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Differences in oxidative stress dependence between gastric adenocarcinoma subtypes

World Journal of Gastroenterology 2006年第7期12卷 1005-1012页

作者： Brigitte Bancel jacauesestève Jean-Christophe Souquet Shinya Toyokuni Hiroshi Ohshima Brigitte Pignatelli Hospital de la Croix-Rousse Department of PathologyLyonFrance Centre Hospital de la Croix-Rousse Department of GastroenterologyLyonFrance Department of Pathology and Biology of Diseases Graduate School of MedicineKyoto UniversityKyotoJapan Brigitte Pignatelli International Agency for Research on Cancer.Endogenous Risk Factors GroupLyon.France Clinical Epidemiology Unit Department of Medical InformationHospices Civils de LyonFrance

AIM： To investigate the extent of oxidative stress in preneoplastic and neoplastic gastric mucosa in relation to their pathological criteria and histological subtypes. METHODS： A total of 104 gastric adenocarcinomas from 98 patients （88 infiltrative and 16 intraepithelial tumors） were assessed immunohistochemically for expression of iNOS and occurrence of nitrotyrosine （NTYR）-containing proteins and 8-hydroxy-2＇-deoxyguanosine （8-OH- dG）-containing DNA, as markers of NO production and damages to protein and DNA. RESULTS： Tumor cells staining for iNOS, NTYR and 8-OH-dG were detected in 41%, 62% and 50% of infiltrative carcinoma, respectively. The three markers were shown for the first time in intraepithelial carcinoma. The expression of iNOS was significantly more frequent in tubular carcinoma （TC） compared to diffuse carcinoma （DC）（54% vs 18%; P=0.008） or in polymorphous carcinoma （PolyC）（54% vs 21% ; P=0.04）. NTYR staining was obviously more often found in TC than that in PolyC （72% vs 30% ; P=0.03）. There was a tendency towards a higher rate of iNOS staining when distant metastasis （pM） was present. In infiltrative TC, the presence of oxidative stress markers was not significantly correlated with histological grade, density of inflammation, the depth of infiltration （pT）, lymph nodes dissemination （pN） and pathological stages （pTNM）.CONCLUSION： The iNOS-oxidative pathway may play an important role in TC, but moderately in PolyC and DC. DNA oxidation and protein nitration occur in the three subtypes. Based on the significant differences of NTYR levels, TC and PolyC appear as two distinct subtypes.

关键词： Gastric neoplasms Nitric oxide synthase Hpylori Nitrotyrosine 8-hydroxydeoxyguanosine Oxidative stress

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论悖论的本质与逻辑

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自然辩证法通讯 2024年第6期46卷 28-38页

作者：王小塞北京大学外国哲学研究所北京100871 北京大学哲学系北京100871

本文提出一个关于悖论的新理论,根据这一理论,悖论即是某种超出信念的东西。我们将通过大量的案例表明这一理论如何避免以往理论(包括蒯因和索伦森的理论)面对的问题,它能够回应过度包容性的反驳,并提供对于悖论对象的本质与逻辑、发现... 详细信息

本文提出一个关于悖论的新理论,根据这一理论,悖论即是某种超出信念的东西。我们将通过大量的案例表明这一理论如何避免以往理论(包括蒯因和索伦森的理论)面对的问题,它能够回应过度包容性的反驳,并提供对于悖论对象的本质与逻辑、发现悖论性事物的认知价值的进一步分析。

关键词：基于论证的悖论理论基于集合的悖论理论信念主体性一般性

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Rare etiology of colonic intussusception involving an adult with emphysematous cystic enteropathy:A case report and review of literature

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World Journal of Clinical Cases 2024年第17期12卷 3161-3167页

作者： Eric Bergeron Maude Pichette Geneviève Boisvert Thibaut Manière Étienne Désilets Department of Surgery Charles LeMoyne HospitalGreenfield Park J4V 2H1QuebecCanada Department of Medical Imaging Charles LeMoyne HospitalGreenfield Park J4V 2H1QuebecCanada Department of Gastroenterology Charles LeMoyne HospitalGreenfield Park J4V 2H1QuebecCanada

