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Single dose of ibutilide for conversion of persistent atrial fibrillation after radiofrequency ablation

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Chinese Medical Journal 2011年第5期124卷 710-713页

作者： HOU Yu FANG Pi-hua LIU Jun LI Xiao-feng HU ji-qiang ZHANG shu Clinical EP Lab and Arrhythmia Center Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background Patients with persistent or permanent atrial fibrillation （AF） often need direct current cardioversion after radiofrequency ablation. The aim of this study was to investigate the effectiveness and safety of ibutilide for cardioversion of persistent or permanent atrial fibrillation after radiofrequency ablation and the factors related to conversion. Methods Patients with persistent or permanent atrial fibrillation were treated with combined ablation strategy including circumferential pulmonary vein isolation, linear ablation and CAFE potential ablation. If AF was not terminated after ablation, ibutilide was used for cardioversion （1 mg, intravenous injection in 10 minutes）. These patients were divided into a conversion group and a non-conversion group according to whether AF was converted to sinus rhythm within 30 minutes after administration. ECG monitoring was performed during the injection of ibutilide. Atrial waves recorded by coronary sinus electrodes were measured for calculating average wavelength of AF waves in six seconds. The QT interval was measured immediately after conversion and 2 hours after injection of *** Forty patients whose AF was not converted to sinus rhythm after radiofrequency ablation were given an intravenous injection of ibutilide. Of the 40 patients, 29 cases were converted to sinus rhythm, with a conversion rate of 72.5%. The average conversion time was （13.2±5.5） minutes. Compared with the conversion group, patients in the non-conversion group had a longer history of AF （9.4±5.3） years vs. （4.3±2.8） years, P 〈0.05）, and a markedly enlarged left atrium （47.3±2.9） mm vs. （42.1±4.5） mm, P〈0.05）. There were no significant differences in gender, age, body mass index and left ventricular function between the two groups. Ibutilide significantly prolonged the average wavelength of the AF wave （171.8±29.5） ms vs. （242.0±40.0） ms, P 〈0.001）. Two hours after ibutilide treatment, the QT interval was significantly shortened （

关键词： ibutilide conversion atrial fibrillation radiofrequency ablation

Solid solution strategy modulated defects engineering of (Cr1-xVx)2AlC MAX phase toward superior electromagnetic wave absorption

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Rare Metals 2024年第7期43卷 3205-3219页

作者： ji-Lin Gou Yu-Kai Chang shu Liu Peng-Hui Li Ping-Hao Cui Qian-Ku Hu Li-Bo Wang Xin Zhang Jun-Kai Wang Qi-Xun Xia Ai-Guo Zhou School of Materials Science and Engineering Henan Polytechnic University Key Laboratory for Microstructural Material Physics of Hebei Province School of ScienceYanshan University State Key Laboratory of Metastable Materials Science and Technology Yanshan University

Defects engineering is an effective strategy for manipulating electromagnetic parameters and enhancing electromagnetic wave（EMW） absorption ***,the relationship between them is not clear,especially in solid solution *** this work,a series of(Cr1-xVx)2AlC MAX phase solid solutions with layered structure were prepared via tuning the ratio of Cr and V to explore their EMW absorption *** experimental results indicated that the doping of V atoms at the M-site could effectively regulate its impedance matching and EMW absorption properties by introducing appropriate numbers of defects in the crystal,such as twin boundaries,dislocations and lattice *** them,if Cr:V=3:1,Cr1.5V0.5AlC,as radar absorption materials,could reach a strong reflection loss of-51.8 dB at the frequency of 12.8 GHz under an ultra-thin thickness of 1.3 *** reflection loss value could attain-10 dB in a wide frequency range of 2.7-18 GHz and thickness range of 1-5 *** addition,after high temperature and acid-alkali immersion treatment,this sample still had good EMW absorption capability,and the effective absorption bandwidth was enhanced from 2.3 to 2.6 GHz after concentrated acid immersion or 3.1 GHz after concentrated alkali *** work has great reference significance for the research and development of high-performance MAX-based EMW absorption materials in harsh environments.

