检索结果-南通市图书馆

Asialo GM1-positive liver-resident CD8 T cells that express CD44 and LFA-1 are essential for immune clearance of hepatitis B virus

引用

Cellular & Molecular Immunology 2021年第7期18卷 1772-1782页

作者： Chi-Chang Sung jau-hau horng Shih-Hong Siao I-Tsu Chyuan Hwei-Fang Tsai Pei-Jer Chen Ping-Ning Hsu Graduate Institute of Immunology College of MedicineNational Taiwan UniversityTaipeiChina Graduate Institute of Microbiology College of MedicineNational Taiwan UniversityTaipeiChina Department of Internal Medicine Cathay General HospitalTaipeiChina School of Medicine College of MedicineFu Jen Catholic UniversityNew Taipei CityChina Department of Internal Medicine Taipei Medical University Shuang Ho HospitalTaipeiChina Graduate Institute of Clinical Medicine College of MedicineNational Taiwan UniversityTaipeiChina Department of Internal Medicine National Taiwan University HospitalTaipeiChina

Persistent hepatitis B virus(HBV)infection results in chronic liver diseases that may progress to chronic hepatitis,liver cirrhosis,and subsequent hepatocellular *** studies demonstrated that adaptive immunity,in particular CD8 T cells,is critical in HBV *** studies have revealed a distinct tissue-localized T cell lineage,tissue-resident memory(TRM)cells,that is crucial for protective immunity in peripheral *** this study,we showed that treatment with an anti-asialo GM1(ASGM1)antibody(Ab),which depletes NK cells,led to impairment of HBV clearance in a mouse animal ***,the ability to clear HBV was not significantly impaired in NFIL3 KO mice,which are deficient in NK cells,implying that other non-NK ASGM1-positive immune cells mediate HBV *** isolated intrahepatic ASGM1-positive cells from NFIL3 KO mice and analyzed the immune phenotype of these *** results demonstrated a distinct population of CD44+LFA-1hi CD8 T cells that were the major intrahepatic ASGM1-positive immune cells in NFIL3 KO ***,transcriptome analysis revealed that these ASGM1-positive CD8 T cells had distinct gene profiles and shared a similar core gene signature with TRM *** addition to both transcriptional and phenotypic liver residency characteristics,ASGM1-positive CD8 T cells were able to home to and be retained in the liver after adoptive *** together,our study results indicate that these ASGM1-positive liver-resident CD8 T cells are the major effector immune cells mediating anti-HBV immunity.

关键词： asialo GM-1 liver-resident CD8 T cells HBV clearance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optimal operating policy for a controllable queueing model with a fuzzy environment

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第2期10卷 311-318页

作者： Chuen-horng LIN jau-chuan KE Department of Information Management Department of Applied Statistics National Taichung Institute of Technology

We construct the membership functions of the fuzzy objective values of a controllable queueing model,in which cost elements,arrival rate and service rate are all fuzzy numbers. Based on Zadeh's extension principle,a set of parametric nonlinear programs is developed to find the upper and lower bounds of the minimal average total cost per unit time at the possibility level. The membership functions of the minimal average total cost are further constructed using different values of the possibility level. A numerical example is solved successfully to illustrate the validity of the proposed approach. Because the object value is expressed and governed by the membership functions,the optimization problem in a fuzzy environment for the controllable queueing models is represented more accurately and analytical results are more useful for system designers and practitioners.

关键词： Controllable queue Fuzzy sets Membership function Nonlinear programming

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fecal calprotectin correlated with endoscopic remission for Asian inflammatory bowel disease patients

引用

World Journal of Gastroenterology 2015年第48期21卷 13566-13573页

作者： Wei-Chen Lin jau-Min Wong Chien-Chih Tung Ching-Pin Lin Jen-Wei Chou horng-Yuan Wang Ming-Jium Shieh Chin-Hao Chang Heng-Hsiu Liu Shu-Chen Wei Division of Gastroenterology Department of internal MedicineMackay Memorial Hospital Departments of Internal Medicine National Taiwan University Hospital Integrated Diagnostics and Therapeutics National Taiwan University Hospital Division of Gastroenterology Department of internal MedicineChung Shan Medical University Hospital Division of Gastroenterology Department of internal MedicineChina Medical University Hospital Medical Research National Taiwan University Hospital Institute of Epidemiology and Preventive Medicine College of Public HealthNational Taiwan University

