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Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated with deteriorating glucose regulation

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Frontiers of Medicine 2023年第1期17卷 68-74页

作者： Cheng Li Xiaojing Ma Jingyi Lu Rui Tao Xia Yu Yifei Mo wei Lu Yuqian Bao jian Zhou weiping jia Department of Endocrinology and Metabolism Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s HospitalShanghai Clinical Center for DiabetesShanghai Diabetes InstituteShanghai Key Laboratory of Diabetes MellitusShanghai 200233China College of Information Science and Engineering Northeastern UniversityShenyang 110819China

Most information used to evaluate diabetic statuses is collected at a special time-point,such as taking fasting plasma glucose test and providing a limited view of individual’s health and disease *** a new parameter for continuously evaluating personal clinical statuses,the newly developed technique“continuous glucose monitoring”(CGM)can characterize glucose *** calculating the complexity of glucose time series index(CGI)with refined composite multi-scale entropy analysis of the CGM data,the study showed for the first time that the complexity of glucose time series in subjects decreased gradually from normal glucose tolerance to impaired glucose regulation and then to type 2 diabetes(P for trend<0.01).Furthermore,CGI was significantly associated with various parameters such as insulin sensitivity/secretion(all P<0.01),and multiple linear stepwise regression showed that the disposition index,which reflectsβ-cell function after adjusting for insulin sensitivity,was the only independent factor correlated with CGI(P<0.01).Our findings indicate that the CGI derived from the CGM data may serve as a novel marker to evaluate glucose homeostasis.

关键词： complexity of glucose time series continuous glucose monitoring impaired glucose regulation insulin secretion and sensitivity refined composite multi-scale entropy

Late Oligocene fossil acorns and nuts of Quercus section Cyclobalanopsis from the Nanning Basin,Guangxi,South China

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Plant Diversity 2023年第4期45卷 434-445页

作者： Xiao-Yan Liu Han-Zhang Song Xin-Kai Wu jia-Rong Hu wei-Ye Huang Cheng Quan jian-Hua Jin State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources School of Life SciencesSun Yat-sen UniversityGuangzhou 510275China School of Geography South China Normal UniversityGuangzhou 510631China State Key Laboratory of Biocontrol School of EcologySun Yat-sen UniversityGuangzhou 510275China School of Earth Science and Resources Chang'an UniversityXi'an 710054China

Quercus is the largest genus within the Fagaceae and has a rich fossil *** of the fossil material is attributed to the subgenus Quercus based on leaves,pollen or rarely acorns and *** records of *** Cyclobalanopsis characterized by ring-cupped acorns are relatively few and especially those described based on nuts are *** this study,we described four new species of Quercus section Cyclobalanopsis based on mummified acorns and nuts:*** *** et *** ***.,*** *** et *** ***.,*** *** et *** *** *** *** et *** *** species closely resemble the extant species ***,***,***,and *** occurrence of *** Cyclobalanopsis in the Oligocene stratum of Guangxi,South China,suggests that the section has diversified within its extant distribution center since the *** combining records from other areas,we propose that the section first appeared in the middle Eocene of East Asia(Sino-Japan),has diversified in situ with a few elements scattering into West Asia and southern Europe since the Oligocene and Pliocene,respectively,and finally became restricted in East Asia since the *** indicates that the section originated and diversified in East Asia,before spreading into West Asia no later than the Oligocene and into southern Europe by the *** it disappeared from South Europe and West Asia due to the appearance of the(summer dry)Mediterranean climate and widespread cooling during the Pleistocene.

