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Comparison of survival outcomes between laparoscopic versus open radical nephroureterectomy in upper tract urothelial cancer patients:Experiences of a tertiary care single center

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Current Urology 2023年第4期17卷 292-298页

作者： Benedikt Hoeh Marina Kosiba Mike Wenzel Nicola Meister Felix Preisser Shahrokh F.Shariat jan lukas hohenhorst Andreas Becker Philipp Mandel Severine Banek Frederik Roos Pierre I.Karakiewicz Felix K.H.Chun Luis A.Kluth Department of Urology University Hospital FrankfurtGoethe University Frankfurt am MainFrankfurt am Main60590Germany Cancer Prognostics and Health Outcomes Unit Division of UrologyUniversity of Montreal Health CenterMontrealQuebecCanada Department of Urology Comprehensive Cancer CenterMedical University of ViennaViennaAustria Department of Urology Weill Cornell Medical CollegeNew YorkNYUSA Department of Urology University of Texas SouthwesternDallasTXUSA Department of Urology Second Faculty of MedicineCharles UniversityPragueCzech Republic Institute for Urology and Reproductive Health I.M.Sechenov First Moscow State Medical UniversityMoscowRussia Division of Urology Department of Special SurgeryJordan University HospitalThe University of JordanAmmanJordan Martini-Klinik Prostate Cancer Center University Hospital Hamburg-EppendorfHamburgGermany

Objectives:To test for differences in overall and recurrence-free survival between laparoscopic and open surgical approaches in patients undergoing radical nephroureterectomy(RNU)for upper tract urothelial carcinoma(UTUC).Materials and methods:We retrospectively identified patients treated for UTUC from 2010 to 2020 from our institutional *** undergoing laparoscopic or open RNU with no suspicion of metastasis(cM0)were for the current study *** with suspected metastases at diagnosis(cM1)or those undergoing other surgical treatments were *** was performed according to the laparoscopic versus open surgical ***-Meier plots were used to test for differences in overall and recurrence-free survival with regard to the surgical ***,separate Kaplan-Meier plots were used to test the effect of preoperative ureterorenoscopy on overall and recurrence-free survival within the overall study ***:Of the 59 patients who underwent nephroureterectomy,29%(n=17)underwent laparoscopic nephroureterectomy,whereas 71%(n=42)underwent open *** and tumor characteristics were comparable between groups(p≥0.2).The median overall survival was 93 and 73 months in the laparoscopic nephroureterectomy group compared to the open nephroureterectomy group(p=0.5),*** median recurrence-free survival did not differ between open and laparoscopic nephroureterectomies(73 months for both groups;p=0.9).Furthermore,the median overall and recurrence-free survival rates did not differ between patients treated with and without preoperative ***:The results of this retrospective,single-center institution showed that overall and recurrence-free survival rates did not differ between patients with UTUC treated with laparoscopic and open ***,preoperative ureterorenoscopy before RNU was not associated with higher overall or recurrence-free survival rates.

关键词： Upper tract urothelial carcinoma Laparoscopic radical nephroureterectomy Open radical nephroureterectomy Overall survival

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Hybrid In-Vehicle Background Noise Reduction for Robust Speech Recognition:The Possibilities of Next Generation 5G Data Networks

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Computers, Materials & Continua 2022年第6期71卷 4659-4676页

作者： Radek Martinek jan Baros Rene Jaros lukas Danys jan Nedoma VSB-Technical University of Ostrava Faculty of Electrical Engineering and Computer ScienceDepartment of Cybernetics and Biomedical Engineering70800Ostrava-PorubaCzechia VSB Technical University of Ostrava Faculty of Electrical Engineering and Computer ScienceDepartment of Telecommunications70800Ostrava-PorubaCzechia

This pilot study focuses on employment of hybrid LMS-ICA system for in-vehicle background noise *** vehicles are nowadays increasingly supporting voice commands,which are one of the pillars of autonomous and SMART *** speaker recognition for context-aware in-vehicle applications is limited to a certain extent by in-vehicle back-ground *** article presents the new concept of a hybrid system which is implemented as a virtual *** highly modular concept of the virtual car used in combination with real recordings of various driving scenarios enables effective testing of the investigated methods of in-vehicle background noise *** study also presents a unique concept of an adaptive system using intelligent clusters of distributed next generation 5G data networks,which allows the exchange of interference information and/or optimal hybrid algorithm settings between individual *** average,the unfiltered voice commands were successfully recognized in 29.34%of all scenarios,while the LMS reached up to 71.81%,and LMS-ICA hybrid improved the performance further to 73.03%.

