Unveiling the nanotoxicological aspects of Se nanomaterials differing in size and morphology

作     者：Hana Stepankova Hana Michalkova Zbynek Splichal Lukas Richtera Pavel Svec Tomas Vaculovic Jan Pribyl Martin Kormunda Simona Rex Vojtech Adam Zbynek Heger 

作者机构：Department of Chemistry and BiochemistryMendel University in BrnoZemedelska 1BrnoCZ-61300Czech Republic Central European Institute of TechnologyBrno University of TechnologyPurkynova 123BrnoCZ-61200Czech Republic Department of ChemistryMasaryk UniversityKamenice 5BrnoCZ-62500Czech Republic Institute of Laboratory Research on GeomaterialsFaculty of Natural SciencesComenius University in BratislavaMlynska dolinaIlkovicova 684215 BratislavaSlovak Republic Central European Institute of TechnologyMasaryk UniversityKamenice 5BrnoCZ-62500Czech Republic Department of PhysicsFaculty of ScienceJ.E.Purkyne UniversityPasteurova 1Usti nad LabemCZ-40096Czech Republic 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2023年第20卷第2期

页      面：489-500页

核心收录：

学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：support from ERDF"Multidisciplinary research to increase application potential of nanomaterials in agricultural practice"(No.CZ.02.1.01/0.0/0.0/16_025/0007314)is gratefully acknowledged We also acknowledge CF Nanobiotechnology(project no.LM2018127)and Research Infrastructure NanoEnviCz(project no.LM2018124)both supported by MEYS CR for perfect assistance with physico-chemical characterization of Se nanomaterials The research was also carried out under the project CEITEC 2020(LQ1601)with financial support from the MEYS CR under the National Sustainability Programme II 

主　　题：Aspect ratio Biocompatibility Nanotoxicology Nanorods 

摘      要：Although the general concept of nanotechnology relies on exploitation of size-dependent properties of nanoscaled materials,the relation between the size/morphology of nanoparticles with their biological activity remains not well ***,we aimed at investigating the biological activity of Se nanoparticles,one of the most promising candidates of nanomaterials for biomedicine,possessing the same crystal structure,but differing in morphology(nanorods *** particles)and aspect ratios(AR,11.5 vs.22.3 vs.1.0)in human cells and BALB/c ***,we report that in case of nanorod-shaped Se nanomaterials,AR is a critical factor describing their cytotoxicity and ***,spherical nanoparticles(AR 1.0)do not fit this statement and exhibit markedly higher cytotoxicity than lower-AR Se *** of cytotoxicity,we also show that morphology and size substantially affect the uptake and intracellular fate of Se *** line with in vitro data,in vivo *** of Se nanomaterials revealed the highest toxicity for higher-AR nanorods followed by spherical nanoparticles and lower-AR ***,we revealed that Se nanomaterials are able to alter intracellular redox homeostasis,and affect the acidic intracellular vesicles and cytoskeletal architecture in a size-and morphology-dependent *** the tested nanoparticles were produced from the similar sources,their behavior differs markedly,since each type is promising for several various application scenarios,and the presented testing protocol could serve as a concept standardizing the biological relevance of the size and morphology of the various types of nanomaterials and nanoparticles.