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Non-Hodgkin's lymphoma involving chronic difficult-to-heal wounds:A case report

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World Journal of Clinical Oncology 2024年第8期15卷 1110-1116页

作者： Pei-Shen Zhang Rong Wang Hu-Wen Wu Han Zhou Han-Bin Deng Wen-Xuan Fan jia-cheng li Shao-Wen cheng Department of Wound Repair Key Laboratory of Emergency and Trauma of Ministry of EducationThe First Affiliated Hospital of Hainan Medical UniversityHaikou 570102Hainan ProvinceChina

BACKGROUND Non-Hodgkin's lymphoma(NHL)is a malignant tumor that originates from the lymphoid tissues and can potentially affect numerous organs within the *** these,the skin stands out as one of the primary sites affected by NHL,often presenting with multiple extra-nodal *** this report,we present an unusual case of NHL involving chronic wounds in the lower extremities that were difficult to *** scars were successfully treated using radiotherapy in combination with extended excision debridement and peroneal artery perforator flap grafting,resulting in satisfactory *** SUMMARY A 19-year-old male patient presented with ulceration of the skin on the left calf near the ankle accompanied by purulent *** pathologic biopsy confirmed a diagnosis of NHL(extranodal NK/T-cell lymphoma,nasal type).Initial treatment comprised local radiotherapy and wound care;however,the wound exhibited prolonged ***,the patient underwent a series of interventions including radiotherapy,wound enlargement excision debridement,and peroneal artery perforator flap ***,successful healing was achieved with favorable postoperative outcomes characterized by good texture of the flap without any signs of rupture or *** The combination of radiotherapy,wound enlargement excision debridement,and peroneal artery perforator flap grafting may present a favorable treatment modality for chronic non-healing lower leg wounds resulting from NHL.

关键词： Non-Hodgkin's lymphoma Extranodal natural killer/T-cell lymphoma Difficult-to-heal wounds Flap therapy Case report

营养包干预对婴幼儿唾液中免疫球蛋白A水平影响的研究

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营养学报 2024年第1期46卷 13-17页

作者：刘婷婷冯静孙静霍军生程家丽宫照龙中国疾病预防控制中心营养与健康所北京100050

目的探讨营养包作为6~24月龄婴幼儿辅食补充剂,对婴幼儿唾液中分泌型免疫球蛋白A含量的影响。方法选择营养包干预地区和其临近未干预地区的婴幼儿,进行早期儿童营养干预与非干预人群营养健康状况的长期队列观察。干预组婴幼儿在6~24月... 详细信息

目的探讨营养包作为6~24月龄婴幼儿辅食补充剂,对婴幼儿唾液中分泌型免疫球蛋白A含量的影响。方法选择营养包干预地区和其临近未干预地区的婴幼儿,进行早期儿童营养干预与非干预人群营养健康状况的长期队列观察。干预组婴幼儿在6~24月龄期间每日辅食中添加一袋营养包,对照组不服用营养包,此外同时为对照组和干预组提供科学健康喂养指导。在2018年至2020年连续3年的监测中,收集婴幼儿唾液并检测其唾液中免疫球蛋白A含量,并对婴幼儿唾液中免疫球蛋白A的含量变化情况进行比较和分析。结果本研究婴幼儿唾液中的免疫球蛋白A含量随着月龄的增加呈增加的趋势,干预组和对照组婴幼儿在2018年基线阶段的免疫球蛋白A含量没有显著性差异。2019年和2020年干预组婴幼儿唾液中的免疫球蛋白A含量均高于地域邻近的对照组,差异有统计学意义(P<0.05)。结论营养包干预能够提升婴幼儿唾液中免疫球蛋白A水平,增强婴幼儿免疫力。

关键词：婴幼儿营养包唾液免疫球蛋白A

超薄锡掺杂氧化镓结合高k栅介质:硅基兼容的4英寸功率场效应晶体管阵列

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Science Bulletin 2024年第12期69卷 1848-1851页

作者：刘子淳李佳诚杨惠霞杨涵黄元张逸韵黎沛涛马远骁王业亮 School of Integrated Circuits and Electronics and Yangtze Delta Region Academy Beijing Institute of TechnologyBeijing 100081China Department of Electrical and Electronic Engineering The University of Hong KongHong Kong 999077China R&D Center for Solid-state lighting Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China

Gallium oxide(Ga_(2)O_(3)),a novel ultrawide-bandgap(UWBG)semiconductor,has attracted considerable attention owing to its large bandgap of up to 4.9 eV,a high breakdown electric field of 8 MV/cm,and a high Baliga's figure of merit exceeding 3000[1,2].These remarkable properties strongly support its potential applications in power electronics,extreme environmentresistance devices,and solar-blind detectors[1–3].

