检索结果-南通市图书馆

A Refined Model of Three-roller Elastoplastic Asymmetrical Pre-bending of Plate

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2014年第3期21卷 328-334页

作者： Zhi-qiang ZHANG jian-li SONG jian-hua fu Yong-tang LI Yi-na GUO School of Material Science and Engineering Taiyuan University of Science and Technology

The geometry of plate after edge pre-bending mode is compared with that after roll-bending mode and the relationship among edge pre-bending angle, pre-bending edge length, and cylindrical desired radius is presented for a three-roller plate bender with bottom rollers adjustable horizontally. The analytical moment-curvature model and springhaek model for pure bending are established, assuming that the stress-strain relationship of material is linear, and the material is in plain strain and yields according to Mises yield criterion. The mathematical model for three- roller edge pre-bending of plate is developed considering the effect of pre-bending edge length, bottom roller radius, friction between plate and roller, etc. The plate tensile test and plate bending test are done and the numerical results agree well with the test data. The results are shown graphically and analyzed in the following aspects：（1） the error between numerical results and test data of top roiler force; （2） the influence of bottom roller radius, relative curva- ture, and bending arc length on springback angle; （3） the relationship between springhack ratio and edge pre-ben- ding angle.

关键词： plate~ elastoplastic~ three-roller edge pre-bending~ asymmetrizal bending~ springback

Risk of asthma in preterm infants with bronchopulmonary dysplasia: a systematic review and meta‑analysis

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2023年第6期19卷 549-556页

作者： Tong Sun Hai-Yang Yu Miao Yang Yi-Fan Song jian-hua fu Department of Pediatrics Shengjing Hospital of China Medical UniversitySanhao StreetHeping DistrictShenyangChina Department of Neurology Shengjing Hospital of China Medical UniversityShenyangChina

Background This study aimed to systematically review and meta-analyze the available literature on the association between preterm infant bronchopulmonary dysplasia(BPD)and pre-adulthood *** Studies examining the association between BPD and asthma in children and adolescents were systematically reviewed,and a meta-analysis was *** searched Scopus,Embase,Web of Science,PubMed,and Cochrane Library from the database inception to March 26,*** pooled odds ratio(OR)estimate was used in our meta-analysis to calculate the correlation between BPD and the probability of developing asthma before *** 12.0 was used to conduct the statistical *** The correlation between asthma and BPD in preterm newborns was examined in nine *** used a random effect model to pool the OR *** results indicated a marked increase in the risk of subsequent asthma in preterm infants with BPD[OR=1.73,95% confidence interval(CI)=1.43-2.09].Moreover,there was no obvious heterogeneity across the studies(P=0.617,I^(2)=0%).The pooled OR remained stable and ranged from 1.65(95%CI=1.35-2.01)to 1.78(95%CI=1.43-2.21).Regarding publication bias,the funnel plot for asthma risk did not reveal any noticeable *** further performed Begg’s and Egger’s tests to quantitatively evaluate publication *** was no evidence of a publication bias for asthma risk(P>|Z|=0.602 for Begg’s test,and P>|t|=0.991 for Egger’s test).Conclusions Our findings indicate that preterm infants with BPD have a much higher risk of developing asthma in the future(OR=1.73,95%CI=1.43-2.09).Preterm infants with BPD may benefit from long-term follow-up.

关键词： Asthma Bronchopulmonary dysplasia Preterm infants

Safety and efficacy of transcatheter arterial embolization in autosomal dominant polycystic kidney patients with gross hematuria: Six case reports

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第11期12卷 1954-1959页

作者： Wei-Fan Sui Yun-Xin Duan jian-Yun Li Wei-Bin Shao jian-hua fu Department of Interventional Radiology Zhenjiang First People's HospitalZhenjiang 212000Jiangsu ProvinceChina Department of Nephrology Zhenjiang First People’s HospitalZhenjiang 212000Jiangsu ProvinceChina

