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Artificial intelligence-driven radiomics study in cancer:the role of feature engineering and modeling

Military Medical Research 2024年第1期11卷 115-147页

作者： Yuan-Peng Zhang Xin-Yun Zhang Yu-Ting Cheng Bing Li Xin-zhi Teng jiang Zhang Saikit Lam Ta Zhou Zong-Rui Ma jia-Bao Sheng Victor CWTam Shara WYLee Hong Ge Jing Cai Department of Medical Informatics Nantong UniversityNantong 226001JiangsuChina Department of Health Technology and Informatics the Hong Kong Polytechnic UniversityHong Kong 999077China The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518000GuangdongChina Department of Radiation Oncology the Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhou 450008China

Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’***,the interpretation of medical images can be highly subjective and dependent on the expertise of ***,some potentially useful quantitative information in medical images,especially that which is not visible to the naked eye,is often ignored during clinical *** contrast,radiomics performs high-throughput feature extraction from medical images,which enables quantitative analysis of medical images and prediction of various clinical *** have reported that radiomics exhibits promising performance in diagnosis and predicting treatment responses and prognosis,demonstrating its potential to be a non-invasive auxiliary tool for personalized ***,radiomics remains in a developmental phase as numerous technical challenges have yet to be solved,especially in feature engineering and statistical *** this review,we introduce the current utility of radiomics by summarizing research on its application in the diagnosis,prognosis,and prediction of treatment responses in patients with *** focus on machine learning approaches,for feature extraction and selection during feature engineering and for imbalanced datasets and multi-modality fusion during statistical ***,we introduce the stability,reproducibility,and interpretability of features,and the generalizability and interpretability of ***,we offer possible solutions to current challenges in radiomics research.

关键词： Artificial intelligence Radiomics Feature extraction Feature selection Modeling Interpretability Multimodalities Head and neck cancer

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Review of 2D Bi_(2)X_(3)(X=S,Se,Te):from preparation to photodetector

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Rare Metals 2024年第6期43卷 2349-2370页

作者： zhi Zeng Dong-Bo Wang Xuan Fang jia-Mu Cao Bing-Ke Zhang Jing-Wen Pan Dong-Hao Liu Si-Hang Liu Shu-Jie jiao Tian-Yuan Chen Gang Liu Lian-Cheng Zhao Jin-Zhong Wang Department of Optoelectronic Information Science School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001China Changchun University Science and Technology School of PhysicsThe State Key Laboratory of High Power Semiconductor LasersChangchun 130022China School of Astronautics Harbin Institute of TechnologyHarbin 150001China Center for High Pressure Science and Technology Advanced Research Shanghai 201203China

Detector has become an indispensable part of human *** increasing demand for photodetectors with high performance has promoted the research of novel *** the same time,with the development of rising material system,two-dimensional(2D)materials attract a lot of attention,while the suitable option for fabricating photodetector is still *** prospering of bismuth chalcogenides injected new vitality for material field,thereinto,the unique topological insulator characteristics make the research on bismuth selenide(Bi_(2)X_(3))and bismuth telluride(Bi_(2)X_(3)) intriguing.2D Bi_(2)X_(3) also exhibits unique features among various 2D materials,of which,the adjustable narrow energy band gap and polarization-sensitive photocurrent contribute to the promising application of high performance and broadband *** this review,from a bottom-up perspective,we summarize fundamental properties,synthesis method,photodetector performance of 2D Bi_(2)X_(3) based on the previous study,which provide an overall perspective of 2D Bi_(2)X_(3).Wherein,the section of the photodetector is specifically discu ssed with regard to pure Bi_(2)X_(3) photodetector and heterojunction photodetector.A brief summary and outlook were also explored in the end.

关键词： Bi_(2)X_(3) Preparation 2D Photodetector

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Electroacupuncture activates AMPKα1 to improve learning and memory in the APP/PS1 mouse model of early Alzheimer’s disease by regulating hippocampal mitochondrial dynamics

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Journal of Integrative Medicine 2024年第5期22卷 588-599页

作者： Wei-wei jia Hua-wei Lin Min-guang Yang Ya-ling Dai Yan-yi Ding Wen-shan Xu Si-nuo Wang Ya-jun Cao Sheng-xiang Liang zhi-fu Wang Cong Chen Wei-lin Liu College of Rehabilitation Medicine Fujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina The Institute of Rehabilitation Industry Fujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology Fujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina Traditional Chinese Medicine Rehabilitation Research Center of State Administration of Traditional Chinese Medicine Fujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina

