Vascular endothelial growth factor protein and gene delivery by novel nanomaterials for promoting liver regeneration after partial hepatectomy
作者机构：Department of Hepatopancreatobiliary SurgeryThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310009Zhejiang ProvinceChina Department of General SurgeryYuhuan Second People’s HospitalTaizhou 317600Zhejiang ProvinceChina
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2023年第29卷第24期
页 面：3748-3757页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
基 金：the Natural Science Foundation of Zhejiang Province No.LQ21H030005
主 题：Liver regeneration Vascular endothelial growth factor Nano materials Liver resection
摘 要：Partial hepatectomy(PH)can lead to severe complications,including liver failure,due to the low regenerative capacity of the remaining liver,especially after extensive *** sinusoidal endothelial cells(LSECs),whose proliferation occurs more slowly and later than hepatocytes after PH,compose the lining of the hepatic sinusoids,which are the smallest blood vessels in the *** endothelial growth factor(VEGF),secreted by hepatocytes,promotes LSEC *** of exogenous VEGF after hepatectomy also increases the number of LSECs in the remaining liver,thus promoting the reestablishment of the hepatic sinusoids and accelerating liver *** present,some shortcomings exist in the methods of supplementing exogenous VEGF,such as a low drug concentration in the liver and the reaching of other ***,VEGF should be administered multiple times and in large doses because of its short *** review summarized the most recent findings on liver regeneration and new strategies for the localized delivery VEGF in the liver.
维普期刊数据库