AIM: To evaluate the correlation between fecal calprotectin(f C), C-reactive protein(CRP), and endoscopic disease score in Asian inflammatory bowel disease(IBD) ***: Stool samples were collected and assessed for calprotectin levels by Quantum Blue Calprotectin High Range Rapid test. Crohn's disease endoscopic index of severity(CDEIS) and ulcerative colitis endoscopic index of severity(UCEIS) were used for endoscopic lesion scoring. RESULTS: A total of 88 IBD patients [36 patients with Crohn's disease(CD) and 52 with ulcerative colitis(UC)] were enrolled. For CD patients, f C correlated with CDEIS(r = 0.465, P = 0.005) and CRP(r = 0.528, P = 0.001). f C levels in UC patients correlated with UCEIS(r = 0.696, P < 0.0001) and CRP(r = 0.529, P = 0.0005). Calprotectin could predict endoscopic remission(CDEIS < 6) with 50% sensitivity and 100% specificity(AUC: 0.74) in CD patients when using 918 μg/g as the cutoff. When using 191 μg/g as the cut-off in UC patients, calprotectin could be used for predicting endoscopic remission(UCEIS < 3) with 88% sensitivity and 75% specificity(AUC: 0.87). CONCLUSION: f C correlated with both CDEIS and UCEIS. f C could be used as a predictor of endoscopic remission for Asian IBD patients.

关键词： Inflammatory bowel disease Endoscopicscore Fecal calprotectin Crohn's disease Ulcerativecolitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Characteristics of PM2.5 mass and water-soluble ions during Background and biomass burning periods observed at *** in Taiwan from 2003 to 2009

Characteristics of PM2.5 mass and water-soluble ions during ...

引用

第七届海峡两岸气胶技术研讨会暨第二届空气污染技术研讨会

作者： Chung-Te Lee Ming-Tung Chuang Neng-Huei Lin Guey-Rong Sheu Shuenn-Chin Chang Sheng-Hsiang Wang Hill Huang horng-Wen Chen Guo-hau Weng Hsin-YoLai Shao-Peng Hsu Graduate Institute of Environmental Engineering National Central University Department of Atmospheric Sciences National Central University

＜正＞This paper analyzes six years’ PM2.5 mass and water-soluble ions collected at Mt. Lulin （2,862 m a.s.l.） from April 2003 to April 2009. Among global high-elevation sites,Mt. Lulin site is the only observatory that receives aerosol from Southeast Asia in the West Pacific region. Based on a six-year observation,the most active biomass

关键词： Biomass burning PM2.5 Water-soluble ions Long-range transport High-elevation site

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

聚合物分散型液晶结构紫外光稳定性分析

引用

液晶与显示 2016年第2期31卷 125-130页

作者：蒋圣评李承璋赖威宏赵宏昌陈君维林宗贤洪子圣中山大学电机工程学系台湾高雄80424 中山大学光电工程学系台湾高雄80424

聚合物分散型液晶组件技术是市面上常用的散射式光开关系统,且常常应用于具隐私保护性之电控切换窗户中。然而对于室外的应用,属于有机高分子材料的液晶材料与聚合物结构对于照射紫外光之稳定性与耐受性值得被讨论,尤其是较少被讨论之... 详细信息

聚合物分散型液晶组件技术是市面上常用的散射式光开关系统,且常常应用于具隐私保护性之电控切换窗户中。然而对于室外的应用,属于有机高分子材料的液晶材料与聚合物结构对于照射紫外光之稳定性与耐受性值得被讨论,尤其是较少被讨论之高分子聚合物结构的影响。本研究主要探讨不同聚合物结构之聚合物分散型液晶组件在紫外光照射下光电特性的变化,期待可以了解聚合物结构特性随曝光时间的变化并提出适当之改善方法。本实验藉由选择具有高紫外光稳定性之主体液晶搭配紫外固化胶调配聚合物分散型液晶预聚物,分别探讨不同固化胶比例与光强度等固化条件下,组件照射紫外光后对于光电特性造成的影响,以此了解各种聚合物形貌照射紫外光后之光电特性变化。实验结果显示,照射紫外光后,各种聚合物分散型液晶组件之临界电压仅仅些微提升,但下降时间剧烈地提高,以聚合物比例35%、固化强度2mW/cm^2为例,临界电压从15.57V些微提升至18.18V,下降时间从195.12ms大幅提升至925.26ms。此外,本研究亦发现相对于照射前,照射紫外光后之组件的下降时间对于电压施加时间长短相当敏感,且此现象可藉由调整固化光强度与固化胶浓度有抑制之趋势。本研究呈现了各种聚合物分散型液晶组件在照射紫外光后光电特性的变化,并了解聚合物结构的特性变化的影响。

关键词：聚合物分散型液晶组件紫外光稳定性临界电压反应时间

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：