BIERMER’s Disease: About 4 Cases Diagnosed at Regional University Hospital of Ouahigouya (Chur/Ohg) and Literature Review

作     者：Zanga Damien Ouattara Stève Léonce Zoungrana Saïdou Santi Emeline Agathe Carama Fabien Dembele Bafima Désiré Diarra Alain Bougouma Zanga Damien Ouattara;Stève Léonce Zoungrana;Saïdou Santi;Emeline Agathe Carama;Fabien Dembele;Bafima Désiré Diarra;Alain Bougouma

作者机构：Department of Gastroenteroly Ouahigouya Regional University Hospital Ouahigouya Burkina Faso Department of Neurology Bogodogo University Hospital Ouagadougou Burkina Faso Department of Gastroenterology Yalgado Oudraogo University Hospital Center Ouagadougou Burkina Faso 

出 版 物：《Open Journal of Gastroenterology》 (肠胃病学期刊（英文）)

年 卷 期：2024年第14卷第9期

页      面：322-329页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Anemia Pernicious Megaloblastic Vitamin B12 

摘      要：Megaloblastic pernicious anemia is an autoimmune disorder, considered rare in African context. The objective of this study was to report four clinical cases collected at the CHUR/OHG, and to review the literature. The study population consisted of two men and two women. The clinical manifestations were mainly neurological and hematological. The neurological signs were mainly paresthesia. One patient presented memory problems. On the biological level, macrocytic anemia and vitamin B12 deficiency were reported in two cases prior to treatment while the other two without serological assay of vitamin B12 were put on trial treatment. Anti-intrinsic factor antibodies were positive in three patients. The Schilling test was not used. Upper gastrointestinal endoscopy revealed atrophic fundic gastritis in all four patients who received treatment through intramuscular injection of hydroxocobalamin (vitamin B12). The evolution was favorable after one month of treatment in all cases. The literature review is dominated by clinical case reports, the largest cohorts of which are from the Maghreb.