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Effect of Yiqihuoxue prescription on myocardial energy metabolism after myocardial infarction via cross talk of liver kinase B1-depen-dent Notch1 and adenosine 5'-monophosphate-activated protein kinase

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Journal of Traditional Chinese Medicine 2017年第3期37卷 378-386页

作者： wu jiangong Chen Xi Guo Shuwen Liu Wenchen Zhang Lu Li Fanghe wu Jiani Huang Xiaolou Cai Qian Tan Xiaobo Wang Hui Institute of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

OBJECTIVE: To investigate the effect of Yiqihuoxue prescription(YQHX) from Traditional Chinese Medicine(TCM) on myocardial glucose and lipid metabolism after myocardial infarction via the cross talk between the liver kinase B1(LKB1)-dependent Notch1 and adenosine 5'-monophosphate(AMP)-activated protein kinase(AMPK). YQHX was prepared with substances with properties that benefit, to activate blood circulation based on the TCM ***: Animal models of myocardial infarction were established by ligating Sprague Dawley rats' left anterior descending coronary arteries. The animals were randomly divided into a myocardial infarction(MI) group, a YQHX group, a perindopril group, a γ-secretase inhibitor, Notch signal inhibitor(DAPT) group, a DAPT+YQHX group and a sham group. The related drugs were administered on the second day after operation, and changes in the relevant indexes were examined on weeks 1 and *** in cardiac structure and function were examined by echocardiography. The glucose and free fatty acids(FFA) were examined by ELISA. The expression of Notch, LKB1 and AMPK m RNA was examined by a real-time fluorescence quantitative method. The expression of glucose transporter 4(GLUT4), and the expression of total acetyl-Co A carboxylase(ACC) and its phosphorylation were examined by western ***: Compared with the sham group, the expression of Notch, LKB1 and AMPK m RNA in the MI group was lower. Compared with the MI group, the expression of these m RNAs in the YQHX and perindopril groups was higher, and their expression in the DAPT group was lower. At all time points, the protein expression of GLUT4 and p ACC decreased in the MI group. On week 1, the expression of p ACC protein was higher. In the DAPT group, the expression of p ACC protein decreased. Compared with the YQHX group, the expression of p ACC protein in the DAPT + YQHX group was lower. On week 4,compared with the MI group, the expression of GLUT4 protein in the YQHX group and the pe

关键词：心肌梗死蛋白激酶磷酸活化能量代谢活血益气葡萄糖转运蛋白腺苷

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益气活血方对心肌梗死大鼠梗死边缘区心肌细胞舒缩功能和Ca^(2+)调节相关蛋白表达的影响

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中华中医药杂志 2023年第7期38卷 3339-3342页

作者：武建功陈曦郭书文北京大学人民医院北京100035 首都医科大学附属北京中医医院北京100010 北京中医药大学房山医院北京102499

目的:探讨益气活血方对心梗大鼠梗死边缘区心肌细胞舒缩功能和Ca^(2+)调节相关蛋白表达的影响。方法:雄性SD大鼠随机分组,制备心肌梗死动物模型,分为模型组、益气活血方组、美托洛尔组、假手术组,4周后取材及行急性心肌细胞分离实验,进... 详细信息

目的:探讨益气活血方对心梗大鼠梗死边缘区心肌细胞舒缩功能和Ca^(2+)调节相关蛋白表达的影响。方法:雄性SD大鼠随机分组,制备心肌梗死动物模型,分为模型组、益气活血方组、美托洛尔组、假手术组,4周后取材及行急性心肌细胞分离实验,进行单细胞收缩与钙瞬变同步测量、检测肌浆网钙泄漏、测定大鼠心肌RYR2,SERCA2α蛋白表达情况。结果:与模型组比较,益气活血方能够显著提高心肌梗死边缘区心肌细胞最大收缩速率、最大舒张速率、50%收缩时间、50%舒张时间(P<0.01);增加心肌细胞收缩幅度(P<0.01);减少心肌细胞收缩达峰时间(P<0.01)。益气活血方组钙离子消除时间常数显著下降(P<0.01);心肌细胞钙泄漏显著下降(P<0.05);RYR2的表达显著增加(P<0.05)。结论:益气活血方对心肌梗死边缘区心肌细胞的舒缩能力有显著的改善作用,这种作用通过影响心肌细胞钙瞬变产生,益气活血方对心肌梗死后肌浆网和线粒体重要的Ca^(2+)调节蛋白有调节作用,这种调节作用与心律失常的易感性和心功能改善表现相一致。

