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Focus on personal finance : an active approach to help you develop successful financial skills / jack R. Kapoor, Les R. Diabay, robert j. Hughes.

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Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets

丛书名： The McGraw-Hill/Irwin series in finance, insurance, and real estate

2006年

作者： jack R. Kapoor Les R. Diabay robert j. Hughes.

Includes index.

ISBN: (数字)0072992395

ISBN: (纸本)0072992395

Includes index.

关键词： Finance Personal.

来源：畅想之星图书光盘版（南... 畅想之星图书光盘版（南... 评论

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World journal of Gastroenterology 2013年第31期19卷 5094-5102页

作者： Sheila K jacobi Adam j Moeser Anthony T Blikslager j Marc Rhoads Benjamin A Corl robert j Harrell jack Odle Laboratory of Developmental Nutrition College of Agriculture and Life Sciences North Carolina State University Raleigh NC 27695United States College of Veterinary Medicine North Carolina State University Raleigh NC 27695United States Department of Pediatrics University of Texas Health Science Center at Houston Medical School Houston TX 77030 United States Department of Dairy Science Virginia Poly-technic Institute and State University Blacksburg VA 24061United States

AIM: To investigate the effect of protein-energy malnutrition on intestinal barrier function during rotavirus enteritis in a piglet ***: Newborn piglets were allotted at day 4 of age to the following treatments:(1) full-strength formula(FSF)/noninfected;(2) FSF/rotavirus infected;(3) half-strength formula(HSF)/noninfected;or(4) HSF/rotavirus *** one day of adjustment to the feeding rates,pigs were infected with rotavirus and acute effects on growth and diarrhea were monitored for 3 d and jejunal samples were collected for Ussingchamber ***: Piglets that were malnourished or infected had lower body weights on days 2 and 3 post-infection(P junction protein,occludin,in the cell membrane and increased localization in the ***: Overall,malnutrition had no additive effects to rotavirus infection on intestinal barrier function at day 3 post-infection in a neonatal piglet model.

关键词： Rotavirus gastroenteritis Kwashiorkor Occludin Ussing chamber Villus

Distal small bowel motility and lipid absorption in patients following abdominal aortic aneurysm repair surgery

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World journal of Gastroenterology 2006年第4期12卷 582-587页

作者： robert j Fraser Marc Ritz Addolorata C Di Matteo Rosalie Vozzo Monika Kwiatek robert Foreman Brendan Stanley jack Walsh jim Burnett Paul jury john Dent Department of Medicine University of AdelaideSouth Australia Department of Gastroenterology Royal Adelaide HospitalAdelaide South Australia Vascular Unit Royal Adelaide Hospital AdelaideSouth Australia Gastrointestinal Investigation Unit Repatriation General Hospital Daw Park South Australia Vascular Unit Repatriation General Hospital Daw Park SouthAustralia

AIM： To investigate distal small bowel motility and lipid absorption in patients following elective abdominal aortic aneurysm （AAA） repair surgery, METHODS： Nine patients （aged 35-78 years; body mass index （BMI） range： 23-36 kg/m2） post-surgery for AAA repair, and seven healthy control subjects （20-50 years; BMI range： 21-29 kg/m^2） were studied, Continuous distal small bowel manometry was performed for up to 72 h, during periods of fasting and enteral feeding （Nutrison）. Recordings were analyzed for the frequency, odgin, length of migration, and direction of small intestinal burst activity. Lipid absorption was assessed on the first day and the third day post surgery in a subset of patients using the ^13C-triolein-breath test, and compared with healthy controls. Subjects received a 20-min intraduodenal infusion of 50 mL liquid feed mixed with 200μL ^13C-triolein. End-expiratory breath samples were collected for 6 h and analyzed for ^13CO2 concentration. RESULTS： The frequency of burst activity in the proximal and distal small intestine was higher in patients than in healthy subjects, under both fasting and fed conditions （P〈 0.005）. In patients there was a higher proportion of abnormally propagated bursts （71% abnormal）, which began to normalize by d 3 （25% abnormal） *** absorption data was available for seven patients on d 1 and four patients on d 3 post surgery. In patients, absorption on d 1 post-surgery was half that of healthy control subjects （AUC ^13CO2 1323±244 vs 2646±365; P〈0.05, respectively）, and was reduced to the one-fitch that of healthy controls by d 3 （AUC ^13CO2 470±832 vs 2646±365; P〈 0.05, respectively）. CONCLUSION： Both proximal and distal small intestinal motor activity are transiently disrupted in critically ill patients immediately after major surgery, with abnormal motility patterns extending as far as the ileum. These motor disturbances may contribute to impaired absorption of enteral nutrition, especially when intralumi

