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Curcumin-loaded polymeric nanoparticles for neuro-protection in neonatal rats with hypoxic-ischemic encephalopathy

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nano Research 2018年第10期11卷 5670-5688页

作者： Andrea Joseph Thomas Wood Chih-Chung Chen Kylie Corry jessica M. Snyder Sandra E. Juul Pratik Parikh Elizabeth nance Department of Chemical Engineering University of Washington Seattle WA 98195 USA Division of neonatology Department of Pediatrics University of Washington Seattle WA 98195 USA Department of Comparative Medicine University of Washington Seattle WA 98195 USA Department of Radiology University of Washington Seattle WA 98195 USA

Hypoxic-ischemic encephalopathy is the leading cause of permanent brain injury in term newborns and currently has no cure. Inflammatory processes play a key role in the progression of this disease and may be amenable to a targeted pharmaceutical intervention. Curcumin is a dietary compound with potent anti-inflammatory, antioxidant, and antiapoptotic properties but is limited in therapeutic applications due to its low aqueous solubility, low bioavailability, and rapid first-pass hepatic metabolism. To address these limitations, loading curcumin into poly（lactic-co-glycolic acid）-poly（ethylene glycol）（PLGA-PEG） nanoparticles may increase relevant pharmacokinetic parameters and allow for effective drug delivery to the brain. Using the Vannucci model of unilateral hypoxic-ischemic brain injury in neonatal rats, we studied the in vivo effect of curcumin-loaded PLGA-PEG nanoparticles on brain uptake and diffusion of curcumin and on neuroprotection. The curcumin-loaded nanoparticles were able to overcome the impaired blood-brain barrier, diffuse effectively through the brain parenchyma, localize in regions of injury, and deliver a protective effect in the injured neonatal brain. The application of curcumin and PLGA-PEG nanoparticle-mediated delivery to a clinically relevant model of neonatal brain injury provides greater opportunities for clinical translation of targeted therapies for hypoxic-ischemic encephalopathy.

关键词： drug delivery neuroprotection brain penetrating neonatal hypoxia-ischemia curcumin nanotherapeutics

A comparison of the clinical, demographic and psychiatric profiles among patients with erosive and non-erosive reflux disease in a multi-ethnic Asian country

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World Journal of Gastroenterology 2005年第23期11卷 3558-3561页

作者： Tiing-Leong Ang Kwong-Ming Fock Tay-Meng ng Eng-Kiong Teo Tju-Siang Chua jessica Tan Division of Gastroenterology

AIM:To examine the clinical spectrum of gastroesophageal reflux disease (GERD) and compare erosive (ERD) with non-erosive (nERD) in terms of clinical, demographic and psychiatric profiles. METHODS: Patients with reflux symptoms were enrolled and stratified to nERD and ERD after endoscopy (LA classification). Patients with ERD presenting with dyspepsia were included. Patients on proton pump inhibitors (PPI) or H2 receptor antagonists before endoscopy were excluded. Demographic data, Helicobacter pylori(H pylori) status and presence of minor psychiatric morbidity (based on General Health Questionnaire-28) were analyzed. RESULTS: Among 690 patients screened, 533 were eligible for analysis (male to female ratio: 3:2; Chinese: 75.4%; Malay: 9.8%; Indian: 14.8%). Clinical spectrum of GERD: n: 40.5%; A: 46%; B: 9.2%; C: 2.1%; D: 0.6%; Barrett's esophagus: 1.7%. Compared to patients with nERD, patients with ERD were significantly older (45 vs 39.4 years), more likely to be male (64.4% vs 53.7%), tended to smoke (19.6% vs 9.7%), less likely to have minor psychiatric morbidity (26.4 vs 46.7%) and were more likely to respond to PPI (79.7 vs 66.8%). There was also a trend towards a higher BMI (24.5 vs 23.5). Race, alcohol consumption and H pylori status were not significant. On multivariate analysis, age and presence of minor psychiatric morbidity remained with significant differences. COnCLUSIOn: The majority of patients who have typical symptoms of GERD have nERD or mild erosive reflux disease. Compared to patients with erosive reflux disease, patients with nERD were younger and had a higher prevalence of minor psychiatric morbidity.

