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Prediction of ash content of unloaded coal based on a discrete element simulation

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International Journal of Mining Science and Technology 2013年第5期23卷 647-651页

作者： deng jianjun Zhuo Jinwu Shi Hongxia School of Chemical Engineering and Technology China University of Mining & Technology China Data Technology Co.Ltd. Coal Mining and Designing Department Tiandi Science and Technology Co.Ltd.

Based on analysis of regularity of stacking coal,discrete element simultaneous simulation is adopted to predict the process of unloading coal,which is proved to be effcient in the prediction of ash *** results show that the altitude of new irregular coal is equal to the income coal volume divided by area of *** distribution of infnitesimal flow velocity helps to induce the motion equation of infnitesimal element,which provides the mathematical model for computer ***,a computer programming language,is utilized in this *** infnitesimal stacking algorithm helps settle the diffculties in attainment of infnitesimal *** result of simulation is similar to the actual situation,which can accurately predict the ash contents of current time and cumulative *** movement in the cabin is a new project,the result of which can also be applied to other solid particles and the widespread of the result will be highly valued.

关键词： Discrete element Simulation Ash content forecast Coal blending Motion equation Mathematical model

Ginsenoside Rk3 is a novel PI3K/AKT-targeting therapeutics agent that regulates autophagy and apoptosis in hepatocellular carcinoma

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Journal of Pharmaceutical Analysis 2023年第5期13卷 463-482页

作者： Linlin Qu Yannan Liu jianjun deng Xiaoxuan Ma Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical EngineeringNorthwest UniversityXi'an710069China Shaanxi R&D Centerof Biomaterials and Fermentation Engineering Schoolof Chemical EngineeringNorthwest UniversityXi'an710069China Biotech.&Biomed.Research Institute Northwest UniversityXi'an710069China Xi'an Giant Biotechnology Co. Ltd.Xi'an710076China

Hepatocellular carcinoma(HCC)is the third leading cause of cancer death *** Rk3,an important and rare saponin in heat-treated ginseng,is generated from Rg1 and has a smaller molecular ***,the anti-HCC efficacy and mechanisms of ginsenoside Rk3 have not yet been ***,we investigated the mechanism by which ginsenoside Rk3,a tetracyclic triterpenoid rare ginsenoside,inhibits the growth of *** first explored the possible potential targets of Rk3 through network *** in vitro(HepG2 and HCC-LM3 cells)and in vivo(primary liver cancer mice and HCC-LM3 subcutaneous tumor-bearing mice)studies revealed that Rk3 significantly inhibits the proliferation of ***,Rk3 blocked the cell cycle in HCC at the G1 phase and induced autophagy and apoptosis in *** proteomics and siRNA experiments showed that Rk3 regulates the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)pathway to inhibit HCC growth,which was validated by molecular docking and surface plasmon *** conclusion,we report the discovery that ginsenoside Rk3 binds to PI3K/AKT and promotes autophagy and apoptosis in *** data strongly support the translation of ginsenoside Rk3 into novel PI3K/AKT-targeting therapeutics for HCC treatment with low toxic side effects.

关键词： Hepatocellular carcinoma Ginsenoside Rk3 Apoptosis Autophagy PI3K/AKT pathway

High efficiency production of ginsenoside compound K by catalyzing ginsenoside Rb1 using snailase

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Chinese Journal of Chemical Engineering 2018年第7期26卷 1591-1597页

作者： Zhiguang Duan Chenhui Zhu Jingjing Shi Daidi Fan jianjun deng Rongzhan Fu Rong Huang Cuiying Fan Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical EngineeringNorthwest UniversityTaibai North Road 229Xi'an 710069China Shanxi R&D Center of Biomaterials and Fermentation Engineering School of Chemical Engineering Northwest University Taibai North Road 229Xi'an 710069China

The rare ginsenoside Compound K （C-K） is attracting more attention because of its good physiological activity and urgent need. There are many pathways to obtain ginsenoside C-K, including chemical and biological methods. Among these, the conversion of PPD-type ginsenosides by enzymatic hydrolysis is a trend due to its high efficiency and mild conditions. For effectively extracting from the other panaxadiol saponins, the conversion process for ginsenoside C-K was investigated using snailases in this study. The univariate experimental design and response surface methodology were used to determine the optimal hydrolysis conditions for the conversion of ginsenoside Rbl into ginsenoside C-K by snailases. The optimum conditions were as follows： pH 5,12, temperature 51 ℃, ratio of snailase/substrate 0.21, and reaction time 48 h. On the basis of these parameters, the addition of 1.0 mmol· L- 1 ferric ion was found to significantly improve the enzymolysis ofsnailases for the first time. With the above conditions, the maximum conversion rate reached 89.7%, suggesting that the process can obviously increase the yield of ginsenoside C-K. The bioassay tests indicated that the ginsenoside C-K showed anti-tumor activity in a series of tumor cell lines. Based on these results, we can conclude that the process of rare ginsenoside C- K production by enzymolysis with snailase is feasible, efficient, and suitable for the industrial production and application.