关键词： 5G noise reduction hybrid algorithms speech recognition 5G data networks in-vehicle background noise

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Structural Aspects of Multistep Phosphorelay- Mediated Signaling in Plants

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Molecular Plant 2016年第1期9卷 71-85页

作者： Blanka Pekarova Agnieszka Szmitkowska Radka Dopitova Oksana Degtjarik lukas Zidek jan Hejatko Faculty of Science Institute of Chemistry and Biochemistry University of South Bohemia Branisovska 1760 370 05 Ceske Budejovice Czech Republic Faculty of Science Institute of Chemistry and Biochemistry University of South Bohemia 370 05 Ceske Budejovice Czech Republic

The multistep phosphorelay （MSP） is a central signaling pathway in plants integrating a wide spectrum of hormonal and environmental inputs and controlling numerous developmental adaptations. For the thor- ough comprehension of the molecular mechanisms underlying the MSP-mediated signal recognition and transduction, the detailed structural characterization of individual members of the pathway is critical. In this review we describe and discuss the recently known crystal and nuclear magnetic resonance structures of proteins acting in MSP signaling in higher plants, focusing particularly on cytokinin and ethylene signaling in Arabidopsis thaliana. We discuss the range of functional aspects of available structural infor- mation including determination of ligand specificity, activation of the receptor via its autophosphorylaUon, and downstream signal transduction through the phosphorelay. We compare the plant structures with their bacterial counterparts and show that although the overall similarity is high, the differences in structural de- tails are frequent and functionally important. Finally, we discuss emerging knowledge on molecular recog- nition mechanisms in the MSP, and mention the latest findings regarding structural determinants of signaling specificity in the Arabidopsis MSP that could serve as a general model of this pathway in all higher plants.

关键词： multistep phosphorelay structure histidine kinase phosphotransfer protein response regulator

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Enhancements of SDR-Based FPGA System for V2X-VLC Communications

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Computers, Materials & Continua 2021年第9期68卷 3629-3652页

作者： lukas Danys Radek Martinek Rene Jaros jan Baros Petr Simonik Vaclav Snasel Department of Cybernetics and Biomedical Engineering Faculty of Electrical Engineering and Computer ScienceVSB–Technical University of OstravaOstrava-Poruba70800Czechia Department of Electronics Faculty of Electrical Engineering and Computer ScienceVSB–Technical University of OstravaOstrava-Poruba70800Czechia Department of Computer Science Faculty of Electrical Engineering and Computer ScienceVSB–Technical University of OstravaOstrava-Poruba70800Czechia

This pilot study focuses on a real measurements and enhancements of a software defined radio-based system for vehicle-to everything visible light communication(SDR-V2X-VLC).The presented system is based on a novel adaptive optimization of the feed-forward software defined equalization(FFSDE)methods of the least mean squares(LMS),normalized LMS(NLMS)and QR decomposition-based recursive least squares(QR-RLS)*** parameters of adaptive equalizations are adjusted in real-time to reach the best possible *** were carried out on a conventional LED Octavia III taillight drafted directly from production line and universal software radio peripherals(USRP)from National *** transmitting/receiving elements used multistate quadrature amplitude modulation(M-QAM)implemented in LabVIEW programming *** results were verified based on bit error ratio(BER),error vector magnitude(EVM)and modulation error ratio(MER).Experimental results of the pilot study unambiguously confirmed the effectiveness of the proposed solution(longer effective communication range,higher immunity to interference,deployment of higher state QAM modulation formats,higher transmission speeds etc.),as the adaptive equalization significantly improved BER,MER and EVM *** best results were achieved using the QR-RLS *** results measured on deployed QR-RLS algorithm had significantly better Eb/N0(improved by approx.20 dB)and BER values(difference by up to two orders of magnitude).

