Mimicking the physical cues of the ECM in angiogenic biomaterials

作     者：Cody O.Crosby Janet Zoldan 

作者机构：Department of Biomedical EngineeringThe University of Texas at AustinAustinTX 78751USA 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2019年第6卷第2期

页      面：61-73页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the National Institute of Biomedical Imaging and Bioengineering(NIBIB)of the National Institutes of Health(grant number EB007507,awarded to C.O.C.) the American Heart Association(grant number 15SDG25740035,awarded to J.Z.) 

主　　题：angiogenesis biomaterial–cell interaction materials signal vascular 

摘      要：A functional microvascular system is imperative to build and maintain healthy *** microvasculature results in ischemia,thereby limiting the tissue’s intrinsic regeneration ***,the ability to regenerate microvascular networks is key to the development of effective cardiovascular *** stimulate the formation of new microvasculature,researchers have focused on fabricating materials that mimic the angiogenic properties of the native extracellular matrix(ECM).Here,we will review biomaterials that seek to imitate the physical cues that are natively provided by the ECM to encourage the formation of microvasculature in engineered constructs and ischemic tissue in the body.