关键词： Ginsenoside Rb1 Ginsenoside Compound K Snailase Enzymolysis

Ginsenoside Rk3 modulates gut microbiota and regulates immune response of group 3 innate lymphoid cells to against colorectal tumorigenesis

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Journal of Pharmaceutical Analysis 2024年第2期14卷 259-275页

作者： Xue Bai Rongzhan Fu Yannan Liu jianjun deng Qiang Fei Zhiguang Duan Chenhui Zhu Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical EngineeringNorthwest UniversityXi'an710069China Biotech&Biomed Research Institute Northwest UniversityXi'an710069China School of Chemical Engineering and Technology Xi'an Jiaotong UniversityXi'an710069China

The gut microbiota plays a pivotal role in the immunomodulatory and protumorigenic microenvironment of colorectal cancer(CRC).However,the effect of ginsenoside Rk3(Rk3)on CRC and gut microbiota remains ***,the purpose of this study is to explore the potential effect of Rk3 on CRC from the perspective of gut microbiota and immune *** results reveal that treatment with Rk3 significantly suppresses the formation of colon tumors,repairs intestinal barrier damage,and regulates the gut microbiota imbalance caused by CRC,including enrichment of probiotics such as Akkermansia muciniphila and Barnesiella intestinihominis,and clearance of pathogenic *** metabolomics data demonstrate that Rk3 can modulate the metabolism of amino acids and bile acids,particularly by upregulating glutamine,which has the potential to regulate the immune ***,we elucidate the regulatory effects of Rk3 on chemokines and inflammatory factors associated with group 3 innate lymphoid cells(ILC3s)and T helper 17(Th17)signaling pathways,which inhibits the hyperactivation of the Janus kinase-signal transducer and activator of transcription 3(JAK-STAT3)signaling *** results indicate that Rk3 modulates gut microbiota,regulates ILC3s immune response,and inhibits the JAK-STAT3 signaling pathway to suppress the development of colon *** importantly,the results of fecal microbiota transplantation suggest that the inhibitory effect of Rk3 on colon tumors and its regulation of ILC3 immune responses are mediated by the gut *** summary,these findings emphasize that Rk3 can be utilized as a regulator of the gut microbiota for the prevention and treatment of CRC.

关键词： Colorectal cancer Ginsenoside Immune cells Gut microbiota

An In Vitro Investigation of Pulmonary Alveolar Macrophage Cytotoxicity Introduced by Fibrous and Grainy Mineral Dusts

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Acta Geologica Sinica(English Edition) 2006年第4期80卷 589-596页

作者： DONG Faqin deng jianjun WU Fengchun PU Xiaoyong John HUANG FENG Qiming HE Xiaochun Institute of Mineral Materials andApplication Southwest University of Science and Technology Mianyang Sichuan 621002 China Clinical Laboratory Fourth People＇s Hospital ofMianyang Mianyang Sichuan 621000 China Department of Clinical Laboratory Third Military Medical University Chongqing 400038 China Central Analytical Facility Laurentian University Sudbury Ontario P3E 2C6 Canada

In order to study the damage mechanism of mineral dusts on the pulmonary alveolar macrophage （AM）, the changes in their death ratio, malandialdthyde （MDA） content and activities of lactate dehydrogenase （LDH） and superoxide dismutase （SOD） were measured, and the technique of cell culture in vitro was used to investigate the cytotoxicity of six mineral dusts （twelve crystal habits） from twelve mineral deposits. The results show that woUastonite and clinoptilolite have no AM cytotoxicity, while other fibrous and grainy mineral dusts damage pulmonary AM in various degrees. The cytotoxicity of fibrous mineral dusts was greater than that of the grainy ones, and the cytotoxicity of dusts was positively correlated with the active OH- content in dusts, but not necessarily so with its SiO2 content. The high pH values produced by dust was unfavorable for the survival of cells and the dusts with low bio-resistance were safe for cells. The content of variable valence elements in dusts might influence their cytotoxicity and the surface charge of dusts was not a stable factor for their toxicity. It is demonstrated that the shape of mineral dusts was one of the factors affecting cytotoxicity, and that the cytotoxicity of mineral dusts depends mainly on their properties.

