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Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo

Light(Science & Applications) 2020年第1期9卷 1298-1308页

作者： Zhongya Qin Sicong He Chao yang Jasmine Sum-yee yung Congping Chen Christopher Kai-Shun Leung Kai Liu jianan y.qu Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Division of Life Science The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong KongChina State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science and TechnologyClear Water BayKowloonHongKongChina Center of Systems Biology and Human Health The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

In vivo fundus imaging offers non-invasive access to neuron structures and biochemical processes in the ***,optical aberrations of the eye degrade the imaging resolution and prevent visualization of subcellular retinal *** developed an adaptive optics two-photon excitation fluorescence microscopy(AO-TPEFM)system to correct ocular aberrations based on a nonlinear fluorescent guide star and achieved subcellular resolution for in vivo fluorescence imaging of the mouse *** accurate wavefront sensing and rapid aberration correction,AOTPEFM permits structural and functional imaging of the mouse retina with submicron ***,simultaneous functional calcium imaging of neuronal somas and dendrites was ***,the timelapse morphological alteration and dynamics of microglia were characterized in a mouse model of retinal *** addition,precise laser axotomy was achieved,and degeneration of retinal nerve fibres was *** highresolution AO-TPEFM is a promising tool for non-invasive retinal imaging and can facilitate the understanding of a variety of eye diseases as well as neurodegenerative disorders in the central nervous system.

关键词： optics functional photon

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Caudal hematopoietic tissue supports definitive erythrocytes via epoa and is dispensable for definitive neutrophils

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Journal of Genetics and Genomics 2024年第6期51卷 669-672页

作者： Zhujuan Huang yongtai Xu Zhongkai Qiu yunyun Jiang Jiaye Wu Qing Lin Sicong He jianan y.qu Jiahao Chen Jin Xu Innovation Centre of Ministry of Education for Development and Diseases School of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China Department of Biology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong 518055China Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyKowloonHongkong 999077China

The blood system originates from hematopoietic stem cells(HSCs),capable of self-renewal and differentiation,generating diverse blood cell types(Eaves,2015;Lucas,2021).The concept of the hematopoietic niche was first proposed in 1978(Schofield,1978),which is crucial for maintaining hematopoietic *** following studies,particularly in mammals,have utilized targeted genetic manipulation to identify and define these niches.

关键词： hematopoietic manipulation utilized

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Fli1 acts in parallel with Pu.1 to control macrophage and neutrophil fate in zebrafish

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Journal of Genetics and Genomics 2024年第3期51卷 359-362页

作者： Ao Zhang Jingao Lu Shachuan Feng Huapeng yu Tao yu Shizheng Zhao Kemin Chen Zhibin Huang Jin Xu jianan y.qu Zilong Wen Division of Life Science Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Division of Cell Developmental and Integrative BiologySchool of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China Department of Immunology and Microbiology School of Life ScienceSouthern University of Science and TechnologyShenzhenGuangdong 518055China Biomedical Research Institute Shenzhen Peking University-Hong Kong University of Science and Technology Medical CenterShenzhenGuangdong 518036China Department of Electronic and Computer Engineering Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Greater Bay Biomedical Innocenter Shenzhen Bay LaboratoryShenzhenGuangdong 518067China

Macrophages and neutrophils are key components of myeloid cells and play critical roles in innate immune responses,organ formation,and tissue *** integrity of their functions heavily relies on the generation of a proper number of mature macrophages and neutrophils through embryonic and adult *** mammalian adult myelopoiesis,oligopotent common myeloid progenitors(CMPs)are known to be the earliest myeloid progenitors,which give rise to granulocyte-macrophage progenitors(GMPs),subsequently differentiate into unipotent neutrophil and macrophage precursors,and finally,mature macrophages and neutrophils(Orkin and Zon,2008).In contrast,the ontogeny of embryonic myelopoiesis and the mechanism underlying the formation of macrophages and neutrophils remainless understood.

