Casein Kinase 2 Negatively Regulates Abscisic Acid-Activated SnRK2s in the Core Abscisic Acid-Signaling Module

作     者：Belmiro Vilela Elena Najar Victoria Lumbreras Jeffrey Leung Montserrat Pages 

作者机构：Centre for Research in Agricultural Genomics Parc de Recerca UAB Edifici CRAG Campus UAB Bellaterra (Cerdanyola del Vallea) 08193 Barcelona Spain ISV - Institut de Sciences du Vegetal CNRS bat 23 avenue de la Terrasse 91198 Gif-sur-Yvette Cedex France 

出 版 物：《Molecular Plant》 (分子植物（英文版）)

年 卷 期：2015年第8卷第5期

页      面：709-721页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0903[农学-农业资源与环境] 0901[农学-作物学] 0902[农学-园艺学] 090102[农学-作物遗传育种] 

基　　金：supported by MCYT, Spain(Consolider-Ingenio 2010CSD2007-00036 BIO2009-13044) Comissionat per Universitats i Recerca de la Generalitat de Catalunya Fundacao para a Ciencia e Tecnologia(PhD grant SFRH/BD/62070/2009) European Union Marie-Curie (Early Stage Training Fellowships MEST-CT-2005-020232-2 ADONIS) 

主　　题：abiotic stress maize protein phosphorylation 

摘      要：SnRK2 kinases, PP2C phosphatases and the PYR/PYL/RCAR receptors constitute the core abscisic acid （ABA） signaling module that is thought to contain all of the intrinsic properties to self-regulate the hormone signal output. Here we identify Casein Kinase （CK）2 as a novel negative regulator of SnRK2. CK2 phosphor- ylates a cluster of conserved serines at the ABA box of SnRK2, increasing its binding to PP2C and triggering protein degradation. Consequently, CK2 action has implications on SnRK2 protein levels, as well as kinase activity and its response to abiotic stimuli.