关键词： 5G feed-forward software defined equalization multistate quadrature amplitude modulation software defined radio visible light communication

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Noise Reduction in Industry Based on Virtual Instrumentation

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Computers, Materials & Continua 2021年第10期69卷 1073-1096页

作者： Radek Martinek Rene Jaros jan Baros lukas Danys Aleksandra Kawala-Sterniuk jan Nedoma Zdenek Machacek Jiri Koziorek Faculty of Electrical Engineering and Computer Science Department of Cybernetics and Biomedical EngineeringVSB–Technical University of Ostrava70800Ostrava-PorubaCzechia Faculty of Electrical Engineering Automatic Control and InformaticsOpole University of TechnologyOpolePoland Faculty of Electrical Engineering and Computer Science Department of TelecommunicationsVSB–Technical University of Ostrava70800Ostrava-PorubaCzechia

This paper discusses the reduction of background noise in an industrial environment to extend *** the Industry 4.0 era,the mass development of voice control(speech recognition)in various industrial applications is possible,especially as related to augmented reality(such as hands-free control via voice commands).As Industry 4.0 relies heavily on radiofrequency technologies,some brief insight into this problem is provided,including the Internet of things(IoT)and 5G *** study was carried out in cooperation with the industrial partner Brose CZ spol.s.r.o.,where sound recordings were made to produce a *** experimental environment comprised three workplaces with background noise above 100 dB,consisting of a laser/magnetic welder and a press.A virtual device was developed from a given dataset in order to test selected commands from a commercial speech recognizer from *** tested a hybrid algorithm for noise reduction and its impact on voice command recognition *** virtual devices,the study was carried out on large speakers with 20 participants(10 men and 10 women).The experiments included a large number of repetitions(100 times for each command under different noise conditions).Statistical results confirmed the efficiency of the tested *** welding environment efficiency was 27%before applied filtering,76%using the least mean square(LMS)algorithm,and 79%using LMS+independent component analysis(ICA).Magnetic welding environment efficiency was 24%before applied filtering,70%with LMS,and 75%with LMS+*** workplace environment efficiency showed no success before applied filtering,was 52%with LMS,and was 54%with LMS+ICA.

关键词： 5G hybrid algorithms signal processing speech recognition

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Investigating inexpensive polymeric 3D printed materials under extreme thermal conditions

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Materials Futures 2022年第1期1卷 101-112页

作者： jan lukas Storck Guido Ehrmann jana Uthoff Elise Diestelhorst Tomasz Blachowicz Andrea Ehrmann Faculty of Engineering and Mathematics Bielefeld University of Applied Sciences33619 BielefeldGermany Virtual Institute of Applied Research on Advanced Materials(VIARAM) Institute of Physics-Center for Science and Education Silesian University of Technology44-100 GliwicePoland

3D printing is nowadays used for many applications far beyond pure rapid *** tools to prepare custom-made objects which may be highly complex,different 3D printing techniques have emerged into areas of application where the mechanical,thermal,optical and other properties have to meet high *** them,applications for space,*** microsatellites,make extreme demands regarding the stability under high ***,polymeric 3D printed materials have several advantages for space application in comparison with metal *** we thus investigate the impact of temperatures up to 85◦C and 185◦C,respectively,on typical 3D printing materials for fused deposition modeling or stereolithography(SLA)with inexpensive 3D *** materials are found to differ strongly in terms of mechanical properties and dimensional stability after the treatment at a higher temperature,with SLA resins and co-polyester showing the best dimensional stability,while acrylonitrile–butadiene–styrene and SLA resin after long UV post-treatment has the best mechanical properties.