BACKGROUND Pneumatosis cystoides intestinalis(PCI),characterized by a collection of gas-filled cysts in the intestinal wall,is an uncommon but well-known condition in *** pain is the most frequent symptom associated with *** represents a potential cause of recurrent abdominal pain or emergency ***,the occurrence of colonic intussusception secondary to PCI is very unusual in *** SUMMARY A 52-year-old male,known with idiopathic PCI,presented seventeen months after initial diagnosis with a new right upper quadrant pain.A computed tomographyscan demonstrated a colonic intussusception at the hepatic *** did not progress compared with initial *** patient underwent an emergency right *** Resection was recommended in this case because PCI proved to be persisting with no identified curable *** allowed to address the underlying pathology,the potential relapse of intussusception,and the likely cause of recurrent abdominal pain,either invagination or PCI itself.

关键词： Pneumatosis cystoides intestinalis Colonic intussusception Colonic obstruction Colonoscopy Case report

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ω-3 Rich Tetracarpidum conophorum Oil Exhibits Better Prevention Effects for Cardiovascular Risk Factors than Corn Oil in Adult of Albinos Wistar Male Rats

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Food and Nutrition Sciences 2024年第8期15卷 663-680页

作者： Nzali Horliane Ghomdim Kenfack Laurette Blandine Mezajoug Eric Serge Ngangoum Stève Djiazet Clergé Tchiegang Bioprocess Laboratory Department of Food Process and Quality Control University Institute of Technology University of Ngaoundere Adamaoua Cameroon School of Agriculture and Natural Resources Catholic University Institute of Buea Buea Cameroon Department of Food Sciences and Nutrition National Advanced School of Agro-Industrial Sciences (ENSAI) University of Ngaoundere Ngaoundere Cameroon

Cardiovascular diseases are serious pathologies that affect an increasing number of people. Several preventive measures are generally used, including supplementing of oils in foods. Our objective was to compare the effects of Tetracarpidum conophorum oil (TC) and corn oil (CO) on serum lipid profiles of normal male rats. 42 Wistar rats were divided into 7 groups. Diets included TC oil (groups TC5, TC10 and TC20) and corn oil (groups CO5, CO10 and CO20) in proportions of 5%, 10% and 20%, with a control group (T). After 5 weeks of feeding, several parameters were measured during and after the study, including body weight, food intake and organ weights (kidney, liver and fat). Lipid profiles (total cholesterol, TG, HDL and LDL), glucose and protein levels were measured in the serum. The increase in body mass was inversely proportional to the amount of oil in the food. The decrease in body mass and adiposomatic index of group TC10 was significant (p ved in the groups supplemented with TC and corn oils compared to controls. Results were also more beneficial for the TC10 group. HDL-cholesterol levels were significantly higher (p vent or alleviate cardiovascular diseases and glycemia.

关键词： Tetracarpidium conophorum Oil ω-3 Corn Oil Lipid Profiles Glycemia

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含二硫化硒洗发水对中-重度头皮脂溢性皮炎外用糖皮质激素/水杨酸治疗后的疗效维持作用

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中华皮肤科杂志 2024年第5期57卷 483-484页

作者： Philippe Massiot Pascal Reygagne Corinne Chagnoleau Leila Kanoun-Copy Florence Pouradier Geneviève Loussouarn Catherine Queille-Roussel Hussein Jouni Delphine Kerob L'Oréal Research and Innovation Saint-Ouen France. Centre Sabouraud Hôpital Saint-Louis 1 avenue Claude-Vellefaux 75010 Paris France. CPCAD Hôpital l'Archet Nice France. L'Oréal Research and Innovation Aulnay-sous-Bois France. Cosmetic Active International Levallois-Perret France.

