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Littoral cell angioma: A case report

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World Journal of Clinical Cases 2015年第10期3卷 894-899页

作者： Amanda Bailey jeffrey Vos Jon Cardinal Department of Surgery West Virginia University Department of Pathology West Virginia University

Primary splenic lesions are rare entities among which littoral cell angioma(LCA) is a recently described, uncommon vascular lesion that is unique to the spleen. It has heretofore been described primarily in pathologic series and has been found mostly to behave as a benign entity. A few reports of malignant variants have been reported. We present a case report of a solitary LCA discovered after splenectomy for an incidentally discovered splenic lesion, along with a literature review.

关键词： Littoral cell angioma Splenic tumor

Efficacy of combined cataract extraction and endoscopic cyclophotocoagulation for the reduction of intraocular pressure and medication burden

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International Journal of Ophthalmology(English edition) 2016年第5期9卷 693-698页

作者： Sammie J.Roberts Matthew Mulvahill jeffrey R.SooHoo Mina B.Pantcheva Malik Y.kahook Leonard k.Seibold Department of Ophthalmology University of Colorado School of MedicineAnschutz Medical Campus Department of Biostatistics University of ColoradoAnschutz Medical Campus

AIM： To report on the efficacy of combined endoscopic cyclophotocoagulation（ECP） and phacoemulsification cataract extraction（PCE） with intraocular lens placement for reduction of intraocular pressure（IOP） and medication burden in glaucoma.·METHODS： A retrospective case review of 91 eyes（73patients） with glaucoma and cataract that underwent combined PCE/ECP surgery was performed. Baseline demographic and ocular characteristics were recorded,as well as intraocular pressure, number of glaucoma medications, and visual acuity postoperatively with 12-month follow-up. Treatment failure was defined as less than 20% reduction in IOP from baseline on two consecutive visits（at 1, 3, 6, or 12 mo postoperatively）,IOP ≥21 mm Hg or ≤5 mm Hg on two consecutive visits, or additional glaucoma surgery performed within12 mo after PCE/ECP.·RESULTS： Overall, mean medicated IOP was reduced from 16.65 mm Hg at baseline to 13.38 mm Hg at 12mo（P 0.0001）. Mean number of glaucoma medications was reduced from 1.88 medications at baseline to 1.48 medications at 12mo（P =0.0003）. At 3mo postoperatively,the success rate was 73.6%（95%CI： 63.3, 81.5）, 57.1% at6mo（95% CI： 46.3, 66.6）, and 49.7% at 12mo（95% CI：38.9, 59.6）. Patient demographic characteristics were not associated with treatment success. The only ocular characteristic associated with treatment success was a higher baseline IOP.· CONCLUSION： Combined PCE/ECP surgery is an effective surgical option for the reduction of IOP and medication burden in glaucoma patients. Patients withhigher baseline IOP levels are most likely to benefit from this procedure.

关键词： endoscopic cyclophotocoagulation glaucoma cataract extraction

Effect of airplane transport of donor livers on post-liver transplantation survival

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World Journal of Gastroenterology 2016年第41期22卷 9154-9161页

作者： Yi Huang Gerry MacQuillan Leon A Adams George Garas Megan Collins Albert Nwaba Linjun Mou Max k Bulsara Luc Delriviere Gary P jeffrey School of Medicine and Pharmacology University of Western Australia Western Australian Liver Transplantation Service Sir Charles Gairdner Hospital Institute of Health Research University of Notre Dame

AIM To evaluate the effect of long haul airplane transport of donor livers on post-transplant outcomes. METHODS A retrospective cohort study of patients who received a liver transplantation was performed in Perth, Australia from 1992 to 2012. Donor and recipient characteristics information were extracted from Western Australian liver transplantation service database. Patients were followed up for a mean of six years. Patient and graft survival were evaluated and compared between patients who received a local donor liver and those who received an airplane transported donor liver. Predictors of survival were determined by univariate and multivariate analysis using cox *** One hundred and ninety-three patients received alocal donor liver and 93 patients received an airplane transported donor liver. Airplane transported livers had a significantly lower alanine transaminase(mean: 45 U/L vs 84 U/L, P = 0.035), higher donor risk index(mean: 1.88 vs 1.42, P k correlation between CIT and transport distance(r2 = 0.29, P < 0.001). Mean follow up was six years and 93 patients had graft failure. Multivariate analysis found only airplane transport retained significance for graft loss(HR = 1.92, 95%CI: 1.16-3.17). One year graft survival was 0.88 for those with a local liver and was 0.71 for those with an airplane transported liver. One year graft loss was due to primary graft non-function or associated with preservation injury in 20.8% of recipients of an airplane transported liver compared with 4.6% in those with a local liver(P = 0.027). CONCLUSION Airplane transport of donor livers was independently associated with reduced graft survival following liver transplantation.