关键词： Reflux disease Clinical spectrum Psychiatric morbidity

Capillary electrophoresis to determine entrapment efficiency of a nanostructured lipid carrier loaded with piroxicam

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Journal of Pharmaceutical Analysis 2015年第1期5卷 70-73页

作者： jessica Otarola Adriana Guillermina Lista Beatriz Fernandez Band Mariano Garrido Analytical Chemistry Section INQUISUR(UNS-CONICET)Av.Alem 1253Bahia BlancaArgentina

A simple and fast capillary electrophoresis method has been developed to determine the amount of piroxicam loaded in a drug delivery system based on nanostructured lipid carriers（nLCs）.The entrapment efficiency of the nanostructured lipid carrier was estimated by measuring the concentration of drug not entrapped in a suspension of *** influence of different parameters on migration times,peak symmetry,efficiency and resolution was studied;these parameters included the pH of the electrophoretic buffer solution and the applied *** piroxicam peak was obtained with a satisfactory *** separation was carried out using a running buffer composed of 50 mM ammonium acetate and 13.75 mM ammonia at pH *** optimal voltage was 20 kV and the cartridge temperature was 20 ℃.The corresponding calibration curve was linear over the range of 2.7-5.4 μg/mL of nLC *** reproducibility of migration time and peak area were investigated,and the obtained RSD%values（n = 5） were 0.99 and ***.

关键词： Capillary electrophoresis Drug delivery system nanostructured lipid carrier Piroxicam

Plant Growth-Promoting Traits in Rhizobacteria of Heavy Metal-Resistant Plants and Their Effects on Brassica nigra Seed Germination

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Pedosphere 2017年第3期27卷 511-526页

作者： Brenda ROMn-POnCE Diana Miryel REZA-VZQUEZ Sonia GUTIRREZ-PAREDES María de Jesús DE HARO-CRUZ jessica MALDOnADO-HERnnDEZ Yanely BAHEnA-OSORIO Paulina ESTRADA-DE LOS SAnTOS En Tao WAnG María Soledad VSQUEZ-MURRIETA Instituto Politécnico nacional Escuela Nacional de Ciencias Biológicas Prolongación Carpio y Plan de Ayala s/n Col.Santo Tomás Del.Miguel Hidalgo Ciudad de México

Phytoremediation is an emerging technology that uses plants and their associated microbes to clean up pollutants from the soil, water, and air. In order to select the plant growth-promoting rhizobacteria （PGPR） for phytoremediation of heavy metal contamination, 60 bacterial strains were isolated from the rhizosphere of two endemic plants, Prosopis laevigata and Spharealcea angustifolia, in a heavy metal-contaminated zone in Mexico. These rhizobacterial strains were characterized for the growth at different pH and salinity, extracellular enzyme production, solubilization of phosphate, heavy metal resistance, and plant growth-promoting （PGP） traits, including production of siderophores and indol-3-acetic acid （IAA）. Overall, the obtained rhizobacteria presented multiple PGP traits. These rhizoba^teria were also resistant to high levels of heavy metals （including As as a metalloid）（up to 480 mmol L-1 As（V）, 24 mmol L-1 Pb（II）, 21 mmol L-1 Cu（II）, and 4.5 mmol L-1 Zn（II））. Seven rhizobacterial strains with the best PGP traits were identified as members of Alcaligenes, Bacillus, Curtobacterium, and Microbacterium, and were selected for further bioassay. The inoculation of Brassica nigra seeds with Microbacteriurn sp. CE3R2, Microbacterium sp. nE1R5, Curtobacterium sp. nM1R1, and Microbacterium sp. nM3E9 facilitated the root development; they significantly improved the B. nigra seed germination and root growth in the presence of heavy metals such as 2.2 mmol L-1 Zn（II）. The rhizobacterial strains isolated in the present study had the potential to be used as efficient bioinoculants in phytorremediation of soils contaminated with multiple heavy metals.

关键词： bioinoculants endemic plants mine railings pH phytoremediation salinity

Multilevel Modeling of PM2.5 and Risk of Cardiovascular Disease and Diabetes Mellitus in Adults Aged 65 and Older

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Journal of Geoscience and Environment Protection 2022年第7期10卷 266-278页

作者： Longjian Liu jessica Grimm Qing Wang Rose Ann DiMaria-Ghalili Charles n. Haas Arthur Frank Department of Epidemiology and Biostatistics Dornsife School of Public Health Drexel University Philadelphia PA USA School of Public Health Shandong University Jinan China Department of Graduate nursing College of Nursing and Health Professions Drexel University Philadelphia PA USA Department of Civil Architectural and Environmental Engineering College of Engineering Drexel University Philadelphia PA USA Department of Environment and Occupational Health Dornsife School of Public Health Drexel University Philadelphia PA USA

