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Reliability of neutrophil gelatinase-associated lipocalin in detecting acute tubular necrosis in decompensated cirrhosis:Systematic review and meta-analysis

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World Journal of Hepatology 2024年第11期16卷 1331-1338页

作者： Nirav Agrawal Scarlet louis-jean Zoya Ladiwala Harsha Adnani Ayesha Kamal Mitchell Karpman Albert Steven Fleisher Sanmeet Singh Department of Internal Medicine Anne Arundel Medical CenterAnnapolisMD 21401United States Department of Biostatistics Anne Arundel Medical CenterAnnapolisMD 21401United States Department of Gastroenterology Anne Arundel Medical CenterAnnapolisMD 21401United States

BACKGROUND Acute kidney injury(AKI)in cirrhosis is *** diagnosis of AKI in cirrhosis patients depends on clinical presentation and laboratory tests like serum ***,urine biomarkers could also be used to assess the type of AKI and the severity of the *** performed a systematic review with metaanalysis to evaluate the association with urine neutrophil gelatinase-associated lipocalin(NGAL)marker in identifying acute tubular necrosis(ATN)in patients with *** To assess the reliability of urine NGAL in the detection of ATN in patients with *** We systematically searched MEDLINE and PubMed using keywords including“urine biomarkers”,“NGAL”,“kidney dysfunction”,and“cirrhosis”to identify relevant *** was screened and *** studies assessed hospitalized cirrhosis patients with AKI using the urine NGAL *** synthesized the data using diagnostic odds ratio(DOR),comparative and descriptive analyses,and Cochran Mantel-Haenszel(CMH)statistics to evaluate *** Three thousand seven hundred and one patients with cirrhosis were analyzed from a total of 21 cohort *** DOR of 14 of those studies[pooled DOR:22.150,(95%CI:17.58-27.89),P<0.0001]demonstrated a significant association between urine NGAL levels and its identification of *** stratification by cirrhosis status,heterogeneity was analyzed and showed a significant non-zero correlation between NGAL and AKI(CMH statistic=702.19,P<0.0001).CONCLUSION In patients with cirrhosis,the use of urine NGAL is a reliable biomarker for detecting ATN and identifying the etiology of AKI.

关键词： Neutrophil gelatinase-associated lipocalin Acute tubular necrosis Acute kidney injury Cirrhosis Biomarker Severe liver dysfunction

Telaprevir- and boceprevir-based tritherapies in real practice for F3-F4 pretreated hepatitis C virus patients

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World Journal of Hepatology 2014年第9期6卷 660-669页

作者： Delphine Bonnet Matthieu Guivarch Anais Palacin Laurent Alric Emilie Bérard jean-Marc Combis Andre jean Remy Andre Glibert jean-louis Payen Sophie Metivier Karl Barange Herve Desmorat Florence Nicot Florence Abravanel Internal Medicine-Digestive Department Purpan University Hospital31059 Toulouse cedex 9France UMR152 IRD Toulouse III University 31400 ToulouseFrance Department of Epidemiology Health Economics and Public HealthToulouse University Hospital31073 ToulouseFrance UMR-1027 INSERM-Toulouse III University 31062 ToulouseFrance Clinique Ambroise Pare 31300 ToulouseFrance Perpignan General Hospital 66000 PerpignanFrance Tarbes General Hospital 65000 TarbesFrance Montauban General Hospital 82000 MontaubanFrance Hepatogastroenterology-Digestive Department Purpan University Hospital31059 Toulouse cedex 9France Clinique du Parc 31078 Toulouse Cedex 4France Virology Unit INSERM U1043 31059 Toulouse cedex 9France

