Efficacy and safety of itraconazole use in infants
Efficacy and safety of itraconazole use in infants作者机构：Department of DermatovenereologyWest China HospitalSichuan UniversityChengdu610041China
出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)
年 卷 期：2016年第12卷第4期
页 面：399-407页
核心收录：
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
基 金：supported by grants from the National Natural Science Foundation of China(No.81472539)
主 题：infant itraconazole prophylaxis superficial fungal infections systemic fungal infections
摘 要：Background:Itraconazole has been used to treat fungal infections,in particular invasive fungal infections in infants or neonates in many *** sources:Literature search was conducted through Ovid EMBASE,PubMed,ISI Web of Science,CNKI and Google scholarship using the following key words:“pediatricor“infantor“neonateand“fungal infectionin combination with“itraconazole.Based on the literature and our clinical experience,we outline the administration of itraconazole in infants in order to develop evidence-based ***:Of 45 articles on the use of itraconazole in infancy,13 are related to superficial fungal infections including tinea capitis,sporotrichosis,mucosal fungal infections and opportunistic *** other 32 articles are related to systemic fungal infections including candidiasis,aspergillosis,histoplasmosis,zygomycosis,trichosporonosis and opportunistic infections as caused by Myceliophthora ***:Itraconazole is safe and effective at a dose of 5 mg/kg per day in a short duration of therapy for superficial fungal infections and 10 mg/kg per day for systemic fungal infections in *** a good compliance,it is cost-effective in treating infantile fungal *** profiles of adverse events induced by itraconazole in infants are similar to those in adults and children.
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