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Acta Pharmaceutica Sinica B 2015年第6期5卷 544-553页

作者： Yuri Cho Jung-Hwan Yoon jeong-ju Yoo Minjong Lee Dong Hyeon Lee Eun Ju Cho jeong-hoon Lee Su Jong Yu Yoon Jun Kim Chung Yong Kim Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine

Fucoidan is a traditional Chinese medicine suggested to possess anti-tumor *** this study the anti-metastatic effects of fucoidan were investigated in vitro in human hepatocellular carcinoma(HCC) cells(Huh-7 and SNU-761) under normoxic and hypoxic conditions and in vivo using a distant liver metastasis model involving injection of MH134 cells into spleen via the portal *** ability to protect hepatocytes against bile acid(BA)-induced apoptosis was investigated in primary *** was found to suppress the invasion of HCC cells through up-regulation of p42/44 MAPKdependent NDRG-1/CAP43 and partly,under normoxic conditions,through up-regulation of p42/44MAPK-dependent VMP-1 *** also significantly decreased liver metastasis in *** regards its hepatoprotective effect,fucoidan decreased BA-induced hepatocyte apoptosis as shown by the attenuation of caspase-8,and-7 cleavages and suppression of the mobilization of caspase-8 and Fas associated death domain(FADD) into the death-inducing signaling *** summary,fucoidandisplays inhibitory effects on proliferation of HCC cells and protective effects on *** results suggest fucoidan is a potent suppressor of tumor invasion with hepatoprotective effects.

关键词： Fucoidan Hepatocellular carcinoma Invasion Hypoxia Hepatoprotective Cultured hepatocyte NDRG-1/CAP43 VMP-1

High-dose dietary zinc promotes prostate intraepithelial neoplasia in a murine tumor induction mode

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Asian Journal of Andrology 2010年第2期12卷 164-170页

作者： Young Hwii Ko Yu jeong Woo Jin Wook Kim hoon Choi Seok Ho Kang jeong Gu Lee je Jong Kim Hong Seok Park Jun Cheon Department of Urology Korea University School of MedicineSeoul 136-705Korea

To evaluate the role of high-dose dietary zinc in the process of prostate malignancy,60 Sprague-Dawley rats were randomly divided into four groups：tumor induction with carcinogen and hormone （group 1）,oral zinc administration without tumor induction （group 2）,oral zinc administration with tumor induction （group 3） and a control without zinc administration or tumor induction （group 4）. Zinc was supplied orally in the form of zinc sulfate heptahydrate dissolved in drinking water to groups 2 and 3 for 20 weeks. Although the serum level of zinc measured at 20 weeks was maintained similarly in each group （P = 0.082）,intraprostatic zinc concentrations were statistically different. Group 1 prostates contained the least amount of zinc in both the dorsolateral and ventral lobes at levels of 36.3 and 4.8 μg g^-1,respectively. However,in group 3,zinc levels increased in both lobes to 59.3 and 12.1 μg g^-1,respectively,comparable with that of group 4 （54.5±14.6 and 14.1±2.4 μg g^-1）. In spite of these increases in zinc concentration,the prevalence of prostate intraepithelial neoplasm was rather increased in group 3 （53.3% and 46.7%） compared with group 1 （33.3% and 33.3%） in both dorsolateral and ventral prostate lobes. Although prostate intraepithelial neoplasm did not develop in any prostate in group 4,zinc administration did induce prostate intraepithelial neoplasm in group 2 （46.7% and 40.0%）. Thus,although high dietary zinc increased intraprostatic zinc concentrations,it promoted,instead of preventing,prostate intraepithelial neoplasm in a murine prostate malignancy induction model.