BACKGROUND To retrospectively report the safety and efficacy of renal transcatheter arterial embolization for treating autosomal dominant polycystic kidney disease(ADPKD)patients with gross *** SUMMARY The purpose of this study is to retrospectively report the safety and efficacy of renal transcatheter arterial embolization for treating ADPKD patients with gross *** and methods:During the period from January 2018 to December 2019,renal transcatheter arterial embolization was carried out on 6 patients with polycystic kidneys and gross *** arteriography was performed first,and then we determined the location of the hemorrhage and performed embolization under digital subtraction angiography *** in routine blood test results,routine urine test results,urine color and postoperative reactions were observed and ***:Renal transcatheter arterial embolization was successfully conducted in 6 *** indices of 5 patients and the color of gross hematuria improved after surgery compared with before *** severe complication reactions *** For autosomal dominant polycystic kidney syndrome patients with gross hematuria,transcatheter arterial embolization was safe and effective.

关键词： Renal artery Autosomal dominant polycystic kidney disease Gross hematuria Interventional radiology Embolization Case report

Prognostic value of preoperative mean corpuscular volume in esophageal squamous cell carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第18期19卷 2811-2817页

作者： Yu-Zhen Zheng Shu-Qin Dai Wei Li Xun Cao Yong Li Lan-Jun Zhang jian-hua fu JunYe Wang Department of Thoracic Oncology Cancer Center Sun Yat-Sen University Department of Clinical Laboratory Sun Yat-Sen University Cancer Center Department of Anesthesia Sun Yat-Sen University Cancer Center Intensive Care Unit Sun Yat-Sen University Cancer Center Department of Pathology Sun Yat-Sen University Cancer Center

AIM: To evaluate whether preoperative mean corpuscular volume (MCV) is a prognostic indicator in patients with resectable esophageal squamous cell carcinoma (ESCC). METHODS: A total of 298 consecutive, prospectively enrolled patients with histologically diagnosed ESCC who underwent surgery with curative intent from 2001 to 2011 were retrospectively evaluated. Patients were excluded if they had previous malignant disease, distant metastasis at the time of primary treatment, a history of neoadjuvant treatment, had undergone nonradical resection, or had died of a non-tumor-associated cause. Survival status was verified in September 2011. Pathological staging was performed based on the 2010 American Joint Committee on Cancer criteria. Preoperative MCV was obtained from blood counts performed routinely within 7 d prior to surgery. Receiver operating characteristic (ROC) curve analysis was used to determine a cutoff for preoperative MCV. RESULTS: The 298 patients consisted of 230 males and 68 females, with a median follow-up of 30.1 mo. ROC analysis showed an optimal cutoff for preoperative MCV of 95.6 fl. Fifty-nine patients (19.8%) had high (> 95.6 fl) and 239 (80.2%) had low (≤ 95.6 fl) preoperative MCV. Preoperative MCV was significantly associated with gender (P=0.003), body mass index (P=0.017), and preoperative red blood cell count (P<0.001). The predicted 1-, 3and 5-year overall survival (OS) rates were 72%, 60% and 52%, respectively. Median OS was significantly longer in patients with low than with high preoperative MCV (27.5 mo vs 19.4 mo, P<0.001). Multivariate analysis showed that advanced pT (P=0.018) and pN (P<0.001) stages, upper thoracic location (P=0.010), lower preoperative albumin concentration (P=0.002), and high preoperative MCV (P=0.001) were negative prognostic factors in patients with ESCC. Preoperative MCV also stratified OS in patients with T3, N1-N3, G2-G3 and stage Ⅲ tumors. CONCLUSION: Preoperative MCV is a prognostic factor in patients with E

关键词： Preoperative markers Mean corpuscular volume Prognosis Resectable Esophageal neoplasms

Transarterial chemoembolization plus stent placement for hepatocellular carcinoma with main portal vein tumor thrombosis:A meta-analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2024年第3期15卷 447-455页

作者： Wei-Fan Sui jian-Yun Li jian-hua fu Department of Interventional Radiology Zhenjiang First People's HospitalZhenjiang 212000Jiangsu ProvinceChina