关键词： fish macrophage homeostasis

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High-resolution two-photon transcranial imaging of brain using direct wavefront sensing

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Photonics Research 2021年第6期9卷 1144-1156页

作者： CONGPING CHEN ZHONGyA QIN SICONG HE SHAOJUN LIU SHUN-FAT LAU WANJIE WU DAN ZHU NANCy y.IP jianan y.qu Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Center of Systems Biology and Human Health The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhanChina MoE Key Laboratory for Biomedical Photonics Collaborative Innovation Center for Biomedical EngineeringSchool of Engineering SciencesHuazhong University of Science and TechnologyWuhanChina Division of Life Science The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Molecular Neuroscience Center The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

Imaging of the brain in its native state at high spatial resolution poses major challenges to visualization ***-photon microscopy integrated with the thinned-skull or optical clearing skull technique provides a minimally invasive tool for in vivo imaging of the cortex of mice without activating immune response and inducing brain ***,the imaging contrast and spatial resolution are severely compromised by the optical heterogeneity of the skull,limiting the imaging depth to the superficial *** this work,an optimized configuration of an adaptive optics two-photon microscope system and an improved wavefront sensing algorithm are proposed for accurate correction for the aberrations induced by the skull window and brain *** this system,we achieved subcellular resolution transcranial imaging of layer 5 pyramidal neurons up to 700μm below pia in living *** addition,we investigated microglia–plaque interaction in living brain of Alzheimer’s disease and demonstrated high-precision laser dendrotomy and single-spine ablation.

关键词： resolution photon system

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quantum Spin Exchange Interactions to Accelerate the Redox Kinetics in Li–S Batteries

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Nano-Micro Letters 2024年第5期16卷 370-383页

作者： yu Du Weijie Chen yu Wang yue yu Kai Guo Gan qu jianan Zhang Key Laboratory of Advanced Energy Catalytic and Functional Materials Preparation of Zhengzhou City College of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001People’s Republic of China

Spin-engineering with electrocatalysts have been exploited to suppress the“shuttle effect”in Li–S *** selec-tion,spin-dependent electron mobility and spin potentials in activation barriers can be optimized as quantum spin exchange interactions lead-ing to a significant reduction of the electronic repulsions in the orbitals of ***,we anchor the MgPc molecules on fluorinated carbon nanotubes(MgPc@FCNT),which exhibits the single active Mg sites with axial *** to the density functional theory calculations,the electronic spin polarization in MgPc@FCNT not only increases the adsorption energy toward LiPSs intermediates but also facilitates the tunneling process of electron in Li–S *** a result,the MgPc@FCNT provides an initial capacity of 6.1 mAh cm^(-2) even when the high sulfur loading is 4.5 mg cm^(-2),and still maintains 5.1 mAh cm^(-2) after 100 *** work provides a new perspective to extend the main group single-atom catalysts enabling high-performance Li–S batteries.

关键词： Metal phthalocyanines Spin polarization Electrocatalysis Li–S batteries

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Cs-Induced Phase Transformation of Vanadium Oxide for High-Performance Zinc-Ion Batteries

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Energy & Environmental Materials 2023年第4期6卷 265-272页

作者： Gan qu Kai Guo Weijie Chen yu Du ye Wang Bingbing Tian jianan Zhang Key Laboratory of Advanced Energy Catalytic and Functional Materials Preparation of Zhengzhou City College of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China

Rechargeable aqueous zinc-ion batteries are promising candidate for gridscale energy ***,the development of zinc-ion batteries has been plagued by the lack of cathode materials with high specific capacity and superior ***,hexagonal Cs_(0.3)V_(2)O_(5)cathode is fabricated and investigated in zinc-ion *** with the traditional vanadium oxides,the introduction of Cs changes the periodic atomic arrangements,which not only stabilizes the open framework structure but also facilitates the Zn^(2+)diffusion with a lower migration energy ***,high specific capacity of 543.8 mA h g^(-1)at 0.1 A g^(-1)is achieved,which surpasses most of reported cathode materials in zinc-ion *** excellent cycle life is achieved over 1000 cycles with about 87.8%capacity retention at 2 A g^(-1).Furthermore,the morphological evolution and energy storage mechanisms are also revealed via a series of *** work opens up a phase engineering strategy to fabricate the hexagonal vanadium oxide and elucidate the application of phase-dependent cathodes in zinc-ion batteries.

