Risk of asthma in preterm infants with bronchopulmonary dysplasia: a systematic review and meta‑analysis
作者机构:Department of PediatricsShengjing Hospital of China Medical UniversitySanhao StreetHeping DistrictShenyangChina Department of NeurologyShengjing Hospital of China Medical UniversityShenyangChina
出 版 物:《World Journal of Pediatrics》 (世界儿科杂志(英文版))
年 卷 期:2023年第19卷第6期
页 面:549-556页
核心收录:
学科分类:1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
基 金:the funding of Key R&D Guidance Plan Projects in Liaoning Province(2020JH1/10300001)
主 题:Asthma Bronchopulmonary dysplasia Preterm infants
摘 要:Background This study aimed to systematically review and meta-analyze the available literature on the association between preterm infant bronchopulmonary dysplasia(BPD)and pre-adulthood *** Studies examining the association between BPD and asthma in children and adolescents were systematically reviewed,and a meta-analysis was *** searched Scopus,Embase,Web of Science,PubMed,and Cochrane Library from the database inception to March 26,*** pooled odds ratio(OR)estimate was used in our meta-analysis to calculate the correlation between BPD and the probability of developing asthma before *** 12.0 was used to conduct the statistical *** The correlation between asthma and BPD in preterm newborns was examined in nine *** used a random effect model to pool the OR *** results indicated a marked increase in the risk of subsequent asthma in preterm infants with BPD[OR=1.73,95% confidence interval(CI)=1.43-2.09].Moreover,there was no obvious heterogeneity across the studies(P=0.617,I^(2)=0%).The pooled OR remained stable and ranged from 1.65(95%CI=1.35-2.01)to 1.78(95%CI=1.43-2.21).Regarding publication bias,the funnel plot for asthma risk did not reveal any noticeable *** further performed Begg’s and Egger’s tests to quantitatively evaluate publication *** was no evidence of a publication bias for asthma risk(P|Z|=0.602 for Begg’s test,and P|t|=0.991 for Egger’s test).Conclusions Our findings indicate that preterm infants with BPD have a much higher risk of developing asthma in the future(OR=1.73,95%CI=1.43-2.09).Preterm infants with BPD may benefit from long-term follow-up.