检索结果-南通市图书馆

Artificial intelligence-driven radiomics study in cancer:the role of feature engineering and modeling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Military Medical Research 2024年第1期11卷 115-147页

作者： Yuan-peng Zhang Xin-Yun Zhang Yu-Ting Cheng Bing Li Xin-Zhi Teng jia.g Zhang Saikit Lam Ta Zhou Zong-Rui Ma jia-Bao Sheng Victor CWTam Shara WYLee Hong ge Jing Cai Department of Medical Informatics Nantong UniversityNantong 226001JiangsuChina Department of Health Technology and Informatics the Hong Kong Polytechnic UniversityHong Kong 999077China The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518000GuangdongChina Department of Radiation Oncology the Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhou 450008China

Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’***,the interpretation of medical images can be highly subjective and dependent on the expertise of ***,some potentially useful quantitative information in medical images,especially that which is not visible to the naked eye,is often ignored during clinical *** contrast,radiomics performs high-throughput feature extraction from medical images,which enables quantitative analysis of medical images and prediction of various clinical *** have reported that radiomics exhibits promising performance in diagnosis and predicting treatment responses and prognosis,demonstrating its potential to be a non-invasive auxiliary tool for personalized ***,radiomics remains in a developmental phase as numerous technical challenges have yet to be solved,especially in feature engineering and statistical *** this review,we introduce the current utility of radiomics by summarizing research on its application in the diagnosis,prognosis,and prediction of treatment responses in patients with *** focus on machine learning approaches,for feature extraction and selection during feature engineering and for imbalanced datasets and multi-modality fusion during statistical ***,we introduce the stability,reproducibility,and interpretability of features,and the generalizability and interpretability of ***,we offer possible solutions to current challenges in radiomics research.

关键词： Artificial intelligence Radiomics Feature extraction Feature selection Modeling Interpretability Multimodalities Head and neck cancer

Pericytes protect rats and mice from sepsis-induced injuries by maintaining vascular reactivity and barrier function:implication of miRNAs and microvesicles

在线全文

学校读者我要写书评

暂无评论

Military Medical Research 2024年第1期11卷 1-18页

作者： Zi-Sen Zhang Yi-Yan Liu Shuang-Shuang He Dai-Qin Bao Hong-Chen Wang Jie Zhang Xiao-Yong peng jia-Tao Zang Yu Zhu Yue Wu Qing-Hui Li Tao Li Liang-Ming Liu State Key Laboratory of Trauma Burns and Combined InjuryDepartment of Shock and TransfusionResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqing 400042China

Background Vascular hyporeactivity and leakage are key pathophysiologic features that produce multi-organ damage upon *** hypothesized that pericytes,a group of pluripotent cells that maintain vascular integrity and tension,are protective against sepsis via regulating vascular reactivity and *** We conducted a series of in vivo experiments using wild-type(WT),platelet-derived growth factor receptor-β(PDgFR-β)-Cre+mT/mg transgenic mice and Tie2-Cre+Cx43^(flox/flox)mice to examine the relative contribution of pericytes in sepsis,either induced by cecal ligation and puncture(CLP)or lipopolysaccharide(LPS)*** a separate set of experiments with Sprague-Dawley(SD)rats,pericytes were depleted using CP-673451,a selective PDgFR-βinhibitor,at a dosage of 40 mg/(kg·d)for 7 consecutive *** pericytes,vascular endothelial cells(VECs)and vascular smooth muscle cells(VSMCs)were used for mechanistic *** effects of pericytes and pericyte-derived microvesicles(PCMVs)and candidate miRNAs on vascular reactivity and barrier function were also *** CLP and LPS induced severe injury/loss of pericytes,vascular hyporeactivity and leakage(Pgenous pericytes protected vascular reactivity and barrier function via microvessel colonization(Pg a protective effect on vascular reactivity and barrier function after sepsis(Pg the sphingosine kinase 2(Sphk2)/sphingosine-1-phosphate receptor(S1PR)1/phosphorylation of myosin light chain 20 pathway,whereas miR-132 effectively improved the barrier function of VECs by activating the Sphk2/S1PR2/zonula occludens-1 and vascular endothelial-cadherin *** Pericytes are protective a