关键词： cathode materials phase engineering vanadium oxide zinc-ion batteries

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Seasonal metal fluxes derived by the interaction of surface water and groundwater in an aquaculture estuary

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Acta Oceanologica Sinica 2023年第8期42卷 113-124页

作者： Xiaoxiong Wang Jordi Garcia-Orellana Xiaogang Chen jianan Liu Fenfen Zhang Jianguo qu Zhuoyi Zhu Jinzhou Du State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai 200062China ICTA-UAB Institut de Ciència i Tecnologia AmbientalsUniversitat Autònoma de BarcelonaBarcelona E-08193Spain Departament de Física Universitat Autònoma de BarcelonaBarcelona E-08193Spain Key Laboratory of Coastal Environment and Resources of Zhejiang Province School of EngineeringWestlake UniversityHangzhou 310024China School of Oceanography Shanghai Jiao Tong UniversityShanghai 200030China

Submarine groundwater discharge(SGD)plays a major role as a conveyor of metals to coastal ***,the seasonal change of metal fluxes derived through SGD is ***,we evaluated the behaviours and fluxes of trace metals(Mn,Fe,Ba,Pb,U,Cr,Zn,Cu)in an estuary under different seasonal *** behaviours of trace metals revealed that SGD was the source of Mn(3.51 mmol/(m^(2)·d)),Fe(0.174 mmol/(m^(2)·d))and Ba(0.024 mmol/(m^(2)·d)),but the Cu sink(−0.55μmol/(m^(2)·d))and other metals exhibited a seasonal source‒sink *** seasonal variation of dissolved organic matter and the fresh groundwater proportion in subterranean estuaries may have an important effect on metals fluxes especially for the Fe,Mn and *** result shows that the single seasonal metal fluxes estimation applied to the annual scale will cause a large deviation,up to 3.6 times for Fe,5.5 times for Mn,and 15 times for ***,the influence of seasonal fluctuations on SGDderived metal fluxes cannot be ignored,and our findings will be important for comprehending the metal budget and cycle in nearshore environment.

关键词： subterranean estuary seawater intrusion heavy metals seasonal changes coastal management

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Atomically Dispersed Fe-N_(4) Sites and Fe_(3)C Particles Catalyzing Polysulfides Conversion in Li-S Batteries

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Chemical Research in Chinese Universities 2022年第5期38卷 1232-1238页

作者： CHEN Weijie XIA Huicong GUO Kai JIN Wangzhe DU yu yAN Wenfu qu Gan ZHANG jianan College of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001P.R.China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012P.R.China

Lithium-sulfur(Li-S)batteries have been puzzled by the“shuttle effect”.In the recent years,catalytic materials present a huge potential for solving this ***,the exploitation for catalytic activity was still challenging in Li-S *** this article,we put forward a single atom catalyst(SAC)of FeN_(4) coupled with Fe_(3)C on the N-doped carbon(FeN_(4)/Fe_(3)C@NC)by one-step pyrolysis *** FeN_(4) and Fe_(3)C synergistically catalyze the polysulfides conversion when the N-doped carbon provides the high conductive three-dimensional skeleton in Li-S *** a result,the FeN_(4)/Fe_(3)C@NC shows a specific capacity of 1100 mA·h/g at 0.2 C(1 C=1675 mA/g).In addition,the FeN_(4)/Fe_(3)C@NC maintains 99.01%of the pristine specific capacity after 100 cycles at 0.5 C,indicating the improved electrochemical performance in Li-S *** work sheds new lights on the design of engineering catalysts for developing high-performance Li-S batteries.