关键词： Airplane transportation Cold ischemic time Graft survival Donor location Organ damage

Stability of Two Conservative,High-Order Fluid-Fluid Coupling Methods

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Advances in Applied Mathematics and Mechanics 2019年第6期11卷 1287-1338页

作者： jeffrey M.Connors Robert D.Dolan University of Connecticut Department of MathematicsStorrsCT 06269USA

This paper investigates two methods of coupling fluids across an interface,motivated by air-sea interaction in application *** method is for sequential configurations,where the air code module in invoked over some time interval prior to the sea *** other method is for concurrent setups,in which the air and sea modules run in *** focus is the temporal representation of air-sea *** methods we study conserve moments of the fluxes,with an arbitrary order of accuracy possible in *** step sizes are allowed for the two fluid *** a posteriori stability indicator is defined,which can be computed efficiently on-the-fly over each coupling *** a model of two coupled fluids with natural heat convection,using finite elements in space,we prove the sufficiency of our stability *** certain conditions,we also prove that stability can be enforced by iteration when the coupling interval is small *** particular,for solutions in a certain class,we show that the step size scaling is no worse than O(h)in three dimensions of space,where Oh is a mesh *** is a sharper result than what has been shown previously for related algorithms with finite element *** examples illustrate the behavior of the algorithms under a wide variety of configurations.

关键词： Air-sea atmosphere-ocean fluid-fluid partitioned time stepping conservative coupling

Back to the drawing board:Overview of the next generation of combination therapy for inflammatory bowel disease

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World Journal of Gastroenterology 2024年第25期30卷 3182-3184页

作者： jeffrey A Lowell Michael J Farber keith Sultan Department of Medicine Zucker School of Medicine at HofstraNorth Shore University Hospital-Long Island Jewish Medical CenterManhassetNY 11030United States Preclinical Studies New York Institute of Technology College of Osteopathic MedicineGlen HeadNY 11545United States Division of Gastroenterology Northwell HealthNorth Shore University Hospital and Long Island Jewish Medical CenterGreat NeckNY 10021United States

Inflammatory bowel disease(IBD)is entering a potentially new era of combined *** et al provide an insightful review of the current state of combination therapy,with a focus on the use of a combined biologic and immunomodulator,as well as emerging data on the future potential of dual-biologic therapy(DBT).While current evidence for DBT is limited,encouraging safety profiles and ongoing trials suggest a brighter future for this *** importance of controlled trials should be stressed in establishing new treatment *** prospective randomized trials of DBT and perhaps future combinations of biologics and small molecule therapies will hopefully guide the next generation of IBD care.

关键词： Inflammatory bowel disease Biologics Immunomodulators Dual-therapy Combination therapy

Advances in Microscale Laser Shock Peening

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Tsinghua Science and Technology 2004年第5期9卷 506-518页

作者： kYSAR jeffrey W. YAO Y.Lawrence Department of Mechanical Engineering Columbia University New York 10027 USADepartment of Mechanical Engineering Columbia University New York 10027 USA

The response of materials after microscale laser shock peening (μLSP) was experimentally characterized and compared with the theoretical prediction from the finite element method (FEM) analysis in microlength level. X-ray micro-diffraction technique was applied to the post-peened single crystal aluminum of (001) and (110) orientations, and X-ray profile was analyzed by sub-profiling and Fourier analysis method. Spatially resolved residual stress and strain deviation was quantified and explained in terms of the hetero- geneous dislocation cell structure. In-plane crystal lattice rotation induced by μLSP was measured by elec- tron backscatter diffraction (EBSD) and compared with the FEM simulation. Average mosaic size was evaluated from X-ray profile Fourier analysis and compared with the result from EBSD. Surface strength in- crease and dislocation cell structure formation were studied. The systematical characterization will lay the ground work for better understanding the effect of μLSP in microlength level and developing more realistic simulations.

