Magnetic lipid nanovehicles synergize the controlled thermal release of chemotherapeutics with magnetic ablation while enabling non-invasive monitoring by MRI for melanoma theranostics
作者机构：Advanced(Magnetic)Theranostic Nanostructures Lab.International Iberian Nanotechnology LaboratoryAvda.Mestre Jose Veiga s/n4715-330BragaPortugal Grupo de Nanomedicina.Universidad de Cantabria-IDIVALHerrera Oria s/n39011SantanderSpain
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2022年第7卷第2期
页 面：153-164页
核心收录：
学科分类：1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 0702[理学-物理学] 10[医学]
基 金：partially supported by NORTE 2020(2014-2020 North Portugal Regional Operational Program) the ERDF(European Regional Development Fund)under Grant NORTE-01-0145-FEDER-000019 by European Union’s Horizon 2020 Research and Innovation Programme under grant agreement No.686009 by“TAMs-targeted and externally controlled nanotheranostics of triple-negative-breast-cancer(Nanother)"project UTAP-EXPL/NTec/0038/2017 by“Local specific treatment of triple-negative-breast-cancer through externally triggered target-less drug carriers(MagtargetON)"project NORTE-01-0145-FEDER-031142 co-funded by FCT and the ERDF through NORTE2020 by 2014-2020 INTERREG Cooperation Programme Spain-Portugal(POCTEP)through the project 0624_2IQBIONEURO_6_E support from Raman4clinics COST Action BM1401 and Radiomag COST action TD1402 the ERDF and the Spanish MINECO under project ref.PI19/00349(AES 2019) the Instituto de Salud Carlos Ⅲ for the Sara Borrell Grant(CD19/00035)
主 题：Drug delivery systems Theranosis Magnetic hyperthermia Magnetic resonance imaging Melanoma
摘 要：Nowadays,a number of promising strategies are being developed that aim at combining diagnostic and therapeutic capabilities into clinically effective ***,the combination of a modified release provided by an organic encapsulation and the intrinsic physico-chemical properties from an inorganic counterpart opens new perspectives in biomedical ***,a biocompatible magnetic lipid nanocomposite vehicle was developed through an efficient,green and simple method to simultaneously incorporate magnetic nanoparticles and an anticancer drug(doxorubicin)into a natural *** theranostic performance of the final magnetic formulation was validated in vitro and in vivo,in melanoma *** systemic administration of the proposed magnetic hybrid nanocomposite carrier enhanced anti-tumoral activity through a synergistic combination of magnetic hyperthermia effects and antimitotic therapy,together with MRI reporting *** application of an alternating magnetic field was found to play a dual role,(i)acting as an extra layer of control(remote,on-demand)over the chemotherapy release and(ii)inducing a local thermal ablation of tumor *** combination of chemotherapy with thermotherapy establishes a synergistic platform for the treatment of solid malignant tumors under lower drug dosing schemes,which may realize the dual goal of reduced systemic toxicity and enhanced anti-tumoral efficacy.
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