AIM:To assess,in a routine practice setting,the sus-tained virologic response(SVR) to telaprevir(TPV) or boceprevir(BOC) in hepatitis C virus(HCV) nullresponders or relapsers with severe liver ***:One hundred twenty-five patients were treated prospectively for 48 wk with TPV or BOC + pegylated-interferon(peg-INF) α2a + ribavirin(PR) according to standard treatment schedules without *** patients were treated in routine practice settings in 10 public or private health care centers,and the data were prospectively *** patients with severe liver fibrosis(Metavir scores of F3 or F4 upon liver biopsy or liver stiffness assessed by elastography),genotype 1 HCV and who were null-responders or relapsers to prior PR combination therapy were included in this ***:The Metavir fibrosis scores were F3 in 35(28%) and F4 in 90(72%) of the *** total,62.9% of the patients were null-responders and 37.1% relapsers to the previous PR *** overall SVR rate at 24 wk post-treatment withdrawal was 59.8%.The SVR was 65.9% in the TPV group and 44.1% in the BOC *** predictive factors of an SVR included a response to previous treatment,relapsers vs null-responders [OR = 3.9;(1.4,10.6),P = 0.0084],a rapid virological response(RVR) [OR 6.9(2.6,18.2),P = 0.001] and liver stiffness lower than 21.3 kPa [OR = 8.2(2.3,29.5),P = 0.001].During treatment,63 patients(50.8%) had at least one severe adverse event(SAE) of grade 3 or 4.A multivariate analysis identified two factors associated with SAEs:female gender [OR = 2.4(1.1,5.6),P = 0.037] and a platelet count below 150 × 103/ mm3 [OR = 5.3(2.3,12.4),P ≤ 0.001].CONCLUSION:More than half of these difficult-to-treat patients achieved an SVR and had SAEs in an actual practice *** SVR rate was influenced by the response to previous PR treatment,the RVR and liver stiffness.

关键词： Hepatitis C virus Hepatitis C Antiviral therapy Protease inhibitors Fibroscan Liver stiffness Cirrhosis Boceprevir Telaprevir Ribavirin

External and Environmental Radiation Dosimetry with Optically Stimulated Luminescent Detection Device Developed at the ***

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World Journal of Nuclear Science and Technology 2012年第1期2卷 6-15页

作者： Reinhard Boons Mark Van Iersel jean louis Genicot 不详

The laboratory of Radiation Dosimetry and Calibration of the Belgian Nuclear Research Centre (***) is using thermoluminescence dosimetry for more than thirty years for routine measurements and for R&D investigations. In 2002, it has developed an experimental device based on the optically stimulated luminescence (OSL) technique. This device is working with AL2O3:C crystals stimulated by the green line (488 nm) emitted by a 150 mW argon laser. This paper describes this device, its characteristics, some applications in space dosimetry and the R&D works initiated in this field during the next few years.

关键词： External Dosimetry OSL Optically Stimulated Dosimetry

Modeling the Dispersion and Atmospheric Mitigation of Pollutants in the Dibamba-Douala Thermal Power Plant

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Journal of Geoscience and Environment Protection 2020年第3期8卷 102-115页

作者： Marius Tony Kibong jean Gaston Tamba louis Monkam Technologies and Applied Sciences Laboratory University Institute of Technology University of Douala Douala Cameroon

This work simulates the dispersion and atmospheric attenuation of pollutants from the Dibamba-Douala thermal power plant. The objective of this research is to study the dispersion of air pollutants and mitigate the impact of pollutants on the populations living around the power plant. The methodology used is as follows: the Gaussian model is used for the representation of the dispersion in the form of a plume, the finite difference method for digital resolution. Finally, dispersion charts are constructed which allow the heights of the chimneys to be fixed for which the concentrations of pollutants discharged comply with ambient air quality standards. The results obtained using the simulation made in the MATLAB software version 2016 show that, for a wind regime of 1.5 m/s;we have a predicted distance of 150 m at which the concentration is canceled out. Then, for the wind speed of 2 m/s;we had a predicted distance of 125 m and finally for a wind speed of 2.5 m/s;we observed the 120 m distance at which the concentration is canceled. In addition, for the same wind regimes, the attenuation of pollutants at ground level is obtained for a height of 60 m.