Objective Studies have shown that electroacupuncture(EA)can alleviate cognitive impairments from Alzheimer’s disease(AD)by regulating the expression of adenosine monophosphate-activated protein kinase(AMPK),but the specific mechanism involved remains to be ***,this study explores the potential mechanism by which EA improves cognitive function from the perspective of mitochondrial *** The four-month-old transgenic mice with amyloid precursor protein(APP)/presenilin 1(PS1)and AMPKα1-subunit conditional knockout(AMPKα1-cKO)were used for *** evaluate the effects of EA treatment on cognitive function,the T-maze and Morris water maze were *** addition,chemical exchange saturation transfer,thioflavin staining,transmission electron microscopy,mitochondrial membrane potential,and Western blotting were used to examine the potential mechanisms underlying the effects of EA on APP/PS1 *** Both APP/PS1 mice and AMPKα1-cKO mice exhibited dysfunction in mitochondrial dynamics accompanied by learning and memory *** of the AMPK/peroxisome proliferator-activated receptor-γcoactivator-1α(PGC-1α)pathway increased pathological amyloid-β(Aβ)deposition and aggravated the dysfunction in mitochondrial *** addition,EA rescued learning and memory deficits in APP/PS1 mice by activating the AMPK/PGC-1αpathway,specifically by reducing pathological Aβdeposition,normalizing energy metabolism,protecting the structure and function of mitochondria,increasing the levels of mitochondrial fusion proteins,and downregulating the expression of fission ***,the therapeutic effect of EA on cognition in APP/PS1 mice was hindered by AMPKα1 *** The regulation of hippocampal mitochondrial dynamics and reduction in Aβdeposition via the AMPK/PGC-1αpathway are critical for the ability of EA to ameliorate cognitive impairment in APP/PS1 mice.

关键词： Adenosine monophosphate-activated protein kinase Alzheimer’s disease Cognitive impairment Electroacupuncture Hippocampus Mitochondrial dynamics

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Downregulation of MUC1 Inhibits Proliferation and Promotes Apoptosis by Inactivating NF-κB Signaling Pathway in Human Nasopharyngeal Carcinoma

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生物化学与生物物理进展 2024年第9期51卷 2182-2193页

作者： WU Shou-Wu LIN Shao-Kun NIAN Zhong-Zhu WANG Xin-Wen LIN Wei-Nian ZHUANG Li-Ming WU zhi-Sheng HUANG zhi-Wei WANG A-Min GAO Ni-Li CHEN jia-Wen YUAN Wen-Ting LU Kai-Xian liao Jun Department of Otolaryngology Quanzhou First HospitalQuanzhou 362001China Department of Otolaryngology Quanzhou First Hospital Affiliated to Fujian Medical UniversityQuanzhou 362001China Department of Ultrasound Quanzhou First Hospital Affiliated to Fujian Medical UniversityQuanzhou 362001China Department of Orthopaedics Dongguan City People’s HospitalDongguan 523016China

Objective To investigate the effect of mucin 1(MUC1)on the proliferation and apoptosis of nasopharyngeal carcinoma(NPC)and its regulatory *** The 60 NPC and paired para-cancer normal tissues were collected from October 2020 to July 2021 in Quanzhou First *** expression of MUC1 was measured by real-time quantitative PCR(qPCR)in the patients with *** 5-8F and HNE1 cells were transfected with siRNA control(si-control)or siRNA targeting MUC1(si-MUC1).Cell proliferation was analyzed by cell counting kit-8 and colony formation assay,and apoptosis was analyzed by flow cytometry analysis in the 5-8F and HNE1 *** qPCR and ELISA were executed to analyze the levels of TNF-αand *** blot was performed to measure the expression of MUC1,NFкB and apoptosis-related proteins(Bax and Bcl-2).Results The expression of MUC1 was up-regulated in the NPC tissues,and NPC patients with the high MUC1 expression were inclined to EBV infection,growth and metastasis of *** of MUC1 restrained malignant features,including the proliferation and apoptosis,downregulated the expression of p-IкB、p-P65 and Bcl-2 and upregulated the expression of Bax in the NPC *** Downregulation of MUC1 restrained biological characteristics of malignancy,including cell proliferation and apoptosis,by inactivating NF-κB signaling pathway in NPC.

关键词： mucin 1 nasopharyngeal carcinoma NF-κB signaling pathway proliferation apoptosis

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物流非高斯振动下的产品损伤分析

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振动工程学报 2024年第4期37卷 645-656页

作者：谢嘉琳王志伟暨南大学包装工程学院广东珠海519070 暨南大学产品包装与物流广东普通高校重点实验室广东珠海519070 暨南大学包装工程研究所广东珠海519070

公路运输过程中的冲击信号造成了物流随机振动的非高斯特性。为研究冲击成分对产品损伤的影响,对8条中型卡车和重型卡车实测道路信号进行了统计分析。将振动信号分为20%的高强度非高斯信号、60%的中等强度高斯信号和20%的低强度高斯信... 详细信息

