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Effect of smoking on the risk of gastrointestinal cancer after cholecystectomy: A national population-based cohort study

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2796-2807页

作者： Minseob Kim Kyung-Do han Seung-hyun Ko Yoonkyung Woo jae hyun han Department of Surgery Graduate School of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoul 06978South Korea Division of Endocrinology and Metabolism Department of Internal MedicineSt Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSuwon 16247South Korea Division of Hepatobiliary-Pancreas Surgery and Liver Transplantation Department of SurgerySt Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSuwon 16247South Korea

BACKGROUND The role of smoking in the incidence of colorectal cancer(CRC)or gastric cancer(GC)in populations undergoing cholecystectomy has not been *** To evaluate the effect of smoking on CRC or GC development in cholecystectomy *** A total of 174874 patients who underwent cholecystectomy between January 1,2010 and December 31,2017 were identified using the Korean National Health Insurance Service claims *** patients were matched 1:1 with mem-bers of a healthy population according to age and *** or GC risk after cholecystectomy and the association between smoking and CRC or GC risk in cholecystectomy patients were evaluated using adjusted hazard ratios(HRs)and 95%*** The risks of CRC(adjusted HR:1.15;95%CI:1.06-1.25;P=0.0013)and GC(adjusted HR:1.11;95%CI:1.01-1.22;P=0.0027)were significantly higher in cholecystectomy *** the population who underwent cholecystectomy,both CRC and GC risk were higher in those who had smoked compared to those who had never *** both cancers,the risk tended to increase in the order of non-smokers,ex-smokers,and current *** addition,a positive correlation was observed between the amount of smoking and the risks of both CRC and *** Careful follow-up and screening should be performed,focusing on the increased risk of gastrointestinal cancer in the cholecystectomy group,particularly considering the individual smoking habits.

关键词： Cholecystectomy Smoking,Gastric cancer Colon cancer Risk factor Hazard ratio

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Clinical advantages of single port laparoscopic hepatectomy

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World Journal of Gastroenterology 2018年第3期24卷 379-386页

作者： jae hyun han Young Kyoung You Ho Joong Choi Tae Ho Hong Dong Goo Kim Division of Hepatobiliary-Pancreas Surgery and Liver Transplantation Department of SurgerySeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea

AIM To evaluate the clinical advantages of single-port laparoscopic hepatectomy(SPLH) compare to multiport laparoscopic hepatectomy(MPLH).METHODS We retrospectively reviewed the medical records of 246 patients who underwent laparoscopic liver resection between January 2008 and December 2015 at our hospital. We divided the surgical technique into two groups; SPLH and MPLH. We performed laparoscopic liver resection for both benign and malignant disease. Major hepatectomy such as right and left hepatectomy was also done with sufficient disease-free margin. The operative time, the volume of blood loss, transfusion rate, and the conversion rate to MPLH or open surgery was evaluated. The post-operative parameters included the meal start date after operation, the number of postoperative days spent in the hospital, and surgical complications was also *** Of the 246 patients, 155 patients underwent SPLH and 91 patients underwent MPLH. Conversion rate was 22.6% in SPLH and 19.8% in MPLH(P = 0.358). We performed major hepatectomy, which was defined as resection of more than 2 sections, in 13.5% of patients in the SPLH group and in 13.3% of patients in the MPLH group(P = 0.962). Mean operative timewas 136.9 ± 89.2 min in the SPLH group and 231.2 ± 149.7 min in the MPLH group(P han in the MPLH group(1.63 ± 1.27 d)(P han in the MPLH group(7.82 ± 2.79 d vs 7.97 ± 3.69 d, P = 0.744). The complication rate was not significantly different(P = 0.397) and there was no major perioperative complication or mortality case in both groups. CONCLUS

关键词： Hepatectomy Laparoscopy Minimally invasive surgery Treatment outcome Feasibility study

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Flexible highly-effective energy harvester via crystallographic and computational control of nanointerfacial morphotropic piezoelectric thin film

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Nano Research 2017年第2期10卷 437-455页

作者： Chang Kyu Jeong Sung Beom Cho jae hyun han Dae Yong Park Suyoung Yang Kwi-II Park Jungho Ryu Hoon Sohn Yong-Chae Chung Keon jae Lee Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea KAISTInstitute for the NanoCentury (KINC) 291 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea Division of Materials Science and Engineering Hanyang University 222 Wangsimni-ro Seongdong-gu Seou104763 Republic of Korea Department of Civil and Environmental Engineering KAIST 291 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea Department of Energy Engineering Gyeongnam National University of Science and Technology 33 Dongjin-ro Jinju Gyeongnam 52725 Republic of Korea Functional Ceramic Group Korea Institute of Materials Science (KIMS) 797 Changwon-daero Seongsan-gu Changwon Gyeongnam.51508 Republic of Korea