关键词： Modeling Atmospheric Pollution Thermal Power Plant Gaussian Model Dispersion

On the Diversity of Long-Term Temperature Responses to Varying Levels of Solar Activity at Ten European Observatories

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Atmospheric and Climate Sciences 2019年第3期9卷 498-526页

作者： Vladimir Kossobokov jean-louis Le Mouel Vincent Courtillot Institute of Earthquake Prediction Theory and Mathematical Geophysics Russian Academy of Sciences Moscow Russia Geomagnetism and Paleomagnetism Institut de Physique du Globe de Paris Sorbonne Paris Cité Paris France

We analyze ten of the longest (127 to 230 year-long) time series of European daily temperatures available from five different Köppen-Geiger climate classes. We split these according to the level of solar cycle activity (H for “higher than median” and L for “lower than median”). This reveals coherent patterns in the temperature differences: when TH-TL?are stacked according to their calendar date, the daily averages from January 1 to December 31st disclose characteristic features in addition to the dominant annual seasonal wave, namely variations up to 2°C lasting for about 1.5 to 3 months. The five observatories at intermediate latitudes in a band from Oxford in the West to Prague in the East (same climate class) have very similar signatures. These similarities are most unlikely to be due to pure chance (confirmed by confidence levels in excess of 99% with the Kolmogorov-Smirnov and Kuiper nonparametric tests). The TH-TL patterns carry a regional signature, modulated by a more local response function. On the other hand, northern European observatories (St Petersburg and Arkhangelsk), those south of the Alps (Milan and Bologna), and the easternmost one in Astrakhan, corresponding to different climate classes, have different signatures. Similarly, preliminary study of long air pressure recordings confirms what emerges from the analysis of temperatures. These new observations lead us to conclude that the climate in different regions presents different responses to variations in solar activity. Moreover, the distributions of the lower, middle, and higher quartiles of the temperature and pressure indices in solar cycles with high versus low activity are significantly different, providing further robust statistical confirmation to this conclusion (confidence level higher to much higher than 99% using the Kuiper test).

关键词： Solar Variability Multi-Decadal Temperature Changes Long Temperature Series Nonparametric Hypotheses Testing Kolmogorov-Smirnov Test Kuiper Test

Modulation of monocyte subsets in infectious diseases

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World Journal of Immunology 2014年第3期4卷 185-193页

作者： Mignane B Ka Daniel Olive jean-louis Mege Inserm Unité Mixte de Recherche(UMR) 1068 Centre de Recherche en Cancérologie de Marseille13009 MarseilleFrance Department of Immunology and Infectious Diseases Aix Marseille UniversityURMITEUM63CNRS 7278IRD 198INSERM 109513005 MarseilleFrance

Monocytes are effector immune cells but a precise anal-ysis of their role in immune response has been preclud-ed by their heterogeneity. Indeed, human monocytesare composed of at least three different subsets withdifferent phenotypic characteristics and functional prop-erties, the so-called classical, intermediate and non-classical monocytes. A review of the literature showsthat these monocyte subsets are differently affectedduring viral, bacterial, parasitic and fungal *** expansion of the CD16＋ compartment （intermedi-ate and non-classical monocytes） is typically observedin the majority of infectious diseases and the increasedproportion of CD16＋ monocytes is likely related totheir activation through their direct interaction with thepathogen or the infammatory context. In contrast, thenumber of non-classical and intermediate monocytesis decreased in Q fever endocarditis, suggesting thatcomplex mechanisms govern the equilibrium among monocyte subsets. The measurement of monocyte sub-sets would be useful in better understanding of the role of monocyte activation in the pathophysiology of infec-tious diseases.

关键词： Monocytes subsets Infection Virus Bacte-ria

A Comparison of 3D Methods for Identifying the Stance Phase in Treadmill Running for Both Rearfoot and Forefoot Runners

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Journal of Sports Science 2016年第3期4卷 124-131页

作者： Dorian Deflandre Cedric Schwartz jean-Pierre Weerts jean-louis Croisier Thierry Bury Department of Motricity Sciences University of Liege Liege Liege 4000 Belgium

We compared six 3D methods, OptoGait, and Myotest Run for the determination of contact time for runners with different foot strike patterns. Twenty male participants were divided into two groups： the heel group, who attack the ground with the heel （n = 12）, and the toe group, who attack the ground with the middle/front of the foot （n = 8）. They performed trials at speeds of 8 km/h then 16 km/h. To detect foot strike, the use of peak velocity of 3D markers located on the heel, the fifth metatarsal, and the great toe provided the best results for both groups. To detect the toe off, the minimum vertical position of a 3D marker placed in line with the great toe gave the most satisfactory results for both groups. In this way, the values of contact time measured with the 3D methods are consistent. Values measured with OptoGait appear consistent too, while those of the Myotest Run underestimate the contact time for both speeds. 3D analysis provides interesting opportunities for calculation of contact time for both rearfoot and forefoot runners, using specific peak velocities to determine foot strike and marker displacement to determine toe off.