公路运输过程中的冲击信号造成了物流随机振动的非高斯特性。为研究冲击成分对产品损伤的影响,对8条中型卡车和重型卡车实测道路信号进行了统计分析。将振动信号分为20%的高强度非高斯信号、60%的中等强度高斯信号和20%的低强度高斯信号。使用有限元软件进行时域振动分析,计算各信号段的损伤占比。结果表明:振动过程中,非高斯信号蕴含了高强度的冲击信号,造成了绝大部分的损伤。中型卡车振动数据冲击幅值大、占比少,相对而言,重型卡车冲击幅值低、占比多。中型卡车高5%的冲击信号造成了90%以上的损伤;重型卡车20%的非高斯信号中除10%的冲击成分外还包含10%的较高幅值振动,其20%的非高斯信号造成的损伤约为80%或更高。在整个运输振动过程中,含量较少的冲击信号主导了损伤的累积。

关键词：随机振动公路运输非高斯疲劳损伤冲击

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Separation of halogens and recovery of heavy metals from secondary copper smelting dust

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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2686-2701页

作者： zhi-lou LIU zhi-kang CHEN Fu-ze SUN zhi-heng ZHANG Kang YAN Shui-ping ZHONG Hui LIU Rui-xiang WANG jia-yuan LI zhi-feng XU School of Metallurgy Engineering Jiangxi University of Science and TechnologyGanzhou 341000China School of Chemistry and Environmental Science Xiangnan UniversityChenzhou 423000China Ganzhou Engineering Technology Research Centre of Green Metallurgy and Process Intensification Ganzhou 341000China Key Laboratory of Ionic Rare Earth Resources and Environment Ministry of Natural ResourcesGanzhou 341000China

The separation of halogens and recovery of heavy metals from secondary copper smelting(SCS)dust using a sulfating roasting−water leaching process were *** thermodynamic analysis results confirm the feasibility of the phase transformation to metal sulfates and to gaseous HF and *** the sulfating roasting conditions of the roasting temperature of 250℃ and the sulfuric acid excess coefficient of 1.8,over 74 wt.%of F and 98 wt.%of Cl were volatilized into flue *** 98.6 wt.%of Zn and 96.5 wt.%of Cu in the roasting product were dissolved into the leaching solution after the water leaching process,while the leaching efficiencies of Pb and Sn were only 0.12%and 0.22%,*** mechanism studies indicate the pivotal effect of roasting temperature on the sulphation reactions from various metal species to metal sulfates and the salting out reactions from various metal halides to gaseous hydrogen halides.

关键词： secondary copper smelting dust sulfating roasting water leaching halogen volatilization heavy metal separation

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基于电化学传感的海水碳循环要素多参数同时检测系统的研制

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分析化学 2024年第5期52卷 645-652页

作者：刘晓琳廖志博韩京龙江天甲秦伟烟台大学环境与材料工程学院中国科学院烟台海岸带研究所中国科学院海岸带环境过程与生态修复重点实验室山东省海岸带环境过程重点实验室康复大学康复科学与工程学院青岛海洋科技中心海洋生物学与生物技术功能实验室中国科学院海洋大科学研究中心

基于全固态聚合物膜离子选择性电极和丝网印刷技术，构建了以NiCo2S4材料为离子-电子转导层的芯片式全固态聚合物膜离子选择性电极阵列，并基于此研制了一种便携式海水碳循环要素同时分析系统，实现了对海水中钙离子(Ca2+)、碳酸根离子(... 详细信息

基于全固态聚合物膜离子选择性电极和丝网印刷技术，构建了以NiCo2S4材料为离子-电子转导层的芯片式全固态聚合物膜离子选择性电极阵列，并基于此研制了一种便携式海水碳循环要素同时分析系统，实现了对海水中钙离子(Ca2+)、碳酸根离子(CO32–)和p H值的同时测定。此分析系统检测海水基体中Ca2+和CO32–的线性响应浓度范围分别为1.0×10–5～1.0×10–1mol/L和3.2×10–5～1.9×10–3mol/L，检测p H值的线性范围为pH 5～9。本方法连续测定的相对标准偏差小于2.5%，单个样品全程分析时间少于15 min，测定结果和比测设备结果的相对偏差小于2.0%。此电化学传感器系统已成功应用于实际海水样品分析。

关键词：电化学传感器碳循环要素海水分析多参数检测聚合物膜离子选择性电极

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国际自贸区新实践、新规则与我国自贸试验区高质量发展

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国际贸易 2024年第6期 45-53页

作者：廖佳黄建忠上海对外经贸大学国际经贸学院上海对外经贸大学上海对外经贸大学亚太培训中心

中国自贸试验区建设已历十载,综合比较国际自贸区发展的理论与实践创新,认真研究和落实国际经贸规则对自贸区建设的相关要求,对推动我国自贸试验区建设高质量发展意义重大。文章首先对国际自贸区研究的学术文献脉络进行了简要梳理,随后... 详细信息

