呈正相关,与PLT呈负相关(P<0.05);sACE2、CK-MB是MPP病儿发生心肌损伤的影响因素(P<0.05);sACE2水平评估MPP病儿发生心肌损伤的AUC为0.94[95%CI:(0.88,0.98)],灵敏度和特异度分别为86.96%和85.88%。结论sACE2水平与MPP病儿心肌损伤具有密切关系,是MPP病儿发生心肌损伤的影响因素,对心肌损伤的发生具有一定预测价值。

关键词：肺炎,支原体可溶性血管紧张素转换酶2 心肌损伤影响因素预测价值

同方期刊数据库

Preliminary experience of the side effects in the BCGtreating non-muscule invasive bladder cancer

在线全文

学校读者我要写书评

暂无评论

Preliminary experience of the side effects in the BCGtreatin...

A novel in vitro prognostic model of bladder cancer based on urine-derived living tumor cells

中国中西医结合学会泌尿外科专业委员会第十四次全国学术会议暨2016年广东省中西医结合学会泌尿外科专业委员会学术年会

作者： Shuai Jiang jianming guo Urology Department of Zhongshan hospital Fudan University

Objective:To study the side effects of BCG treating non-muscule invasive bladder ***:Retrospective analysis of 20 cases ofB CG treating non-muscule invasive bladder *** patients were admitted from September 2015 to Ju...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Genes & Diseases 2023年第6期10卷 2586-2596页

作者： Jiaqi Wang Jiying Zhu Junchi Hu Ziruoyu Wang Xiaobo Wang Jianbo Pan Yiwei Chu Zengxia Li Wei Jiang Chunmin Liang Jun Hou jianming guo Yongjun Dang Shuai Jiang Key Laboratory of Metabolism and Molecular Medicine Ministry of Education and Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesFudan UniversityShanghai 200032China Department of Immunology School of Basic Medical SciencesFudan UniversityShanghai 200032China Laboratory of Tumor Immunology Department of AnatomyHistologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghai 200032China Center for Novel Target and Therapeutic Intervention Chongqing Medical UniversityChongqing 400016China Department of Pathology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Urology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Urology Zhongshan Hospital Wusong BranchFudan UniversityShanghai 200940China

Bladder cancer(BLCA)remains a difficult malignancy to manage because of its high recurrence,intense follow-up,and invasive diagnostic and treatment *** checkpoint inhibitors(ICIs)have forged a new direction for the treatment of BLCA,but it is currently challenging to predict whether an individual patient will be sensitive to *** collected 43 urine/tumor samples from BLCA patients for primary bladder cancer cells(BCCs)culturing using our previously reported BCC culture *** used flow cytometry(FCM)to measure the expression levels of Programmed Death-Ligand 1(PD-L1)on BCCs before and after interferon-gamma(IFN-γ)treatment and found that PD-L1 expression and the sensitivities to IFN-γvaried among ***-sequencing,western blotting,and programmed death-1(PD-1)binding assays confirmed that the BCC FCM-based PD-L1 detection platform(BC-PD-L1)was reliable and was not hindered by the glycosylation of *** the subsequent retrospective study,we found that IFN-γ-stimulated PD-L1(sPD-L1)expression on BCCs detected by BC-PD-L1 could predict the prognosis of BLCA ***,the prognostic value was similar or even better in urine-derived BC-PD-L1(UBC-PD-L1).Transcriptome analysis showed that BCCs with high sPD-L1 tended to enrich genes associated with the collagen-containing extracellular matrix,cell–cell adhesion,and positive regulation of the immune *** addition,the UBC-PD-L1 also exhibited predictive value for ICI response in BLCA *** conclusion,as a novel personalized urine-detection method,UBC-PD-L1 may provide a rapid,accurate,and non-invasive tool for monitoring tumor progression,predicting therapeutic responses,and helping improve BLCA clinical treatment in future.

关键词： Bladder cancer Immune checkpoint inhibitors Predictive model Primary cells Urine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

民主理性蜕化与西方“政治性赤字”的膨胀

学术月刊 2010年第11期42卷 5-11页

作者：郭剑鸣浙江财经学院财政学重点研究基地浙江杭州310018

西方国家普遍面临的主权债务风险不是简单的经济性赤字,而是政治性赤字,是五十年来西方民主理性蜕化的结果。20世纪60年代始,由于功能财政模式对平衡财政模式的替代,选举理性中的公共责任内涵渐渐模糊,选民追求少缴税又能多享受公共福利... 详细信息

西方国家普遍面临的主权债务风险不是简单的经济性赤字,而是政治性赤字,是五十年来西方民主理性蜕化的结果。20世纪60年代始,由于功能财政模式对平衡财政模式的替代,选举理性中的公共责任内涵渐渐模糊,选民追求少缴税又能多享受公共福利,而政治家热衷于扩大公共支出又避免增加选民税负,双方共同的理性都落脚于"取其需而不担其责",政府举债支出便成为满足选民需求、延续政治家前途的必由之路。当政府普遍以债务恶性膨胀为代价来满足同样恶性膨胀的选民需求时,"理性民主"便蜕变为"赤字民主"。因此,仅仅从经济学视角探讨防范和化解主权债务风险之策是不够的,关键还在于复兴政治家与选民博弈中的民主理性。

关键词：赤字民主主权债务西方政治性赤字