关键词： Contact time running 3D OptoGait Myotest Run.

采用中子衍射研究内锡法Nb_3Sn的相形成

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稀有金属材料与工程 2006年第9期35卷 1367-1370页

作者：张超武周廉唐先德 jean-louis Soubeyroux Andre Sulpice 张平祥卢亚峰陕西科技大学西北有色金属研究院陕西西安710016 西北有色金属研究院法国国家科研中心

选取2种ITER用内锡法Nb3Sn复合超导线,采用原位中子衍射测量技术检测超导相的形成过程,通过添加第3种元素研究合金化Sn芯和合金化Nb芯对超导相形成过程及超导线超导性能的影响。结果表明:合金化Sn芯比合金化Nb芯丝有利于提高超导性能;... 详细信息

选取2种ITER用内锡法Nb3Sn复合超导线,采用原位中子衍射测量技术检测超导相的形成过程,通过添加第3种元素研究合金化Sn芯和合金化Nb芯对超导相形成过程及超导线超导性能的影响。结果表明:合金化Sn芯比合金化Nb芯丝有利于提高超导性能;少量添加第3种元素Ti与Sn形成合金能显著促进Sn的扩散和A15相的形成,并且能有效抑制Nb3Sn晶粒的生长,因此增加了晶界面积和钉扎力,增强了超导特性,提高了非铜区临界电流密度Jcn。

关键词： Nb3Sn超导线内锡法中子衍射

Identifying sex-specific differences in the carotid revascularisation literature:findings from a scoping review

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Stroke & Vascular Neurology 2021年第3期6卷 496-499,I0085-I0096页

作者： Vignan Yogendrakumar Michel Shamy Brian Dewar Dean A Fergusson Dar Dowlatshahi Candyce Hamel Sophia Gocan Mark Fedyk jean-louis Mas Peter Rothwell Virginia Howard Olena Bereznyakova On behalf of the WoW-CAD Investigators Department of Medicine Division of Neurology and Ottawa Hospital Research InstituteUniversity of OttawaOttawaOntarioCanada Epidemiology Program Ottawa Hospital Research InstituteOttawaOntarioCanada Stroke Prevention Clinic Ottawa HospitalOttawaOntarioCanada Bioethics Program UC Davis Department of MedicineSacramentoCaliforniaUSA Universite Paris Descartes Faculte de Medecine Site Cochin Parislle-de-FranceFrance Service de Neurologie Hôital Sainte-AnneParisFrance The University of Alabama at Birmingham School of Medicine BirminghamAlabamaUSA School of Public Health University of Alabama at BirminghamBirminghamAlabamaUSA 不详

Objective No systematic review of the literature has dedicated itself to looking at the management of symptomatic carotid stenosis in female *** this scoping review,we aimed to identify all randomised controlled trials(RCTs)that reported sex-specific outcomes for patients who underwent carotid revascularisation,and determine whether sufficient information is reported within these studies to assess short-term and long-term outcomes in female ***,setting and participants We systematically searched Medline,Embase,Pubmed and Cochrane libraries for RCTs published between 1991 and 2020 that included female patients and compared either endarterectomy with stenting,or any revascularisation(endarterectomy or stenting)with medical therapy in patients with symptomatic high-grade(>50%)carotid *** From 1537 references examined,27 eligible studies were ***-specific outcomes were reported in 13 *** patient characteristics of enrolled female patients were reported in 2 of those 13 *** outcomes reported included stroke and death,however,there was significant heterogeneity in the reporting of both periprocedural and long-term ***-specific differences relating to the degree of stenosis and time from index event to treatment are largely limited to studies comparing endarterectomy to medical *** events were not reported by *** Only half of the previously published RCTs and systematic reviews report sex-specific *** analyses on the results of carotid artery intervention for female patients with symptomatic stenosis are limited.

关键词： carotid stenosis finding