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Genes & Diseases 2023年第3期10卷 743-745页

作者： Mengjie Feng Xiu Yu Yongjian Yue jiacheng zhong Lingwei Wang Department of Respiratory and Critical Care Medicine Shenzhen Key Laboratory of Respiratory DiseasesShenzhen Respiratory Disease Prevention CenterShenzhen Institute of Respiratory DiseasesShenzhen People's Hospital(Second Clinical Medical College of Jinan University&First Affiliated Hospital of Southern University of Science and Technology)ShenzhenGuangdong 518020China

Primary ciliary dyskinesia(PCD)is an autosomal recessive disease caused by defects in motile cilia and clinically characterized by bronchiectasis,situs inversus,nasosinusitis,recurrent respiratory infections,tympanitis,and/or male infertility.In PCD,impaired function or structure of motile cilia leads to abnormality of mucociliary clearance。

关键词： respiratory impaired Primary

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抗体免疫缺陷病成年患者的呼吸系统表现

中华结核和呼吸杂志 2024年第4期47卷 388-392页

作者：钟佳成王凌伟深圳市人民医院呼吸与危重症医学科暨南大学第二临床医学院南方科技大学附属第一医院深圳市呼吸疾病研究所深圳518020

抗体免疫缺陷病是一组由遗传缺陷引起的先天性疾病,影响机体免疫防御机制的发育和功能。患者可表现为反复感染、淋巴细胞增殖、自身免疫性疾病、自身炎症或恶性肿瘤。呼吸系统可表现为支气管扩张症、支气管哮喘、间质性肺疾病等。深入... 详细信息

抗体免疫缺陷病是一组由遗传缺陷引起的先天性疾病,影响机体免疫防御机制的发育和功能。患者可表现为反复感染、淋巴细胞增殖、自身免疫性疾病、自身炎症或恶性肿瘤。呼吸系统可表现为支气管扩张症、支气管哮喘、间质性肺疾病等。深入了解抗体免疫缺陷病将有助于将其从呼吸系统常见疾病中甄别出来。

关键词：支气管扩张症机体免疫防御间质性肺疾病自身免疫性疾病先天性疾病支气管哮喘淋巴细胞增殖遗传缺陷

不确定环境下收费与信息对路径选择行为影响的实验研究

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同济大学学报（自然科学版） 2024年第2期52卷 241-251页

作者：刘诗序王叔雨黄国良孙浩岩钟家承黄易丹福州大学土木工程学院福建福州350108 福建永福电力设计股份有限公司福建福州350108

在不确定环境下考虑信息发布与拥挤收费两种措施,基于交通网络均衡,推导了两路径简单路网的最优收费模型,并推广至一般路网。基于两路径路网设计逐日路径选择行为实验,分析了两种措施对路径选择行为的影响。结果表明:完美信息与收费的... 详细信息

在不确定环境下考虑信息发布与拥挤收费两种措施,基于交通网络均衡,推导了两路径简单路网的最优收费模型,并推广至一般路网。基于两路径路网设计逐日路径选择行为实验,分析了两种措施对路径选择行为的影响。结果表明:完美信息与收费的实施均能减少流量波动,单独实施收费的效果最佳,但只有两种措施相结合时,路网流量趋于用户均衡的趋势最稳定;完美信息会增加路径切换行为,而收费可有效抑制大幅的路径切换;无收费时路径切换往往会造成出行成本增加,而收费时则相反;收费与信息结合时的出行时间比两种措施单独实施时小。

关键词：不确定性路网行为实验最优拥挤收费出行信息交通均衡路径选择行为

鹅源副鸡禽杆菌全基因组重测序及比较基因组学分析

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畜牧兽医学报 2024年第3期55卷 1208-1216页

作者：苏文楠刘佳琪钟嘉诚陈济铛朱婉君张溢珊张济培佛山科学技术学院佛山528225 佛山天牧生物科技有限公司佛山528225

为了分析鹅源副鸡禽杆菌(Apg)与鸡源菌株的基因组差异,对3株鹅源Apg和4株鸡源Apg进行全基因重测序及基因组分析。全基因重测序结果显示7株菌株基因组片段大小为2.567 832~2.607 127 Mb, GC含量介于40.80%~40.93%之间。SNPs同源性分析结... 详细信息

为了分析鹅源副鸡禽杆菌(Apg)与鸡源菌株的基因组差异,对3株鹅源Apg和4株鸡源Apg进行全基因重测序及基因组分析。全基因重测序结果显示7株菌株基因组片段大小为2.567 832~2.607 127 Mb, GC含量介于40.80%~40.93%之间。SNPs同源性分析结果显示,3株鹅源菌株和鸡源C-AP3株聚集在p4chr1株的小分支上,另外3株鸡源菌株分布在其它国内菌株分支上。基因同源性分析结果显示鹅源菌株特有基因76个,鸡源菌株特有基因37个。对鹅适应性基因的筛查共聚类出79个基因,其中编码已知蛋白的基因有22个,其余编码假定蛋白;对鸡适应性基因的筛查聚类出39个基因,其中10个编码已知蛋白,29个编码假定基因。通过比较基因组学发现与Apg宿主适应性有关的基因为118个,为进一步阐释Apg跨物种感染的分子生物学机制奠定了基础。

