Fecal calprotectin correlated with endoscopic remission for Asian inflammatory bowel disease patients

作     者：Wei-Chen Lin Jau-Min Wong Chien-Chih Tung Ching-Pin Lin Jen-Wei Chou Horng-Yuan Wang Ming-Jium Shieh Chin-Hao Chang Heng-Hsiu Liu Shu-Chen Wei 

作者机构：Division of GastroenterologyDepartment of internal MedicineMackay Memorial Hospital Departments of Internal MedicineNational Taiwan University Hospital Integrated Diagnostics and TherapeuticsNational Taiwan University Hospital Division of GastroenterologyDepartment of internal MedicineChung Shan Medical University Hospital Division of GastroenterologyDepartment of internal MedicineChina Medical University Hospital Medical ResearchNational Taiwan University Hospital Institute of Epidemiology and Preventive MedicineCollege of Public HealthNational Taiwan University 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2015年第21卷第48期

页      面：13566-13573页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by Liver Disease Prevention and Treatment Research Foundation,Taiwan as well as the National Research Program for Biopharmaceuticals at the Ministry of Science and Technology of Taiwan MOST 103-2325-B-002-033 

主　　题：Inflammatory bowel disease Endoscopicscore Fecal calprotectin Crohn's disease Ulcerativecolitis 

摘      要：AIM: To evaluate the correlation between fecal calprotectin(f C), C-reactive protein(CRP), and endoscopic disease score in Asian inflammatory bowel disease(IBD) ***: Stool samples were collected and assessed for calprotectin levels by Quantum Blue Calprotectin High Range Rapid test. Crohn s disease endoscopic index of severity(CDEIS) and ulcerative colitis endoscopic index of severity(UCEIS) were used for endoscopic lesion scoring. RESULTS: A total of 88 IBD patients [36 patients with Crohn s disease(CD) and 52 with ulcerative colitis(UC)] were enrolled. For CD patients, f C correlated with CDEIS(r = 0.465, P = 0.005) and CRP(r = 0.528, P = 0.001). f C levels in UC patients correlated with UCEIS(r = 0.696, P 0.0001) and CRP(r = 0.529, P = 0.0005). Calprotectin could predict endoscopic remission(CDEIS 6) with 50% sensitivity and 100% specificity(AUC: 0.74) in CD patients when using 918 μg/g as the cutoff. When using 191 μg/g as the cut-off in UC patients, calprotectin could be used for predicting endoscopic remission(UCEIS 3) with 88% sensitivity and 75% specificity(AUC: 0.87). CONCLUSION: f C correlated with both CDEIS and UCEIS. f C could be used as a predictor of endoscopic remission for Asian IBD patients.