关键词： grainy mineral fibrous mineral dust pulmonary alveolar macrophage cytotoxicity

Dietary phytochemicals: As a potential natural source for treatment of Alzheimer's Disease

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Food Innovation and Advances 2023年第1期2卷 36-43页

作者： Zhuo Ren Haixia Yang Chenhui Zhu Daidi Fan jianjun deng Shaanxi Key Laboratory of Degradable Biomedical Materials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringBiotech&Biomed Research InstituteSchool of Chemical EngineeringNorthwest UniversityXi’an 710069China College of Food Science and Nutritional Engineering China Agricultural UniversityBeijing 100083China

Alzheimer's disease(AD)is a common neurodegenerative disease,which seriously impairs human health and *** present,scientists have proposed more than a dozen hypotheses about the pathogenesis of AD,including the tau propagation ***,the exact ultimate pathogenic factor of AD remains *** on the current hypotheses,some anti-AD drugs(e.g.,donepezil and Ketamine)have been developed and used in clinical treatment,which fall into two main categories,acetylcholinesterase inhibitors(AChEIs)and N-methyl-D-aspartate(NMDA)receptor antagonists,the former representative drug is donepezil,and the latter representative drug is *** these drugs have undesirable side effects,it is necessary to find safer alternatives for AD ***,dietary phytochemicals have the advantages of wide source,safety,and high biological activity,which is the natural route for screening anti-AD *** this study,several representatives’dietary phytochemicals with anti-AD effect,including resveratrol,lycopene,gallic acid,berberine,ginsenoside Rg1,pseudoginsenoside-F11,ginsenoside Rh2,artemisinin,and torularhodin were selected from the published data over the last 10 years and their potential molecular mechanisms and clinical applications reviewed in the treatment of AD.

关键词： drugs Alzheimer treatment

A Radial Graded Solid Insulation Structure In Vacuum

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A Radial Graded Solid Insulation Structure In Vacuum

Man-made mineral fibers effects on the expression of anti-oncogenes and oncogenes in lung tissues of rats

作者： Meng Wang jianjun deng Guangsen Dai

The technique of radial insulation support structure is widely used in pulsed power *** the requirement of high coaxiality between cathode and anode,and the adjustment probability of output beam’s intensity in the 2M...

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Man-made mineral fibers effects on the expression of anti-on...

中国毒理学会第七次全国会员代表大会暨中国毒理学会第六次中青年学者科技论坛

作者： Yan Cui Liuwen Huang jianjun deng Qingbi Zhang Southwest Medical University Southwest University of Science and Technology

Objective Man-made mineral fibers (MMMFs), as a substitute for asbestos, refers to noncrystalline fibrous inorganic substances (silicates) made from several types of minerals. Since the harms associated with the use of asbestos were fully realized, people tend to use MMMFs more frequently than asbestos. Most MMMFs are used for soundproof, heat insulation, fire protection,

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适用于超低空拦截的复合制导律设计方法

系统工程与电子技术 2021年第1期43卷 208-215页

作者：杨宇吴达高峰邓建军空军工程大学防空反导学院陕西西安710051

防空导弹在拦截超低空目标时,多径效应的存在会大大降低导弹雷达导引头探测跟踪目标的精度。为降低多径干扰的影响,可将弹目视线角(line of sight,LOS)约束在布儒斯特角附近,但是多数的研究仅仅是在弹目交汇处将其约束至布儒斯特角。基... 详细信息

防空导弹在拦截超低空目标时,多径效应的存在会大大降低导弹雷达导引头探测跟踪目标的精度。为降低多径干扰的影响,可将弹目视线角(line of sight,LOS)约束在布儒斯特角附近,但是多数的研究仅仅是在弹目交汇处将其约束至布儒斯特角。基于模型预测控制可跟踪期望LOS的特点,设计出一种模型预测制导律。针对超低空目标机动扰动对制导精度的影响,设计了滑模扰动观测器对目标加速度进行估计。最后,将模型预测制导律与目标加速度的估计值相结合设计了一种复合模型预测制导律。仿真结果表明,采用复合制导律能够保证拦截弹以期望的布儒斯特弹道对超低空目标进行跟踪和拦截,同时可将LOS速率收敛至0,最大程度降低多径干扰的影响,从而提高拦截精度。

关键词：多径效应布儒斯特角模型预测控制滑模扰动观测器