关键词： Pericyte Vascular reactivity Vascular permeability Cx43 Microvesicle

Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2024年第3期14卷 401-415页

作者： Ke-gang Linghu Tian Zhang guang-Tao Zhang peng Lv Wen-Jun Zhang guan-Ding Zhao Shi-Hang Xiong Qiu-Shuo Ma Ming-Ming Zhao Meiwan Chen Yuan-jia Hu Chang-Sheng Zhang Hua Yu State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SARChina Macao Centre for Research and Development in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SARChina Key Laboratory of Tropical Marine Bio-resources and Ecology Guangdong Key Laboratory of Marine Materia MedicaRNAM Center for Marine MicrobiologySouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou510301China State Key Laboratory of Functions and Applications of Medicinal Plants&School of Pharmaceutical Sciences Guizhou Medical UniversityGuiyang550025China

Activation of nuclear factor erythroid 2-related factor 2(Nrf2)by Kelch-like ECH-associated protein 1(Keap1)alkylation plays a central role in anti-inflammatory ***,activators of Nrf2 through alkylation of Keap1-Kelch domain have not been ***(DNQ)is a natural small molecule discovered from marine *** current study was designed to investigate the anti-inflammatory effects and molecular mechanisms of DNQ via alkylation of *** exhibited significant anti-inflammatory properties both in vitro and in *** pharmacophore responsible for the anti-inflammatory properties of DNQ was determined to be theα,β-unsaturated amides moieties by a chemical reaction between DNQ and *** exerted anti-inflammatory effects through activation of Nrf2/ARE ***1 was demonstrated to be the direct target of DNQ and bound with DNQ through conjugate addition reaction involving *** specific alkylation site of DNQ on Keap1 for Nrf2 activation was elucidated with a synthesized probe in conjunction with liquid chromatography-tandem mass *** triggered the ubiquitination and subsequent degradation of Keap1 by alkylation of the cysteine residue 489(Cys489)on Keap1-Kelch domain,ultimately enabling the activation of *** findings revealed that DNQ exhibited potent anti-inflammatory capacity throughα,β-unsaturated amides moieties active group which specifically activated Nrf2 signal pathway via alkylation/ubiquitination of Keap1-Kelch domain,suggesting the potential values of targeting Cys489 on Keap1-Kelch domain by DNQ-like small molecules in inflammatory therapies.

关键词： Deoxynyboquinone Anti-inflammation Target Keap1/Nrf2 Alkylation Ubiquitination

发展一种面向工程师的技术治理教育——基于从“工程人”到“治理人”角色转变的思考

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

南京大学学报（哲学．人文科学．社会科学） 2024年第3期61卷 64-72,157,158页

作者：彭家锋西南大学哲学系西南大学哲学博士后流动站重庆市400715

随着工业社会发展的推进,工程师群体开始广泛分布于各行各业,成为相关领域的实际操控者。随着整个社会生产系统和工业体系不断技术化和工程化,想要保持整个现代化的工业社会平稳有效运行,必然要求社会的治理方式和管理手段发生转变,使... 详细信息

随着工业社会发展的推进,工程师群体开始广泛分布于各行各业,成为相关领域的实际操控者。随着整个社会生产系统和工业体系不断技术化和工程化,想要保持整个现代化的工业社会平稳有效运行,必然要求社会的治理方式和管理手段发生转变,使社会以技术治理和科学管理的原则运行。掌握科技知识和实践技能的工程师的社会职能也将悄然改变,不仅是改造世界的工程造物实践者,他们在一定程度上也是合乎社会伦理和追求人类福祉的工程师。工程师从一个有道德的工程实践者开始转变为一个掌权的社会治理参与者。既有的工程师教育体系一直比较偏向于工程师的专业技能培养,近年来才开始重视工程师的职业伦理和责任伦理教育,但仍然缺乏对技术治理教育的关注,迫切需要将技术治理教育融入工程师教育体系。工程师技治素养的培养可以着重从以下三个方面展开:第一,树立谦逊主义的技治观念;第二,把握“治理—反治理—再治理”的技治逻辑;第三,遵循以有限技治为中心的技治原则。