脂溢性皮炎是一种慢性炎症性皮肤病,好发于头皮、面部和躯干等皮脂腺分布丰富的部位。头皮脂溢性皮炎主要表现为红斑和片状鳞屑,程度从轻度鳞屑到弥漫性大片黏着性鳞屑不等,伴有明显的瘙痒,并容易反复发作。目前认为脂溢性皮炎的发生与... 详细信息

脂溢性皮炎是一种慢性炎症性皮肤病,好发于头皮、面部和躯干等皮脂腺分布丰富的部位。头皮脂溢性皮炎主要表现为红斑和片状鳞屑,程度从轻度鳞屑到弥漫性大片黏着性鳞屑不等,伴有明显的瘙痒,并容易反复发作。目前认为脂溢性皮炎的发生与亲脂性马拉色菌定植增加以及遗传、环境和全身健康状况等因素相关,上述因素共同导致皮脂腺代谢活动异常、皮脂成分改变、表皮屏障功能障碍,最终加重炎症反应。

关键词：头皮脂溢性皮炎二硫化硒洗发水亲脂性炎症反应马拉色菌皮脂腺黏着性

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BIERMER’s Disease: About 4 Cases Diagnosed at Regional University Hospital of Ouahigouya (Chur/Ohg) and Literature Review

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Open Journal of Gastroenterology 2024年第9期14卷 322-329页

作者： Zanga Damien Ouattara Stève Léonce Zoungrana Saïdou Santi Emeline Agathe Carama Fabien Dembele Bafima Désiré Diarra Alain Bougouma Department of Gastroenteroly Ouahigouya Regional University Hospital Ouahigouya Burkina Faso Department of Neurology Bogodogo University Hospital Ouagadougou Burkina Faso Department of Gastroenterology Yalgado Oudraogo University Hospital Center Ouagadougou Burkina Faso

Megaloblastic pernicious anemia is an autoimmune disorder, considered rare in African context. The objective of this study was to report four clinical cases collected at the CHUR/OHG, and to review the literature. The study population consisted of two men and two women. The clinical manifestations were mainly neurological and hematological. The neurological signs were mainly paresthesia. One patient presented memory problems. On the biological level, macrocytic anemia and vitamin B12 deficiency were reported in two cases prior to treatment while the other two without serological assay of vitamin B12 were put on trial treatment. Anti-intrinsic factor antibodies were positive in three patients. The Schilling test was not used. Upper gastrointestinal endoscopy revealed atrophic fundic gastritis in all four patients who received treatment through intramuscular injection of hydroxocobalamin (vitamin B12). The evolution was favorable after one month of treatment in all cases. The literature review is dominated by clinical case reports, the largest cohorts of which are from the Maghreb.

关键词： Anemia Pernicious Megaloblastic Vitamin B12

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Nurses’perceptions about neonatal intensive care units providing family-centered care are associated with skin-to-skin contact implementation

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Pediatric Investigation 2024年第1期8卷 61-65页

作者： Marilyn Aita Gwenaëlle De Clifford-Faugère Geneviève Laporte Sébastien Colson Nancy Feeley Faculty of Nursing Universitéde MontréalMontrealCanada CHU Sainte-Justine Research Centre MontrealCanada Quebec Network on Nursing Intervention Research MontrealCanada Faculty of Medical and Paramedical Sciences CEReSSAix-Marseille UniversitéMarseilleFrance Ingram School of Nursing McGill UniversityMontrealCanada Centre for Nursing Research and Lady Davis Institute Jewish General HospitalMontrealCanada

Skin-to-skin contact(SSC)consists of positioning the diaper-clad infant against the parent’s chest and is considered a nursing practice rooted in family-centered care(FCC).1 SSC implies simultaneous parental presence and helps to facilitate their involvement from the earliest hours of their preterm infants’lives as this intervention is delivered by parents.1 FCC has gained worldwide popularity in recent years to promote parental presence and active participation of parents in care during neonatal intensive care units(NICUs)hospitalization.2 Both practices relate to developmental care(DC),which regroups specific interventions aimed at reducing stress and improving infant neurological development.

