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Glucose-6-Phosphate Dehydrogenase Deficiency: Difficulties in Diagnosis at the Souro Sanou University Hospital, Burkina Faso

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Open Journal of Blood Diseases 2023年第1期13卷 24-32页

作者： Salifo Sawadogo Koumpingnin Nébié jerôme kouldiati Catherine Traoré Salam Sawadogo Aimée S. Kissou Eléonore Kafando Souro Sanou University Hospital Bobo-Dioulasso Burkina Faso National Blood Transfusion Center Ouagadougou Burkina Faso Yalgado Ouédraogo University Hospital Ouagadougou Burkina Faso Charles De Gaule University Pediatric Hospital Ouagadougou Burkina Faso

Glucose-6-phosphate dehydrogenase deficiency is the most common enzymopathy worldwide. The precise prevalence of G6PD is unknown in Burkina Faso. The objective of the study was to describe the difficulties to diagnose this disease at the Souro Sanou University hospital (CHUSS) in Bobo-Dioulasso. It involved five patients comprising one child with homozygous SS sickle cell disease, one adolescent screened following a family investigation, and three adults including a man and two women. Blood smear stained with May Grunwald Giemsa was performed to look for specific signs of G6PD-deficient red blood cell and brilliant cresyl Blue for Heinz Bodies. A microscope Olympus BX53 equipped with a Camera (XC10) and connected to a computer was used to read blood smears and capture images. Genes sequencing by Sanger method were performed in a specialized laboratory in molecular genetics. For each analysis, the protocol and instructions of the equipment and reagent manufacturer were applied. Of the five patients, three had anemia and only one had hyperreticulocytosis. Two patients had biological signs of hemolysis and one patient had an elevated CRP. Blood smear stained with MGG and cresyl blue showed specific signs of G6PD-deficient red blood cells and Heinz bodies in all patients. Biochemical analysis and molecular typing confirmed G6PD deficiency. The presence of G6PD-deficient red blood cells in the blood smear guides the diagnosis of G6PD deficiency. The diagnosis is biochemical and is based on the combined measurement of G6PD plus pyruvate kinase and/or hexokinase.

关键词： G6PD Deficiency G6PD-Deficient Red Cell Diagnosis Difficulties Burkina Faso

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Simulation of Random Waves and Associated Laminar Bottom Shear Stresses

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China Ocean Engineering 2008年第3期22卷 477-490页

作者： Ching-jer HUANG Department of Hydraulic and Ocean Engineering National Cheng Kung University

This work presents a new approach for simulating the random waves in viscous fluids and the associated bottom shear stresses. By generating the incident random waves in a numerical wave flume and solving the unsteady two-dimensional Navier-Stokes equations and the fully nonlinear free surface boundaiy conditions for the fluid flows in the flume, the viscous flows and laminar bottom shear stresses induced by random waves axe determined. The deterministic spectral amplitude method implemented by use of the fast Fourier transform algorithm was adopted to generate the incident random waves. The accuracy of the numerical scheme is confirmed by comparing the predicted wave spectrum with the target spectrum and by comparing the nanlerical transfer function between the shear stress and the surface elevation with the theoretical transfer function. The maximum bottom shear stress caused by random waves, computed by this wave model, is compared with that obtained by Myrhaug＇ s model （1995）. The transfer function method is also employed to determine the maximum shear stress, and is proved accurate.

关键词： random waves laminar bottom shear stresses spectra Coda- JONSWAP spectral density transfer function Navier-Stokes equations boundary-layer flows

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Osteocyte pericellular and perilacunar matrices as markers of bone-implant mechanical integrity

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BIOCELL 2022年第10期46卷 2209-2216页

作者： ReMY GAUTHIER HeLÈNE FOLLET ANA-MARIA TRUNFIO-SFARGHIU DELPHINE FARLAY NINA ATTIK SYLVAIN meILLE jerÔme CHEVALIER DAVID MITTON Universite de Lyon CNRSINSA de LyonUniversite Claude Bernard Lyon 1MATEISUMR5510VilleurbanneF-69621France Universite de Lyon Universite Claude Bernard Lyon 1INSERMLYOS UMR 1033LyonF-69008France Universite de Lyon INSA-LyonCNRS UMR5259LaMCoSVilleurbanneF-69621France Universite de Lyon Universite Claude Bernard Lyon 1UMR CNRS 5615Laboratoire des Multimateriaux et InterfacesVilleurbanneF-69622France Universite de Lyon Universite Claude Bernard Lyon 1Faculte d’OdontologieLyonF-69008France Universite de Lyon Universite Gustave EiffelUniv Claude Bernard Lyon 1LBMC UMR_T 9406LyonF-69622France