关键词：工程师教育技术治理工程伦理

Perioperative complication incidence and risk factors for retroperitoneal neuroblastoma in children:analysis of 571 patients

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第3期20卷 250-258页

作者： Min He jia-Bin Cai Xuan Wu Yin-Bing Tang Jin-Yan Wang Jun-Qin Mao Ji-Jun Chen Li-Feng Zhang Zhong-Hai guan Jie-Ni Xiong Wan-Xin peng Jin-Hu Wang Ting Tao Pediatric Cancer Research Center National Clinical Research Center for Child HealthHangzhouChina Department of Surgical Oncology Children's HospitalZhejiang University School of MedicineHangzhouChina Cancer Center Zhejiang UniversityNo.3333 Binsheng RodeHangzhouChina

Background Surgery plays an important role in the treatment of *** complications may impact the course of neuroblastoma *** date,comprehensive analyses of complications and risk factors have been *** Patients with retroperitoneal neuroblastoma undergoing tumor resection were retrospectively analyzed between 2014 and *** data collected included clinical characteristics,operative details,operative complications and postopera-tive *** factors for perioperative complications of retroperitoneal neuroblastoma were *** A total of 571 patients were enrolled in this *** complications were observed in 255(44.7%)*** leakage(28.4%),diarrhea(13.5%),and injury(vascular,nerve and organ;7.5%)were the most frequent *** were three operation-related deaths(0.53%):massive hemorrhage(n=1),biliary tract perforation(n=1)and intestinal necrosis(n=1).The presence of image-defined risk factors(IDRFs)[odds ratio(OR)=2.09,Pgh stage of the International Neuroblastoma Risk group staging system(INRgSS)(OR=0.454,P=0.04),retroperitoneal lymph node metastasis(OR=2.433,P=0.026),superior mesenteric artery encasement(OR=3.346,P=0.003),and inferior mesenteric artery encasement(OR=2.218,P=0.019)were identified as independent risk factors for perioperative *** Despite the high incidence of perioperative complications,the associated mortality rate was quite ***-perative complications of retroperitoneal neuroblastoma were associated with IDRFs,INRgSS,retroperitoneal lymph node metastasis and vascular *** with high-risk factors should receive more serious attention during surgery but should not discourage the determination to pursue total resection of neuroblastoma.

关键词： Complication Neuroblastoma Risk factors Surgery

Prognostic implications of overt congestion in heart failure with preserved ejection fraction and the interaction with spironolactone:Insights from TOPCAT

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第10期137卷 1249-1251页

作者： Yingwen Lin Hengli Zhao Dongtu Hu jia Huang You peng Juncong Li Dingli Xu Qingchun Zeng State Key Laboratory of Organ Failure Research Department of CardiologyNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China guangdong Provincial Key Laboratory of Clinical Pharmacology Medical Research InstituteGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510515China Department of Radiology The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510150China Department of Obstetrics and gynecology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

To the Editor:Heart failure with preserved ejection fraction(HFpEF)is a clinical entity characterized by impaired diastolic *** recently,there have been few studies directly evaluating how volume status impacts future cardiac events for patients with *** supporting the application of spironolactone in HFpEF is mainly derived from the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist(TOPCAT)*** though primary analysis of the trial reached a neutral result,subgroup and subsequent post hoc analyses have confirmed its efficacy in selected groups of patients,suggesting that identifying the potential subgroups of patients who would benefit from spironolactone treatment is important.[1]Data regarding the impact of congestion status on the efficacy of spironolactone in HFpEF are lacking.

