Protective Effects of Salvianolate on Myocardial Injury or MyocardiaMnfarction after Elective Percutaneous Coronary Intervention in NSTE-ACS Patients:A Randomized Placebo-Controlled Trial

作     者：OU Yang SUN Sheng-jia SHI Hai-ming LUO Jian-feng LUO Xin-ping SHEN Yun-zhi CHEN Yu-fei FAN Wei-hu LIU Hong-ying SHEN Wei OU Yang;SUN Sheng-jia;SHI Hai-ming;LUO Jian-feng;LUO Xin-ping;SHEN Yun-zhi;CHEN Yu-fei;FAN Wei-hu;LIU Hong-ying;SHEN Wei

作者机构：Department of Cardiovascular DiseaseHuashan HospitalFudan UniversityShanghai(200040)China Department of BiostatisticsSchool of Public HealthFudan UniversityShanghai(200032)China Medical DepartmentShanghai Green Valley Pharmaceutical Co.Ltd.Shanghai(201203)China 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2020年第26卷第9期

页      面：656-662页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the National Natural Science Foundation of China(No.81673701 and No.81573710) 

主　　题：myocardial infarction acute coronary syndrome percutaneous coronary intervention salvianolate 

摘      要：Objective:To evaluate the protective effects of salvianolate on percutaneous coronary intervention(PCI)related myocardial injury or myocardial infarction after elective PCI in non-ST-segment elevation acute coronary syndrome(NSTE-ACS)***:A total of 149 patients with NSTE-ACS who underwent elective PCI were *** patients were randomly allocated in a 1:1 ratio to the salvianolate group(74 cases)or the control group(75 cases).After exclusion criteria of coronary angiography,60 patients with PCI therapy remained in the salvianolate group and 68 in the control *** incidence and the severity of PCI related myocardial injury or myocardial infarction,in addition to major adverse cardiac events(MACEs)during 1 year follow-up after PCI were studied between the two *** logistic regression analysis was used to determine the independent factors for PCI related myocardial injury or myocardial infarction after elective ***:Compared with the control group,salvianolate treatment reduced the incidence of PCI related severe myocardial injury or myocardial infarction(11.7%vs.26.5%,P=0.035).The rate of MACEs or all-cause death within 1 month or 1 year after the procedure was not significantly different between the two ***:Periprocedural treatment with salvianolate reduces the incidence of PCI related severe myocardial injury or myocardial infarction,although it does not influence clinical prognosis.