关键词： FeN_(4) Fe_(3)C Li-S battery Shuttle effect

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Oxygen variation in titanium powder and metal injection molding

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International Journal of Minerals,Metallurgy and Materials 2024年第12期31卷 2706-2713页

作者： Junping Shen Chang Liu Muhammad Dilawer Hayat jianan Chen Hanqing Tian Fusheng Xin Gang Chen Fei yang Mingli Qin Xuanhui qu Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China School of Engineering The University of WaikatoHamilton 3216New Zealand Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation Beijing 100083China Ningbo Titan Advanced Materials Technology Co. Ltd.Ningbo 315012China

The control of oxygen is paramount in achieving high-performance titanium(Ti)parts by powder metallurgy such as metal in-jection molding(MIM).In this study,we purposely selected the Ti and Ti-6Al-4V powders as the reference materials since these two are the most representative Ti materials in the ***,hydride-dehydride(HDH)Ti powders were pre-oxidized to examine the ef-fect of oxygen variation on the characteristics of oxide layer on the particle surface and its resultant color *** results indicate that the thickness and Ti oxide level(Ti^(0)→Ti^(4+))of the oxide layer on the HDH Ti powders increased as the oxygen content increased,lead-ing to the transition of color appearance from grey,brown to *** work aids in the powder feedstock selection at the initial stage in powder *** addition,the development of oxygen content was comprehensively studied during the MIM process using the gas-atomized(GA)Ti-6Al-4V ***,the oxygen variation in the form of oxide layer,the change of oxygen content in the powders,and the relevant parts were investigated during the processes of kneading,injection,debinding,and *** oxygen vari-ation was mainly concentrated in the sintering stage,and the content increased with the increase of sintering *** variation of oxygen content during the MIM process demonstrates the crucial role of powder feedstock and sintering stage in controlling oxygen *** work provides a piece of valuable information on oxygen detecting,control,and manipulation for the powder and processing in the industry of Ti and its alloys by powder metallurgy.

关键词： titanium alloys oxygen metal injection molding powder metallurgy

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Picroside Ⅱ promotes HSC apoptosis and inhibits the cholestatic liver fibrosis in Mdr2^(−/−)mice by polarizing M1 macrophages and balancing immune responses

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Chinese Journal of Natural Medicines 2024年第7期22卷 582-598页

作者： JIA Kexin MA Zhi ZHANG yinhao XIE Kaihong LI jianan WU Jianzhi qu Jiaorong LI Fanghong LI Xiaojiaoyang School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China

Liver fibrosis is characterized by chronic inflammatory responses and progressive fibrous scar *** play a central role in the pathogenesis of hepatic fibrosis by reconstructing the immune *** Ⅱ(PIC Ⅱ),extracted from Picrorhizae Rhizoma,has demonstrated therapeutic potential for various liver ***,the mechanisms by which macrophage polarization initiates immune cascades and contributes to the development of liver fibrosis,and whether this process can be influenced by PIC Ⅱ,remain *** the current study,RNA sequencing and multiple molecular approaches were utilized to explore the underlying mechanisms of PIC Ⅱ against liver fibrosis in multidrug-resistance protein 2 knockout(Mdr2^(−/−))*** findings indicate that PIC Ⅱ activates M1-polarized macrophages to recruit natural killer cells(NK cells),potentially via the CXCL16-CXCR6 ***,PIC Ⅱ promotes the apoptosis of activated hepatic stellate cells(aHSCs)and enhances the cytotoxic effects of NK cells,while also reducing the formation of neutrophil extracellular traps(NETs).Notably,the anti-hepatic fibrosis effects associated with PIC Ⅱ were largely reversed by macrophage depletion in Mdr2^(−/−)***,our research suggests that PIC Ⅱ is a potential candidate for halting the progression of liver fibrosis.

关键词： Liver fibrosis PicrosideⅡ M1 macrophage Hepatic stellate cell Natural killer cell Neutrophil

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