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公众健康乃重中之重 FDA在美国仿制药市场中的角色

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中国食品药品监管 2017年第12期 40-45页

作者： janet woodcock 甘珏美国FDA药审中心中国药科大学外语系

本文为美国FDA药审中心主任janet woodcock于2016年9月在美国国会参议院农业、偏远地区发展、食品药品管理局和政府其他相关部门的专业委员会上的陈述报告。主要阐述了FDA在美国仿制药市场所起的至关重要作用。janet woodcock博士详细... 详细信息

本文为美国FDA药审中心主任janet woodcock于2016年9月在美国国会参议院农业、偏远地区发展、食品药品管理局和政府其他相关部门的专业委员会上的陈述报告。主要阐述了FDA在美国仿制药市场所起的至关重要作用。janet woodcock博士详细介绍了FDA在Hatch-Waxman法案的指导下,通过简略新药的申请、GDUFA、企业沟通信和各种指南,大力推动仿制药加快上市,不断满足美国公众的医疗需求,大大节约了医疗支出。与此同时,FDA也很好地保护了知识产权,并在应对组合产品不断涌现的新形势下,积极与医药行业沟通,不断改进监管措施,以期更好保护公众健康。

关键词： FDA 创新药仿制药新药申请公众健康

Materials and technology of Chinese jades dating to the Western Zhou period (1050―771 BCE)

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Science China(Technological Sciences) 2008年第4期51卷 467-480页

作者： janet G DOUGLAS Department of Conservation and Scientific Research Freer Gallery of Art / Arthur M. Sackler Gallery Smithsonian Institution

Excavated jades dating to the Western Zhou period (1050―771 BCE) from the Xi’an area in Shaanxi Province, China, and contemporaneous jades in the collections of the Arthur M. Sackler Gallery at the Smithsonian Institution have been studied to learn about the jade and stone materials and how they were worked during the Western Zhou period. Materials identification was carried out using a combination of techniques such as Fourier-transform infrared spectroscopy and X-ray diffraction. Tool marks were studied using stereomicroscopy and examination of mold impressions using scanning electron microscopy. All of these objects were pro- duced through simple processes involving solid drilling, riffling, and sharp point abrasion; and no evidence was found for the use of rotary tools for incising or sawing.

关键词： jade nephrite stone China Western Zhou scanning electron microscopy materials technology tool marks

Sexual selection and hermaphroditic organisms： Testing theory

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Current Zoology 2013年第4期59卷 579-588页

作者： janet L. LEONARD Joseph M. Long Marine Laboratory University of California-Santa Cruz Santa Cruz CA 94019 USA

Sexual selection is widespread if not ubiquitous in hermaphroditic organisms. Although many phenomena that have been described as sexual selection in gonochores, （e.g. harem polygamy, multiple mating, elaborate courtship, even secondary sexual characters） can be found in some hermaphrodites, what is more interesting is the ways in which sexual selection in her- maphrodites may differ from dioecious taxa. In hermaphrodites, an individual＇s mating success includes its success from both sexual roles. Secondly, in many simultaneously hermaphroditic taxa there is strong evidence of sexual selection and yet the ope- rational sex ratio is 1：1, by definition. Many simultaneous hermaphrodites have elaborate courtship and genital anatomy, suggest- ing sexual selection plays an important role in reproductive success. Sperm competition and cryptic female choice mean that the number of mates acquired is not necessarily a predictor of reproductive success. Even in simultaneous hermaphrodites with re- ciprocal mating, variance in reproductive success through the male role and through the female role may differ in a population. Moreover hermaphrodites may choose to emphasize one sexual role over the other. Data suggest that the preferred role varies in hermaphrodites, which creates an opportunity to test fundamental predictions and assumptions of sexual selection theory. Hermaphrodites may vary their emphasis on one sexual role over the other either developmentally or behaviorally in response to environmental or social parameters. How they use this capability in acquiring more or higher quality mates still requires study

