Lung carcinoma signaling pathways activated by smoking

作     者：Jing Wen Jian-Hua Fu Wei Zhang Ming Guo 

作者机构：Department of Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030-4009 USA State Key Laboratory of Oncology in South China Department of Thoracic Oncology Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China 

出 版 物：《Chinese Journal of Cancer》 (Chin. J. Cancer)

年 卷 期：2011年第30卷第8期

页      面：551-558页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 08[工学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 0822[工学-轻工技术与工程] 

基　　金：supported by a fellowship from China Education Council 

主　　题：信号通路 吸烟者 肺癌 激活 死亡人数 危险因素 烟草烟雾 吸烟行为 

摘      要：Lung cancer is the leading cause of cancer death in men and women worldwide,with over a million deaths *** smoke is the major etiologic risk factor for lung cancer in current or previous smokers and has been strongly related to certain types of lung cancer,such as small cell lung carcinoma and squamous cell lung *** recent years,there has been an increased incidence of lung *** change is strongly associated with changes in smoking behavior and cigarette *** present in tobacco products and their intermediate metabolites can activate multiple signaling pathways that contribute to lung cancer *** this review,we summarize the smoking-activated signaling pathways involved in lung cancer.