关键词： MAX phases Solid solution Defects engineering Electromagnetic wave absorption Harsh environments

广西扶绥那派盆地早白垩世棘龙类牙齿化石新材料

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地质通报 2022年第9期41卷 1509-1515页

作者：姬书安张培陆道林中国地质科学院地质研究所/自然资源部地层与古生物重点实验室北京100037 中国古生物化石保护基金会北京100034 广西自然资源档案博物馆广西南宁530028

广西扶绥县那派盆地早白垩世新隆组中产有以蜥脚类、兽脚类、禽龙类等恐龙为代表并包含弓鲛类、辐鳍鱼类、龟鳖类、鳄形类的脊椎动物群,其与泰国东北地区Khorat群Khok Kruat组(阿普特阶)脊椎动物群面貌相近。最新发现于那派盆地的棘龙... 详细信息

广西扶绥县那派盆地早白垩世新隆组中产有以蜥脚类、兽脚类、禽龙类等恐龙为代表并包含弓鲛类、辐鳍鱼类、龟鳖类、鳄形类的脊椎动物群,其与泰国东北地区Khorat群Khok Kruat组(阿普特阶)脊椎动物群面貌相近。最新发现于那派盆地的棘龙类牙齿化石新材料,其齿冠横断面为宽略小于长的亚圆形,齿冠前后缘无小锯齿,齿冠表面具明显纵嵴和纵沟,单侧面纵嵴数目12~15条。这些形态表明,那派盆地的棘龙类牙齿可归入棘龙亚科(Spinosaurinae),且与泰国东北地区Khok Kruat组棘龙类牙齿的形态类型Ⅱ(Siamosaurus形态类型)可对比。新发现的牙齿化石还显示,那派盆地目前仅存在一种类型的棘龙类,其可能与泰国的暹罗龙(Siamosaurus)关系较密切。

关键词：棘龙亚科牙齿下白垩统那派盆地广西

Improvement of Ga_(2)O_(3)vertical Schottky barrier diode by constructing NiO/Ga_(2)O_(3)heterojunction

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Journal of Semiconductors 2024年第4期45卷 63-68页

作者： Xueqiang ji jinjin Wang Song Qi Yijie Liang Shengrun Hu Haochen Zheng Sai Zhang jianying Yue Xiaohui Qi Shan Li Zeng Liu Lei shu Weihua Tang Peigang Li School of Integrated Circuits&State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China College of Integrated Circuit Science and Engineering Nanjing University of Posts and TelecommunicationsNanjing 210023China Beijing Microelectronics Technology Institute Beijing 100076China

The high critical electric field strength of Ga_(2)O_(3)enables higher operating voltages and reduced switching losses in power electronic *** Schottky metals and epitaxial films are essential for further enhancing device *** this work,the fabrication of vertical Ga_(2)O_(3)barrier diodes with three different barrier metals was carried out on an n--Ga_(2)O_(3)homogeneous epitaxial film deposited on an n+-β-Ga_(2)O_(3)substrate by metal-organic chemical vapor deposition,excluding the use of edge *** ideal factor,barrier height,specific on-resistance,and breakdown voltage characteristics of all devices were investigated at room *** addition,the vertical Ga_(2)O_(3)barrier diodes achieve a higher breakdown volt-age and exhibit a reverse leakage as low as 4.82×10^(-8)A/cm^(2)by constructing a NiO/Ga_(2)O_(3)***,Ga_(2)O_(3)power detailed investigations into Schottky barrier metal and NiO/Ga_(2)O_(3)heterojunction of Ga_(2)O_(3)homogeneous epitaxial films are of great research potential in high-efficiency,high-power,and high-reliability applications.

