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Chemokines: the past, the present and the future

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Cellular & Molecular Immunology 2018年第4期15卷 295-298页

作者： Peng Tang ji ming wang Department of Breast Surgery Southwest HospitalArmy Medical UniversityChongqing 400038China Cancer and Inflammation Program Center for Cancer ResearchNational Cancer Institute at FrederickFrederick 21702MDUSA

We are very excited to publish our article in the“Chemokine Special Issue”of Cellular and Molecular Immunology,which has received increasing attention in the field of immunology.A natural question emerging regarding this issue is,why chemokines?The answer may of course not be simple,but if we consider only the essential,a shortened answer should be because chemokines are among the first mobilizers of host responses in homeostasis and diseases associated with inflammation(Figure 1).

关键词： has Figure among

The Essential Role of Phosphoinositide 3-Kinases(PI3Ks)in Regulating Pro-Inflammatory Responses and the Progression of Cancer

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Cellular & Molecular Immunology 2005年第4期2卷 241-252页

作者： Keqiang Chen Pablo Iribarren wanghua Gong ji-ming wang School of Agriculture and Biology Shanghai Jiaotong University Shanghai 201101 China Laboratory of Molecular Immunoregulation Center for Cancer Research National Cancer Institute-Frederick Frederick MD 21702 USA Basic Research Program SAIC-Frederick National Cancer Institute at Frederick Frederick MD 21702 USA Laboratory of Molecular Immunoregulation Center for Cancer Research National Cancer Institute at Frederick Building 560 Room 31-40 Frederick MD 21702-1201 USA

Phosphoinositide 3-Kinases （PI3Ks） are proteins coupled to a variety of cell surface receptors and play a key role in signal transduction cascade regulating fundamental cellular functions such as transcription, proliferation, and survival. PI3Ks also are important in disease processes such as inflammation and cancer. The aim of this review is to outline current understandings of the PI3K family, mechanism of their activation, their role in inflammatory responses and the development of malignant tumors.

关键词： PI3K signal transduction inflammation malignant tumor

Styrene/Butadiene Copolymer Synthesized by Reactive Extrusion

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Chinese Journal of Polymer Science 2015年第8期33卷 1096-1103页

作者： ji-ming wang Bo Chen Sheng-jie Tang Dong Shan 郑安呐 Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and Technology Department of Mechanical Engineering University of Houston

In this study, we present a method to synthesize styrene-butadiene copolymer, using anionic polymerization in a co-rotating closely intermeshing twin-screw extruder. The weight content of polybutadiene in these copolymers was above 50% although in the past studies it had been possible to accomplish levels higher than 30%. ^1H-NMR and GPC show that the molecular structure of the two polymers is different due to different feeding method. In terms of the structure of the polymerized products, the mechanism of polymerization in the bulk polymerization is discussed. TEM and DMA show that two phases in the block copolymer are completely incompatible, leading to sharp phase separation, while the case is complicated in the copolymer through the mixture feeding. Traditionally, styrene-butadiene rubber is mainly synthesized by solution polymerization. Reactive extrusion in this paper provides a possibility to synthesize these products in an environmentally friendly way.

关键词： Reactive extrusion Styrene Butadiene Anionic polymerization.

Chemokines in homeostasis and diseases

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Cellular & Molecular Immunology 2018年第4期15卷 324-334页

作者： Keqiang Chen Zhiyao Bao Peng Tang wanghua Gong Teizo Yoshimura ji ming wang Cancer and Inflammation Program Center for Cancer ResearchNational Cancer Institute at FrederickFrederickMD 21702USA Department of Pulmonary&Critical Care Medicine Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025P.R.China Department of Breast Surgery Southwest HospitalThird Military Medical UniversityChongqing 400038China Basic Research Program Leidos Biomedical ResearchInc.FrederickMD 21702USA Department of Pathology and Experimental Medicine Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama UniversityOkayama 700-8558Japan

For the past twenty years,chemokines have emerged as a family of critical mediators of cell migration during immune surveillance,development,inflammation and cancer *** bind to seven transmembrane G protein-coupled receptors(GPCRs)that are expressed by a wide variety of cell types and cause conformational changes in trimeric G proteins that trigger the intracellular signaling pathways necessary for cell movement and *** chemokines have evolved to benefit the host,inappropriate regulation or utilization of these small proteins may contribute to or even cause ***,understanding the role of chemokines and their GPCRs in the complex physiological and diseased microenvironment is important for the identification of novel therapeutic *** review introduces the functional array and signals of multiple chemokine GPCRs in guiding leukocyte trafficking as well as their roles in homeostasis,inflammation,immune responses and cancer.