关键词： function. fraction impaired

在线全文

学校读者我要写书评

暂无评论

不同加载速率下冻融砂岩的动态劈裂特性

东北大学学报（自然科学版） 2024年第1期45卷 111-119页

作者：贾蓬毛松泽钱一锦卢佳亮东北大学资源与土木工程学院辽宁沈阳110819

为研究加载速率和冻融循环对砂岩动态劈裂特性的影响,对冻融0,25,50,75,100次的砂岩进行了静态和不同加载速率的动态劈裂试验,分析了冻融砂岩的静动态抗拉强度及冲击荷载作用下耗散能变化规律.研究结果表明:冻融砂岩的静动态抗拉强度、... 详细信息

为研究加载速率和冻融循环对砂岩动态劈裂特性的影响,对冻融0,25,50,75,100次的砂岩进行了静态和不同加载速率的动态劈裂试验,分析了冻融砂岩的静动态抗拉强度及冲击荷载作用下耗散能变化规律.研究结果表明:冻融砂岩的静动态抗拉强度、纵波波速、质量损失率均随冻融次数增加而劣化.随冻融次数、加载速率增加,动强度增加因子(DIF)不断增大,且砂岩冻融损伤越大,DIF随加载速率增加越明显.建立的基于冻融损伤和加载速率的动态抗拉强度预测模型可以很好地反映砂岩的强度变化.砂岩的冻融损伤越大,动态抗拉强度随加载速率的变化速率越快;冲击荷载作用下的耗散能随冻融次数增加而减小,随加载速率增加而增大.

关键词：冻融循环加载速率损伤动态抗拉强度能量耗散

Senolystics from natural products for extending health and lifespan

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2024年第11期9卷 76-77页

作者： jia Chen De-peng Ma Le-Min He Dong-Liang Yang School of Radiology Shandong First Medical University&Shandong Academy of Medical SciencesTai’an 271016China Medical Science and Technology Innovation Center Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250062China Key Laboratory of Flexible Electronics and Institute of Advanced Materials School of Physical and Mathematical SciencesNanjing Tech UniversityNanjing 211816China.

Senescence,a multifaceted cellular process,intricately regulates organismal aging by imposing irreversible growth arrest on *** phenomenon,characterized by altered gene expression and the accumulation of senescent cells,significantly contributes to age-related physiological decline and the onset of various age-associated pathologies[1].Cellular senescence,the irreversible cessation of cell division,is intricately linked to the aging process in individuals[2].As organisms age,the accumulation of senescent cells increases,contributing to tissue dysfunction and the development of age-related *** the mechanisms underlying cellular senescence holds promise for elucidating the fundamental processes governing aging and may pave the way for targeted interventions to mitigate age-associated decline[3].

关键词： irreversible holds aging

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

单电压环构网型并网逆变器暂态稳定性分析

电力系统保护与控制 2024年第10期52卷 118-127页

作者：王泽昆程鹏贾利民华北电力大学国家能源交通融合发展研究院北京102206 先进轨道交通自主运行全国重点实验室(北京交通大学) 北京100044

随着电力电子化电力系统的快速发展,构网型并网逆变器作为新型电源得到了广泛关注,其中单电压环构网型并网逆变器因具有更强的小信号稳定性而在新能源并网中具有独特优势。同时,构网型并网逆变器在大扰动下呈现与同步电机不同的暂态响应... 详细信息

随着电力电子化电力系统的快速发展,构网型并网逆变器作为新型电源得到了广泛关注,其中单电压环构网型并网逆变器因具有更强的小信号稳定性而在新能源并网中具有独特优势。同时,构网型并网逆变器在大扰动下呈现与同步电机不同的暂态响应,容易产生暂态失稳。针对这一问题,以单电压环构网型并网逆变器大扰动模型为基础,采用相平面图的方法分析了大扰动下功率控制环、电压控制环对逆变器的暂态作用,给出了关键控制器参数对暂态稳定性的影响,刻画了功角的暂态响应特性。同时,揭示了有功控制环、无功控制环和单电压环在暂态期间会改变功角超调量、逆变器输出电压幅值和变化率,进而影响并网逆变器的暂态稳定性。基于上述分析,给出了减小有功和无功下垂系数,增大电压积分系数和低通滤波器截止角频率的控制参数优化方法,可增强单电压环构网型并网逆变器暂态稳定性。最后,通过Matlab/Simulink仿真验证了分析的准确性与可行性。

关键词：构网型并网逆变器暂态稳定性单电压环相平面图大扰动

维普期刊数据库博看期刊