关键词： Ga_(2)O_(3) Schottky barrier diode NiO/Ga_(2)O_(3)heterojunction

Mannitol inhibits the proliferation of neural stem cell by a p38 mitogen-activated protein kinase-dependent signaling pathway

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Chinese Journal of Traumatology 2024年第1期27卷 42-52页

作者： Hai-Zhen Duan Xin Zhou Quan Hu Meng-Long Liu shu-Hong Wang ji Zhang Xu-Heng jiang Tian-Xi Zhang An-Yong Yu Department of Emergency Affiliated Hospital of Zunyi Medical UniversityZunyi563000Guizhou provinceChina Dazhou Vocational College of Chinese Medicine Dazhou635000Sichuan provinceChina Dachuan District Traditional Chinese Medicine Hospital Dazhou635000Sichuan provinceChina

Purpose:Mannitol is one of the first-line drugs for reducing cerebral edema through increasing the extracellular osmotic ***,long-term administration of mannitol in the treatment of cerebral edema triggers damage to neurons and *** that neural stem cell(NSC)is a subpopulation of main regenerative cells in the central nervous system after injury,the effect of mannitol on NSC is still *** present study aims to elucidate the role of mannitol in NSC ***:C57 mice were derived from the animal house of Zunyi Medical University.A total of 15 pregnant mice were employed for the purpose of isolating NSCs in this ***,mouse primary NSCs were isolated from the embryonic cortex of mice and subsequently identified through immunofluorescence *** order to investigate the impact of mannitol on NSC proliferation,both cell counting kit-8 assays and neurospheres formation assays were *** vitro effects of mannitol were examined at various doses and time *** order to elucidate the role of Aquaporin 4(AQP4)in the suppressive effect of mannitol on NSC proliferation,various assays including reverse transcription polymerase chain reaction,western blotting,and immunocytochemistry were conducted on control and mannitol-treated ***,the phosphorylated p38(p-p38)was examined to explore the potential mechanism underlying the inhibitory effect of mannitol on NSC ***,to further confirm the involvement of the p38 mitogen-activated protein kinase-dependent(MAPK)signaling pathway in the observed inhibition of NSC proliferation by mannitol,SB203580 was *** data were analyzed using SPSS 20.0 software(SPSS,Inc.,Chicago,IL).The statistical analysis among multiple comparisons was performed using one-way analysis of variance(ANOVA),followed by Turkey’’s post hoc test in case of the data following a normal distribution using a Shapiro-Wilk normality *** betwe

关键词： Mannitol Cerebral edema Neural stem cell Proliferation AQP4 p38 MAPK signaling pathway

Vulnerable brain regions in adolescent major depressive disorder:A resting-state functional magnetic resonance imaging activation likelihood estimation meta-analysis

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World Journal of Psychiatry 2024年第3期14卷 456-466页

作者： Hui Ding Qin Zhang Yan-Ping shu Bin Tian ji Peng Yong-Zhe Hou Gang Wu Li-Yun Lin jia-Lin Li Department of Radiology The Second People’s Hospital of Guizhou ProvinceGuiyang 550000Guizhou ProvinceChina Department of Radiology Guizhou Provincial People’s HospitalGuiyang 550000Guizhou ProvinceChina Department of Psychiatry of Women and Children The Second People's Hospital of Guizhou ProvinceGuiyang 550000Guizhou ProvinceChina Department of Radiology Zhijin County People's HospitalBijie 552100Guizhou ProvinceChina Medical Humanities College Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina

BACKGROUND Adolescent major depressive disorder(MDD)is a significant mental health concern that often leads to recurrent depression in ***-state functional magnetic resonance imaging(rs-fMRI)offers unique insights into the neural mechanisms underlying this ***,despite previous research,the specific vulnerable brain regions affected in adolescent MDD patients have not been fully *** To identify consistent vulnerable brain regions in adolescent MDD patients using rs-fMRI and activation likelihood estimation(ALE)*** We performed a comprehensive literature search through July 12,2023,for studies investigating brain functional changes in adolescent MDD *** utilized regional homogeneity(ReHo),amplitude of low-frequency fluctuations(ALFF)and fractional ALFF(fALFF)*** compared the regions of aberrant spontaneous neural activity in adolescents with MDD vs healthy controls(HCs)using *** Ten studies(369 adolescent MDD patients and 313 HCs)were *** the ReHo and ALFF/fALFF data,the results revealed that the activity in the right cuneus and left precuneus was lower in the adolescent MDD patients than in the HCs(voxel size:648 mm3,P<0.05),and no brain region exhibited increased *** on the ALFF data,we found decreased activity in the right cuneus and left precuneus in adolescent MDD patients(voxel size:736 mm3,P<0.05),with no regions exhibiting increased *** Through ALE meta-analysis,we consistently identified the right cuneus and left precuneus as vulnerable brain regions in adolescent MDD patients,increasing our understanding of the neuropathology of affected adolescents.

