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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 697-711页

作者： Baosheng Liu jiali wei Shaohua Zhang Yuezhong Zhang Pengpeng Wu Daqing Fang Guorui Ma School of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China Intelligent Equipment Research and Development Center Zhuhai Institute of Advanced Technology Chinese Academy of SciencesZhuhai 519080China Advanced Materials Research Institute Zhuhai Dingmei Medical Technology Co.Ltd.Zhuhai 519000China

Mg-6Zn-2X(Fe/Cu/Ni)alloys were prepared through semi-continuous casting,with the aim of identifying a degradable magnesium(Mg)alloy suitable for use in fracturing balls.A comparative analysis was conducted to assess the impacts of adding Cu and Ni,which result in finer grains and the formation of galvanic corrosion sites.Scanner electronic microscopy examination revealed that precipitated phases concentrated at grain boundaries,forming a semi-continuous network structure that facilitated corrosion penetration in Mg-6Zn-2Cu and Mg-6Zn-2Ni alloys.Pitting corrosion was observed in Mg-6Zn-2Fe,while galvanic corrosion was identified as the primary mechanism in Mg-6Zn-2Cu and Mg-6Zn-2Ni alloys.Among the tests,the Mg-6Zn-2Ni alloy exhibited the highest corrosion rate(approximately 932.9 mm/a)due to its significant potential difference.Mechanical testing showed that Mg-6Zn-2Ni alloy possessed suitable ultimate compressive strength,making it a potential candidate material for degradable fracturing balls,effectively addressing the challenges of balancing strength and degradation rate in fracturing applications.

关键词： magnesium alloys microstructure micro-galvanic corrosion mechanical properties

Can Tibetan medicine Honghua Ruyi pills relieve endometriosisassociated dysmenorrhea?Protocol for a randomized placebocontrolled trial

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Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 78-85页

作者： Mei Han Jiahui Cao jiali wei Hui Luo Chaoqin Yu Xuefang Liang Nyangmotse Guoyan Yang Huilan Du Jianping Liu Centre for Evidence-Based Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China College of Management Beijing University of Chinese MedicineBeijing 102488China College of Acupuncture and Moxibustion Beijing University of Chinese MedicineBeijing 102488China Institute for Tibetan Medicine China Tibetology Research CenterBeijing 100101China Changhai Hospital Naval Medical UniversityShanghai 200433China Department of Gynaecology Guangdong Provincial Hospital of Chinese MedicineGuangdong 510120China Department of Gynaecology Tibetan Medicine Hospital of Qinghai ProvinceXining 810007China NICM Health Research Institute Western Sydney UniversityPenrithNSW 2751Australia College of Integrated Chinese and Western Medicine Hebei University of Chinese MedicineShijiazhuang 050200China

Objective:To provide high-quality clinical evidence of the efficacy of Tibetan medicine Honghua Ruyi(HHRY)pills for endometriosis-associated dysmenorrhea.Methods:This study constitutes a multicenter,randomized,double-blind,placebo-controlled trial encompassing a three-menstrual cycle intervention followed by a three-menstrual cycle follow-up period.A total of 164 eligible females with endometriosis-associated dysmenorrhea were randomly divided into HHRY pills and placebo groups in a 1:1 ratio.The primary outcome included dysmenorrhea symptoms assessed using Visual Analog Scale(VAS)scores and quality of life,whereas the secondary outcome measures included the maximum VAS for non-menstrual pelvic pain,duration of pain episodes(in days),frequency and quantity of the consumption of ibuprofen sustained-release capsules(or other non-steroidal anti-inflammatory drugs),and days off work/study for staff/student due to dysmenorrhea,ovarian cyst,and/or pelvic nodule size.The safety was monitored throughout the treatment period.All the analyses were based on the intention-to-treat principle.For continuous outcomes,simple or multiple linear regressions were used to estimate the differences between the HHRY pills and placebo groups,with categorical data expressed as the number and percentage of occurrences.Differences were compared using the chi-square test or Fisher's exact test.The predefined analysis was adjusted for concomitant treatment,a variable considered to be associated with outcomes but unaffected by treatment allocation.Estimates of treatment effects were reported with 95%confidence intervals.Two-tailed P values≤.05 were considered statistically significant.Conclusion:Positive results from this trial,upon completion would provide robust evidence for the efficacy and safety of HHRY pills in treating dysmenorrhea in patients with endometriosis.