关键词： Quercus section Cyclobalanopsis Fossil acorn and nut Oligocene Guangxi South China

经导管主动脉瓣置换术后新发传导阻滞的危险因素分析及预测

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中国介入心脏病学杂志 2024年第1期32卷 32-38页

作者：刘家乐陈泽伟易岩峰唐一瑞方臻飞中南大学湘雅二医院心血管内科湖南长沙410011

目的探究经导管主动脉瓣置换术(TAVR)后新发传导阻滞(NOCD)的相关因素,建立预测模型对传导阻滞发生风险进行评估。方法纳入2016年1月至2022年3月中南大学湘雅二医院行TAVR的症状性重度主动脉瓣狭窄或重度主动脉瓣反流的184例患者,通过... 详细信息

目的探究经导管主动脉瓣置换术(TAVR)后新发传导阻滞(NOCD)的相关因素,建立预测模型对传导阻滞发生风险进行评估。方法纳入2016年1月至2022年3月中南大学湘雅二医院行TAVR的症状性重度主动脉瓣狭窄或重度主动脉瓣反流的184例患者,通过医院信息系统和影像数据库收集患者的人口学、病史、检查结果、影像图像等临床数据,测量人工瓣膜置入深度等传导阻滞相关数据,由专科医师对心电图、超声心动图、CT血管造影(CTA)、手术资料等进行数据的提取和分析。使用SPSS软件对数据进行统计学分析,构建NOCD的多因素Logistic回归预测模型。结果以TAVR术后NOCD作为结局事件,184例患者分为NOCD组(57例)和非NOCD组(127例)。TAVR术后NOCD发生率为31.0%,单纯重度主动脉瓣反流患者TAVR术后NOCD发生率为63.6%(7/11)。NOCD组较非NOCD组的主动脉角度更大[(57.7±10.3)°比(52.0±9.0)°,P54.5°(OR 3.78,95%CI 1.86~7.63,P5.7 mm(OR 3.39,95%CI 1.68~6.85,P54.5°、人工瓣膜置入深度>5.7 mm和锚定区尺寸比>122.9%为变量的预测模型。受试者工作特征曲线下面积(AUC)0.709(95%CI 0.623~0.795),可预测TAVR术后NOCD。结论主动脉角度>54.5°和人工瓣膜置入深度>5.7 mm是TAVR术后NOCD的独立危险因素。

关键词：经导管主动脉瓣置换术传导阻滞危险因素预测模型

基于神经网络PI的电静液作动器温度补偿控制方法研究

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液压气动与密封 2024年第6期44卷 48-56页

作者：黄昊刘家辉朱威霖高光发姚建勇南京理工大学中法工程师学院江苏南京210094 南京理工大学机械工程学院江苏南京210094

电静液作动器(Electro-hydrostatic Actuator,EHA)作为一种高性能集成化的动力执行器,广泛应用于航天航空、工业生产和军事领域。在不同油液温度下,液压油的体积弹性模量、黏度等性质会发生变化,从而对EHA的控制精度产生影响。针对此问... 详细信息

电静液作动器(Electro-hydrostatic Actuator,EHA)作为一种高性能集成化的动力执行器,广泛应用于航天航空、工业生产和军事领域。在不同油液温度下,液压油的体积弹性模量、黏度等性质会发生变化,从而对EHA的控制精度产生影响。针对此问题,首先建立了EHA数学模型;其次,设计了反向传播(BP)神经网络对比例积分控制器(PI)控制参数进行在线调节,补偿温度变化对跟踪精度的影响;最后,通过实验验证了传统PI控制的EHA跟踪精度与温度变化有着密切关系,并将BPPI控制器与PI控制器进行实验对比。实验结果表明,所设计的BPPI控制器在不同油液温度下平均跟踪误差之间的差值较PI控制器降低80%以上;且在相同温度下,平均跟踪误差较PI控制器降低60%以上。

关键词：电静液作动器反向传播神经网络温度补偿比例积分控制

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家兔奇异变形杆菌的分离鉴定及致病性分析

中国预防兽医学报 2024年第1期46卷 32-38页

作者：王佳宁李双军张自强王帅帅位兰朱雪敏刘玉梅河南科技大学动物科技学院河南洛阳471000 河南德邻生物制品有限公司河南郑州450000

为探究河南省某规模化兔场暴发的以精神萎靡、腹泻为主要症状的疾病病原,本实验随机选取6只病死兔剖检并观察其各组织剖检病变后,通过四区划线法分离纯化并增菌培养后,分别于普通琼脂培养基、血琼脂培养基和麦康凯琼脂培养基培养,并对... 详细信息

