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Concerns about the application of resistance exercise with blood-flow restriction and thrombosis risk in hemodialysis patients

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Journal of Sport and Health Science 2024年第4期13卷 548-558,F0003页

作者： Hugo de Luca Correa Lysleine Alves Deus Dahan da Cunha nascimento Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araujo Carmen Tzanno-Martins Fernanda Silveira Tavares Luiz Sinesio Silva Neto Claudio Avelino Rodrigues santos Paolo Lucas Rodrigues-Silva Fernando Honorato Souza Vitoria Marra da Motta Vilalva Mestrinho rafael Lavarini dos santos Rosangela Vieira Andrade Jonato Prestes Thiago dos santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Background:Hemodialysis(HD) per se is a risk factor for *** the growing body of evidence on blood-flow restriction(BFR) exercise in HD patients,identification of possible risk factors related to the prothrombotic agent D-dimer is required for the safety and feasibility of this training *** aim of the present study was to identify risk factors associated with higher D-dimer levels and to determine the acute effect of resistance exercise(RE) with BFR on this ***:Two hundred and six HD patients volunteered for this study(all with a glomerular filtration rate of 70 years old),and HD ***,RE+BFR significantly increases D-dimer after 4 *** with borderline baseline D-dimer levels(400-490 ng/mL) displayed increased risk of elevating D-dimer over the normal range(≥500 ng/mL).Conclusion:These results identified factors associated with a heightened prothrombotic state and may assist in the screening process for HD patients who wish to undergo RE+BFR.D-dimer and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary measure to maximize safety during RE+BFR.

关键词： Blood-flow restriction Chronic kidney disease Coagulation Hemodialysis Vascular occlusion exercises

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Response to Commentary by Dr. Matthew J. Clarkson on

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Journal of Sport and Health Science 2024年第5期13卷 670-671页

作者： Hugo de Luca Corrêa Lysleine Alves Deus Dahan da Cunha nascimento Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araújo Carmen Tzanno-Martins Fernanda Silveira Tavares Luiz Sinésio Silva Neto Cláudio Avelino Rodrigues santos Paolo Lucas Rodrigues-Silva Fernando Honorato Souza Vitória Marra da Motta Vilalva Mestrinho rafael Lavarini dos santos Rosangela Vieira Andrade Jonato Prestes Thiago dos santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil g Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Dear editor:We sincerely thank Matthew *** for his insightful commentary1 on our recent publication in the Journal of Sport and Health Science.2 Clarkson's pioneering work in the development and application of blood flow restriction (BFR) exercise protocols has undeniably laid the groundwork for subsequent investigations in this field,including our own.(3-6)His commentary not only highlights the relevance and timeliness of our study but also offers valuable perspectives on refining safety considerations for intradialytic BFR exercise among hemodialysis patients.

关键词： patients application flow

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Detection of Gram-Negative Bacteria Carrying the blaKPC-2 Gene from Mangrove Sediments

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Journal of Pharmacy and Pharmacology 2019年第8期7卷 485-492页

作者： Wallace Ribeiro Nunes Neto Jessica Mayara Mendes Araujo Darlan Ferreira da Silva Joveliane de Melo Monteiro Wallace Borges Pachêco jessflan rafael nascimento santos Maria Raimunda Chagas Silva Maria Rosa Quaresma Bomfim Andrea de Souza Monteiro Laboratory of Applied Microbiology CEUMA UniversitySao Luis Maranhao 65000-000Brazil Laboratory of Environmental Sciences CEUMA UniversitySao Luis Maranhao 65000-000Brazil Laboratory of Molecular Biology Sciences CEUMA UniversitySao Luis Maranhao 65000-000Brazil

Mangroves are environments that have fast cycles associated with high concentration of bacterial *** are impacted by anthropogenic pollution due to contamination of bacterial species carrying resistance *** study aims to evaluate the metabolic profile of the microbiota in mangrove sediments,and verify the presence of Gram-negative bacteria resistant to *** samples were obtained from location along the Anil river and were seeded in medium supplemented with the antibiotic meropenem in increasing *** DNA was analyzed by multiplex PCR for detecting resistance genes forβ-lactam *** bacteria were identified by Matrix-assisted laser desorption ionization–time of flight mass spectrometry(MALDI-TOF MS).The genes were sequenced by ABI PRISM 3100,analyzed by MEGA 6.0 program,and the sequence identified was assessed by GenBank using the BLAST ***■the kit was used to determine the metabolic profile of the *** results of the six bacterial isolates showed the blaKPC-2 gene and were identified as Stenotrophomonas maltophilia and Pseudomonas *** samples showed a greater diversity Shannon index,a rich substrate consumption and high *** was a metabolic richness such as carbon consumption profiles,being a factor of adaptation of pathogenic bacteria carrying resistance genes toβ-lactamics antibiotics.

关键词： Antibiotic resistant meropenem bacterial isolates

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Hormonal modulation of reproduction and fertility signaling in polistine wasps

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Current Zoology 2021年第5期67卷 519-530页

作者： Cintia Akemi OI rafael Carvalho DA SILVA Ian STEVENS Helena Mendes FERREIRA Fabio santos nascimento Tom WENSELEERS Laboratory of Socioecology and Social Evolution KU LeuvenLeuven 3000Belgium Faculdade de Filosofia Ciencias e Letras de Ribeirao PretoDepartamento de BiologiaUniversidade de Sao Paulo—USPRibeirao PretoSP 14040-901Brazil