BACKGROUND Portal vein tumor thrombus is an important indicator of poor prognosis in patients with hepatocellular *** chemoembolization is recommended as the standard first-line therapy for unresectable hepatocellular *** vein stent placement is a safe and effective therapy for promptly restoring flow and relieving portal hypertension caused by tumor *** To assess the clinical significance of transarterial chemoembolization plus stent placement for the treatment of hepatocellular carcinoma with main portal vein tumor *** We searched English and Chinese databases,assessed the quality of the included studies,analyzed the characteristic data,tested heterogeneity,explored heterogeneity,and tested publication *** In total,eight clinical controlled trials were *** results showed that the pressure in the main portal vein after stent placement was significantly lower than that with no stent *** cumulative stent patency and survival rates at 6 and 12 months were lower in the transarterial chemoembolization+stent placement group than in the transarterial chemoembolization+stent placement+brachytherapy/radiotherapy *** survival rates of patients treated with transarterial chemoembolization+stent placement for 6 and 12 months were higher than those of patients treated with transarterial chemoembolization *** For Chinese patients with hepatocellular carcinoma with main portal vein tumor thrombosis,transarterial chemoembolization plus stenting is *** chemoembolization+stent placement is more effective than transarterial chemoembolization *** chemoembolization+stent placement+brachytherapy/radiotherapy is more effective than transarterial chemoembolization+stenting.

关键词： Hepatocellular carcinoma Transarterial chemoembolization Portal vein tumor thrombus Stent Meta-analysis

Lung carcinoma signaling pathways activated by smoking

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2011年第8期30卷 551-558页

作者： Jing Wen jian-hua fu Wei Zhang Ming Guo Department of Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030-4009 USA State Key Laboratory of Oncology in South China Department of Thoracic Oncology Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China

Lung cancer is the leading cause of cancer death in men and women worldwide,with over a million deaths *** smoke is the major etiologic risk factor for lung cancer in current or previous smokers and has been strongly related to certain types of lung cancer,such as small cell lung carcinoma and squamous cell lung *** recent years,there has been an increased incidence of lung *** change is strongly associated with changes in smoking behavior and cigarette *** present in tobacco products and their intermediate metabolites can activate multiple signaling pathways that contribute to lung cancer *** this review,we summarize the smoking-activated signaling pathways involved in lung cancer.

关键词：信号通路吸烟者肺癌激活死亡人数危险因素烟草烟雾吸烟行为

Prognostic role of neutrophil-lymphocyte ratio in operable esophageal squamous cell carcinoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第18期21卷 5591-5597页

作者： Hao Duan Xu Zhang Fei-Xiang Wang Mu-Yan Cai Guo-Wei Ma Hong Yang jian-hua fu Zi-Hui Tan Yu-Qi Meng Xia-Yu fu Qi-Long Ma Peng Lin Department of Thoracic Oncology Sun YatSen University Cancer Center Department of Pathology Sun Yat-sen University Cancer Center Guangdong Esophageal Cancer Research Institute

AIM:To explore the relationship of clinicopathological features and the distribution of neutrophils in the t umor mic roenvironment wi t h t he prognosis of ***:Two hundred and fifty-four formalin-fixed and paraffin embedded tissue blocks were analyzed, including tissues from cholangiocarcinoma(n = 254), and tumor adjacent tissues(n = 238).Tissue sections were stained for CD15 using immunohistochemical ***15 expression was detected to identify the distribution of neutrophils in the local tumor *** neutrophil density of the tumor tissues and the adjacent tumor tissues was detected to reflect their inflammatory *** data and follow-up information of cholangiocarcinoma patients who underwent surgery from January 2004 to December 2010 were analyzed *** relationship between clinicopathological features and the distribution of neutrophils with prognosis of the patients were ***:The positive expression level of CD15 was only significantly related to the TNM ***15 expression was higher in tumor tissues than in adjacent tissues(73.6% vs 54.6%), with significant *** with high expression of CD15 had significantly shorter overall survival(OS) than those with low expression of CD15(median overall survival time 39.77 mo vs 16.87 mo, P = 0.008).Patients with high CD15 expression had significantly shorter disease free survival time(DFS) than those with low expression of CD15(median DFS 38.27 mo vs 16.83 mo, P = 0.029).COX multivariate analysis indicated that high CD15 expression in tumor tissues was an independent risk factor for predicting OS for patients with cholangiocarcinoma [P = 0.012, relative risk(RR) = 1.601], but it was not an independent risk factor for predicting DFS(P = 0.073, RR = 1.462).CONCLUSION:Patients with high CD15 expression in cancer tissues had shorter DFS and *** expression of CD15 is an independent risk factor for OS.

