Advances in the study of protein folding and endoplasmic reticulum-associated degradation in mammal cells
[哺乳动物细胞蛋白质折叠和内质网相关降解的研究进展]作者机构：Department of Sport RehabilitationShanghai University of SportShanghai 200438China National Key Laboratory of Immunity and InflammationNaval Medical UniversityShanghai 200433China
出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)
年 卷 期：2024年第25卷第3期
页 面：212-232页
核心收录：
学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 08[工学] 0817[工学-化学工程与技术] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种]
基 金：This work was supported by the National Natural Science Foundation of China(No.82071762) the Shanghai Key Lab of Human Performance(Shanghai University of Sport)(No.11DZ2261100) the 2021 Capacity Building of Shanghai Universities(No.21010503600),China
主 题：Endoplasmic reticulum-associated degradation(ERAD) Protein folding Ubiquitination Retrotranslocation
摘 要：The endoplasmic reticulum is a key site for protein production and quality *** than one-third of proteins are synthesized and folded into the correct three-dimensional conformation in the endoplasmic ***,during protein folding,unfolded and/or misfolded proteins are prone to occur,which may lead to endoplasmic reticulum *** can monitor the quality of the proteins produced by endoplasmic reticulum quality control(ERQC)and endoplasmic reticulum-associated degradation(ERAD),which maintain endoplasmic reticulum protein homeostasis by degrading abnormally folded *** underlying mechanisms of protein folding and ERAD in mammals have not yet been fully ***,this paper reviews the process and function of protein folding and ERAD in mammalian cells,in order to help clinicians better understand the mechanism of ERAD and to provide a scientific reference for the treatment of diseases caused by abnormal ERAD.
维普期刊数据库