Asialo GM1-positive liver-resident CD8 T cells that express CD44 and LFA-1 are essential for immune clearance of hepatitis B virus

作     者：Chi-Chang Sung Jau-Hau Horng Shih-Hong Siao I-Tsu Chyuan Hwei-Fang Tsai Pei-Jer Chen Ping-Ning Hsu 

作者机构：Graduate Institute of ImmunologyCollege of MedicineNational Taiwan UniversityTaipeiChina Graduate Institute of MicrobiologyCollege of MedicineNational Taiwan UniversityTaipeiChina Department of Internal MedicineCathay General HospitalTaipeiChina School of MedicineCollege of MedicineFu Jen Catholic UniversityNew Taipei CityChina Department of Internal MedicineTaipei Medical University Shuang Ho HospitalTaipeiChina Graduate Institute of Clinical MedicineCollege of MedicineNational Taiwan UniversityTaipeiChina Department of Internal MedicineNational Taiwan University HospitalTaipeiChina 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2021年第18卷第7期

页      面：1772-1782页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：supported by grants from the Ministry of Science and Technology(MOST 105-2320-B-038-065 MOST 106-2320-B-038-0193 MOST 107-2321-B-002-003 and MOST 108-2320-B-002-036-MY3) 

主　　题：asialo GM-1 liver-resident CD8 T cells HBV clearance 

摘      要：Persistent hepatitis B virus(HBV)infection results in chronic liver diseases that may progress to chronic hepatitis,liver cirrhosis,and subsequent hepatocellular *** studies demonstrated that adaptive immunity,in particular CD8 T cells,is critical in HBV *** studies have revealed a distinct tissue-localized T cell lineage,tissue-resident memory(TRM)cells,that is crucial for protective immunity in peripheral *** this study,we showed that treatment with an anti-asialo GM1(ASGM1)antibody(Ab),which depletes NK cells,led to impairment of HBV clearance in a mouse animal ***,the ability to clear HBV was not significantly impaired in NFIL3 KO mice,which are deficient in NK cells,implying that other non-NK ASGM1-positive immune cells mediate HBV *** isolated intrahepatic ASGM1-positive cells from NFIL3 KO mice and analyzed the immune phenotype of these *** results demonstrated a distinct population of CD44+LFA-1hi CD8 T cells that were the major intrahepatic ASGM1-positive immune cells in NFIL3 KO ***,transcriptome analysis revealed that these ASGM1-positive CD8 T cells had distinct gene profiles and shared a similar core gene signature with TRM *** addition to both transcriptional and phenotypic liver residency characteristics,ASGM1-positive CD8 T cells were able to home to and be retained in the liver after adoptive *** together,our study results indicate that these ASGM1-positive liver-resident CD8 T cells are the major effector immune cells mediating anti-HBV immunity.