关键词： Major depressive disorder Resting-state functional magnetic resonance imaging Adolescent Activation likelihood estimation Meta-analysis

NLRP3 activation in macrophages promotes acute intestinal injury in neonatal necrotizing enterocolitis

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World Journal of Pediatrics 2024年第2期20卷 153-164页

作者： Bo Shi Cheng-jie Lyu Zhen-Kai Le Hao-Sen ji Yi Xiao Yuan-Yuan Zhang Shou-jiang Huang Lin-Jun Yu Qiang shu jin-Fa Tou Deng-Ming Lai Department of Neonatal Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Pulmonology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Thoracic and Cardiovascular Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China

Background Macrophages are involved in various immune inflammatory disease *** study aimed to investigate the role and mechanism of macrophages in regulating acute intestinal injury in neonatal necrotizing enterocolitis(NEC).Methods CD68,nucleotide-binding oligomerization domain,leucine-rich repeat,and pyrin domain-containing 3(NLRP3),cysteine aspartate-specific protease-1(caspase-1),and interleukin-1β(IL-1β)in paraffin sections of intestinal tissues from NEC and control patients were detected with immunohistochemistry,immunofluorescence,and western *** pet milk,hypoxia and cold stimulation were used to establish a mouse(wild type and Nlrp3^(-/-))model of *** mouse macrophage(RAW 264.7)and rat intestinal epithelial cell-6 lines were also cultured followed by various ***,intestinal epithelial cell injuries,and IL-1β release were *** Compared to the gut“healthy”patients,the intestinal lamina propria of NEC patients had high macrophage infiltration and high NLRP3,caspase-1,and IL-1β ***,in vivo,the survival rate of Nlrp3^(-/-)NEC mice was dramatically improved,the proportion of intestinal macrophages was reduced,and intestinal injury was decreased compared to those of wild-type NEC ***3,caspase-1,and IL-1β derived from macrophages or supernatant from cocultures of macrophages and intestinal epithelial cells also caused intestinal epithelial cell *** Macrophage activation may be essential for NEC ***3/caspase-1/IL-1β cellular signals derived from macrophages may be the underlying mechanism of NEC development,and all these may be therapeutic targets for developing treatments for NEC.

关键词： Caspase-1 Interleukin-1β Macrophage Necrotizing enterocolitis NLRP3

Neuroprotection by cattle encephalon glycoside and ignotin beyond the time window of thrombolysis in ischemic stroke

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Neural Regeneration Research 2021年第2期16卷 312-318页

作者： Jun Zhong Rong-Wei Li Ju Wang Ying Wang Hong-Fei Ge ji-shu Xian Hua Feng Liang Tan Department of Neurosurgery Southwest HospitalThe Third Military Medical University(Army Medical University)ChongqingChina Department of Neurosurgery Hanzhong Central HospitalHanzhongShaanxi ProvinceChina Department of Oncology Hanzhong Central HospitalHanzhongShaanxi ProvinceChina State Key Laboratory of Power Transmission Equipment and System Security and New Technology School of Electrical EngineeringChongqing UniversityChongqingChina