关键词： Cholangiocarcinoma Surgery Neutrophils CD15 Prognosis Tumor microenvironment

Hawthorn Leaves Flavonoids Decreases Inflammation Related to Acute Myocardial Ischemia/Reperfusion in Anesthetized Dogs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2013年第8期19卷 582-588页

作者： jian-hua fu 付建华 (11250) Yong-qiu Zheng 郑咏秋 (11250) Peng Li 李鹏 (11250) Xin-zhi Li 李欣志 (11250) Xiao-hong Shang 尚晓泓 (11250) jian-xun Liu 刘建勋 (11250) 11250. Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing 100091 China

Objective： To investigate the effects and mechanisms of hawthorn leaves flavonoids （HLF） on acute myocardial ischemiaJreperfusion in anesthetized dogs. Methods： The acute ischemia models were prepared by ligating left anterior descending （LAD） artery for 60 min. Qualified 15 male dogs were randomly divided into 3 groups with 5 in each group： blank control （treated with normal saline 3 mL/kg） group, HLF low dosage （5 mg/kg） group and high dosage （10 mg/kg） group, with an once injection through a femoral vein 5 min before reperfusion. Epicardial electrocardiogram was adopted to measure the scope and degree of myocardial ischemia. Simultaneously, neutrophil infiltration in infarct （Inf） and remote site （RS） of myocardial tissue was measured by myeloperoxidase （MPO） activity assay. The serum interleukin-1 （IL-1） and tumor necrosis factor~ （TNF-~） content were quantified by radioimmuno-assay. furthermore, expression of G protein-coupled receptor kinase 2 （GRK2） and nuclear factor K B （NF- K B） in Inf and RS tissue were detected by Western blotting technique. Results： Ischemia and reperfusion increased the MPO activity and IL-1 and TNF-~ content. HLF （10 and 5 mg/kg） could significantly decrease the degree and scope of myocardial ischemia; markedly inhibit the increase of MPO activity, and IL-1 and TNF-o~ content induced by myocardial ischemia/infarction. furthermore, HLF increased GRK2 expression and inhibited NF- K B expression in Inf tissue. Conclusion： HLF could improve the situation of acute myocardial ischemia and inhibit the inflammation in anesthetized dogs, which might be due to its increasing effect on the GRK2 and NF- K B expressions.

关键词： hawthorn leaves flavonoids acute myocardial ischemia reperfusion inflammation G protein-coupled receptor kinase 2

JMJD3 promotes esophageal squamous cell carcinoma pathogenesis through epigenetic regulation of MYC

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2020年第1期5卷 1043-1045页

作者： Shu-Man Li Li-Ru He Jie-Wei Chen Jie Zhou Run-Cong Nie Xiao-Han Jin Xin Wang jian-hua fu Feng-Wei Wang Dan Xie State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouPR China Department of Medical Oncology Henan Cancer Hospitalthe Affiliated Cancer Hospital of Zhengzhou UniversityHenanPR China Department of Pathology Sun Yat-sen University Cancer CenterGuangzhouPR China Guangdong Esophageal Cancer Institute GuangzhouPR China

Dear Editor,Esophageal squamous cell carcinoma(ESCC)is a common cancer worldwide with a 5-year survival rate less than 25%.Reliable molecular markers that could serve as predictors for diagnosis and treatment for ESCC patients are greatly *** dysregulation of epigenetic control is one of the common features in ***3 is a histone demethylase specific for H3K27me3/me2 that switches a gene from its repressive state to an active form.1 The dysregulation of JMJD3 is reported to play key roles in many cancer ***,JMJD3 was reported to be overexpressed in ESCC,2 but the potential mechanism of JMJD3 in ESCC remains poorly understood.

关键词： JMJD3 squamous epigenetic