We aimed to test a hypothesis that elevated ambient particulate matter (PM) 2.5 concentrations are significantly associated with risk of coronary heart disease (CHD), stroke, and diabetes mellitus (DM) in adults aged 65 and older. We analyzed data (2010-2013) from U.S. 1118 counties to examine the association between PM2.5 concentrations and risk of prevalent CHD, stroke, and DM, and mortality from cardiovascular disease (CVD), CHD, stroke, and DM in adults aged ≥ 65. Multilevel regression analysis technique was applied to test these associations. The results show that the annual mean of PM2.5 concentration was 8.7 μg/m3 in the total study sample. Significant differences in mean PM2.5 concentrations were observed across counties and states in the U.S. Multilevel regression analysis indicates that an average annual concentration of 1 μg/m3 increase in PM2.5 concentration was significantly associated with an increased prevalence of CHD, stroke, and DM by 4.9‰ (95% CI: 3.1‰ - 6.7‰), 0.8‰ (0.5‰ - 1.1‰), and 3.3‰ (2.9‰ - 4.4‰), respectively. State-level correlation analyses indicate that increased PM2.5 concentrations were significantly associated with increased age-adjusted mortality from CVD (r = 0.76, p n conclusion, Elevated PM2.5 concentrations were significantly associated with an increased risk of the prevalence and mortality from CVD, CHD, stroke, and DM. Continued effort to control ambient PM2.5 concentrations could play an important role in risk reduction of cardiovascular disease and diabetes in the elderly.

关键词： PM2.5 Cardiovascular Disease Coronary Heart Disease Stroke Diabetes Mellitus

Methanogenic archaea and sulfate reducing bacteria induce severe corrosion of steel pipelines after hydrostatic testing

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Journal of Materials Science & Technology 2020年第13期47卷 72-83页

作者： Enze Zhou Jianjun Wang Masoumeh Moradi Huabing Li Dake Xu Yuntian Lou Jinheng Luo Lifeng Li Yulei Wang Zhenguo Yang Fuhui Wang jessica A.Smith Shenyang national Laboratory for Materials Science Northeastern UniversityShenyang 110819China Key Laboratory for Anisotrotropy and Texture of Materials(Ministry of Education) School of Materials Science and EngineeringNortheastern UniversityShenyang 110819China Corrosion and Protection Center University of Science and Technology BeijingBeijing 100083China CnPC Tubular Goods Research Institute Xian 710065China CnPC Pipeline Construction Administration Department Beijing 100101China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China Department of Biomolecular Sciences Central Connecticut State UniversityNew BritainCT 06050USA

Complex interactions within a microbial consortium can induce severe corrosion in oil *** study investigated the mechanism of microbiologically influenced corrosion(MIC)that led to failure of X52 steel pipelines after hydrostatic *** hydrostatic testing with untreated lake water and underground water were used to simulate and study the events that led to the actual *** analysis,weight loss,and several electrochemical measurements demonstrated rapid corrosion rates after hydrostatic *** of microbial community structures revealed that methanogenic archaea and sulfate reducing bacteria(SRB),introduced by the hydrotest water,formed corrosive biofilms on X52 steel coupon surfaces that induced severe pitting.

关键词： Pipeline steel Microbiologically influenced corrosion Sulfate-reducing bacteria(SRB) Pitting corrosion

Magnetic lipid nanovehicles synergize the controlled thermal release of chemotherapeutics with magnetic ablation while enabling non-invasive monitoring by MRI for melanoma theranostics

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Bioactive Materials 2022年第2期7卷 153-164页

作者： Lorena Garcia-Hevia Inigo Casafont jessica Oliveira nuria Teran Monica L.Fanarraga Juan Gallo Manuel Banobre-Lopez Advanced(Magnetic)Theranostic nanostructures Lab.International Iberian nanotechnology Laboratory Avda.Mestre Jose Veiga s/n4715-330BragaPortugal Grupo de nanomedicina.Universidad de Cantabria-IDIVAL Herrera Oria s/n39011SantanderSpain

nowadays,a number of promising strategies are being developed that aim at combining diagnostic and therapeutic capabilities into clinically effective ***,the combination of a modified release provided by an organic encapsulation and the intrinsic physico-chemical properties from an inorganic counterpart opens new perspectives in biomedical ***,a biocompatible magnetic lipid nanocomposite vehicle was developed through an efficient,green and simple method to simultaneously incorporate magnetic nanoparticles and an anticancer drug(doxorubicin)into a natural *** theranostic performance of the final magnetic formulation was validated in vitro and in vivo,in melanoma *** systemic administration of the proposed magnetic hybrid nanocomposite carrier enhanced anti-tumoral activity through a synergistic combination of magnetic hyperthermia effects and antimitotic therapy,together with MRI reporting *** application of an alternating magnetic field was found to play a dual role,(i)acting as an extra layer of control(remote,on-demand)over the chemotherapy release and(ii)inducing a local thermal ablation of tumor *** combination of chemotherapy with thermotherapy establishes a synergistic platform for the treatment of solid malignant tumors under lower drug dosing schemes,which may realize the dual goal of reduced systemic toxicity and enhanced anti-tumoral efficacy.