Cattle encephalon glycoside and ignotin(CEGI)injection is known as a multi-target neuroprotective drug that contains numerous liposoluble molecules,such as polypeptides,monosialotetrahexosyl ganglioside(GM-1),free amino acids,hypoxanthine and *** has been approved by the Chinese State Food and Drug Administration and widely used in the treatments of various diseases,such as stroke and Alzheimer's ***,the neuroprotective effects of CEGI beyond the time window of thrombolysis(within 4.5 hours)on acute ischemic stroke remain *** study constructed a rat middle cerebral artery occlusion model by suture-occluded method to simulate ischemic *** first daily dose was intraperitoneally injected at 8 hours post-surgery and the CEGI treatments continued for 14 *** of the modified five-point Bederson scale,beam balance test and rotameric test showed the neurological function of ischemic stroke rats treated with 4 m L/kg/d CEGI improved significantly,but the mortality within 14 days did not change *** MRI and 2,3,5-triphenyltetrazolium chloride staining confirmed that the infarct size in the 4 m L/kg/d CEGI-treated rats was significantly reduced compared with ischemic insult *** results of transmission electron microscopy and double immunofluorescence staining showed that the hippocampal neuronal necrosis in the ischemic penumbra decreased whereas the immunopositivity of new neuronal-specific protein doublecortin and the percentage of Ki67/doublecortin positive cells increased in CEGI-treated rats compared with untreated *** results suggest that CEGI has an effective neuroprotective effect on ischemic stroke when administered after the time window of *** study was approved by the Animal Ethics Committee of The Third Military Medical University,China.

关键词： apoptosis brain cattle encephalon glycoside and ignotin central nervous system neurological function plasticity rat regeneration stroke

沙丁鱼鱼鳞胶原蛋白肽的制备及其抗氧化活性研究

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食品安全质量检测学报 2024年第3期15卷 214-224页

作者：曾丽琴陈雅茹刘淑集张玉苍陈晓婷苏永昌罗联钰刘智禹福建农林大学食品科学学院闽台特色海洋食品加工及营养健康教育部工程研究中心福州350002 福建省水产研究所国家海水鱼类加工技术研发分中心(厦门)福建省海洋生物增养殖与高值化利用重点实验室福建省海洋生物资源开发利用协同创新中心厦门361013 集美大学食品与生物工程学院厦门361000 福建省深蓝生物科技有限公司福州350000

目的优化沙丁鱼(Sardinapilchardus)鱼鳞胶原蛋白肽的制备工艺和评价不同分子量大小胶原蛋白肽的抗氧化活性。方法以沙丁鱼鱼鳞为原料,通过酶工程结合单因素与响应面实验优化胶原蛋白肽制备工艺,采用超滤膜分级分离鱼鳞胶原蛋白肽,并通... 详细信息

目的优化沙丁鱼(Sardinapilchardus)鱼鳞胶原蛋白肽的制备工艺和评价不同分子量大小胶原蛋白肽的抗氧化活性。方法以沙丁鱼鱼鳞为原料,通过酶工程结合单因素与响应面实验优化胶原蛋白肽制备工艺,采用超滤膜分级分离鱼鳞胶原蛋白肽,并通过体外自由基化学体系分析对比不同分子量大小(10、5、1 kDa)的胶原蛋白肽的抗氧化活性。结果采用碱性蛋白酶进行酶解鱼鳞,胶原蛋白肽的得率最高;最优酶解工艺参数为:碱性蛋白酶加酶量7526 U/g、料液比1:20(g/mL)、pH 10.5、酶解温度67℃、酶解时间4 h,此条件下鱼鳞胶原蛋白肽得率最高,达43.44%±1.59%。通过超滤获得的分子量小于1k Da的鱼鳞胶原蛋白肽对1,1-二苯基-2-三硝基苯肼(1,1-diphenyl-2-picrylhydrazyl,DPPH)自由基和羟基自由基(hydroxyl radical,·OH)的清除能力最强,其半抑制浓度(half maximal inhibitory concentration,IC_(50))分别为0.72 mg/mL和1.76 mg/mL;分子量为1~5 kDa的鱼鳞胶原蛋白肽对超氧阴离子自由基(superoxide radical,O^(2-)·)的清除效果最好,其IC50为1.45 mg/mL。结论碱性蛋白酶能够有效制备鱼鳞胶原蛋白肽,且小于1 kDa的鱼鳞胶原蛋白肽抗氧化活性最好。

关键词：沙丁鱼鱼鳞胶原蛋白肽蛋白酶膜分离抗氧化活性