关键词： chemokines chemotaxis diseases GPCRs homeostasis inflammatory cells

Research on the Encapsulation Device for Lunar Samples

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 104-117页

作者： Yonggang Du Chunyong wang Haoling Li Ying Zhou ming ji Xuesong wang Lanzhou Institute of Physics CASTLanzhou 730000China

The encapsulation of lunar samples is a core research area in the third phase of the Chinese Lunar Exploration *** seal assembly,opening and closing mechanism(OCM),and locking mechanism are the core components of the encapsulation device of the lunar samples,and the requirements of a tight seal,lightweight,and low power make the design of these core components *** this study,a combined sealing assembly,OCM,and locking mechanism were investigated for the *** sealing architecture consists of rubber and an Ag-In alloy,and a theory was built to analyze the *** of the electroplate Au coating on the knife-edge revealed that the hermetic seal can be significantly *** driving principle for coaxial double-helical pairs was investigated and used to design the ***,a locking mechanism was created using an electric initiating explosive device with orifice *** optimizing the design,the output parameters were adjusted to meet the requirements of the lunar *** experimental results showed that the helium leak rate of the test pieces were not more than 5×10^(-11) Pa·m^(3)·s^(-1),the minimum power of the OCM was 0.3 W,and the total weight of the principle prototype was 2.9 *** explosive driven locking mechanism has low *** investigation solved the difficulties in achieving tight seal,light weight,and low power for the lunar explorer,and the results can also be used to explore other extraterrestrial objects in the future.

关键词： Lunar samples Encapsulation Vacuum seal Mechanism

Differentiation of isolated human umbilical cord mesenchymal stem cells into neural stem cells

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International Journal of Ophthalmology(English edition) 2016年第1期9卷 41-47页

作者： Song Chen Wei Zhang ji-ming wang Hong-Tao Duan jia-Hui Kong Yue-Xin wang Meng Dong Xue Bi jian Song Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual Science Tianjin Eye Institute Clinical College of Ophthalmology Tianjin Medical University

AIM：To investigate whether umbilical cord human mesenchymal stem cell（UC-MSC）was able to differentiate into neural stem cell and neuron.·METHODS：The umbilical cords were o btained from pregnant women with their written consent and the approval of the Clinic Ethnics ***-MSC were isolated by adherent culture in the medium contains 20%fetal bovine serum（FBS）,then they were maintained in the medium contain 10%FBS and induced to neural cells in neural differentiation *** investigated whether UC-MSC was able to differentiate into neural stem cell and neuron by using flow cytometry,reverse transcriptase-polymerase chain reaction（RT-PCR）and immunofluorescence（IF）analyzes.·R ESULTS：A substantial number of UC-MSC was harvested using the tissue explants adherent method at about *** cytometric study revealed that these cells expressed common markers of MSCs,such as CD105（SH2）,CD73（SH3）and *** induction of differentiation of neural stem cells,the cells began to form clusters;RT-PCR and IF showed that the neuron specific enolase（NSE）and neurogenic differentiation 1-positive cells reached 87.3%±14.7%and 72.6%±11.8%,*** showed neuronal cell differentiation after induced,including neuron-like protrusions,plump cell body,obviously and stronger ***-PCR and IF analysis showed that microtubule-associated protein 2（MAP2）and nuclear factor-M-positive cells reached 43.1%±10.3%and 69.4%±19.5%,respectively.·CONCLUSION：Human umbilical cord derived MSCs can be cultured and proliferated and differentiate into neural stem cells,which may be a valuable source for cell therapy of neurodegenerative eye diseases.