为探究河南省某规模化兔场暴发的以精神萎靡、腹泻为主要症状的疾病病原,本实验随机选取6只病死兔剖检并观察其各组织剖检病变后,通过四区划线法分离纯化并增菌培养后,分别于普通琼脂培养基、血琼脂培养基和麦康凯琼脂培养基培养,并对分离菌进行疑似病原菌的PCR鉴定、球虫检测、生化鉴定、16S r RNA基因的PCR扩增、测序和序列分析,构建分离菌16S r RNA基因的进化树,进一步确定病原菌。剖检观察可见病死兔肾脏呈土黄色、肝脏肿大有出血点、胸腺出血、脾脏萎缩呈深褐色、肺脏发白且有散在出血点等。疑似病原菌的鉴定结果显示,大肠杆菌、肺炎克雷伯氏菌、魏氏梭菌、沙门氏菌、波氏杆菌及球虫均呈阴性,且通过细菌的分离培养、16S r RNA基因的PCR扩增、测序并构建系统进化树,进一步确定引起该兔场发病的病原菌为奇异变形杆菌,并将其命名为HN001株。通过PCR检测该菌携带的毒力基因,并采集病死兔肝、肾、肠等病变组织制作病理切片,观察其病理变化。将HN001株以1011cfu/mL感染家兔,一周后剖杀,观察各组兔的剖检病变,并再次从兔的内脏分离并鉴定病原菌。毒力基因的PCR检测结果显示,HN001菌株中鞭毛基因FliL和菌毛结构亚单位基因Mrp A均为阳性,溶血素基因Hpm A、金属蛋白酶结构亚单位基因ZapA和“雾蔓”菌毛迁移能力的调控基因Rsb A均为阴性。组织病理学结果显示,病死兔肾、肝、胸腺、脾、肺脏和空肠组织均损伤严重,主要表现为炎性细胞浸润、散在分布部分红细胞等病理变化。家兔致病性试验结果显示,该病原菌感染兔后出现与自然感染兔类似的症状和脏器的剖检症状,但病变程度与自然感染兔相比较轻。且从病兔体内再次分离到与感染菌相同的菌株,表明奇异变形杆菌为该兔场暴发疾病的病原菌。本研究为兔奇异变形杆菌病的防控提供参考依据。

关键词：兔奇异变形杆菌消化道疾病组织病理学毒力基因

Protective Effects of Salvianolate on Myocardial Injury or MyocardiaMnfarction after Elective Percutaneous Coronary Intervention in NSTE-ACS Patients:A Randomized Placebo-Controlled Trial

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Chinese Journal of Integrative Medicine 2020年第9期26卷 656-662页

作者： OU Yang SUN Sheng-jia SHI Hai-ming LUO jian-feng LUO Xin-ping SHEN Yun-zhi CHEN Yu-fei FAN wei-hu LIU Hong-ying SHEN wei Department of Cardiovascular Disease Huashan HospitalFudan UniversityShanghai(200040)China Department of Biostatistics School of Public HealthFudan UniversityShanghai(200032)China Medical Department Shanghai Green Valley Pharmaceutical Co.Ltd.Shanghai(201203)China

Objective:To evaluate the protective effects of salvianolate on percutaneous coronary intervention(PCI)related myocardial injury or myocardial infarction after elective PCI in non-ST-segment elevation acute coronary syndrome(NSTE-ACS)***:A total of 149 patients with NSTE-ACS who underwent elective PCI were *** patients were randomly allocated in a 1:1 ratio to the salvianolate group(74 cases)or the control group(75 cases).After exclusion criteria of coronary angiography,60 patients with PCI therapy remained in the salvianolate group and 68 in the control *** incidence and the severity of PCI related myocardial injury or myocardial infarction,in addition to major adverse cardiac events(MACEs)during 1 year follow-up after PCI were studied between the two *** logistic regression analysis was used to determine the independent factors for PCI related myocardial injury or myocardial infarction after elective ***:Compared with the control group,salvianolate treatment reduced the incidence of PCI related severe myocardial injury or myocardial infarction(11.7%vs.26.5%,P=0.035).The rate of MACEs or all-cause death within 1 month or 1 year after the procedure was not significantly different between the two ***:Periprocedural treatment with salvianolate reduces the incidence of PCI related severe myocardial injury or myocardial infarction,although it does not influence clinical prognosis.