关键词：副鸡禽杆菌比较基因组学全基因重测序跨物种传播

Metabolic and proteostatic differences in quiescent and active neural stem cells

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Neural Regeneration Research 2024年第1期19卷 43-48页

作者： jiacheng Yu Gang Chen Hua Zhu Yi zhong Zhenxing Yang Zhihong Jian Xiaoxing Xiong Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Adult neural stem cells are neurogenesis progenitor cells that play an important role in neurogenesis.Therefore,neural regeneration may be a promising target for treatment of many neurological illnesses.The regenerative capacity of adult neural stem cells can be chara cterized by two states:quiescent and active.Quiescent adult neural stem cells are more stable and guarantee the quantity and quality of the adult neural stem cell pool.Active adult neural stem cells are chara cterized by rapid proliferation and differentiation into neurons which allow for integration into neural circuits.This review focuses on diffe rences between quiescent and active adult neural stem cells in nutrition metabolism and protein homeostasis.Furthermore,we discuss the physiological significance and underlying advantages of these diffe rences.Due to the limited number of adult neural stem cells studies,we refe rred to studies of embryonic adult neural stem cells or non-mammalian adult neural stem cells to evaluate specific mechanisms.

关键词： adult neurogenesis cell metabolic pathway cellular proliferation neural stem cell niches neural stem cells neuronal differentiation nutrient sensing pathway proteostasis

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不同禽源副鸡禽杆菌的人工交叉致病试验

中国家禽 2024年第1期46卷 77-83页

作者：卢玉葵刘佳琪苏文楠钟嘉诚陈济铛朱婉君张溢珊张济培佛山科学技术学院广东佛山528225 佛山天牧生物科技有限公司广东佛山528225

为探讨鸡源和鹅源副鸡禽杆菌(Avibacterium paragallinarum,Apg)对鸡、鹅的跨禽种感染致病力情况,试验将3株鹅源Apg和4株鸡源Apg培养物经鼻窦腔接种60日龄鸡和鹅,观察接种禽的临床症状并进行表征评分。通过组织病理学检查、细菌分离培养... 详细信息

为探讨鸡源和鹅源副鸡禽杆菌(Avibacterium paragallinarum,Apg)对鸡、鹅的跨禽种感染致病力情况,试验将3株鹅源Apg和4株鸡源Apg培养物经鼻窦腔接种60日龄鸡和鹅,观察接种禽的临床症状并进行表征评分。通过组织病理学检查、细菌分离培养和Apg种特异性PCR鉴定,研究鸡源和鹅源Apg对不同宿主的致病性情况。结果显示:鸡源和鹅源Apg均可导致鸡、鹅出现典型症状与病变,且对原宿主禽种致病性高于非原宿主禽种;发病鸡、鹅的病理变化相似,以面部皮下和鼻窦黏膜水肿、充血出血、纤维素性渗出,鼻甲骨变形为特征;发病鹅和鸡组织病理变化相似,鼻窦黏膜与鼻甲黏膜出现大量炎性细胞浸润,黏膜上皮水肿、坏死、崩解脱落,固有层结构疏松,局部可见纤维结缔组织增生;3株鸡源Apg接种鸡试验组能从鼻窦部、肝脏和脾脏中重新分离到接种菌,而接种鹅试验组仅从鼻窦部分离接种菌,未能从其他组织中分离到。研究表明,鸡源和鹅源Apg均可感染鸡或鹅并引起发病,但在致病程度上以本禽源菌株强于非本禽源菌株。

关键词：副鸡禽杆菌鹅鸡交叉致病性黏膜

Impulsive Synchronization for Uncertain Delayed Complex Dynamical Networks with Minimal Coupling Strength

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Impulsive Synchronization for Uncertain Delayed Complex Dyna...

Gigahertz-rate-switchable wavefront shaping through integration of metasurfaces with photonic integrated circuit

第26届中国控制与决策会议

作者： Wu-Hua Chen Zhiyong Jiang jiacheng zhong Xiaomei Lu College of Mathematics and Information Science Guangxi University

This paper investigates the impulsive synchronization problem of complex dynamical network system（CDNs）with uncertainty and coupling time-varying delay. The aim is to design distributed impulsive controllers with minimum necessary coupling strength. A time-varying Lyapunov function based method is proposed to find the synchronization condition for the impulsively controlled CDNs. By utilizing a convex combination technique, the derived synchronization condition is expressed in terms of linear matrix inequalities（LMIs）. Then, an optimization algorithm is proposed to design the distributed impulsive controller with minimum coupling strength. Finally, an example is presented to illustrate the effectiveness of the theoretical results.