关键词： Sexual selection Hermaphrodites Mate choice Reproductive success

Parameter-Free Search of Time-Series Discord

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Journal of Computer Science & Technology 2013年第2期28卷 300-310页

作者： Wei Luo Marcus Gallagher janet Wiles School of Information Technology Deakin University School of Information Technology and Electrical Engineering University of Queensland

Time-series discord is widely used in data mining applications to characterize anomalous subsequences in time series. Compared to some other discord search algorithms, the direct search algorithm based on the recurrence plot shows the advantage of being fast and parameter free. The direct search algorithm, however, relies on quasi-periodicity in input time series, an assumption that limits the algorithm＇s applicability. In this paper, we eliminate the periodicity assumption from the direct search algorithm by proposing a reference function for subsequences and a new sampling strategy based on the reference function. These measures result in a new algorithm with improved efficiency and robustness, as evidenced by our empirical evaluation.

关键词： time series anomaly detection recurrence structure direct discord search parameter-free algorithm

The intermediate water in the Philippine Sea

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Journal of Oceanology and Limnology 2020年第5期38卷 1343-1353页

作者： ZANG Nan WANG Fan SPRINTALL janet CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao 266071China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Pilot National Laboratory for Marine Science and Technology(Qingdao) Qingdao 266237China College of Marine Science University of Chinese Academy of SciencesQingdao 266400China Scripps Institution of Oceanography U.C.San DiegoLa Jolla CA 92093-0230U.S.A

The dimensional and temporal distribution of Antarctic Intermediate Water(AAIW)and North Pacifi c Intermediate Water(NPIW)in the Philippine Sea were explored using Argo profi les and gridded Argo *** the salinity minimum of intermediate water from mid-high latitude of the southern and northern hemisphere of the Pacifi c Ocean,the properties of AAIW and NPIW merge at about 10°N with diff erent properties in the Philippine *** core of AAIW is located below 600 dbar with potential density of 27≤σθ≤27.3 kg/m 3 and salinity of 34.5≤S≤*** core of NPIW is located between 300–700 dbar with potential density of 26.2≤σθ≤27 kg/m 3 and salinity of 34≤S≤*** volume of AAIW and NPIW during January 2004 to December 2017 is negatively *** time series of AAIW and NPIW is dominated by signifi cant periods of 6 and 8 months,*** variations of AAIW and NPIW are mainly aff ected by volume transport through a 130°E section by the North Equatorial Current(NEC)and North Equatorial Undercurrent(NEUC).

关键词： the intermediate water the Antarctic Intermediate Water the North Pacifi c Intermediate Water seasonal variation

Cultural Studies:Return to Beauty——An Interview with Professor janet Wolff

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马克思主义美学研究 2012年第1期15卷 187-197页

作者： janet Wolff Manchester University Shanghai Jiaotong University

珍妮特·伍尔芙(janet Wolff)是曼彻斯特大学文化社会学荣誉退休教授,2008-2010年担任曼彻斯特大学跨学科艺术研究中心主任。主要研究领域涉及社会学、文化研究、视觉文化、女性主义等。2012年4月珍妮特·伍尔芙参加了在英国曼彻斯特大... 详细信息

珍妮特·伍尔芙(janet Wolff)是曼彻斯特大学文化社会学荣誉退休教授,2008-2010年担任曼彻斯特大学跨学科艺术研究中心主任。主要研究领域涉及社会学、文化研究、视觉文化、女性主义等。2012年4月珍妮特·伍尔芙参加了在英国曼彻斯特大学举行的第二届中英马克思主义美学研究双边论坛。并发表了有关文化研究的社会学问题的专题演讲,在这次演讲之后,我们对她做了此次访谈。这个访谈围绕着文化研究的社会学研究领域展开,探讨了文化研究中的批判理论与女性主义美学价值问题,并进一步探讨了在当代文化社会学研究与审美的相关问题域中如何展开审美分析的问题。