中国自贸试验区建设已历十载,综合比较国际自贸区发展的理论与实践创新,认真研究和落实国际经贸规则对自贸区建设的相关要求,对推动我国自贸试验区建设高质量发展意义重大。文章首先对国际自贸区研究的学术文献脉络进行了简要梳理,随后总结归纳了国际主要自贸区的最新实践,阐明了国际经贸规则的创新演变。指出当前我国自贸试验区总体上偏重于贸易便利化框架下的制度改革,与投资便利化相关领域的制度创新需要进一步加强,政府采购制度需要进一步深化改革,未来发展战略需要进一步明确等问题。并提出从投资者视角调校自贸试验区建设方向、从可持续发展和新产业技术革命趋势要求出发促进我国自贸试验区(港)高质量发展的思路和政策建议。

关键词：自贸试验区国际经验国际经贸规则高质量发展

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Applying Hybrid Clustering in Pulsar Candidate Sifting with Multi-modality for FAST Survey

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Research in Astronomy and Astrophysics 2024年第3期24卷 283-296页

作者： Zi-Yi You Yun-Rong Pan zhi Ma Li Zhang Shuo Xiao Dan-Dan Zhang Shi-Jun Dang Ru-Shuang Zhao Pei Wang Ai-Jun Dong jia-Tao jiang Ji-Bing Leng Wei-An Li Si-Yao Li School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550025China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550025China College of Big Data and Information Engineering Guizhou UniversityGuiyang 550025China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Key Laboratory of Information and Computing Guizhou Province Guizhou Normal UniversityGuiyang 550001China School of Big data and Computer Science Guizhou Normal UniversityGuiyang 550025China Guizhou Software Engineering Research Center Guiyang 550000China

Pulsar search is always the basis of pulsar navigation,gravitational wave detection and other research ***,the volume of pulsar candidates collected by the Five-hundred-meter Aperture Spherical radio Telescope(FAST)shows an explosive growth rate that has brought challenges for its pulsar candidate filtering ***,the multi-view heterogeneous data and class imbalance between true pulsars and non-pulsar candidates have negative effects on traditional single-modal supervised classification *** this study,a multi-modal and semi-supervised learning based on a pulsar candidate sifting algorithm is presented,which adopts a hybrid ensemble clustering scheme of density-based and partition-based methods combined with a feature-level fusion strategy for input data and a data partition strategy for *** on both High Time Resolution Universe SurveyⅡ(HTRU2)and actual FAST observation data demonstrate that the proposed algorithm could excellently identify pulsars:On HTRU2,the precision and recall rates of its parallel mode reach0.981 and 0.988 *** FAST data,those of its parallel mode reach 0.891 and 0.961,meanwhile,the running time also significantly decreases with the increment of parallel nodes within ***,we can conclude that our algorithm could be a feasible idea for large scale pulsar candidate sifting for FAST drift scan observation.

关键词： methods data analysis-surveys-methods numerical

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城镇化发展新视域:数据要素的创新驱动与信息牵动

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中国农村经济 2024年第6期 25-49页

作者：王理廖祖君贾男成都师范学院经济与管理学院四川省社会科学院四川大学经济学院

本文通过估算2006一2020年中国272个地级行政单元或直辖市的新增数据要素价值,进而构建理论与实证模型,揭示了数据要素对城镇化的影响及其机制。结果显示:第一,在传统工业化对城镇化带动作用减弱的背景下,数据要素能够通过创新驱动机制... 详细信息

本文通过估算2006一2020年中国272个地级行政单元或直辖市的新增数据要素价值,进而构建理论与实证模型,揭示了数据要素对城镇化的影响及其机制。结果显示:第一,在传统工业化对城镇化带动作用减弱的背景下,数据要素能够通过创新驱动机制和信息牵动机制推动城镇化,为城镇化发展提供新视域;第二,创新驱动机制体现在数据要素通过促进技术创新,从生产方式、生活方式、治理方式三个层面增强城镇吸纳乡村劳动力的能力;第三,信息牵动机制表现为数据要素凭借其所承载的有效事实信息,一方面降低生产不确定性,助力城镇企业扩大生产规模并创造更多就业机会,另一方面提供转移决策所需信息,助力乡村劳动力向城镇转移;第四,目前中国数字基础设施的规模滞后于数据要素的产生规模;第五,数据要素不仅能提升城镇化率,还能改善城镇化区域失衡、促进城乡融合发展和以县城为载体的城镇化,是现阶段加快形成新质生产力的重要资源。

关键词：数据要素素城镇化数据价值数字基础设施新质生产力

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