Controlling the properties of piezoelectric thin films is a key aspect for designing highly efficient flexible electromechanical devices. In this stud）~ the crystallographic phenomena of PbZr1-xTixO3 （PZT） thin films caused by distinguished interfacial effects are deeply investigated by overlooking views, including not only an experimental demonstration but also ab initio modeling. The polymorphic phase balance and crystallinity, as well as the crystal orientation of PZT thin films at the morphotropic phase boundary （MPB）, can be stably modulated using interfacial crystal structures. Here, interactions with MgO stabilize the PZT crystallographic system well and induce the texturing influences, while the PZT film remains quasi-stable on a conventional A1203 wafer. On the basis of this fundamental understanding, a high-output flexible energy harvester is developed using the controlled-PZT system, which shows significantly higher performance than the unmodified PZT generator. The voltage, current, and power densities are improved by 556%, 503%, and 822%, respectively, in comparison with the previous flexional single-crystalline piezoelectric device. Finally, the improved flexible generator is applied to harvest tiny vibrational energy from a real traffic system, and it is used to operate a commercial electronic unit. These results clearly indicate that atomic-scale designs can produce significant impacts on macroscopic applications.

关键词： energy harvesting morphotropic phaseboundary (MPB) piezoelectric first-principles calculation lead zirconium titanate(PZT)

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Clinical outcome in patients with hepatocellular carcinoma after living-donor liver transplantation

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World Journal of Gastroenterology 2013年第29期19卷 4737-4744页

作者： Ho Joong Choi Dong Goo Kim Gun hyung Na jae hyun han Tae Ho Hong Young Kyoung You Hepatobiliary-Pancreas Surgery and Liver Transplantation Division Department of Surgery Seoul St. Mary's Hospital The Catholic University of Korea Seoul 137-701 South Korea

AIM: To investigate risk factors for hepatocellular carcinoma (HCC) recurrence after living donor liver transplantation (LDLT) and efficacy of various criteria. METHODS: From October 2000 to November 2011, 233 adult patients underwent LDLT for HCC at our institution. After excluding nine postoperative mortality cases, we analyzed retrospectively 224 patients. To identify risk factors for recurrence, we evaluated recurrence, disease-free survival (DFS) rate, survival rate, and various other factors which are based on the characteristics of both the patient and tumor. Additionally, we developed our own criteria based on our data. Next, we compared our selection criteria with various tumor-grading scales, such as the Milan criteria, University of California, San Francisco (UCSF) criteria, TNM stage, Barcelona Clinic Liver Cancer (BCLC) stage and Cancer of the Liver Italian Program (CLIP) scoring system. The median follow up was 68 (6-139) ***: In 224 patients who received LDLT for HCC, 37 (16.5%) experienced tumor recurrence during the follow-up period. The 5-year DFS and overall survival rates after LDLT in all patients with HCC were 80.9% and 76.4%, respectively. On multivariate analysis, the tumor diameter {5 cm; P < 0.001; exponentiation of the B coefficient [Exp(B)], 11.89; 95%CI: 3.784-37.368} and alpha fetoprotein level [AFP, 100 ng/mL; P = 0.021; Exp(B), 2.892; 95%CI: 1.172-7.132] had significant influences on HCC recurrence after LDLT. Therefore, these two factors were included in our criteria. Based on these data, we set our selection criteria as a tumor diameter ≤ 5 cm and AFP ≤ 100 ng/mL. Within our new criteria (140/214, 65.4%), the 5-year DFS and overall survival rates were 88.6% and 81.8%, respectively. Our criteria (P = 0.001), Milan criteria (P = 0.009), and UCSF criteria (P = 0.001) showed a significant difference in DFS rate. And our criteria (P = 0.006) and UCSF criteria (P = 0.009) showed a significant difference in overall survival rate. Bu

关键词： Hepatocellular carcinoma Living donor liver transplantation Selection criteria Milan criteria University of California, San Francisco criteria Barcelona Clinic Liver Cancer Cancer of the Liver Italian Program

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The beneficial impacts of splanchnic vasoactive agents on hepatic functional recovery in massive hepatectomy porcine model

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 325-336页

作者： Hye-Sung Jo jae hyun han Yoon Young Choi Jin-I Seok Young-In Yoon Dong-Sik Kim Division of HBP Surgery and Liver Transplantation Department of SurgeryKorea University College of MedicineSeoulRepublic of Korea Department of Surgery St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSeoulRepublic of Korea Department of Biomedical Science Korea University College of Medicine Graduate SchoolSeoulRepublic of Korea Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryAsan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea

Background:Excessive portal pressure after massive hepatectomy can cause hepatic sinusoidal injury and have deleterious impacts on hepatic functional recovery,contributing to developing post-hepatectomy liver *** study aimed to assess the effects of splanchnic vasoactive agents on hepatic functional recovery and regeneration while clarifying the underlying mechanism,using a 70%hepatectomy porcine ***:Eighteen pigs undergoing 70%hepatectomy were involved in this study and divided into three groups:control(n=6),terlipressin(n=6),and octreotide(n=6).Terlipressin(0.5 mg)and octreotide(0.2 mg)were administered 3 times a day for each group with the first dose starting just before surgery until the 7th postoperative day,at which time the surviving pigs were *** the period,portal pressure,liver weight,biochemical analysis,histological injury score,and molecular markers were evaluated and compared between ***:The 7-day survival rates in the octreotide,terlipressin,and control groups were 100%,83.3%,and 66.7%,*** portal pressures decreased in both terlipressin and octreotide groups than the control group at 30 minutes,1 hour and 6 hours after *** amount of regeneration measured by liver weight to body weight ratio at the time of sacrifice in the terlipressin group was smaller than that in the control group(117%vs.129%,P=0.03).Serum aspartate aminotransferase(AST)and total bilirubin levels at 1 and 6 hours after hepatectomy and prothrombin time/international normalized ratio(PT/INR)at 6 hours after hepatectomy were significantly improved in the terlipressin and octreotide groups compared to the control *** endothelin-1(ET-1)was significantly lower in the terlipressin group than that in the control group 6 hours after hepatectomy(Phan that in the terlipressin group on the 7th postoperative day(P<0.01).Conclusions:Splanc

关键词： Hepatectomy portal pressure terlipressin somatostatin

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Inflammatory markers as selection criteria of hepatocellular carcinoma in living-donor liver transplantation

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World Journal of Gastroenterology 2014年第21期20卷 6594-6601页

作者： Gun hyung Na Dong Goo Kim jae hyun han Eun Young Kim Soo Ho Lee Tae Ho Hong Young Kyoung You Department of Surgery Seoul St. Mary’s HospitalThe Catholic University of KoreaSeoul 137-701South Korea

AIM: To investigate that inflammatory markers can predict accurately the prognosis of hepatocelluar carcinoma (HCC) patients in living-donor liver transplantation (LDLT).

关键词： C-reactive protein Hepatocellular carcinoma Liver transplantation Neutrophil-lymphocyte ratio Selection criteria

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Evaluation of prognostic factors on recurrence after curative resections for hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第45期20卷 17132-17140页

作者： jae hyun han Dong Goo Kim Gun hyung Na Eun Young Kim Soo Ho Lee Tae Ho Hong Young Kyoung You Department of Surgery The Catholic University of Korea Seoul St.Mary’s Hospital

AIM: To select appropriate patients before surgical resection for hepatocellular carcinoma (HCC), especially those with advanced tumors.

关键词： Carcinoma Hepatocellular Hepatectomy Prognostic factor Survival Recurrence

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Adenosine triphosphate-binding pocket inhibitor for mixed lineage kinase domain-like protein attenuated alcoholic liver disease via necroptosis-independent pathway

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World Journal of Gastroenterology 2025年第6期31卷 44-61页

作者： han-Ning Xuan Yuan hyun Sung Kim Gye Ryeol Park jae Eun Ryu Ji Eun Kim In Young Kang Hye Young Kim Seung Min Lee Ju Hee Oh Eileen L Yoon Dae Won Jun Department of Internal Medicine Hanyang University School of MedicineSeoul 04763South Korea Department of Pathology Hanyang University School of MedicineSeoul 04763South Korea Department of Translational Medicine Graduate School of Biomedical Science and EngineeringHanyang UniversitySeoul 04763South Korea Department of Obstetrics and Gynecology Institute of Women’s Medical Life ScienceYonsei Cancer CenterSeverance HospitalYonsei University College of MedicineSeoul 04763South Korea Department of Internal Medicine Sanggye Paik HospitalInje University College of MedicineSeoul 01757South Korea