关键词： Endometriosis Dysmenorrhea Honghua Ruyi pills Randomized controlled trial Traditional Chinese medicine

The role of cAMP-dependent protein kinase A in the formation of long-term memory in Bactrocera dorsalis

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Journal of Integrative Agriculture 2024年第2期23卷 605-620页

作者： Jinxin Yu Yanmin Hui Jiayi He Yinghao Yu Zhengbing Wang Siquan Ling wei Wang Xinnian Zeng jiali Liu National Key Laboratory of Green Pesticides/Guangdong Engineering Research Center for Insect Behavior Regulation/College of Plant Protection South China Agricultural UniversityGuangzhou 510642China College of Life Science and Agronomy Zhoukou Normal UniversityZhoukou 466001China Guangdong Provincial Key Laboratory of Silviculture Protection and UtilizationGuangdong Academy of ForestryGuangzhou 510520China

The cAMP-dependent protein kinase A(PKA)signaling pathway has long been considered critical for long-term memory(LTM)formation.Previous studies have mostly focused on the role of PKA signaling in LTM induction by multiple spaced conditioning with less attention to LTM induction by a single conditioning.Here,we conducted behavioral-pharmacology,enzyme immunoassay and RNA interference experiments to study the role of the PKA signaling pathway in LTM formation in the agricultural pest Bactrocera dorsalis,which has a strong memory capacity allowing it to form a two-day memory even from a single conditioning trial.We found that either blocking or activating PKA prior to conditioning pretreatment affected multiple spaced LTM,and conversely,they did not affect LTM formed by single conditioning.This was further confirmed by enzyme-linked immunosorbent assay(ELISA)and silencing of the protein kinase regulatory subunit 2 and catalytic subunit 1.Taken together,these results suggest that activating PKA during memory acquisition helps to induce the LTM formed by multiple spaced conditioning but not by a single conditioning.Our findings challenge the conserved role of PKA signaling in LTM,which provides a basis for the greater diversity of molecular mechanisms underlying LTM formation across species,as well as possible functional and evolutionary implications.

关键词： Bactrocera dorsalis LTM multiple spaced PKA single

Transcriptome Analysis via RNA Sequencing Reveals the Molecular Mechanisms Underlying the Hedera helix Response to High Temperature

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Phyton-International Journal of Experimental Botany 2022年第11期91卷 2403-2417页

作者： Ting Zhang Ping Li jiali wei Shanghai Botanical Garden Shanghai200231China Shanghai Engineering Research Center of Sustainable Plant Innovation Shanghai200231China Shanghai Key Laboratory of Bio-Energy Crops School of Life SciencesShanghai UniversityShanghai200444China

Hedera helix is an evergreen ornamental plant that is resistant to cool but not high temperature and deserves to be further researched for improving its adaptability to heat stress.Two Hedera helix cultivars,heat-tolerant(HT)‘Jessica’and heat-sensitive(HS)‘Shamrock’,were used for differences analyses of transcriptome.We detected 6179 differentially expressed genes(DEGs)and 5992 DEGs in‘Jessica’and‘Shamrock’to heat stress,respectively.Among these,1983 upregulated DEGs and 1400 downregulated DEGs were shared between both varieties,resulting in enhancement of various pathways such as biosynthesis of secondary metabolites,glyoxylate dicarboxylate metabolism,and protein processing in endoplasmic reticulum(PPER),RNA transport,respectively.Among the common downregulated DEGs,72 TFs in 25 gene families were found,including members of the MYB and MYBrelated families,the bHLH family,etc.In‘Jessica’(HT),634 unique up-regulated DEGs were identified,including genes associated with phenylpropanoid biosynthesis,starch and sucrose metabolism,biosynthesis of amino acids.Most upregulated TFs of HT were upregulated much more rapidly than those of HS in response to high temperature.Eleven TF-encoding genes were selected to verify the RNA sequencing data by qPCR.This study revealed the gene expression patterns of ivy in response to heat stress and the molecular basis of heat tolerance,which provided theoretical references for improving the heat tolerance of ivy.