关键词： experimental animal model prostatic cancer prostatic intraepithelial neoplasia zinc

The effect of fair disclosure regulation on timeliness and informativeness of earnings announcements

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China Journal of Accounting Research 2013年第1期6卷 35-49页

作者： Yeonhee Park Inman Song Dong-hoon Yang Mahmud Hossain jeong-Ho Koo Department of Business Information Education Kongju National UniversityRepublic of Korea Department of Accounting SungKyunKwan UniversityRepublic of Korea School of Accountancy University of Hawaii at ManoaUSA Dongguk Business School Dongguk University3-26 Pil-dong Chung-gu Seoul 100-715 Republic of Korea School of Accounting Curtin UniversityAustralia Department of Accounting Kumoh National Institute of TechnologyRepublic of Korea

This paper examines the effect of Korea's fair disclosure regulation on the timeliness and informativeness of earnings announcements. The present regulation for Korean listed firms requires that if a company's sales revenue, operating income(or loss) and net income(or loss) have changed by over 30%compared to the prior year, the firm must disclose this information through a preliminary financial report(PFR) even before the company is audited by external auditors. To analyze the effects of this policy, we first investigate the timeliness of preliminary financial report disclosures. We examine the extent to which Korean listed companies actually comply with the requirement for prompt notification of information concerning material changes in financial performance. Second, we investigate the informativeness of preliminary financial reports by analyzing differential stock market reactions to different timings of preliminary financial report disclosures. Our empirical results reveal that more than half of our sample firms release their preliminary financialreports after external audits are completed, thereby potentially invalidating the effectiveness of the regulation. In addition, we find that preliminary financial reports have information value only if they are disclosed prior to annual audit report dates. This finding supports the notion that timeliness increases the informativeness of preliminary financial report disclosure by curbing insiders' ability to potentially profit from their information advantage.

关键词： Fair disclosure Preliminary reports Interim information Timeliness of information Korea

Sexual function and psychological characteristics ofpenile paraffinoma

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Asian Journal of Andrology 2003年第3期5卷 191-194页

作者： Du Geon Moon jeong Woo Yoo Jae Hyun Bae Chang Su Han Yong Ku Kim je Jong Kim Department of Urology Korea University College of Medicine Seoul 136705 KoreaDepartment of Urology Korea University College of Medicine Seoul 136705 KoreaDepartment of Urology Korea University College of Medicine Seoul 136705 KoreaDepartment of Psychiatry Korea University College of Medicine Seoul 136705 KoreaDepartment of Psychiatry Korea University College of Medicine Seoul 136705 KoreaDepartment of Urology Korea University College of Medicine Seoul 136705 Korea

Aim: To identify the sexual, emotional and psychological status of men who augmented their penis with mineral oil injection for their small penis. Methods: Men who had penile paraffin were asked to answer the semi-structured questionnaire. The questionnaire was designed to assess the motivation, method of penile injection, changes in erectile function and satisfaction after penile injection. SCL (Symptom checklist)-90-R, STAI (State and Trait Anxiety Inventory) and Zung SDS (Self-rating depression scale) were also included in the questionnaire for psychological evaluation. Results: A total of 357 men completed the questionnaire. The first-ranked motivation of the injection was recommendation by their acquaintances (48.9 %). The majority of the respondents had the procedure by non-medical person (78.0 %). Before injection, 17.2 % had a sense of inferiority in their penis and 32 % worried about their weak erectile function. After injection, 33.0 % have found relief from their sense of inferiority and 17.8 % wish to feel improvement in their erectile function. Most of the respondents (91 %) were not satisfied with their penis and 74 % of them replied that they want to remove the injected material. Only 15.6 % did not experience side effects. Most of the subjects have suffered from various side effects such as inflammation, skin necrosis, pain, etc. No evidence of psychiatric pathology was found in psychological evaluation. Conclusion: The motivations of mineral oil injection were recommendation by their acquaintances or desire to be more mannish. Most of them had suffered from various side effects and only a small number of them felt improvement in their sense of inferiority, in their penis and erectile function. Increased public awareness is needed for the prevention of this physically and psychologically debilitating problem.