To develop durable bone healing strategies through improved control of bone repair,it is of critical importance to understand the mechanisms of bone mechanical integrity when in contact with biomaterials and *** mechanical integrity is defined here as the adaptation of structural properties of remodeled bone in regard to an applied mechanical ***,the authors present why future investigations in bone repair and regeneration should emphasize on the matrix surrounding the *** are mechanosensitive cells considered as the orchestrators of bone remodeling,which is the biological process involved in bone *** bone cells are trapped in an interconnected porous network,the lacunocanalicular network,which is embedded in a bone mineralized extracellular *** a consequence of an applied mechanical loading,the bone deformation results in the deformation of this lacunocanalicular network inducing a shift in interstitial fluid pressure and velocity,thus resulting in osteocyte *** material environment surrounding each osteocyte,the so called perilacunar and pericellular matrices properties,define its *** this mechanical stimulation pathway is well known,the laws used to predict bone remodeling are based on strains developing at a tissue scale,suggesting that these strains are related to the shift in fluid pressure and velocity at the lacunocanalicular *** this relationship has been validated through observation in healthy bone,the fluid behavior at the bone-implant interface is more *** presence of the implant modifies fluid behavior,so that for the same strain at a tissue scale,the shift in fluid pressure and velocity will be different than in a healthy bone *** that context,new markers for bone mechanical integrity,considering fluid behavior,have to be *** viewpoint exposed by the authors indicates that the properties of the pericellular and the perilacunar

关键词： Bone mechanical integrity Osteocytes Pericellular Perilacunar mechanosensitivity

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SRC-3/AIB1:transcriptional coactivator in oncogenesis

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Acta Pharmacologica Sinica 2006年第4期27卷 387-394页

作者： Sophia Y TSAI Ming-jer TSAI Department of Molecular and Cellular Biology Department of Molecular and Cellular Biology Prostate SPOREBaylor College of MedicineOne Baylor PlazaHouston.Texas 77030USA

Steroid receptor coactivator-3(SRC-3,also known as NCoA3,AIB1,p/CIP,RAC3,ACTR,and TRAM 1),localized on a frequently amplified region,20q 12,has beenassociated with multiple cancers,including breast,gastric and prostate *** SRC-3 has been implicated as an oncogene,compelling evidence hasonly recently emerged implicating it as a causal factor in the genesis of ***,we summarize recent evidence that indicates aberrant SRC-3 ex-pression is important in hormone-sensitive and -insensitive human cancers.

关键词： SRC-3/AIB1 oncogene mouse model cancer signal transduction

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Updates on the treatment and outcomes of dual chronic hepatitis C and B virus infection

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World Journal of Gastroenterology 2014年第11期20卷 2955-2961页

作者： Chun-Jen Liu Pei-jer Chen Graduate Institute of Clinical medicine Department of Internal Medicineand Hepatitis Research CenterNational Taiwan University College of Medicine and National Taiwan University Hospital

Dual hepatitis C virus(HCV)/hepatitis B virus(HBV)infection is found in HBV or HCV endemic areas,and in specific populations exhibiting a high risk of parenteral viral *** observations have revealed that HCV/HBV dually infected patients demonstrate a higher risk of liver disease progression compared with HBV or HCV monoinfected *** viral activity responsible for liver disease progression can be determined by examining the viral loads of HCV and HBV and by conducting liver biopsy *** trials have confirmed that the combination therapy of peginterferon alpha-2a or 2b and ribavirin for dual hepatitis patients with HCV dominance appears to be as effective and safe as it is in patients with HCV ***,approximately 60% of dually infected patients with inactive hepatitis B before treatment develop HBV reactivation after the clearance of the *** clinical significance of this HBV reactivation and the strategy to prevent and treat this event should be ***,approximately 30%of dually infected patients lost hepatitis B surface antigen(HBsAg)within 5 years after the start of peginterferonbased therapy,and 40%of them harbored occult HBV *** underlying mechanisms of their accelerating HBsAg seroclearance and the development of occult HBV await further ***,the optimal treatment strategies for dually infected patients who are seropositive for the hepatitis B e antigen must be ***,the advent of new direct-acting antiviral-based anti-HCV therapy may change the optimal therapies for patients with dual hepatitis in the near future,which warrants further clinical trials.

关键词： Dual infection Hepatitis B virus Hepatitis C virus Interferon Pegylated interferon Ribavirin Sustained virological response Hepatitis B surface antigen clearance

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Modifying and Reducing Numerical Dissipation in A Two-Dimensional Central-Upwind Scheme

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Advances in Applied Mathematics and mechanics 2012年第3期4卷 340-353页

作者： Chi-jer Yu Chii-Tung Liu Department of Applied Mathematics National Chiao Tung University1001 University RoadHsinchu 300Taiwan Department of Computer Science and Information Engineering Chaoyang University of Technology168 Jifong E.Rd.Wufong Township Taichung County 41349Taiwan

This study presents a modification of the central-upwind Kurganov scheme for approximating the solution of the 2D Euler *** prototype,extended from a 1D model,reduces substantially less dissipation than *** problem arises from over-restriction of some slope limiters,which keep slopes between interfaces of cells to be *** study reports the defect and presents a re-derived optimal *** experiments highlight the significance of this formula,especially in long-time,large-scale simulations.