关键词： centered gained Skin

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Finite Projective Geometries and Classification of the Weight Hierarchies of Codes(Ⅰ)

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Acta Mathematica Sinica,English Series 2004年第2期20卷 333-348页

作者： WenDeCHEN TorleivKLφve LaboratoryofSystemsandControl CenterofInformationSecurityAcademyofMathematicsandSystemsScienceChineseAcademyofSciencesBeijing100080P.R.China Departmentoflnformatics UniversityofBergenBergenHighTechnologyCenterN-5020BergenNorway

The weight hierarchy of a binary linear [n, k] code C is the sequence (d 1, d 2, . . . , d k ), where d r is the smallest support of an r-dimensional subcode of C. The codes of dimension 4 are collected in classes and the possible weight hierarchies in each class is determined by finite projective geometries. The possible weight hierarchies in class A, B, C, D are determined in Part (I). The possible weight hierarchies in class E, F, G, H, I are determined in Part (II).

关键词： Weight hierarchy Support weight Finite projective geometries Binary linear code Chain condition Difference sequence

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The Commitment to Promoting a Culture of Equity in Quebec Secondary Schools: Insights from School Stakeholders - A Secondary Publication

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Journal of Contemporary Educational Research 2024年第3期8卷 161-172页

作者： Corina Borri-Anadon Geneviève Audet Eve Lemaire University of Quebec at Trois-Rivières Canada University of Quebec in Montreal Canada

This paper presents the results of a research project on the intercultural climate in schools and the academic success of immigrant students in *** intercultural climate in eight secondary public schools is documented from the standpoint of various school and community stakeholders,students,and *** specifically,the paper focuses on the commitment to promoting cultural equity,which is identified through interviews with the targeted stakeholders on exclusionary practices and processes and the practices implemented to counter *** results identify five areas of vulnerability among certain minoritized groups of students:the transition from welcoming to regular classes for those students learning French,evaluation and support for those experiencing learning or behavioral difficulties,the referral of these students to adult education programs or work-oriented training programs,their participation in extracurricular activities,and their access to special school ***,some schools do report the introduction of many equity practices in response to the exclusionary ***,these initiatives are mostly occasional and voluntary and pertain to interactions between *** findings call for a discussion on the importance of systemic and concerted initiatives towards achieving equity.

关键词： Educational inclusion and exclusion Educational inequalities Immigration and ethnicity Canada

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The Long-term Survival Chances of Young Massive Star Clusters

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Chinese Journal of Astronomy and Astrophysics 2007年第2期7卷 155-186页

作者： Richard de Grijs Geneviève Parmentier Department of Physics & Astronomy The University of Sheffield Hicks Building Hounsfield Road Sheffield S3 7RH U. K.National Astronomical Observatories Chinese Academy of SciencesBeijing 100012 Institute of Astrophysics & Geophysics Université de LiègeAllée du 6 Aot17Sart-Tilman (B5c)B-4000 LiègeBelgium

We review the long-term survival chances of young massive star clusters （YMCs）, hallmarks of intense starburst episodes often associated with Violent galaxy interactions. We address the key question as to whether at least some of these YMCs can be considered protoglobular clusters （GCs）, in which case these would be expected to evolve into counterparts of the ubiquitous old GCs believed to be among the oldest galactic building blocks. In the absence of significant external perturbations, the key factor determining a cluster＇s long-term survival chances is the shape of its stellar initial mass function （IMF）. It is, however, not straightforward to assess the IMF shape in unresolved extragalactic YMCs. We discuss in detail the promise of using high-resolution spectroscopy to make progress towards this goal, as well as the numerous pitfalls associated with this approach. We also discuss the latest progress in worldwide efforts to better understand the evolution of entire cluster systems, the disruption processes they are affected by, and whether we can use recently gained insights to determine the nature of at least some of the YMCs observed in extragalactic starbursts as proto-GCs. We conclude that there is an increasing body of evidence that GC formation appears to be continuing until today; their long-term evolution crucially depends on their environmental conditions, however.

关键词： stellar dynamics - globular clusters general - galaxies interactions - Magellanic Clouds - galaxies starburst - galaxies star clusters

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