关键词： Hedera helix RNA-sequencing heat stress heat tolerance transcriptome

Health risks and sources of trace elements and black carbon in PM_(2.5)from 2019 to 2021 in Beijing

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Journal of Environmental Sciences 2024年第8期142卷 69-82页

作者： Chenjie Hua wei Ma Feixue Zheng Yusheng Zhang jiali Xie Li Ma Boying Song Chao Yan Hongyan Li Zhen Liu Qian Liu Markku Kulmala Yongchun Liu Aerosol and Haze Laboratory Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Institute for Atmospheric and Earth System Research Faculty of ScienceUniversity of HelsinkiHelsinki 00014Finland School of Environment and Safety Taiyuan University of Science and TechnologyTaiyuan 030024China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

A comprehensive health risk assessment of PM_(2.5)is meaningful to understand the current status and directions regarding further improving air quality from the perspective of human health.In this study,we evaluated the health risks of PM_(2.5)as well as highly toxic inorganic components,including heavy metals(HMs)and black carbon(BC)based on longterm observations in Beijing from 2019 to 2021.Our results showed that the relative risks of chronic obstructive pulmonary disease,lung cancer,acute lower respiratory tract infection,ischemic heart disease,and stroke decreased by 4.07%-9.30%in 2020 and 2.12%-6.70%in2021 compared with 2019.However,they were still at high levels ranging from 1.26 to 1.77,in particular,stroke showed the highest value in 2021.Mn had the highest hazard quotient(HQ,from 2.18 to 2.56)for adults from 2019 to 2021,while Ni,Cr,Pb,As,and BC showed high carcinogenic risks(CR>1.0×10^(-6))for adults.The HQ values of Mn and As and the CR values of Pb and As showed constant or slight upwards trends during our observations,which is in contrast to the downward trends of other HMs and PM_(2.5).Mn,Cr,and BC are crucial toxicants in PM_(2.5).A significant shrink of southern region sourcesof HMs and BCshrank suggests the increased importance of local sources.Industry,dust,and biomass burning are the major contributors to the non-carcinogenic risks,while traffic emissions and industry are the dominant contributors to the carcinogenic risks in Beijing.

关键词： PM_(2.5) Heavy metals Black carbon Health risk Source apportionment

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi jiali Song Luojia Wu wei Wan Xiuqin Rao Yue Lin Gen wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

不同大小甲状腺髓样癌与甲状腺乳头状癌的超声特征比较

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中华肿瘤杂志 2024年第2期46卷 133-139页

作者：张岱杨凡王莹穆佳丽魏雪晴魏玺天津医科大学肿瘤医院超声诊疗科、国家恶性肿瘤临床医学研究中心、天津市肿瘤防治重点实验室、天津市恶性肿瘤临床医学研究中心天津300060

目的探讨不同大小甲状腺髓样癌(MTC)的超声特征,为不同大小MTC和甲状腺乳头状癌(PTC)的鉴别诊断提供有效信息。方法2018年6月至2022年3月在天津医科大学肿瘤医院超声检查发现并经病理证实的MTC患者87例,PTC患者220例。以甲状腺结节最大... 详细信息

目的探讨不同大小甲状腺髓样癌(MTC)的超声特征,为不同大小MTC和甲状腺乳头状癌(PTC)的鉴别诊断提供有效信息。方法2018年6月至2022年3月在天津医科大学肿瘤医院超声检查发现并经病理证实的MTC患者87例,PTC患者220例。以甲状腺结节最大径1 cm为界值,将患者分为小结节组(最大径≤1 cm)和大结节组(最大径>1 cm)。小结节组97例,其中MTC 28例,PTC 69例。大结节组210例,其中MTC 59例,PTC 151例。按甲状腺结节分层后,比较MTC与PTC患者甲状腺结节和转移性淋巴结的超声声像图特征、术前血清降钙素(CT)和癌胚抗原(CEA)水平。结果在小结节组中,MTC表现为低回声、边缘光滑、有血流信号的比例高于PTC,差异有统计学意义(均P0.05)。在小结节组中,分别有6例甲状腺髓样癌转移性淋巴结(LNM-MTC)和11例甲状腺乳头状癌转移性淋巴结(LNM-PTC)被超声正确诊断,超声对二者的诊断符合率分别为78.6%(22/28)和78.3%(54/69),差异无统计学意义(P=0.973)。大结节组中,分别有28例LNM-MTC和83例LNM-PTC被超声正确诊断,超声对二者的诊断符合率分别为88.1%(52/59)和73.5%(111/151),差异有统计学意义(P=0.022),其中82.1%的LNM-MTC和56.6%的LNM-PTC表现为血流信号异常,二者比较差异有统计学意义(P=0.016)。小结节组和大结节组MTC患者术前血清CT、CEA水平差异均有统计学意义(均P<0.05)。结论不同大小的MTC超声特征不同,淋巴结内异常血流信号对LNM-MTC的诊断具有重要意义。在缺乏超声特征的情况下,结合术前血清CT检测有助于MTC的诊断。