BACKGROUND Mixed lineage kinase domain-like protein(MLKL)serves as a critical mediator in necroptosis,a form of regulated cell death linked to various liver *** study aims to specifically investigate the role of MLKL’s adenosine triphosphate(ATP)-binding pocket in facilitating necroptosis-independent pathways that may contribute to liver disease *** focusing on this mechanism,we seek to identify potential therapeutic targets that can modulate MLKL activity,offering new strategies for the prevention and treatment of liver-related *** To investigate the possibility of using the ATP-binding pocket-associated,necro-ptosis-independent MLKL pathway as a target for liver *** Cell death following necroptosis stimuli was evaluated using cell proliferation assays,flow cytometry,and electron microscopy in various *** human liver organoid system was used to evaluate whether the MLKL ATP pocket-binding inhibitor could attenuate ***,alcoholic and non-alcoholic fatty liver diseases animal models were used to determine whether MLKL ATP pocket inhibitors could attenuate liver *** While an MLKL ATP pocket-binding inhibitor did not prevent necroptosis-induced cell death in RAW 264.7 cells,it did reduce the necroptosis-led expression of CXCL2,ICAM,and ***,MLKL ATP pocket inhibitor diminishes the expression of CXCL2,ICAM,and VCAM by inhibiting the IκB kinase and nuclear factor kappa-B pathways without inducing necroptosis-induced cell death in two-dimensional cell culture as well as the human-derived liver organoid *** MLKL ATP-binding inhibitor was ineffective in non-alcoholic fatty liver disease animal models,MLKL ATP-binding inhibitor attenuated hepatic inflammation in the alcoholic liver disease *** MLKL ATP pocket-binding inhibitor exerted anti-inflammatory effects through the necroptosis-independent MLKL pathway in an animal model of alcoholic liver disease.

关键词： RAW 264.7 cell Cell death Necroptosis Mixed lineage kinase domain-like protein Non-alcoholic fatty liver disease Mixed lineage kinase domain-like protein adenosine triphosphate binding inhibitor Alcoholic liver disease

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Increased risk of colorectal cancer in young males with higher cardiovascular risk:A nationwide population-based cohort study

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 69-80页

作者： Ji hyun Song Su-Yeon Choi Young Sun Kim Sun Young Yang Kyung-Do han Internal Medicine and Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam CenterSeoul 06236South Korea Internal Medicine Seoul National University HospitalSeoul National University College of MedicineSeoul 06236South Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoul 06978South Korea

BACKGROUND Although the link between cardiovascular disease(CVD)and various cancers is well-established,the relationship between CVD risk and colorectal cancer(CRC)remains *** To elucidate the relationship between CVD risk scores and CRC *** In this population-based cohort study,participants from the 2009 National Health Checkup were followed-up until *** cardiovascular(CV)risk score was calculated as the sum of risk factors(age,family history of coronary artery disease,hypertension,smoking status,and high-density lipoprotein levels)with high-density lipoprotein(≥60 mg/dL)reducing the risk score by *** primary outcome was incidence of newly diagnosed *** Among 2526628 individuals,30329 developed CRC during a mean follow-up of 10.1 *** by CV risk scores(0,1,2,and≥3).CRC risk increased with higher CV risk scores after adjusting for covariates[(hazard ratio=1.155,95%confidence interval:1.107-1.205)in risk score≥3,P<0.001].This association individuals not using ***,even in participants without diabetes,a higher CV risk was associated with an increased CRC *** Increased CV risk scores were significantly associated with higher CRC risk,especially among males,younger populations,and non-statin ***,males with a higher CV risk score,even at a younger age,are recommended to control their risk factors and undergo individualized CRC screening.

关键词： Colorectal cancer Cardiovascular disease Cohort study Age Gender

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Primordial germ cell-mediated transgenesis and genome editing in birds

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Journal of Animal Science and Biotechnology 2018年第2期9卷 257-267页

作者： jae Yong han Young hyun Park Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences College of Agriculture and Life Sciences Seoul National University Institute for Biomedical Sciences Shinshu University

Transgenesis and genome editing in birds are based on a unique germline transmission system using primordial germ cells(PGCs), which is quite different from the mammalian transgenic and genome editing system. PGCs are progenitor cells of gametes that can deliver genetic information to the next generation. Since avian PGCs were first discovered in nineteenth century, there have been numerous efforts to reveal their origin, specification, and unique migration pattern, and to improve germline transmission efficiency. Recent advances in the isolation and in vitro culture of avian PGCs with genetic manipulation and genome editing tools enable the development of valuable avian models that were unavailable before. However, many challenges remain in the production of transgenic and genome-edited birds,including the precise control of germline transmission, introduction of exogenous genes, and genome editing in ***, establishing reliable germline-competent PGCs and applying precise genome editing systems are critical current issues in the production of avian models. Here, we introduce a historical overview of avian PGCs and their application, including improved techniques and methodologies in the production of transgenic and genome-edited birds, and we discuss the future potential applications of transgenic and genome-edited birds to provide opportunities and benefits for humans.

关键词： Avian Genome editing Primordial germ cell Transgenesis

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