In social insects,it has been suggested that reproduction and the production of particular fertilitylinked cuticular hydrocarbons(CHC)may be under shared juvenile hormone(JH)control,and this could have been key in predisposing such cues to later evolve into full-fledged queen pheromone ***,to date,only few studies have experimentally tested this“hormonal pleiotropy”***,we formally test this hypothesis using data from four species of Polistine wasps,Polistes dominula,Polistes satan,Mischocyttarus metathoracicus,and Mischocyttarus cassununga,and experimental treatments with JH using the JH analogue methoprene and the anti-JH *** line with reproduction being under JH control,our results show that across these four species,precocene significantly decreased ovary development when compared with both the acetone solvent-only control and the methoprene *** with the hormonal pleiotropy hypothesis,these effects on reproduction were further matched by subtle shifts in the CHC profiles,with univariate analyses showing that in *** and *** the abundance of particular linear alkanes and mono-methylated alkanes were affected by ovary development and our hormonal *** results indicate that in primitively eusocial wasps,and particularly in Polistes,reproduction and the production of some CHC cues are under joint JH *** suggest that pleiotropic links between reproduction and the production of such hydrocarbon cues have been key enablers for the origin of true fertility and queen signals in more derived,advanced eusocial insects.

关键词： Polistinae wasps fertility cues queen pheromones cuticular hydrocarbons juvenile hormone

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Sweet syndrome as a paraneoplastic manifestation of cholangiocarcinoma:A case report

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World Journal of Clinical Cases 2020年第18期8卷 4122-4127页

作者： Camille Carneiro Lemaire Ana Luisa Carvalho Portilho Luciana V Pinheiro rafael Alves Vivas Maíra Britto Melaine Montenegro Luiz Felipe de Farias Rodrigues Sérgio Arruda AndréCastro Lyra Lourianne nascimento Cavalcante Department of Internal Medicine Escola Bahiana de Medicina e Saúde PúblicaSalvador 40290-000BahiaBrazil Department of Internal Medicine Hospital Geral Roberto SantosSalvador 41180-780BahiaBrazil Department of Surgery Hospital Geral Roberto SantosSalvador 41180-780BahiaBrazil Department of Gastroenterology and Hepatology Hospital Geral Roberto SantosSalvador 41180-780BahiaBrazil Department of Radiology Hospital Geral Roberto SantosSalvador 41180-780BahiaBrazil Pathological Anatomy Fiocruz-BahiaUniversidade Estadual da BahiaSalvador 40000-000BahiaBrazil Department of Medicine Division of Gastroenterology and HepatologyFederal University of Bahia and Gastro-Hepatology ServiceSalvador 40295-050BahiaBrazil Department of Medicine Division of Gastroenterology and HepatologyFederal University of Bahia and SED-CHD Hospital Geral Roberto SantosSalvador 40295-050BahiaBrazil

BACKGROUND Sweet’s syndrome,also known as acute febrile neutrophilic dermatosis,is a rare skin disorder that may be associated with *** SUMMARY A 58-year-old female presented with a cholestatic syndrome and significant weight loss three months before *** months earlier,she had abruptly developed skin lesions with erythematous papules that evolved to erythematous *** evaluation and laboratory tests confirmed hepatic *** lesions histopathological findings showed neutrophilic dermatosis,massive edema,fibrin,necrosis,and *** results,in association with the macroscopic aspects of the findings,led to the diagnosis of paraneoplastic Sweet’s syndrome due to *** staging was consistent with an advanced tumor without a cure perspective,we opted to perform percutaneous biliary drainage,and subsequently,palliative ***,after a few weeks,the patient *** In conclusion,the diagnosis of the underlying disease-causing Sweet’s syndrome must be accurate,and patients need to be followed-up,as neoplasia such as cholangiocarcinoma may be a later manifestation.

关键词： Cholangiocarcinoma Paraneoplastic syndrome Sweet syndrome Case report Bullous lesions Cholestasis

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Epidemiological profile of alcoholic liver disease hospital admissions in a Latin American country over a 10-year period

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World Journal of Hepatology 2020年第5期12卷 230-238页

作者： Andre Castro Lyra Lorena Mascarenhas Carneiro de Almeida Yukari Figueroa Mise Lourianne nascimento Cavalcante Gastro-Hepatology Service Hospital Sao RafaelSalvadorBahia 41253-190Brazil Gastro-Hepatology Service Hospital Universitario Prof.Edgard SantosFederal University of BahiaSalvadorBahia 40301-155Brazil de Saude Coletiva-Federal University of Bahia SalvadorBahia 40110-040Brazil

BACKGROUND Alcoholic liver disease(ALD)is a major cause of chronic liver disease *** To describe the epidemiological profile and mortality rates of patients with ALD admitted to public hospitals in different regions of Brazil from 2006 to *** This is a descriptive study that evaluated aggregate data from the five Brazilian geographic *** A total of 160093 public hospitalizations for ALD were *** was a 34.07%increase in the total number of admissions over 10 years,from 12879 in 2006 to 17267 in *** region with the highest proportion(49.01%)of ALD hospitalizations was Southeast(n=78463).The North region had the lowest absolute number of patients throughout the study period,corresponding to 3.9%of the total(n=6242).There was a 24.72%increase in the total number of ALD deaths between 2006 and *** found that the age group between 50 and 59 years had the highest proportion of both hospitalizations and deaths:28.94%(n=46329)of total hospital admissions and 29.43%(n=28864)of all *** were more frequently hospitalized than women and had the highest proportions of deaths in all *** coefficient rates increased over the years,and simple linear regression analysis indicated a statistically significant upward trend in this mortality(R^2=0.744).CONCLUSION Our study provides a landscape of the epidemiological profile of public hospital admissions due to ALD in *** detected an increase in the total number of admissions and deaths due to ALD over 10 years.

关键词： Alcoholic liver disease Epidemiology Mortality Liver Cirrhosis Hospital admissions

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