关键词：心肌梗死益气活血方钙离子钙稳态线粒体

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Cardioprotective effect of Yiqi Huoxue granule through regulation of mitophagy after myocardial infarction in rats

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Journal of Traditional Chinese Medical Sciences 2020年第2期7卷 171-180页

作者： Xi Chen jiangong wu Shuwen Guo Hanrong Mo Tianwei Zhan Fanghe Li Hui Wang Pengfei Feng Lulu Wei School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing100029China Department of Traditional Chinese Medicine Peking University People’s HospitalBeijing100044China Fangshan Hospital Beijing University of Chinese Medicine Beijing102499China

Objective:To investigate the cardioprotective effect of Yiqi Huoxue granule(YQHXG)in the regulation of autophagy in rats induced with myocardial infarction(MI).Methods:An acute MI animal model was established by ligation of the left anterior descending branch of the coronary artery in Sprague-Dawley ***,20 rats received sham operation were classified into a control *** remaining 59 rats were randomly divided into MI model group(n=19),YQHXG group(n=20),and perindopril group(n=20).Relevant indicators on days 7 and 28 were observed in each *** ventricular function was determined by *** structure and morphology of mitochondria,and the number of autophagic vesicles,were observed by transmission electron *** mRNA and protein expression levels of LC3,FUNDC1,Beclin-1,and BNIP3 were examined in the tissue of the MI marginal ***:Compared with the MI model group,YQHXG showed obvious improvements in cardiac *** the microscopic morphology of the heart tissue,myocardial tissue damage attenuated,autophagic signs of autophagosomes and autolysosomes reduced,vacuolization in mitochondria mitigated,and mitochondria arranged in *** could reduce the degree of tissue lesion after MI and regulate the expression of autophagy-related molecules at different *** Day 7,YQHXG significantly downregulated the expression of Fundc1,Becn1,Bnip3 mRNA and reduced the levels of FUNDC1,Beclin-1,BNIP3,and LC3 B proteins expression(all P<.001).On Day 28,YQHXG could upregulate the expression of Becn1,Fundc1 and Bnip3 mRNA and increased the levels of the corresponding proteins expression(all P<.001).Besides,it also increased LC3 B protein expression level(P=.0344).Conclusion:YQHXG regulated the expression of mitochondrial autophagy-related factors in myocardial tissue and mitochondrial autophagic activity at different stages to protect the heart following MI.

关键词： Myocardial infarction Yiqi Huoxue granule Mitochondrial autophagy

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Autophagosome activity in macrophage for atherosclerotic plaques in ApoE^-/-mice enhanced by Tiaozhi Tongmai Granules

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Journal of Traditional Chinese Medical Sciences 2015年第3期2卷 194-204页

作者： Chenglong Zheng Qing Sun Lu Zhang Shuwen Guo Min Zheng Yan Tang jiangong wu Jiani wu Wenchen Liu Zhaoduo Su Xi Chen Beijing Drum Tower Hospital of Traditional Chinese Medicine BeijingChina Beijing Chinese Medicine Hospital affiliated to the Capital Medicine University BeijingChina Beijing University of Chinese Medicine BeijingChina Department of Ultrasound Diagnosis China-Japan Friendship HospitalBeijingChina