关键词： Critical illness Small intestine Motility Lipid absorption

Geant4 applications for modeling molecular transport in complex vacuum geometries

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International journal of Modeling, Simulation, and Scientific Computing 2014年第2期5卷 53-64页

作者： jack Singal j.Brian Langton Rafe Schindler Department of Physics University of Richmond Gottwald Center for the Sciences 28 Westhampton DriveRichmondVA 23173 Kavli Institute for Particle Astrophysics and Cosmology SLAC National Accelerator Laboratory and Stanford University Menlo Park CA 94025

We discuss a novel use of the Geant4 simulation toolkit to model molecular transport in a vacuum environment,in the molecular flow *** Geant4 toolkit was originally developed by the high energy physics community to simulate the interactions of elemen-tary particles within complex detector *** its capabilities are utilized to model molecular vacuum transport in geometries where other techniques are *** techniques are verified with an application representing a simple vacuum geometry that has been studied previously both analytically and by basic Monte Carlo *** discuss the use of an application with a very complicated geometry,that of the Large Synoptic Survey Telescope camera cryostat,to determine probabilities of transport of contaminant molecules to optical surfaces where control of contamination is crucial.

关键词： Gas flow dynamics Monte Carlo methods vacuum systems pumping sys-tems contamination sources

The globalization of messenger RNA regulation

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National Science Review 2014年第2期1卷 184-186页

作者： jack D.Keene Department of Molecular Genetics & Microbiology Duke University Medical Center

Transcriptional regulation has been a dominant area of research in gene expression for more than 50 ***,the past 20 years of research in biology brought new focus on posttranscriptional events,namely RNA *** emphasis on understanding the regulatory functions of RNAs emerged with the identiication of cis-and trans-regulatory regions in

关键词： The globalization of messenger RNA regulation RNA

Influence of birth order, birth weight, colostrum and serum immunoglobulin G on neonatal piglet survival

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journal of Animal Science and Biotechnology 2013年第2期4卷 128-136页

作者： Rafael A Cabrera Xi Lin joy M Campbell Adam j Moeser jack Odle Laboratory of Developmental Nutrition Department of Animal Science North Carolina State University Huvepharma USA Inc. 525 West Park Drive Suite 230 Peachtree City American Protein Corporation Department of Population Health and Pathobiology College of Veterinary Medicine North Carolina State University 101 Polk Hall North Carolina State University

Background： Intake of colostrum after birth is essential to stimulate intestinal growth and function, and to provide systemic immunological protection via absorption of Immunoglobulin G （IgG）. The birth order and weight of 745 piglets （from 75 litters） were recorded during a one-week period of farrowing. Only pigs weighing greater than 0.68 kg birth weight were chosen for the trial. Sow colostrum was collected during parturition, and piglets were bled between 48 and 72 hours post-birth. Piglet serum IgG and colostral IgG concentrations were determined by radial immunodiffusion. Results： Sow parity had a significant （P 〈 0.001） effect on sow colostral IgG concentration, being 5% higher in multiparous females. Sow colostral IgG concentration explained 6% and piglet birth order accounted for another 4% of the variation observed in piglet serum IgG concentration （P 〈 0.05）; however, birth weight had no detectable effect. Piglet serum IgG concentration had both a linear （P 〈 0.05） and quadratic effect （P 〈 0.05） on % survival. Piglets with 1,000 mg/dl serum IgG or less （n=24） had a 67% survival; whereas, piglets with IgG concentrations between 2250 to 2500 mg/dl （n=247） had a 91% survival. Birth order had no detectable effect on survival, but birth weight had a positive linear effect （P 〈 0.05）. Piglets weighing 0.9 kg （n = 107） at birth had a 68% survival rate, and those weighing 1.6 kg （n = 158） had an 89% survival. Conclusion： We found that the combination of sow colostrum IgG concentration and birth order can account for 10% of the variation of piglet serum IgG concentration and that piglets with less than 1,000 mg/dl IgG serum concentration and weight of 0.9 kg at birth had low survival rate when compared to their larger siblings. The effective management of colostrum uptake in neonatal piglets in the first 24 hrs post-birth may potentially improve survival from birth to weaning.