关键词： myocardial infarction acute coronary syndrome percutaneous coronary intervention salvianolate

基于网络药理学、分子对接和实验验证探讨加味活络效灵丹干预结直肠癌的作用机制

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中国中药杂志 2024年第13期49卷 3657-3667页

作者：江威赵秋萍黄琳姜家旺李明莉陈小春徐燕王国娟邓兰张磊昌李志明江西中医药大学临床医学院江西南昌330004 江西中医药大学附属医院江西南昌330019 上海中医药大学附属龙华医院上海200032

借助网络药理学和分子对接预测加味活络效灵丹抗结直肠癌(colorectal cancer,CRC)可能的作用靶点及相关信号通路,并通过实验验证。采用中药系统药理学数据库与分析平台(TCMSP)获取加味活络效灵丹的活性成分及靶点,利用GeneCards、DrugB... 详细信息

借助网络药理学和分子对接预测加味活络效灵丹抗结直肠癌(colorectal cancer,CRC)可能的作用靶点及相关信号通路,并通过实验验证。采用中药系统药理学数据库与分析平台(TCMSP)获取加味活络效灵丹的活性成分及靶点,利用GeneCards、DrugBank、OMIM、TTD数据库获取CRC的相关靶点,Cytoscape软件构建药物-活性成分-靶点网络,STRING数据库构建蛋白-蛋白互作(PPI)网络,DAVID平台对靶点进行基因本体论(Gene Ontology,GO)功能和京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)通路富集分析,AutoDock Vina进行分子对接。设置不同浓度加味活络效灵丹含药血清组分别处理HCT 116细胞,利用cell counting kit-8(CCK-8)检测各组HCT 116细胞增殖抑制情况,Transwell检测HCT 116细胞侵袭能力,蛋白免疫印迹法(Western blot)检测β-连环蛋白(β-catenin)、细胞周期蛋白D1(cyclinD1)、V-Myc骨髓细胞瘤病毒癌基因同源物(c-Myc),以及上皮间质转化(EMT)标志蛋白E-钙黏蛋白(E-cadherin)、N-钙黏蛋白(N-cadherin)、波形蛋白(vimentin)、基质金属蛋白酶2(MMP2)、基质金属蛋白酶7(MMP7)、基质金属蛋白酶9(MMP9)、转录因子TWIST的表达水平。网络药理学分析,得到加味活络效灵丹活性成分242个,CRC靶点1844个,CRC与加味活络效灵丹交集靶点127个,与CRC相关的信号通路涉及PI3K-Akt、TNF、HIF-1、IL-17、Wnt等。分子对接显示,主要活性成分与核心蛋白有较稳定的结合构象。CCK-8检测显示,加味活络效灵丹能显著抑制HCT 116细胞的增殖;Transwell检测显示,随着加味活络效灵丹含药血清浓度的增加,抑制HCT 116细胞的侵袭能力越明显;经含药血清处理后,β-catenin、cyclinD1、c-Myc、N-cadherin、vimentin、MMP2、MMP7、MMP9和TWIST蛋白表达受抑制,E-cadherin表达上调。结果表明,加味活络效灵丹通过多成分、多靶点、多途径抑制结直肠癌细胞的增殖、侵袭和转移,其机制可能与抑制Wnt/β-catenin信号通路激活,从而影响EMT的发生有关。

关键词：加味活络效灵丹结直肠癌网络药理学分子对接细胞实验上皮间质转化

Physicochemical properties and antibacterial mechanism of theabrownins prepared from different catechins catalyzed by polyphenol oxidase and peroxidase