关键词： human umbilical cord mesenchymal stemcells neural stem cells neuron neurodegenerative eye diseases

Identification of methylation profile of HOX genes in extrahepatic cholangiocarcinoma

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World Journal of Gastroenterology 2011年第29期17卷 3407-3419页

作者： Yi Shu Bing wang ji wang jian-ming wang Sheng-Quan Zou General Surgery Department of Tongji Hospital Tongji Medical College of Huazhong University of Science and Technology1095 Jiefang AvenueWuhan 430030Hubei ProvinceChina

AIM:To identify methylation profile and novel tumor marker of extrahepatic cholangiocarcinoma(CCA)with high throughout ***:Differential methylation profile was compared between normal bile duct epithelial cell lines and CCA cell lines by methyl-DNA immunoprecipitation (MeDIP)***-polymerase chain reaction (BSP)was performed to identify the methylated allels of target *** of target genes was investigated before and after the treatment with DNA demethylating *** of candidate genes was also evaluated by immunofluorescence in 30 specimens of CCA tissues and 9 normal bile duct ***:Methylation profile of CCA was identified with MeDIP microarray in the respects of different gene functions and signaling ***,97 genes with hypermethylated CpG islands in the promoter region were homeobox *** top 5 hypermethylated homeobox genes validated by BSP were HOXA2(94.29%),HOXA5(95.38%),HOXA11 (91.67%),HOXB4(90.56%)and HOXD13(94.38%).Expression of these genes was reactivated with 5’-aza2’-*** expression differences were found between normal bile duct and extrahepatic CCA tissues(66.67%-100%vs 3.33%-10%).CONCLUSION:HOXA2,HOXA5,HOXA11,HOXB4 and HOXD13 may work as differential epigenetic biomarkers between malignant and benign biliary tissues.

关键词： DNA methylation Epigenetic Promoter microarray Cholangiocarcinoma

Inter-stage performance and energy characteristics analysis of electric submersible pump based on entropy production theory

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Petroleum Science 2024年第2期21卷 1354-1368页

作者： Hui wang Yang Yang Bin Xi Wei-Dong Shi Chuan wang Lei-Lei ji Xiang-Yu Song Zhao-ming He College of Hydraulic Science and Engineering Yangzhou UniversityYangzhou225009JiangsuChina College of Electrical and Mechanical Engineering Nanchang Institute of TechnologyNanchang330044JiangxiChina College of Mechanical Engineering Nantong UniversityNantong226019JiangsuChina National Research Center of Pumps Jiangsu UniversityZhenjiang212013JiangsuChina Zhejiang Zhenxing Petrochemical Machinery Co. Ltd.Ruian325204ZhejiangChina Department of Mechanical Engineering of Texas Tech University Lubbock79411TXUSA

The electric submersible pump(ESP) is a crucial apparatus utilized for lifting in the oil extraction *** lifting capacity is enhanced by the multi-stage tandem structure, but variations in energy characteristics and internal flow across stages are also introduced. In this study, the inter-stage variability of energy characteristics in ESP hydraulic systems is investigated through entropy production(EP) analysis,which incorporates numerical simulations and experimental validation. The EP theory facilitates the quantification of energy loss in each computational subdomain at all ESP stages, establishing a correlation between microscopic flow structure and energy dissipation within the system. Furthermore, the underlying causes of inter-stage variability in ESP hydraulic systems are examined, and the advantages and disadvantages of applying the EP theory in this context are evaluated. Consistent energy characteristics within the ESP, aligned with the distribution of internal flow structure, are provided by the EP theory, as demonstrated by our results. The EP theory also enables the quantitative analysis of internal flow losses and complements existing performance analysis methods to map the internal flow structure to hydraulic losses. Nonetheless, an inconsistency between the energy characterization based on EP theory and the traditional efficiency index when reflecting inter-stage differences is identified. This inconsistency arises from the exclusive focus of the EP theory on flow losses within the flow field, disregarding the quantification of external energy input to the flow field. This study provides a reference for the optimization of EP theory in rotating machinery while deeply investigating the energy dissipation characteristics of multistage hydraulic system, which has certain theoretical and practical significance.

关键词： Electric submersible pump(ESP) Entropy production theory Energy characteristics Inter-stage differences

Outcomes of simple saline-coupled bipolar electrocautery for hepatic resection

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World Journal of Gastroenterology 2014年第26期20卷 8638-8645页

作者： jian-Yang Guo De-Wei Li Rui Liao Ping Huang Xian-Bing Kong ji-ming wang Hong-Lin wang Shi-Qiao Luo Xiong Yan Cheng-You Du Department of Hepatobiliary Surgery The First Affiliated HospitalChongqing Medical University

AIM: To evaluate the application of bipolar coagulation (BIP) in hepatectomy by comparing the efficacy of BIP alone, cavitron ultrasonic surgical aspirator (CUSA) + BIP and conventional clamp crushing (CLAMP).

关键词： Hepatectomy Surgical procedures Blood loss Complications Hospital stay Comparative study