关键词： Birth order Birth weight Immunoglobulin G Colostrum Survivability

Immunotherapy as maintenance treatment in metastatic triple negative breast cancer

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journal of Cancer Metastasis and Treatment 2021年第1期7卷 315-322页

作者： Tira j.Tan jack j.Chan Rebecca A.Dent Division of Medical Oncology National Cancer CentreSingapore 169610Singapore.

Metastatic triple negative breast cancer(mTNBC)is an aggressive disease associated with a poor prognosis as compared to other subtypes of breast *** advances have been made in recent years with new approvals for PARP inhibitors for those patients who harbor germline BRCA mutations and immune checkpoint inhibitors for patients with programmed death ligand-1(PD-L1)expressing *** therapies are associated with favorable toxicity profiles and improved health-related quality of life when compared with *** therapy,now recognized as the mainstay for patients with ovarian malignancies,takes advantage of the benefit of low-intensity therapies to suppress a disease over a prolonged period of time following maximal response to induction *** strategy has been little explored in the treatment of ***,we briefly discuss the evidence to date lending credence to this treatment paradigm and examine the potential role of immunotherapy as maintenance in the management of mTNBC.

关键词： Triple negative breast cancer maintenance therapy immunotherapy PARP inhibitor

Problems on Graphs with Fixed Smallest Eigenvalue

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Algebra Colloquium 2020年第1期27卷 51-54页

作者： jack Koolen Qianqian Yang Wen-Tsun Wu Key Laboratory of CAS School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026China School of Mathematical Sciences University of Science and Technology of China Hefei 230026China

In this note we give several problems and conjectures on graphs with fixed smallest eigenvalue.

关键词： 5-integrability lattice graph

Physics-based,data-driven approach for predicting natural ventilation of residential high-rise buildings

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Building Simulation 2022年第1期15卷 129-148页

作者： Vincent j.L.Gan Boyu Wang C.M.Chan A.U.Weerasuriya jack C.P.Cheng Department of Building School of Design and EnvironmentNational University of SingaporeSingapore117566 Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong Kong999077China

Natural ventilation is particularly important for residential high-rise buildings as it maintains indoor human comfort without incurring the energy demands that air-conditioning *** improve a building’s natural ventilation,it is essential to develop models to understand the relationship between wind flow characteristics and the building's *** more effort is still needed for developing such reliable,accurate,and computationally economical models instead of currently the most popular physics-based models such as computational fluid dynamics(CFD)*** paper,therefore,presents a novel model developed based on physics-based modelling and a data-driven approach to evaluate natural ventilation in residential high-rise *** model first uses CFD to simulate wind pressures on the exterior surfaces of a high-rise *** the surface pressures have been obtained,multizone modelling is used to predict the air change per hour(ACH)for different flats in various ***-driven prediction models are then developed using data from the simulation and deep neural networks that are based on mean absolute error,mean absolute percentage error,and a fusion algorithm *** data-driven models are used to predict the ACH of 25 *** results from multizone modelling and data-driven modelling are *** results imply a high accuracy of the data-driven prediction in comparison with physics-based *** fusion algorithm-based neural network performs best,achieving 96%accuracy,which is the highest of all models *** study contributes a more efficient and robust method for predicting wind-induced natural *** findings describe the relationship between building design(e.g.,plan layout),distribution of surface pressure,and the resulting ACH,which serve to improve the practical design of sustainable buildings.

关键词： computational fluid dynamics data-driven prediction machine learning multizone model natural ventilation residential building