Chemokines in homeostasis and diseases

作     者：Keqiang Chen Zhiyao Bao Peng Tang Wanghua Gong Teizo Yoshimura Ji Ming Wang 

作者机构：Cancer and Inflammation ProgramCenter for Cancer ResearchNational Cancer Institute at FrederickFrederickMD 21702USA Department of Pulmonary&Critical Care MedicineRuijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025P.R.China Department of Breast SurgerySouthwest HospitalThird Military Medical UniversityChongqing 400038China Basic Research ProgramLeidos Biomedical ResearchInc.FrederickMD 21702USA Department of Pathology and Experimental MedicineGraduate School of MedicineDentistry and Pharmaceutical SciencesOkayama UniversityOkayama 700-8558Japan 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2018年第15卷第4期

页      面：324-334页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This project was funded in part by federal funds from the National Cancer Institute,National Institutes of Health,under Contract No.HHSN261200800001E was supported in part by the Intramural Research Program of the NCI,NIH 

主　　题：chemokines chemotaxis diseases GPCRs homeostasis inflammatory cells 

摘      要：For the past twenty years,chemokines have emerged as a family of critical mediators of cell migration during immune surveillance,development,inflammation and cancer *** bind to seven transmembrane G protein-coupled receptors(GPCRs)that are expressed by a wide variety of cell types and cause conformational changes in trimeric G proteins that trigger the intracellular signaling pathways necessary for cell movement and *** chemokines have evolved to benefit the host,inappropriate regulation or utilization of these small proteins may contribute to or even cause ***,understanding the role of chemokines and their GPCRs in the complex physiological and diseased microenvironment is important for the identification of novel therapeutic *** review introduces the functional array and signals of multiple chemokine GPCRs in guiding leukocyte trafficking as well as their roles in homeostasis,inflammation,immune responses and cancer.