关键词： laser shock peening X-ray micro-diffraction single crystal

Stability of Finite Difference Discretizations of Multi-Physics Interface Conditions

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Communications in Computational Physics 2013年第2期13卷 386-410页

作者： Björn Sjögreen jeffrey W.Banks Center for Applied Scientific Computing Lawrence Livermore National LaboratoryLivermoreCA 94551USA

We considermulti-physics computationswhere theNavier-Stokes equations of compressible fluid flow on some parts of the computational domain are coupled to the equations of elasticity on other parts of the computational *** different subdomains are separated by well-defined *** consider time accurate computations resolving all time *** such computations,explicit time stepping is very *** address the issue of discrete interface conditions between the two domains of different physics that do not lead to instability,or to a significant reduction of the stable time step *** such interface conditions is *** discretize the problem with high order centered difference approximations with summation by parts boundary *** derive L2 stable interface conditions for the linearized one dimensional discretized ***,we generalize the interface conditions to the full non-linear equations and numerically demonstrate their stable and accurate performance on a simple model *** energy stable interface conditions derived here through symmetrization of the equations contain the interface conditions derived through normal mode analysis by Banks and Sj¨ogreen in[8]as a special case.

关键词： Fluid-structure interaction finite difference method summation by parts multiphysics interface condition

MEASUREMENT OF NANOMETER SCALE CADMIUM SELENIDE NANOCRYSTALS AND CLUSTER MOLECULES

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China Particuology 2003年第4期1卷 181-182页

作者： jeffrey Yang SiberHegner China Ltd. 26/F West Tower Hanwei Plaza No.7 Guanghua Road Beijing 100004 P. R. China

High performance Dynamic Light Scattering (DLS) has been used to determine the hydrodynamic di-ameters of CdSe nanocrystals as well as CdSe cluster molecules in a size range of 1 to 10 nm (Eichh鰂er et al., 2001). The method enables the determination of their particle size, including their ligand shells, in solution. The results are consistent with the blue shift of the absorption bands, as well as Transmission Electron Microscope (TEM) experiments. The sizes of the cluster molecules were estimated from space filling models constructed from the results of a single crystal X-ray structure determination. DLS gave comparable results for the size of both types of compound, indicating that it is potentially an important additional measurement technique to TEM, which uses harsh measurement conditions, and to powder X-ray diffraction, which is difficult to interpret below 5 nm.

关键词： CdSe were MEASUREMENT OF NANOMETER SCALE CADMIUM SELENIDE NANOCRYSTALS AND CLUSTER MOLECULES

Casein kinase 2 Negatively Regulates Abscisic Acid-Activated SnRk2s in the Core Abscisic Acid-Signaling Module

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Molecular Plant 2015年第5期8卷 709-721页

作者： Belmiro Vilela Elena Najar Victoria Lumbreras jeffrey Leung Montserrat Pages Centre for Research in Agricultural Genomics Parc de Recerca UAB Edifici CRAG Campus UAB Bellaterra (Cerdanyola del Vallea) 08193 Barcelona Spain ISV - Institut de Sciences du Vegetal CNRS bat 23 avenue de la Terrasse 91198 Gif-sur-Yvette Cedex France

SnRk2 kinases, PP2C phosphatases and the PYR/PYL/RCAR receptors constitute the core abscisic acid （ABA） signaling module that is thought to contain all of the intrinsic properties to self-regulate the hormone signal output. Here we identify Casein kinase （Ck）2 as a novel negative regulator of SnRk2. Ck2 phosphor- ylates a cluster of conserved serines at the ABA box of SnRk2, increasing its binding to PP2C and triggering protein degradation. Consequently, Ck2 action has implications on SnRk2 protein levels, as well as kinase activity and its response to abiotic stimuli.

关键词： abiotic stress maize protein phosphorylation