关键词： paraffinoma penis augmentation psychology

The predictability of T3 disease in staging MRI following prostate biopsy decreases in patients with high initial PSA and Gleason score

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Asian Journal of Andrology 2011年第3期13卷 487-493,515页

作者： Young Hwii Ko Deuk Jae Sung Sung Gu Kang Seok Ho Kang jeong Gu Lee je Jong Kim Jun Cheon Department of Urology Korea University School of Medicine Seoul Korea Department of Radiology Korea University School of Medicine Seoul Korea

To obtain improved accuracy in predicting extracapsular extension （ECE） and seminal vesicle invasion （SVI）, we evaluated the variables affecting the predictability of staging magnetic resonance imaging （MRI, phased-array coil） and estimated their impact on accuracy between preoperative MRI staging and histological outcome. A total of 121 patients with localized or locally advanced prostate cancer who underwent robotic radical prostatectomy （RALP） were included. Following transrectal biopsy, all enrolled patients had undergone MRI for staging work-up. After RALP, only 43.8% （53/121） of the patients were matched with the MRI predicted stage. Compared to the matched group in the prediction of ECE, the unmatched group had significantly higher initial prostate-specific antigen （PSA, 12.8 ng m1-1 versus 8.1 ng m1-1, P=0.048）. In the prediction of SVI, initial PSA （8.1 ng ml- 1 versus 17.3 ng ml- 1, P=0.009） and biopsy Gleason score （6.5 versus 7.6, P=0.035） were significantly higher in the unmatched group. When applying clinical cutoffs of initial PSA of 10 and 20 ng ml-1, the accuracy of MRI in the prediction of ECE was decreased in the group with PSA over 20 ng ml- 1 （75.6, 64.5 and 37.5%, P=0.01）, and this group had significantly decreased accuracy of MRI in the prediction of SVI （91.5, 77.4 and 37.5%, P〈0.01）. Applying the clinical cutoff of a Gleason score of 7, the accuracy of MRI in the prediction of SVI was decreased in the higher G leason score group （93.9, 82.1 and 62.9%, P= 0.01）. Thus, for these patient groups, to obtain margin negativity during radical prostatectomy, operative findings, rather than post-biopsy MRI images, may provide substantial information, implying a clinical advantage in conducting MRI before prostate biopsy.

关键词： magnetic resonance imaging neoplasm staging prostatic neoplasms

Controlling hypoxia-inducible factor-2α is critical for maintaining bone homeostasis in mice

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Bone Research 2019年第2期7卷 210-223页

作者： Sun Young Lee Ka Hyon Park Hyung-Gu Yu Eunbyul Kook Won-Hyun Song Gyuseok Lee jeong-Tae Koh Hong-In Shin je-Yong Choi Yun Hyun Huh je-Hwang Ryu Department of Pharmacology and Dental Therapeutics School of DentistryChonnam National UniversityGwangju 61186Korea Research Center for Biomineralization Disorders School of DentistryChonnam National UniversityGwangju 61186Korea Department of Oral Pathology and IHBR School of DentistryKyungpook National UniversityDaegu 41940Korea Department of Biochemistry and Cell Biology BK21 Plus KNU Biomedical Convergence ProgramSkeletal Diseases Analysis CenterKorea Mouse Phenotyping Center (KMPC)School of MedicineKyungpook National UniversityDaegu 41944Korea School of Life Sciences Gwangju Institute of Science and TechnologyGwangju 61005Korea

Pathological bone loss is caused by an imbalance between bone formation and *** bone microenvironments are hypoxic,and hypoxia-inducible factor (HIF) is known to play notable roles in bone ***,the relevant functions of HIF-2α are not well ***,we have shown that HIF-2α deficiency in mice enhances bone mass through its effects on the differentiation of osteoblasts and *** vitro analyses revealed that HIF-2α inhibits osteoblast differentiation by targeting Twist2 and stimulates RANKL-induced osteoclastogenesis via regulation of *** addition,HIF-2α appears to contribute to the crosstalk between osteoblasts and osteoclasts by directly targeting RANKL in osteoprogenitor *** performed with osteoblast- and osteoclast-specific conditional knockout mice supported a role of HIF-2α in this ***-2α deficiency alleviated ovariectomy-induced bone loss in mice,and specific inhibition of HIF-2α with ZINC04179524 significantly blocked RANKLmediated ***,our results suggest that HIF-2α functions as a catabolic regulator in bone remodeling,which is critical for the maintenance of bone homeostasis.

