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Efficacy and safety of itraconazole use in infants

World Journal of Pediatrics 2016年第4期12卷 399-407页

作者： Shuang Chen Kai-Yi Sun Xiao-Wei Feng Xin Ran jebina lama Yu-Ping Ran Department of Dermatovenereology West China HospitalSichuan UniversityChengdu610041China

Background:Itraconazole has been used to treat fungal infections,in particular invasive fungal infections in infants or neonates in many *** sources:Literature search was conducted through Ovid EMBASE,PubMed,ISI Web of Science,CNKI and Google scholarship using the following key words:“pediatric”or“infant”or“neonate”and“fungal infection”in combination with“itraconazole”.Based on the literature and our clinical experience,we outline the administration of itraconazole in infants in order to develop evidence-based ***:Of 45 articles on the use of itraconazole in infancy,13 are related to superficial fungal infections including tinea capitis,sporotrichosis,mucosal fungal infections and opportunistic *** other 32 articles are related to systemic fungal infections including candidiasis,aspergillosis,histoplasmosis,zygomycosis,trichosporonosis and opportunistic infections as caused by Myceliophthora ***:Itraconazole is safe and effective at a dose of 5 mg/kg per day in a short duration of therapy for superficial fungal infections and 10 mg/kg per day for systemic fungal infections in *** a good compliance,it is cost-effective in treating infantile fungal *** profiles of adverse events induced by itraconazole in infants are similar to those in adults and children.

关键词： infant itraconazole prophylaxis superficial fungal infections systemic fungal infections

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Translational medical mycology guides clinical and laboratory practice on fungal diseases

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World Journal of Translational Medicine 2014年第1期3卷 31-36页

作者： jebina lama Xin Ran Yu-Ping Ran Department of Dermatovenerology West China Hospital of Sichuan University Department of Dermatology and Rheumatology The Second Affiliated Hospital of Kunming Medical University

Patients with fungal infection having skin lesions may consult a dermatologist, which is a diagnostic and therapeutic challenge. Dermatologists take samples from the lesion to check the fungal elements under a microscope by KOH preparation and then treat the patient. This model has advanced from bedside to bench and from bench to bedside(B to B to B), which is defined as Translational Medical Mycology. Dermatologists have an advantageous position in finding, isolating and identifying the pathogenic fungi and treating the patient with antifungal drugs. Samples should be cultured in different media with or without chloramphenicol and cycloheximide and incubated at room temperature or 37 ℃. Non-culture techniques such as polymerase chain reaction based molecular identification, transmission electron microscopy, scanning electron microscopy, biochemistry tests and histopathology are also necessary to confirm the identification of the species, especially when the routine culture is negative. We start treatment upon obtaining evidence of fungal infection,i.e., positive KOH examination. Antifungal drugs such as itraconazole, fluconazole, terbinafine and amphotericin B can be used alone or in combination based on the fungal species and the location of the lesion. Practice on fungal infection includes screening of the patient, merging all of the laboratory techniques and methods from the microbiologists, pathologists, molecular researchers, identification of the pathogen and determination of the optimum antifungal drug.

关键词： Translational Mycology Bedside Bench Fungal infections

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Is it inflammatory linear verrucous epidermal nevus or linear psoriasis？

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Chinese Medical Journal 2013年第9期126卷 1794-1795页

作者： YIN Bin RAN Yu-ping WANG Peng jebina lama Department of Dermatovenereology West China Hospital Sichuan UmversityChengdu Sichuan 610041 China

To the editor： Inflammatory linear verrucous epidermal nevus （ILVEN） is an epidermal nevus reflecting genetic mosaicism.1It resembles linear psoriasis clinically and histologically, and there are no generally accepted pathognomonic features.2 Therefore differentiation of the two diseases has always been difficult in clinical settings.

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