关键词： Impulsive synchronization Distributed impulsive control Time-varying Lyapunov function Linear matrix inequalities

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Advanced Photonics 2024年第1期6卷 106-114页

作者： Haozong zhong Yong Zheng jiacheng Sun Zhizhang Wang Rongbo Wu Ling-en Zhang Youting Liang Qinyi Hua Minghao Ning Jitao Ji Bin Fang Lin Li Tao Li Ya Cheng Shining Zhu East China Normal University School of Physics and Electronic ScienceState Key Laboratory of Precision SpectroscopyShanghaiChina Nanjing University College of Engineering and Applied SciencesNational Laboratory of Solid State MicrostructuresNanjingChina China Jiliang University College of Optical and Electronic TechnologyHangzhouChina Shanxi University Collaborative Innovation Center of Extreme OpticsTaiyuanChina Chinese Academy of Sciences(CAS) Shanghai Institute of Optics and Fine Mechanics(SIOM)State Key Laboratory of High Field Laser Physics and CAS Center for Excellence in Ultra-Intense Laser ScienceShanghaiChina

Achieving spatiotemporal control of light at high speeds presents immense possibilities for various applications in communication,computation,metrology,and sensing.The integration of subwavelength metasurfaces and optical waveguides offers a promising approach to manipulate light across multiple degrees of freedom at high speed in compact photonic integrated circuit(PIC)devices.Here,we demonstrate a gigahertz-rate-switchable wavefront shaping by integrating metasurface,lithium niobate on insulator photonic waveguides,and electrodes within a PIC device.As proofs of concept,we showcase the generation of a focus beam with reconfigurable arbitrary polarizations,switchable focusing with lateral focal positions and focal length,orbital angular momentum light beams as well as Bessel beams.Our measurements indicate modulation speeds of up to the gigahertz rate.This integrated platform offers a versatile and efficient means of controlling the light field at high speed within a compact system,paving the way for potential applications in optical communication,computation,sensing,and imaging.

关键词： metasurface photonic integrated circuit lithium niobate on insulator high-speed modulation

αExtractor: a system for automatic extraction of chemical information from biomedical literature

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Science China(Life Sciences) 2024年第3期67卷 618-621页

作者： jiacheng Xiong Xiaohong Liu Zhaojun Li Hongzhong Xiao Guangchao Wang Zhenjiang Niu Chaoyuan Fei Feisheng zhong Gang Wang Wei Zhang Zunyun Fu Zhiguo Liu Kaixian Chen Hualiang Jiang Mingyue Zheng Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China AI Department Suzhou Alphama Biotechnology Co.Ltd.Suzhou 215125China College of Computer and Information Engineering Dezhou UniversityDezhou 253023China

Dear Editor,Great progress has been made using artificial intelligence(AI) techniques in learning knowledge from biomedical databases in recent years, revolutionizing the study of many fields, such as protein structure prediction and protein design(Madani et al., 2023). However, there is massive biomedical knowledge not curated in the form of structured data but hidden in primary scientific literature.

关键词： has such knowledge

西藏东部主要建群树种径向生长对极端干旱的响应差异

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生态学报 2024年第3期44卷 1221-1230页

作者：钟元郑嘉诚邱红岩吕利新中国科学院植物研究所植被与环境变化国家重点实验室北京100093 中国科学院大学北京100049

不同坡向、不同海拔树木生长对极端干旱事件的响应可能不同,然而这方面的认识不足。为此,选取西藏东部珠角拉山阴、阳坡的建群树种川西云杉(Picea likiangensis var.rubescens)和大果圆柏(Juniperus tibetica),在不同海拔高度建立了树... 详细信息

不同坡向、不同海拔树木生长对极端干旱事件的响应可能不同,然而这方面的认识不足。为此,选取西藏东部珠角拉山阴、阳坡的建群树种川西云杉(Picea likiangensis var.rubescens)和大果圆柏(Juniperus tibetica),在不同海拔高度建立了树轮宽度年表,分析了径向生长的气候响应,以及对极端干旱事件的抵抗力和恢复力。结果表明:阳坡大果圆柏和阴坡川西云杉的树木生长对气候的响应存在相似性,均与前一年3—6月、11—12月气温显著正相关,与当年4—5月气温显著负相关,与当年4—5月降水和帕尔默干旱指数(PDSI,Palmer Drought Severity Index)显著正相关(P<0.05)。阳坡大果圆柏的抵抗力显著低于阴坡川西云杉。随着海拔升高,阴坡川西云杉树木个体的抵抗力和恢复力均显著提高,而阳坡大果圆柏树木个体抵抗力、恢复力在不同海拔无显著区别。结合混合效应模型表明树木抵抗力主要受当年4—5月平均最高气温限制,树木恢复力主要受干旱事件后四年4-5月平均最高气温限制(P<0.01),说明生长季高温引起的极端干旱是树木径向生长下降的主要原因。

关键词：大果圆柏川西云杉径向生长气候响应极端干旱抵抗力恢复力