关键词： Hyperbolic systems of conservation laws Godunov-type finite-volume methods central-upwind scheme Kurganov numerical dissipation anti-diffusion

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Benzimidazole and its derivatives as cancer therapeutics:The potential role from traditional to precision medicine

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Acta Pharmaceutica Sinica B 2023年第2期13卷 478-497页

作者： Yeuan Ting Lee Yi jer Tan Chern Ein Oon Institute for Research in Molecular medicine(INFORMM) Universiti Sains Malaysia11800 MindenPenangMalaysia

Cancer is the second leading cause of mortality globally which remains a continuing threat to human health *** insensitivity and resistance are critical hurdles in cancer treatment;therefore,the development of new entities targeting malignant cells is considered a high *** therapy is the cornerstone of precision *** synthesis of benzimidazole has garnered the attention of medicinal chemists and biologists due to its remarkable medicinal and pharmacological *** has a heterocyclic pharmacophore,which is an essential scaffold in drug and pharmaceutical *** studies have demonstrated the bioactivities of benzimidazole and its derivatives as potential anticancer therapeutics,either through targeting specific molecules or non-gene-specific *** review provides an update on the mechanism of actions of various benzimidazole derivatives and the structure-activity relationship from conventional anticancer to precision healthcare and from bench to clinics.

关键词： Benzimidazole derivatives Targeted therapy Anticancer Precision medicine

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The regulatory pathways leading to stem-like cells underlie prostate cancer progression

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Asian Journal of Andrology 2019年第3期21卷 233-240页

作者： Chun-Jung Lin U-Ging Lo jer-Tsong Hsieh Department of Urology UT Southwestern Medical Center Dallas TX 75390 USA

Prostate cancer (PCa) is the most common cause of malignancy in males and the third leading cause of cancer mortality in the United States. The standard care for primary PCa with local invasive disease mainly is surgery and radiation. For patients with distant metastases, androgen deprivation therapy (ADT) is a gold standard. Regardless of a favorable outcome of ADT, patients inevitably relapse to an end-stage castration-resistant prostate cancer (CRPC) leading to mortality. Therefore, revealing the mechanism and identifying cellular components driving aggressive PCa is critical for prognosis and therapeutic intervention. Cancer stem cell (CSC) phenotypes characterized as poor differentiation, cancer initiation with self-renewal capabilities, and therapeutic resistance are proposed to contribute to the onset of CRPC. In this review, we discuss the role of CSC in CRPC with the evidence of CSC phenotypes and the possible underlying mechanisms.

关键词： cancer stem cell castration-resistant prostate cancer neuroendocrine differentiation transdifferentiation

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ANDROGEN REPRESSION OF CYTOKERATIN GENE EXPRESSION DURING RAT PROSTATE DIFFERENTIATION:EVIDENCE FOR AN EPITHELIAL STEM CELL-ASSOCIATED MARKER

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Chinese medical Sciences Journal 1994年第4期9卷 237-241页

作者：王晓怀 jer-TsongHsieh TheThirdmedicalDept. OuaxlgzhouGeneralHospitalofPLA.Guangzhou510010. DepartmentofUrology TheUniversityofTexasMDAndersonCancerCenterHoustonTX77030U.S.A.

Cytokeratin (CK) 8 mRNA expression in developing and degenerating rat prostate was studied using in situ hybridization with an antisense RNA-probe. It was found that : 1) the CK 8 antisense probe was accumulated only within prostatic epithelial cells ; 2) after castration, CK 8 mRNA signals in ventral prostute(VP) sections were significantly increased, and elevated CK 8 mRNA expression persisted even long after prostate involution was complete; and 3) during prostate development,the strongest CK 8 mRNA staining was found in the early neonatal prostatic epithelia which were composed mainly of prostatic stem cells. Thereafter, a shift of CK 8 mRNA staining to peripheral regions and decreased overall CK 8 mRNA levels were noted. These data indicate that excessive expression of CK 8 mRNA is a characteristic of prostatic stem cells, and CK molecules are excellent markers for determing the hierarchical pathway of cell differentiation in prostate epithelium.

关键词： prostate differentiation cytokeratin in situ hybridization

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A Variational Approach to Norm Attainment of Some Operators and Polynomials

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Acta Mathematica Sinica,English Series 2010年第12期26卷 2259-2268页

作者： María D.ACOSTA jernimo ALAMINOS Domingo GARCA Manuel MAESTRE Departamento de Anlisis Matemtico Universidad de Granada Departamento de Anlisis Matemtico Universidad de Valencia

If X is an Asplund space, then every uniformly continuous function on Bx＊ which is holomorphic on the open unit ball, can be perturbed by a w＊ continuous and homogeneous polynomial on X＊ to obtain a norm attaining function on the dual unit ball. This is a consequence of a version of Bourgain-Stegall＇s variational principle. We also show that the set of N-homogeneous polynomials between two Banach spaces X and Y whose transposes attain their norms is dense in the corresponding space of N-homogeneous polynomials. In the case when Y is the space of Radon measures on a compact K, this result can be strengthened.

关键词： Banach space variational principle operator polynomial holomorphic function

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