关键词：文化研究批判理论女性主义社会学审美

Mimicking the physical cues of the ECM in angiogenic biomaterials

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Regenerative Biomaterials 2019年第2期6卷 61-73页

作者： Cody O.Crosby janet Zoldan Department of Biomedical Engineering The University of Texas at AustinAustinTX 78751USA

A functional microvascular system is imperative to build and maintain healthy *** microvasculature results in ischemia,thereby limiting the tissue’s intrinsic regeneration ***,the ability to regenerate microvascular networks is key to the development of effective cardiovascular *** stimulate the formation of new microvasculature,researchers have focused on fabricating materials that mimic the angiogenic properties of the native extracellular matrix(ECM).Here,we will review biomaterials that seek to imitate the physical cues that are natively provided by the ECM to encourage the formation of microvasculature in engineered constructs and ischemic tissue in the body.

关键词： angiogenesis biomaterial–cell interaction materials signal vascular

Tribological behavior of lubricant-impregnated porous polyimide

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Friction 2024年第4期12卷 711-725页

作者： Jinbang LI Ningning ZHOU janet S.S.WONG School of Mechanical Engineering and Mechanics Ningbo UniversityNingbo 315211China Beijing Key Laboratory of Long-life Technology of Precise Rotation and Transmission Mechanisms Beijing Institute of Control EngineeringBeijing 100029China Department of Mechanical Engineering Imperial College LondonLondon SW72AZUK

Porous materials impregnated with lubricants can be used in conditions where limited lubricant is *** this work,three porous polyimides(PPI)with different densities were ***(PAO)impregnated PPI(iPPI)discs were rubbed against steel and sapphire *** operando observations of the iPPI-sapphire contacts show that oil is released under an applied load,forming a meniscus around *** at the outlet is created at high sliding *** amount of released oil increases with increasing PPI *** moduli,E*,estimated based on the actual contact size show that trapped oil in iPPIs contributes to load *** higher speeds,tribological rehydration of the contact occurs in low density iPPI,with that E*rises with *** high density PPIs,high speeds give a constantly high E*which is limited by the viscoelastic properties of the PPI network and possibly the rate of oil *** of iPPI-steel contacts is governed by the mechanical properties of the PPI,the flow of the lubricant,and the roughness of the PPI *** low-and medium-density(highly porous,high roughness)PPIs,large amount of oil is released,and lubrication is mainly via lubricant restricted in the contact in the pores and possibly tribological *** high density(low porosity)PPI,with lower roughness,hydrodynamic lubrication is achieved which gives the lowest *** results show that polymeric porous materials for effective lubrication require the optimization of its surface roughness,stiffness,oil flow,and oil retentions.

关键词： polyimide porous material friction mechanism polymer limited lubrication

走向跨文化教育:孙有中教授和janet Bennett博士学术对话

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外语与外语教学 2017年第2期 1-8页

作者：孙有中 janet Bennett 北京外国语大学英语学院北京100089 美国跨文化交际学院美国波特兰or97225

本文是对孙有中教授与janet ***博士的联合采访实录。孙教授和Bennett博士探讨了全球化背景下外语教育乃至整个高等教育与跨文化教育的关系,进而揭示了在人才培养的全过程中实施跨文化教育的有效途径。在他们的对话中,Bennett还阐释了... 详细信息

本文是对孙有中教授与janet ***博士的联合采访实录。孙教授和Bennett博士探讨了全球化背景下外语教育乃至整个高等教育与跨文化教育的关系,进而揭示了在人才培养的全过程中实施跨文化教育的有效途径。在他们的对话中,Bennett还阐释了如何运用DMIS模型进行跨文化交际研究,介绍了她领导的跨文化交际学院的使命和她的团队最新研发的跨文化能力量表。孙有中教授则倡导外语教育走向跨文化教育,培养高层次国际化人才。他们的真知灼见不仅有助于我们反思当前外语教育的改革方向,而且对推进跨文化交际研究具有重要启示。

关键词：跨文化交际跨文化能力外语教育跨文化教育跨文化培训