关键词： additive manufacturing polymers space microsatellites thermal stability dimensions mechanical properties

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Boron isotopic variations in tourmaline from metacarbonates and associated calc-silicate rocks from the Bohemian Massif: Constraints on boron recycling in the Variscan orogen

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Geoscience Frontiers 2021年第1期12卷 219-230页

作者： lukas Krmcek Milan Novak Robert B.Trumbull jan Cempirek Stanislav Houzar Department of Geological Sciences Faculty of ScienceMasaryk UniversityKotlarska 2CZ-61137BrnoCzech Republic Institute of Geology of the Czech Academy of Sciences Rozvojova 269CZ-16502Prague 6Czech Republic Brno University of Technology Faculty of Civil EngineeringAdMaS CentreVeve■rí95CZ-60200BrnoCzech Republic GFZ German Research Centre for Geosciences TelegrafenbergD-14473PotsdamGermany Department of Mineralogy and Petrography Moravian MuseumZelnyTrh 6CZ-67401BrnoCzech Republic

Various metacarbonate and associated calc-silicate rocks form minor but genetically significant components of the lithological units in the Bohemian Massif of the Variscan orogen in Central *** rocks vary in terms of their lithostratigraphy,chemical composition and mineral assemblage(dolomite/calcite ratio,silicate abundance).Tourmaline is present in five paragenetic settings within the metacarbonate and calc-silicate ***Ⅰcomprises individual,euhedral,prismatic grains and grain aggregates in a carbonate-dominant(calcite±dolomite)matrix poor in ***Ⅱis characterized by euhedral to subhedral grains and coarse-to fine-grained aggregates in silicate-rich layers/nests within metacarbonate bodies whereas typeⅢoccurs as prismatic grains and aggregates at the contact zones between carbonate and associated silicate host ***Ⅳis in veins crosscutting metacarbonate bodies,and typeⅣtourmaline occurs at the exocontacts of elbaite-subtype granitic *** from the different settings shows distinctive compositional *** for typeⅠare Mg-rich compositions,with fluor-uvite>dravite>>*** from typeⅡsilicate-rich layers/nests are highly variable,corresponding to oxy-schorl,magnesio-foitite,Al-rich dravite and *** for typeⅢtourmalines are Ca,Ti-bearing oxy-dravite *** typeⅣveins feature dravite and fluor-uvite tourmaline compositions whereas typeⅤtourmaline is Li,F-rich *** is the only Bbearing phase in paragenetic typesⅠ-Ⅳ,where it is characterised by two principal ranges of B-isotope composition(δ^11B=-13‰to-9‰and-18‰to-14‰).These ranges correspond to regionally different units of the Moldanubian ***,the Svratka Unit(Moldanubian Zone s.l.)contains only isotopically lighter tourmaline(δ^11B=-18‰to-14‰),whereas metacarbonates in the Poli?ka unit(Teplá-Barrandian Zone)and Olesnice unit(Moravicum of the Moravo-Silesian Zone)has exclusively isotopically heav

关键词： Boron isotopes Tourmaline Metacarbonates Moldanubicum Variscan orogeny

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New Hybrid IoT LoRaWAN/IRC Sensors:SMARTWater Metering System

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Computers, Materials & Continua 2022年第6期71卷 5201-5217页

作者： Vlastimil Slany Petr Koudelka Eva Krcalova jan Jobbagy lukas Danys Rene Jaros Zdenek Slanina Michal Prauzek Radek Martinek Mendel University in Brno Faculty of AgrisciencesDepartment of AgriculturalFood and Environmental Engineering61300BrnoCzechia Slovak University of Agriculture in Nitra Faculty of EngineeringDepartment of Machines and Production Biosystems94976NitraSlovakia VSB-Technical University of Ostrava Faculty of Electrical Engineering and Computer ScienceDepartment of Cybernetics and Biomedical Engineering70800Ostrava-PorubaCzechia

The massive development of internet of things(IoT)technologies is gaining momentum across all areas of their possible deployment—spanning from Industry 4.0 to eHealth,smart city,agriculture or waste *** ongoing development is further pushed forward by the gradual deployment of 5G *** 5G capable smart devices,it will be possible to transfer more data with shorter latency thereby resulting in exciting new use cases such as Massive ***-IoT(low-power wide area network-LPWAN)enables improved network coverage,long device operational lifetime and a high density of *** all the advantages of massive-IoT technology,there are certain cases where the original concept cannot be *** them are dangerous explosive environments or issues caused by subsurface deployment(operation during winter months or dense greenery).This article presents the concept of a hybrid solution of IoT LoRaWAN(long range wide area network)/IRC-VLC(infrared communication,visible light communication)technology,which combines advantages of both technologies according to the deployment scenario.