Objective:Atherosclerosis is the fundamental pathophysiologic component of cardiovascular disease,and Tiaozhi Tongmai Granules show great efficiency in the treatment of the ***,the mechanism of Tiaozhi Tongmai Granules is still *** this study,we have combined experiments with network pharmacology to explore the antiatherosclerosis mechanism of Tiaozhi Tongmai ***:120 male ApoE/mice were randomly divided into three groups:the model group,Chinese herb group and Atorvastatin *** model group,Atorvastatin group and Chinese herb group were fed with a high-fat diet,a high-fat diet plus atorvastatin(5.1 mg/kg/d)and a high-fat diet plus Tiaozhi Tongmai Granules(16.5 g/kg/d)for 16 weeks,*** was identified by H&E *** colocalization of neutral lipid stain BODIPY and microtubule-associated protein 1 light chain 3(LC3)and the colocalization of BODIPY and lysosomal-associated membrane protein 1(LAMP1)within ApoE/mice aortic plaques were tested using fluorescence confocal microscopy and the Pearson’s coefficients were *** further explore the anti-atherosclerosis mechanism of Tiaozhi Tongmai Granules,the network pharmacology was used to construct the herb-compound-target ***:The size of the aortic lipid plaque in the Chinese herb group and Atorvastatin group were smaller compared with the model group on the 16th *** with the model group on the 16th week,the BODIPY and LC3 colocalization rate,the BODIPY and LAMP1 colocalization rate of the Chinese herb group and Atorvastatin group all presented significant increase in the aortic plaque(P<.001),showing that Tiaozhi Tongmai Granules could enhance autophagosome activity in the *** the herb-compound-target network,17 active compounds and 27 targets were obtained through literature searching and using LHRI&DAVID *** was found that 23 targets were correlated with the *** of them participated in macrop

关键词： Atherosclerosis Autophagy Chinese medicine Immunofluorescence System pharmacology

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调制控制策略在大功率电机车上的应用研究

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机械管理开发 2022年第11期37卷 303-304页

作者：吴建功中车大同电力机车有限公司山西大同037000

为解决当前大功率电力机车无法实现全速度范围之内对其稳定、安全控制的问题,在对大功率电力机车牵引系统简单概述的基础上,以HXD2C型电力机车为研究对象,为其匹配性设计了全速度范围之内的分段矢量控制策略;针对无电状态和传统准转矩... 详细信息

为解决当前大功率电力机车无法实现全速度范围之内对其稳定、安全控制的问题,在对大功率电力机车牵引系统简单概述的基础上,以HXD2C型电力机车为研究对象,为其匹配性设计了全速度范围之内的分段矢量控制策略;针对无电状态和传统准转矩控制劳动量大的问题,设计了直流电压控制策略和准恒速度控制策略。经试验表明,调制控制策略可实现对电力机车的稳定安全控制,且总效率可达86%。

关键词：电力机车矢量控制直流电压控制准恒速度控制总效率

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Yiqi Huoxue prescription can prevent and treat post-MI myocardial remodeling through promoting the expression of AMPK signal pathway

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Journal of Traditional Chinese Medical Sciences 2017年第3期4卷 235-244页

作者： jiangong wu Shuwen Guo Xi Chen Wenchen Liu Mingjing Zhao Lu Zhang Zhaoduo Su Yuqin Zhang Beijing University of Chinese Medicine Beijing 100029China Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine Internal Medicine of Traditional Chinese Medicine Key Laboratory of the Ministry of EducationBeijing 100700China

Objective:To investigate how Yiqi Huoxue (YQHX) prescription regulates mitochondrial biosynthesis and ATP synthesis via AMP-activated protein kinase (AMPK) and to reveal its molecular mechanism in preventing and treating post-MI myocardial ***:The MI animal model of myocardial infarction were established by ligating Sprague Dawley (SD) rats' left anterior descending coronary arteries;the animals were randomly divided into MI group,YQHX prescription group and perindopril group,and a sham operation group was set at the same *** drug intervention was administered on the 2nd day after surgery,the YQHX group was given Astragalus,angelica,ginseng,Ligusticum wallichii and pseudoginseng,provided by the Dongzhimen Hospital of Beijing University of Chinese Medicine,once per day,at a dose of 21 g/kg body weight/day (the clinical equivalent dose based on a previous study),and the changes in relevant indicators were observed at 1 week and 4 *** (ECG) was used to observe the changes in rat cardiac structure and functions;the morphology-based technique was used to observe the changes in myocardial cells and mitochondria;the expression of AMPK signal pathway-related proteins and mRNA was detected using western blotting and real-time fluorescence quantification respectively,while fluorescence enzyme-labeled method was used for detecting ATP ***:Cardiac structure and functions:Compared with the MI group at 1 week,the YQHX prescription group and the perindopril group exhibited increased LVEF and LVFS (Pall .05).At 4 weeks,both LVEF and LVFS were elevated in the YQHX prescription group (P =.008,.009) and the perindopril group (P =.279,.333),where differences in the later group indicated no statistical significance;the YQHX prescription group and the perindopril group were also featured by reduced LVEDs and LVE

