Benzimidazole and its derivatives as cancer therapeutics:The potential role from traditional to precision medicine

作     者：Yeuan Ting Lee Yi Jer Tan Chern Ein Oon Yeuan Ting Lee;Yi Jer Tan;Chern Ein Oon

作者机构：Institute for Research in Molecular Medicine(INFORMM)Universiti Sains Malaysia11800 MindenPenangMalaysia 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2023年第13卷第2期

页      面：478-497页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the Ministry of Higher Education Malaysia for the Fundamental Research Grant Scheme with the Project Code:FRGS/1/2021/SKK06/USM/02/7 for supporting this work 

主　　题：Benzimidazole derivatives Targeted therapy Anticancer Precision medicine 

摘      要：Cancer is the second leading cause of mortality globally which remains a continuing threat to human health *** insensitivity and resistance are critical hurdles in cancer treatment;therefore,the development of new entities targeting malignant cells is considered a high *** therapy is the cornerstone of precision *** synthesis of benzimidazole has garnered the attention of medicinal chemists and biologists due to its remarkable medicinal and pharmacological *** has a heterocyclic pharmacophore,which is an essential scaffold in drug and pharmaceutical *** studies have demonstrated the bioactivities of benzimidazole and its derivatives as potential anticancer therapeutics,either through targeting specific molecules or non-gene-specific *** review provides an update on the mechanism of actions of various benzimidazole derivatives and the structure-activity relationship from conventional anticancer to precision healthcare and from bench to clinics.