Fermentation of mulberry leaves with Cordyceps militaris enhanced anti-adipogenesis activity in 3T3-L1 cells through down-regulation of PPAR-γ pathway signaling
作者机构：Department of Horticultural BiosciencePusan National UniversityMiryang 50463Republic of Korea Department of Biomaterials SciencePusan National UniversityMiryang 50463Republic of Korea Department of Biology and ChemistryChangwon National UniversityChangwon 51140Republic of Korea Life and Industry Convergence Research InstitutePusan National UniversityMiryang 50463Republic of Korea
出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)
年 卷 期：2020年第13卷第12期
页 面：557-565页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 10[医学]
基 金：This work was supported by Korea Institute of Planning and Evaluation for Technology in Food Agriculture Forestry and Fisheries(IPET)through High Value-added Food Technology Development Program funded by Ministry of Agriculture Food and Rural Affairs(MAFRA)(116027032HD020)
主 题：dried fermentation silkworm
摘 要：Objective:To establish an efficacious and efficient fermentation method of enhancing the anti-adipogenesis effect of mulberry(Morus alba) leaves using Cordyceps ***:Dried mulberry leaves,dried mulberry leaves with50% raw silkworm pupa and raw silkworm pupa were fermented with Cordyceps militais for 4 weeks at 25℃,after which the dried mulberry leaves and fermented product were extracted with 70%ethanol and subjected to high performance liquid chromatography(HPLC).The contents of cordycepin,pelargonidin,chlorogenic acid,iso-quercetin and caffeic acid were *** then used the 3 T3-L1 cells to investigate whether extracts of fermentation enhanced anti-adipogenesis activity in ***:HPLC showed that fermentation changed the contents of cordycepin,pelargonidin,chlorogenic acid,iso-quercetin and caffeic ***,fermented dried mulberry leaves with 50% raw silkworm pupa had a better efficacy of anti-adipogenesis than dried mulberry leaves,fermented dried mulberry leaves and fermented silkworm pupa and inhibited triglycerides accumulation and glucose ***,fermented dried mulberry leaves with50% raw silkworm pupa inhibited PPAR-γ ***:Fermentation with Cordyceps militaris enhanced antiadipogenesis efficacy of mulberry leaves.
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