关键词： Myocardial infarction YQHX prescription Mitochondria ATP

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WAVE CHARACTERISTICS IN PIEZOELECTRIC HOLLOW CYLINDERS

WAVE CHARACTERISTICS IN PIEZOELECTRIC HOLLOW CYLINDERS

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庆祝中国力学学会成立50周年暨中国力学学会学术大会’2007

作者： YU jiangong wu Bin (College of Mechanical Engineering and Applied Electronic Technology,Beijing University of Technology,Beijing 100022,China)

Piezoelectric materials(PEM) are key materials for fabricating the acoustic *** have been used as integrated structural *** behavior of the wave mode selected directly affects the performance of the ***,it is signific...

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大学生体质健康监测理念传承、实然之需与实践进路——以中山大学为个案

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科教文汇 2024年第11期 16-20页

作者：武东海单建功中山大学体育部广东广州510275

学生体质健康事关全民福祉与其个人长远发展,是衡量人才培养质量的重要标准。该文运用文献资料、数理统计与归纳演绎等方法,以做好学生体质健康监测工作的现实需要为论述基础,以理念传承为研究脉络,以取得监测的实际效能为落脚点,解析... 详细信息

学生体质健康事关全民福祉与其个人长远发展,是衡量人才培养质量的重要标准。该文运用文献资料、数理统计与归纳演绎等方法,以做好学生体质健康监测工作的现实需要为论述基础,以理念传承为研究脉络,以取得监测的实际效能为落脚点,解析中山大学以“体能提高班”为建设基石的学生体质健康监测实施路径、方法与成效,以期为相关学校提供可参考、可借鉴的实际案例,从而助益我国青少年体质健康监测工作的实际效能提高与高质量发展。

关键词：体质监测训导健康促进理念体能提高班

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印刷电路板式换热器的研究进展与应用

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机电设备 2024年第3期41卷 27-30页

作者：王涛陈江龙吴璇沪东重机有限公司上海200129 中船动力(集团)有限公司上海200129

热交换器作为热量传递的关键设备,在工业生产中起至关重要的作用。文章介绍了印刷电路板式换热器(PCHE)的应用背景、特点和优势,论述了国内外针对PCHE的研究进展,分析了研究过程中存在的难题,提出现阶段研究存在的不足,以期为PCHE设计... 详细信息

热交换器作为热量传递的关键设备,在工业生产中起至关重要的作用。文章介绍了印刷电路板式换热器(PCHE)的应用背景、特点和优势,论述了国内外针对PCHE的研究进展,分析了研究过程中存在的难题,提出现阶段研究存在的不足,以期为PCHE设计和应用等方面的深入研究提供参考,以期指导实际工程应用。

关键词：印刷电路板式换热器研究应用

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焊缝无损检测标准应用及问题探讨

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无损探伤 2023年第6期47卷 45-48页

作者：林思波余海军李仁吴建功中车大同电力机车有限公司山西大同037038

企业应用无损检测评价焊缝质量时存在诸多问题。结合ISO 17635,通过建立桥梁式结构形成焊缝无损检测标准应用逻辑,指导标准应用。对于应用中的典型问题,给出了解决方案。阐述了无损检测中的显示和焊接缺欠的区别,解释了验收等级对应的... 详细信息

企业应用无损检测评价焊缝质量时存在诸多问题。结合ISO 17635,通过建立桥梁式结构形成焊缝无损检测标准应用逻辑,指导标准应用。对于应用中的典型问题,给出了解决方案。阐述了无损检测中的显示和焊接缺欠的区别,解释了验收等级对应的客观性。提出了正确执行检测频次和检测比例的方式。基于理论和标准,确定了可操作性强的检测时机。

关键词：标准应用逻辑显示和缺欠检测时机

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