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农业科学学报:英文版 2023年第9期22卷 2905-2916页

作者： CHEN Xiao-qiang LIU jia-yan HUANG Xue-jun wei Yan-an SHAO Rui-xiang CHEN Ting-ting XIE jian-chun Cooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province)/Key Laboratory of Fermentation Engineering(Ministry of Education)/School of Bioengineering and Food Hubei University of TechnologyWuhan 430068P.R.China School of Light Industry Beijing Technology&Business University(BTBU)Beijing 100048P.R.China

Theabrownins(TBs)are the characteristic functional and quality components of dark teas such as Pu’er tea and Chin-brick *** are a class of water-soluble brown polymers with multi-molecular weight distribution produced by the oxidative polymerisation of tea polyphenols during the fermentation process of dark tea,both enzymatically and *** have been extracted and purified from dark tea all the time,but the obtained TBs contain heterogeneous components such as polysaccharides and caffeine in the bound state,which are difficult to *** isolation and purification process was tedious and required the use of organic solvents,which made it difficult to industrialise *** this study,epigallocatechin(EGC),epigallocatechin gallate(EGCG),epigallocatechin gallate(ECG),EGC/EGCG(mass ratio 1:1),EGCG/ECG(mass ratio 1:1),EGC/ECG(mass ratio 1:1)and EGC/EGCG/ECG(mass ratio 1:1:1)as substrates and catalyzed by polyphenol oxidase(PPO)and peroxidase(POD)in turn to produce TBs,named TBs-dE-1,TBs-dE-2,TBs-dE-3,TBs-dE-4,TBs-dE-5,TBs-dE-6 and *** physicochemical properties and the antibacterial activity and mechanism of TBs-dE-1–7 were *** and colour difference measurements showed that all seven tea browning samples showed varying degrees of brownish *** potential in aqueous solutions at pH 3.0–9.0 indicated that TBs-dE-1–7 was negatively charged and the potential increased with increasing *** characteristic absorption peaks of TBs-dE-1–7 were observed at 208 and 274 nm by UV-visible(UV-vis)scanning *** transform infrared(FT-IR)spectra indicated that they were phenolic ***-dE-1–7 showed significant inhibition of Escherichia coli DH5α(*** DH5α).TBs-dE-3 showed the strongest inhibitory effect with minimum inhibitory concentration(MIC)of 1.25 mg mL–1 and MBC of 10 mg mL–1,followed by TBs-dE-5 and *** three TBs-dEs were selected to further investigate their inhibition *** TBs-dE was

关键词： theabrownins catechin enzymatic oxidation physicochemical properties antibacterial mechanism

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中药制剂国际注册质量标准要求与对策

中国食品药品监管 2024年第4期 100-107页

作者：刘明李铂杨洋屠佳峰白剑赵胜楠张伟中关村现代医药生产力促进中心北京市药品检验研究院北京市药品监督管理局国家药品监督管理局药品审评中心中国药品监督管理研究会

自“一带一路”倡议实施以来,中药出口贸易额呈逐年上升趋势。现如今国际药品主流国家和地区包括美国、欧盟、加拿大、澳大利亚等均已将天然药品/植物药(含中药制剂)纳入非处方药管理。但因我国中药制剂现行标准无法在国际注册中与上述... 详细信息

自“一带一路”倡议实施以来,中药出口贸易额呈逐年上升趋势。现如今国际药品主流国家和地区包括美国、欧盟、加拿大、澳大利亚等均已将天然药品/植物药(含中药制剂)纳入非处方药管理。但因我国中药制剂现行标准无法在国际注册中与上述国家和地区药品监管完全对标,导致无法顺利完成注册。本文着重从中药制剂标准的监管角度,对比上述国家和地区对天然药品/植物药质量标准中农药残留、重金属及有害元素、黄曲霉毒素、微生物检验项目的规定,并从原料把关、检验检测方法学建立和制剂质量标准提升等方面提出建议。

关键词：中药制剂国际注册质量标准强制检验