关键词：功率场效应晶体管高k栅介质氧化镓

Paratesticular liposarcoma: Two case reports

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World Journal of Clinical Cases 2021年第2期9卷 457-462页

作者： Qi-Gang Zheng Zhao-Hui Sun jia-jian Chen jia-cheng li Xiao-Jun Huang The Second Clinical Medical College Zhejiang Chinese Medical UniversityHangzhou 310011Zhejiang ProvinceChina Department of Urology The Second Clinical Medical College of Zhejiang Chinese Medical UniversityThe Second Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310011Zhejiang ProvinceChina

BACKGROUND Paratesticular liposarcoma accounts for approximately 7%of scrotal *** are rare lesions of the reproductive system with approximately 90%of the lesions originating from the spermatic ***,with the goal of complete resection,is the mainstay for treatment of this ***,treatment consisting of extended resection to decrease local recurrence remains *** SUMMARY We report the cases of two patients with paratesticular liposarcomas who were treated with radical testicular tumor resection without adjuvant *** investigations at 9 mo showed no sign of *** Surgery is the first-line treatment,regardless of whether it is a recurrent or primary *** resection carries a higher risk of complications and should not be performed *** radiotherapy can reduce the local recurrence rate without affecting the overall survival.

关键词： Case report Paratesticular liposarcoma Andrology Radiotherapy Surgery Extended resection

Insights into Formation and li-Storage Mechanisms of Hierarchical Accordion-Shape Orthorhombic CuNb_(2)O_(6) toward lithium-Ion Capacitors as an Anode-Active Material

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Energy & Environmental Materials 2024年第2期7卷 287-298页

作者： Chao cheng Yunsheng Yan Minyu jia Yang liu linrui Hou Changzhou Yuan School of Material Science and Engineering University of JinanJinan 250022China

The orthorhombic CuNb_(2)O_(6)(O-CNO)is established as a competitive anode for lithium-ion capacitors(liCs)owing to its attractive compositional/structural ***,the high-temperature synthesis(>900℃)and controversial charge-storage mechanism always limit its ***,we develop a low-temperature strategy to fabricate a nano-blocks-constructed hierarchical accordional O-CNO framework by employing multilayered Nb_(2)CT_(x)as the niobium *** intrinsic stress-induced formation/transformation mechanism of the monoclinic CuNb_(2)O_(6)to O-CNO is tentatively put ***,the integrated phase conversion and solid solution lithium-storage mechanism is reasonably unveiled with comprehensive in(ex)situ *** to its unique structural merits and lithium-storage process,the resulted O-CNO anode is endowed with a large capacity of 150.3 mAh g^(-1)at 2.0 A g^(-1),along with long-duration cycling ***,the constructed O-CNO-based liCs exhibit a high energy(138.9 Wh kg^(-1))and power(4.0 kW kg^(-1))densities with a modest cycling stability(15.8%capacity degradation after 3000 consecutive cycles).More meaningfully,the in-depth insights into the formation and charge-storage process here can promote the extensive development of binary metal Nb-based oxides for advanced liCs.

关键词： high-rate anodes lithium-ion capacitors lithium-storage mechanisms orthorhombic CuNb_(2)O_(6) phase transform

Dual modification of liNi_(0.83)Co_(0.11)Mn_(0.06)O_(2) cathode materials by K^(+) doping and li_(3)PO_(4) coating for lithium ions batteries

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Rare Metals 2024年第7期43卷 3007-3018页

作者： Wei Xiao jia-Le Wang Zhi-cheng Yi cheng-Jin liu Chang Miao Yu Xin Shu-Qing Nie College of Chemistry and Environmental Engineering Yangtze UniversityJingzhou 434023China

li_(3)PO_(4)@li_(0.99)K_(0.01)Ni_(0.83)Co_(0.11)Mn_(O.06)O_(2)(NCM-KP) cathode powders are synthesized via K^(+)doping in calcination processes and H_3PO_4 coating in sol-gel processes.K^(+) precisely enters into the lattice to widen the(003) plane to 0.4746 nm with a lower cationic disordered degree of 1.87%.Moreover,the surface residual lithium salts are treated by H_3PO_4 to generate a uniform li_(3)PO_(4) coating layer of approximately 11.41 nm,which completely covers on the surface of secondary spherical particles to improve the interfacial *** 25℃,the NCM-KP electrode delivers a discharge specific capacity of 148.9 mAh·g^(-1) with a remarkable capacity retention ratio of 84.1% after 200 cycles at 1.0C and retains a high reversible specific capacity of 154.4 mAh·g^(-1) at *** at 1.0C and 60℃,it can maintain a reversible discharge specific capacity of 114.6 mAh·g^(-1) with 0.21% of capacity decay per cycle after 200 cycles,which is significantly lower than 0.40% for the pristine NCM ***,the charge transfer resistance of 238.89 Ω for the NCM-KP electrode is significantly lower than 947.41 Ω for the pristine NCM one by restricting the interfacial side ***,combining K+doping and li_(3)PO_(4) coating is an effective strategy to enable the significant improvement of the electrochemical property of high-nickel cathode materials,which may be mainly attributed to the widened diffusion pathway and the formed li_(3)PO_(4) protective layer,thus promoting li~+diffusion rate and preventing the erosion of HF.