关键词：甲状腺髓样癌甲状腺乳头状癌超声降钙素

注意力引导全尺度连接网络的高分辨率影像变化检测

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遥感学报 2024年第4期28卷 1052-1065页

作者：刘英何雪李单阳岳辉魏嘉莉西安科技大学测绘科学与技术学院西安710054 中国地质大学(武汉)国家地理信息系统工程技术研究中心武汉430000

针对普通跳跃连接缺乏从全尺度角度获取变化信息及编码器特征提取能力不足的问题,本文设计了耦合注意力机制CBAM(Convolutional Block Attention Module)的UNet+++高分辨率遥感影像变化检测网络CBAM UNet+++。CBAM UNet+++基于融合全尺... 详细信息

针对普通跳跃连接缺乏从全尺度角度获取变化信息及编码器特征提取能力不足的问题,本文设计了耦合注意力机制CBAM(Convolutional Block Attention Module)的UNet+++高分辨率遥感影像变化检测网络CBAM UNet+++。CBAM UNet+++基于融合全尺度特征的语义分割结构UNet+++,同时替换基本卷积单元为残差注意力模块ResBlock_CBAM(Residual Block_CBAM)抑制背景影响,增强编码器对显著特征的学习能力,并利用两种不同变化类型的高分辨率遥感影像变化检测数据集进行验证。结果表明:该方法在LEBEDEV多地物变化数据集上取得最高精度,F1(F1-Score)和OA(Overall Accuarcy)值分别为88.9%、97.3%;在LEVIR-CD建筑物变化数据集上取得次高精度,F1和OA值分别为86.7%、96.8%;同时,该法能有针对性的获取深层语义,定性结果优于其他基准网络。

关键词：遥感变化检测 UNet+++ 注意力机制编码解码

ISO15189:2022标准对室内质量控制要求实施的再思考

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中华检验医学杂志 2024年第5期47卷 493-497页

作者：王薇王治国刘佳丽北京医院、国家老年医学中心、国家卫生健康委临床检验中心/北京市临床检验工程技术研究中心、中国医学科学院老年医学研究院北京100730

国际标准化组织(ISO)15189:2022《医学实验室-质量和能力要求》已正式发布。作为我国医学实验室质量管理和能力建设的科学依据,新版标准将对我国临床实验室质量水平的提高起到重要的推动作用。室内质量控制是质量监测系统的重要组成部分... 详细信息

国际标准化组织(ISO)15189:2022《医学实验室-质量和能力要求》已正式发布。作为我国医学实验室质量管理和能力建设的科学依据,新版标准将对我国临床实验室质量水平的提高起到重要的推动作用。室内质量控制是质量监测系统的重要组成部分,在保证检验结果有效性方面意义重大,同时ISO15189:2022文件将基于患者数据室内质量控制方法纳入为一种质量控制程序,也是目前室内质量控制发展的新趋势。随着实验室信息学的不断发展和新版标准ISO15189:2022的发布,我们有必要对室内质量控制进行再一次的深度思考,探究当前形势下室内质量控制所面临的问题和挑战。

关键词：临床实验室技术质量控制质控品

Titanium Dioxide Nanoparticles Promote Root Growth by Interfering with Auxin Pathways in Arabidopsis thaliana

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Phyton-International Journal of Experimental Botany 2020年第4期89卷 883-891页

作者： jiali wei Ying Zou Ping Li Xiaojun Yuan Shanghai Key Laboratory of Bio-Energy Crops Research Center for Natural ProductsPlant Science CenterSchool of Life SciencesShanghai UniversityShanghai200444China

TiO_(2) nanoparticles(nano-TiO_(2))are widely used in the world,and a considerable amount of nano-TiO_(2) is released into the environment,with toxic effects on organisms.In the various species of higher plants,growth,including seed germination,root elongation,and biomass accumulation,is affected by nano-TiO_(2).However,the underlying molecular mechanisms remain to be elucidated.In this study,we observed that nano-TiO_(2) promoted root elongation in a dose-dependent manner.Furthermore,we found that nano-TiO_(2) elevated auxin accumulation in the root tips of the auxin marker lines DII-VENUS and DR5::GUS,and,correspondingly,quantitative real-time PCR analysis revealed that nano-TiO_(2) increased the expression levels of auxin biosynthesis-and transport-related genes.GFP fluorescence observation using transgenic PIN2-GFP indicated that nano-TiO_(2) promoted root growth by inducing PIN2 accumulation.Thus,we propose that nano-TiO_(2) promote root growth in Arabidopsis thaliana by altering the expression levels of auxin biosynthesis-and transport-related genes.

关键词： Nanoparticles nano-TiO_(2) root length auxin PIN2 auxin-related genes