关键词： Drug delivery systems Theranosis Magnetic hyperthermia Magnetic resonance imaging Melanoma

Peripheral leukocyte and endometrium molecular biomarkers of inflammation and oxidative stress are altered in peripartal dairy cows supplemented with Zn,Mn,and Cu from amino acid complexes and Co from Co glucoheptonate

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Journal of Animal Science and Biotechnology 2017年第4期8卷 885-896页

作者： Fernanda Batistel Johan S.Osorio Muhammad Rizwan Tariq Cong Li jessica Caputo Michael T.Socha Juan J.Loor Department of Animal Sciences and Division of nutritional Sciences University of Illinois1207 West Gregory DriveUrbanaIL 61801USA Department of Dairy Science South Dakota State UniversityBrookingsSDUSA. Department of Food Science and Technology University College of Agriculture&Environmental SciencesThe Islamia University of BahawalpurBahawalpurPunjabPakistan College of Animal Science and Technology Key Laboratory of Animal Genetics and Breeding of Ministry of AgricultureNational Engineering Laboratory for Animal BreedingChina Agricultural UniversityBeijing 100193China Zinpro Corporation Eden PrairieMNUSA

Background: Immune dysfunction and a higher risk of uterine infections are characteristics of the transition into lactation in dairy cows. The supply of complexed trace minerals, which are more bioavailable, could help overcome the greater needs of these nutrients in tissues around parturition and early ***: Twenty Holstein cows received an oral bolus with a mix of inorganic trace minerals(InO) or complexed trace minerals(AAC) to achieve 75, 65, 11, and 1 ppm supplemental Zn, Mn, Cu, and Co, respectively, in the total diet dry matter from -30 d through +30 d relative to parturition. Blood for polymorphonuclear leukocyte(PMnL) isolation was collected at-30,-15, +10, and + 30 d relative to parturition, whereas endometrium biopsies were performed at +14 and +30 d. Feeding AAC led to greater PMnL expression of genes related with inflammation response(DDX58), oxidative stress response(MPO), eicosanoid metabolism(PLA2G4A and ALOX5AP), transcription regulation(PPARG), and cellular adhesion(TLn1). The upregulation by AAC in endometrium of genes related with inflammation response( TLR2, TLR4, nFKB1, TnF, IL6, IL1 B, IL10, IL8), prostaglandin synthesis(PTGS2, PTGES), and antioxidant responses(nFE2 L2, SOD1) indicated a faster remodeling of uterine tissue and potentially greater capacity to control a local bacterial ***: Data indicate that trace mineral supplementation from amino acid complexes improves PMnL activity and allows the prompt recovery of uterine tissue during early lactation. As such, the benefits of complexed trace minerals extend beyond an improvement of liver function and productive performance.

关键词： Inflammation Oxidative stress Trace minerals Transition period

A peptide-based assay discriminates individual antibody response to SARS-CoV-2

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Genes & Diseases 2022年第1期9卷 275-281页

作者： Immacolata Polvere Serena Voccola Gaetano Cardinale Maurizio Fumi Francesca Aquila Alfredina Parrell jessica Raffaella Madera Romania Stilo Pasquale Vito Tiziana Zotti Dipartimento di Scienze e Tecnologie Universitàdegli Studi del SannioVia dei Mulini snc82100 BeneventoItaly Genus Biotech Universitàdegli Studi del SannioVia Appia s.n.c.82030 Apollosa(BN)Italy Azienda Ospedaliera San Pio Via Pacevecchia5382100 Benevento(BN)Italy

SARS-CoV-2 virus is responsible for the current worldwide coronavirus disease 2019 (COVID-19) pandemic, infecting millions of people and causing hundreds of thousands of deaths. Understanding the antibody response to SARS-CoV-2 is crucial for the development of vaccines, therapeutics and public health interventions. However, lack of consistency in methods used to monitor antibody response to SARS-CoV-2 leaves some uncertainty in our fine understanding of the human antibody response mounted following SARS-CoV-2 infection. We developed a peptide-based enzyme-linked immunosorbent assay (ELISA) by selecting 7 synthetic peptides from the spike, membrane, and nucleocapsid protein sequences of SARS-CoV-2, which effectively detects the antibody response mounted by all COVID-19 convalescent tested. Strikingly, the assay shows a profound difference in antibody response among individual subjects, which may have a significant impact on disease severity. Together, our results define an efficient and specific serological assay to consistently measure the antibody response following SARS-CoV-2 infection, as well as help the design of vaccine and therapeuticals for prevention and treatment of COVID-19.

关键词： Antibodies Assay COVID-19 ELISA Peptides SARS-Cov-2