关键词： High-nickel cathode material Residual lithium K^(+)doping li_(3)PO_(4)coating lithium ions battery

Vascular endothelial growth factor protein and gene delivery by novel nanomaterials for promoting liver regeneration after partial hepatectomy

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World Journal of Gastroenterology 2023年第24期29卷 3748-3757页

作者： Yun Jin Ying-Hao Guo jia-cheng li Qi li Dan Ye Xiao-Xiao Zhang jiang-Tao li Department of Hepatopancreatobiliary Surgery The Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310009Zhejiang ProvinceChina Department of General Surgery Yuhuan Second People’s HospitalTaizhou 317600Zhejiang ProvinceChina

Partial hepatectomy(PH)can lead to severe complications,including liver failure,due to the low regenerative capacity of the remaining liver,especially after extensive *** sinusoidal endothelial cells(LSECs),whose proliferation occurs more slowly and later than hepatocytes after PH,compose the lining of the hepatic sinusoids,which are the smallest blood vessels in the *** endothelial growth factor(VEGF),secreted by hepatocytes,promotes LSEC *** of exogenous VEGF after hepatectomy also increases the number of LSECs in the remaining liver,thus promoting the reestablishment of the hepatic sinusoids and accelerating liver *** present,some shortcomings exist in the methods of supplementing exogenous VEGF,such as a low drug concentration in the liver and the reaching of other ***,VEGF should be administered multiple times and in large doses because of its short *** review summarized the most recent findings on liver regeneration and new strategies for the localized delivery VEGF in the liver.

关键词： liver regeneration Vascular endothelial growth factor Nano materials liver resection

Triclosan-induced Oxidative Stress Injury and Apoptosis by Regulating the PI3K/Akt/Caspase-3 Signaling Pathway in Human Renal Glomerular Endothelial Cells

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Biomedical and Environmental Sciences 2022年第6期35卷 547-551页

作者： MA Yan CHEN Chen WANG Jing Bo cheng jia li SHEN Shi CHEN Xi HUO Jun Sheng Key Laboratory of Trace Element Nutrition National Institute for Nutrition and HealthChinese Center for Disease Control and PreventionBeijing 100050China

Triclosan(TCS)is widely used in personal-care products because of its bactericidal and antibacterial ***,TCS and its toxic byproducts have been detected in aquatic environments,animals,and plants *** is a common phenolic environmental endocrine disruptor,and TCS in the environment enters the body mainly through diet and *** of the absorbed TCS is metabolized by the human kidneys and is eliminated in the urine[1].Some epidemiological studies have suggested a positive correlation between the TCS exposure level in urine and albumin(a biomarker of renal function),which could cause renal dysfunction[2].However,the potential effects of TCS on the mammalian kidney and its mechanisms are currently ***,we initiated an in vitro trial to study the molecular mechanism of cytotoxicity of TCS to glomeruli.

关键词： PI3K/Akt urine Apoptosis

Impact of next-generation sequencing on antimicrobial treatment in immunocompromised adults with suspected infections

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World Journal of Emergency Medicine 2024年第2期15卷 105-110页

作者： jia li jiazhen Luo Tao Hu ling cheng Weiwei Shang li Yan Department of Intensive Care Unit Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Emergency Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030China Department of Geriatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

BACKGROUND:Prompt pathogen identification can have a substantial impact on the optimization of antimicrobial *** objective of the study was to assess the diagnostic value of next-generation sequencing(NGS)for identifying pathogen and its clinical impact on antimicrobial intervention in immunocompromised patients with suspected ***:This was a retrospective *** January and August 2020,47 adult immunocompromised patients underwent NGS testing under the following clinical conditions:1)prolonged fever and negative conventional cultures;2)new-onset fever despite empiric antimicrobial treatment;and 3)afebrile with suspected infections on *** data,including conventional microbial test results and antimicrobial treatment before and after NGS,were *** were analyzed according to documented changes in antimicrobial treatment(escalated,no change,or deescalated)after the NGS ***:The median time from hospitalization to NGS sampling was 19 *** relevant pathogens were detected via NGS in 61.7% of patients(29/47),more than half of whom suffered from fungemia(n=17),resulting in an antimicrobial escalation in 53.2% of patients(25/47)and antimicrobial de-escalation in 0.2% of patients(1/47).Antimicrobial changes were mostly due to the identification of fastidious organisms such as Legionella,Pneumocystis jirovecii,and *** the remaining three cases,NGS detected clinically relevant pathogens also detected by conventional cultures a few days *** antimicrobial treatment was subsequently adjusted according to the susceptibility test ***,NGS changed antimicrobial management in 55.3%(26/47)of patients,and conventional culture detected clinically relevant pathogens in 14.9% of the patients(7/47).CONCLUSION:With its rapid identification and high sensitivity,NGS could be a promising tool for identifying relevant pathogens and enabling rapid appropriate treatment in immunocompromised patients w

关键词： Immunocompromised patients Next-generation sequencing Antimicrobial management