关键词： is RANKL its via

Fermentation of mulberry leaves with Cordyceps militaris enhanced anti-adipogenesis activity in 3T3-L1 cells through down-regulation of PPAR-γ pathway signaling

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Asian Pacific Journal of Tropical Medicine 2020年第12期13卷 557-565页

作者： Lu Guo Jum Soon Kang Young hoon Park Beong Il je Dae Youn Hwang Woo Hong Joo Young Whan Choi Department of Horticultural Bioscience Pusan National UniversityMiryang 50463Republic of Korea Department of Biomaterials Science Pusan National UniversityMiryang 50463Republic of Korea Department of Biology and Chemistry Changwon National UniversityChangwon 51140Republic of Korea Life and Industry Convergence Research Institute Pusan National UniversityMiryang 50463Republic of Korea

Objective:To establish an efficacious and efficient fermentation method of enhancing the anti-adipogenesis effect of mulberry(Morus alba) leaves using Cordyceps ***:Dried mulberry leaves,dried mulberry leaves with50% raw silkworm pupa and raw silkworm pupa were fermented with Cordyceps militais for 4 weeks at 25℃,after which the dried mulberry leaves and fermented product were extracted with 70%ethanol and subjected to high performance liquid chromatography(HPLC).The contents of cordycepin,pelargonidin,chlorogenic acid,iso-quercetin and caffeic acid were *** then used the 3 T3-L1 cells to investigate whether extracts of fermentation enhanced anti-adipogenesis activity in ***:HPLC showed that fermentation changed the contents of cordycepin,pelargonidin,chlorogenic acid,iso-quercetin and caffeic ***,fermented dried mulberry leaves with 50% raw silkworm pupa had a better efficacy of anti-adipogenesis than dried mulberry leaves,fermented dried mulberry leaves and fermented silkworm pupa and inhibited triglycerides accumulation and glucose ***,fermented dried mulberry leaves with50% raw silkworm pupa inhibited PPAR-γ ***:Fermentation with Cordyceps militaris enhanced antiadipogenesis efficacy of mulberry leaves.

关键词： dried fermentation silkworm

Antiinflammatory and analgesic effect of herbal cocktail Hongbaekjeong via inhibition of proinflammatory cytokines and prostaglandin E2 release

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Chinese Science Bulletin 2014年第25期59卷 3127-3133页

作者： Jinwon Lim Hyo-Jung Lee Bonglee Kim jeong-Un Choi Yoeok Shin Eun Jung Sohn Sung-hoon Kim Cancer Preventive Material Development Research Center College of Oriental Medicine Kyung Hee University

Though Hongbaekjeong(HBJ),a hebal mixture of three medicinal plants,has been traditionally used for arthritis and muscular pain,its scientific evidence still remains ***,in the present study,analgesic and anti-inflammatory mechanism of HBJ was evaluated in vitro and in *** significantly reduced NO production and prostaglandin E2(PGE2)release and also attenuated the expression of cyclooxygenase 2(COX-2)in lipopolysaccharides(LPS)and interferon(IFN)-c treated RAW 264.7 ***,HBJ abrogated the production of proinflammatory cytokines such as interleukin(IL)1b,IL-6,IL-8 and monocyte chemoattractant protein-1(MCP-1)in LPS and IFN-c treated RAW 264.7 *** addition,HBJ significantly decreased the number of writhing syndrome induced by acetic acid,and also increased latency in hot-plate method and tail flick test in ***,HBJ significantly reduced the edema volume in the hind paw of the rats with arthritis induced by Freund’s complete adjuvant(FCA)compared to untreated ***,our findings demonstrate the antiinflammatory and analgesic potential of HBJ via inhibition of proinflammatory cytokines and PGE2 release for treatment of arthritis and muscular pain.