关键词： IRC/VLC LoRaWAN LPWAN massive IoT smart metering

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The Criterion of Choosing the Proper Seeding Particles

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Journal of Mechanics Engineering and Automation 2012年第12期2卷 754-761页

作者： jan Novotny lukas Manoch Department of Fluid Dynamics and Thermodynamics Faculty of Mechanical Engineering CTU in Prague Prague 160 00 CzechRepublics

This paper is focused on the problem of the ability of seeding particles to follow the flow field. One of the most important factors influencing the resultant accuracy of the measurement is using the proper seeding particles for feeding the flow when measuring by PIV （Particle Image Velocimetry） method. The aim of the paper is to provide comprehensible instruction for choosing the proper type of seeding particles with regard to the flow characteristics and required measurement accuracy. The paper presents two methods with the help of which it is possible to determine the seeding particles＇ ability to follow the flow field. The first method is based on the direct calculation of the phase lag and amplitude ratio between the particle and the fluid. The calculation is based on solution of the BBO （Basset Boussinesq Oseen） equation for spherical particle. The other method results from the calculation of the particle time response, which defines the maximum frequency of disturbances, which are to be followed by the particle. In the conclusion, the method of choosing the seeding particles is proposed, depending on the required measurement accuracy.

关键词： PIV (particle image velocimetry) BBO (Basset Boussinesq Oseen) accuracy seeding particle.

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Unveiling the nanotoxicological aspects of Se nanomaterials differing in size and morphology

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Bioactive Materials 2023年第2期20卷 489-500页

作者： Hana Stepankova Hana Michalkova Zbynek Splichal lukas Richtera Pavel Svec Tomas Vaculovic jan Pribyl Martin Kormunda Simona Rex Vojtech Adam Zbynek Heger Department of Chemistry and Biochemistry Mendel University in BrnoZemedelska 1BrnoCZ-61300Czech Republic Central European Institute of Technology Brno University of TechnologyPurkynova 123BrnoCZ-61200Czech Republic Department of Chemistry Masaryk UniversityKamenice 5BrnoCZ-62500Czech Republic Institute of Laboratory Research on Geomaterials Faculty of Natural SciencesComenius University in BratislavaMlynska dolinaIlkovicova 684215 BratislavaSlovak Republic Central European Institute of Technology Masaryk UniversityKamenice 5BrnoCZ-62500Czech Republic Department of Physics Faculty of ScienceJ.E.Purkyne UniversityPasteurova 1Usti nad LabemCZ-40096Czech Republic

Although the general concept of nanotechnology relies on exploitation of size-dependent properties of nanoscaled materials,the relation between the size/morphology of nanoparticles with their biological activity remains not well ***,we aimed at investigating the biological activity of Se nanoparticles,one of the most promising candidates of nanomaterials for biomedicine,possessing the same crystal structure,but differing in morphology(nanorods *** particles)and aspect ratios(AR,11.5 vs.22.3 vs.1.0)in human cells and BALB/c ***,we report that in case of nanorod-shaped Se nanomaterials,AR is a critical factor describing their cytotoxicity and ***,spherical nanoparticles(AR 1.0)do not fit this statement and exhibit markedly higher cytotoxicity than lower-AR Se *** of cytotoxicity,we also show that morphology and size substantially affect the uptake and intracellular fate of Se *** line with in vitro data,in vivo *** of Se nanomaterials revealed the highest toxicity for higher-AR nanorods followed by spherical nanoparticles and lower-AR ***,we revealed that Se nanomaterials are able to alter intracellular redox homeostasis,and affect the acidic intracellular vesicles and cytoskeletal architecture in a size-and morphology-dependent *** the tested nanoparticles were produced from the similar sources,their behavior differs markedly,since each type is promising for several various application scenarios,and the presented testing protocol could serve as a concept standardizing the biological relevance of the size and morphology of the various types of nanomaterials and nanoparticles.

关键词： Aspect ratio Biocompatibility Nanotoxicology Nanorods

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