The beneficial impacts of splanchnic vasoactive agents on hepatic functional recovery in massive hepatectomy porcine model

作     者：Hye-Sung Jo Jae Hyun Han Yoon Young Choi Jin-I Seok Young-In Yoon Dong-Sik Kim 

作者机构：Division of HBP Surgery and Liver TransplantationDepartment of SurgeryKorea University College of MedicineSeoulRepublic of Korea Department of SurgerySt.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSeoulRepublic of Korea Department of Biomedical ScienceKorea University College of Medicine Graduate SchoolSeoulRepublic of Korea Division of Hepatobiliary Surgery and Liver TransplantationDepartment of SurgeryAsan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea 

出 版 物：《Hepatobiliary Surgery and Nutrition》 (肝胆外科与营养（英文）)

年 卷 期：2021年第10卷第3期

页      面：325-336页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This investigation was supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT Ministry of Education Science and Technology)(No.NRF-2017R1A2B2005754) 

主　　题：Hepatectomy portal pressure terlipressin somatostatin 

摘      要：Background:Excessive portal pressure after massive hepatectomy can cause hepatic sinusoidal injury and have deleterious impacts on hepatic functional recovery,contributing to developing post-hepatectomy liver *** study aimed to assess the effects of splanchnic vasoactive agents on hepatic functional recovery and regeneration while clarifying the underlying mechanism,using a 70%hepatectomy porcine ***:Eighteen pigs undergoing 70%hepatectomy were involved in this study and divided into three groups:control(n=6),terlipressin(n=6),and octreotide(n=6).Terlipressin(0.5 mg)and octreotide(0.2 mg)were administered 3 times a day for each group with the first dose starting just before surgery until the 7th postoperative day,at which time the surviving pigs were *** the period,portal pressure,liver weight,biochemical analysis,histological injury score,and molecular markers were evaluated and compared between ***:The 7-day survival rates in the octreotide,terlipressin,and control groups were 100%,83.3%,and 66.7%,*** portal pressures decreased in both terlipressin and octreotide groups than the control group at 30 minutes,1 hour and 6 hours after *** amount of regeneration measured by liver weight to body weight ratio at the time of sacrifice in the terlipressin group was smaller than that in the control group(117%vs.129%,P=0.03).Serum aspartate aminotransferase(AST)and total bilirubin levels at 1 and 6 hours after hepatectomy and prothrombin time/international normalized ratio(PT/INR)at 6 hours after hepatectomy were significantly improved in the terlipressin and octreotide groups compared to the control *** endothelin-1(ET-1)was significantly lower in the terlipressin group than that in the control group 6 hours after hepatectomy(P0.01).The histological injury score in the control group was significantly higher than that in the terlipressin group on the 7th postoperative day(P0.01).Conclusions:Splanc