关键词：前列腺素E2 炎性细胞因子和镇痛抗炎单核细胞趋化蛋白-1 鸡尾酒 IFN-γ

Network-based identification of feedback modules that control RhoA activity and cell migration

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分子细胞生物学报:英文版 2015年第3期7卷 242-252页

作者： Tae-Hwan Kim Naser Monsefi je-hoon Song Alex von Kriegsheim Drieke Vandamme Olivier Pertz Boris NKholodenko Walter Kolch Kwang-Hyun Cho Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 305-701Republic of Korea Systems Biology Ireland University College DublinBelfieldDublin 4Ireland Department of Biomedicine University of BaselBaselSwitzerland School of Medicine and Medical Science University College DublinBelfieldDublin 4Ireland Conway Institute of Biomolecular&Biomedical Research University College DublinBelfieldDublin 4Ireland

Cancer cell migration enables metastatic spread causing most cancer ***-family GTPases control cell migration,but being embedded in a highly interconnected feedback network,the control of their dynamical behavior during cell migration remains *** address this question,wereconstructed the Rho-family GTPases signaling network involved in cell migration,and developed a Boolean network model to analyze the different states and emergent rewiring of the Rho-family GTPases signaling network at protrusions and during extracellular matrix-dependent cell *** simulations and experimental validations revealed that the bursts of RhoA activity induced at protrusions by EGFare regulated by a negative-feedback module composed of Src,FAK,and ***,perturbing this module interfered with cyclic Rho activation and extracellular matrix-dependent migration,suggesting that CSK inhibition can be a novel and effective intervention strategy for blocking extracellular matrix-dependent cancer cell migration,while Src inhibition might fail,depending on the genetic background of ***,this study provides new insights into the mechanisms that regulate the intricate activation states of Rho-family GTPases during extracellular matrix-dependent migration,revealing potential new targets for interfering with extracellular matrix-dependent cancer cell migration.

关键词： cell migration Rho-family GTPases signaling network Boolean network model cyclical RhoA bursts

Soft wearable flexible bioelectronics integrated with an anklefoot exoskeleton for estimation of metabolic costs and physical effort

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npj Flexible Electronics 2023年第1期7卷 535-544页

作者： Jihoon Kim Prakyath Kantharaju hoon Yi Michael Jacobson Hyungkeun jeong Hojoong Kim Jinwoo Lee Jared Matthews Nathan Zavanelli Hyeonseok Kim Heejin jeong Myunghee Kim Woon-Hong Yeo IEN Center for Human-Centric Interfaces and Engineering and George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Department of Mechanical and Industrial Engineering the University of Illinois at ChicagoChicagoIL 60607USA Department of Mechanical Roboticsand Energy EngineeringDongguk UniversitySeoulRepublic of Korea Human Systems Engineering The Polytechnic SchoolIra A.Fulton Schools of EngineeringArizona State UniversityMesaAZ 85212USA Wallace H.Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University School of MedicineAtlantaGA 30332USA Institute for Robotics and Intelligent Machines Parker H.Petit Institute for Bioengineering and BiosciencesInstitute for MaterialsNeural Engineering CenterGeorgia Institute of TechnologyAtlantaGA 30332USA

Activities and physical effort have been commonly estimated using a metabolic rate through indirect calorimetry to capture breath *** physical effort represents the work hardness used to optimize wearable robotic ***,personalization and rapid optimization of the effort are *** respirometry is the gold standard for estimating metabolic costs,this method requires a heavy,bulky,and rigid system,limiting the system’s field ***,this paper reports a soft,flexible bioelectronic system that integrates a wearable ankle-foot exoskeleton,used to estimate metabolic costs and physical effort,demonstrating the potential for real-time wearable robot adjustments based on *** from a set of activities,including walking,running,and squatting with the biopatch and exoskeleton,determines the relationship between metabolic costs and heart rate variability root mean square of successive differences(HRV-RMSSD)(R=−0.758).Collectively,the exoskeleton-integrated wearable system shows potential to develop a field-deployable exoskeleton platform that can measure wireless real-time physiological signals.

关键词： skeleton wear estimation