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NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in jaK2^(V617F)-positive myeloproliferative neoplasm cells

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2440-2449页

作者： bruna Alves Fenerich jaqueline Cristina Fernandes Ana Paula Nunes Rodrigues Alves Juan Luiz Coelho-Silva Renata Scopim-Ribeiro Priscila Santos Scheucher Christopher A.Eide Cristina E.Tognon brian J.Druker Eduardo Magalhães Rego João Agostinho Machado-Neto Fabiola Traina Department of Medical Images Hematologyand Clinical OncologyUniversity of Sao Paulo at Ribeirao Preto Medical SchoolRibeirao PretoSao PauloBrazil Center for Cell-based Therapy Sao Paulo Research FoundationRibeirao PretoSao PauloBrazil Knight Cancer Institute Oregon Health&Science UniversityPortlandORUSA Howard Hughes Medical Institute PortlandORUSA Department of Internal Medicine University of Sao Paulo Medical SchoolSao PauloBrazil Department of Pharmacology Institute of Biomedical Sciences of the University of Sao PauloSao PauloBrazil

Recent data indicate that IGF1R/IRS signaling is a potential therapeutic target in bCR-AbL1-negative myeloproliferative neoplasms(MPN);in this pathway,IRS2 is involved in the malignant transformation induced by jaK2^(V617F),and upregulation of IGF1R signaling induces the MPN ***157,a synthetic compound designed as an IGF1R-IRS1/2 inhibitor,has been shown to induce antineoplastic effects in solid ***,we aimed to characterize the molecular and cellular effects of NT157 in jaK2^(V617F)positive MPN cell lines(HEL and SET2)and primary patient hematopoietic *** jaK2^(V617F)cell lines,NT157 decreased cell viability,clonogenicity,and cell proliferation,resulting in increases in apoptosis and cell cycle arrest in the G2/M phase(pbited IRS1/2,jaK2/STAT,and NFκb signaling,and it activated the AP-1 complex,downregulated four oncogenes(CCND1,MYb,WT1,and NFKb1),and upregulated three apoptotic-related genes(CDKN1A,FOS,and JUN)(pess in a jaK2/STAT-independent ***157 inhibited erythropoietin-independent colony formation in cells from polycythemia vera patients(pese findings further elucidate the mechanism of NT157 action in a MPN context and suggest that targeting IRS1/2 proteins may represent a promising therapeutic strategy for MPN.

关键词： jaK2 IGF1R neoplasms STAT3

biocontrol Potential of bacillus amyloliquefaciens bc2 and Trichoderma harzianum TR against Strawberry Anthracnose under Laboratory and Field Conditions

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Agricultural Sciences 2020年第3期11卷 260-277页

作者： Rababe es-Soufi Houda Tahiri Latifa Azaroual Aicha El Oualkadi Patrick Martin Alain badoc Ahmed Lamarti Laboratory of Plant biotechnology Biology DepartmentFaculty of SciencesAbdelmalek Essaadi UniversityTetouanMorocco INRA-CRRA-Tangier TangerMorocco Water Laboratory Environmental Studies and Analyzes(L2EAE)Department of ChemistryFaculty of ScienceAbdelmalek Essaadi UniversityTétouanMorocco Artois university UniLaSalleULR7519-Transformations&Agroressources UnitBéthuneFrance MIb(Molecules of biological Interest) Research Unit(Enology EA 4577USC 1366 INRA)UFR of Pharmaceutical SciencesBordeaux UniversityISVV(Institute of Vine and Wine Sciences)BordeauxFrance

The increasingly strict regulation of the use of phytosanitary products and the will of the populations to move towards sustainable development allow bio-sourced products and more particularly for biocontrol in the field of pesticides to progress. The study carried out here concerns the evaluation of the potency of bacillus amyloliquefaciens bc2 and Trichoderma harzianum to fight against strawberry cultures infected with anthracnose (Fragaria × ananassa Duch.). The studies were carried out in the laboratory and in the field. The results indicate that b. amyloliquefaciens bc2 and Trichoderma harzianum TR are effective for the biological control of anthracnose, gray mold and powdery mildew on strawberries grown in field conditions. The increase in plant size and the number of fruits produced with these control agents has also been observed.

关键词： biocontrol bacillus amyloliquefaciens Trichoderma harzianum Strawberry Anthracnose Colletotrichum acutatum

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了解JesD204b链路参数

中国电子商情 2014年第10期 17-19页

作者： Jonathan harris ADI公司

高速数据转换器接口正从LVDS过渡到JesD204b。该接口于2006年发布原型JesD204,2008年发布修订版JesD204A,并于2011年8月再次修订,即当前的JesD204b。该接口可提供高效率,较之其前代CMOS和LVDS产品在速度、尺寸和成本上更有优势。采用Jes... 详细信息

高速数据转换器接口正从LVDS过渡到JesD204b。该接口于2006年发布原型JesD204,2008年发布修订版JesD204A,并于2011年8月再次修订,即当前的JesD204b。该接口可提供高效率,较之其前代CMOS和LVDS产品在速度、尺寸和成本上更有优势。采用JesD204b的设计拥有更快的接口带来的好处,能与转换器更快的采样速率同步。其引脚数量减少,从而实现了更小封装、更少布线以及更低的整体系统成本,

关键词：采样速率 JesD204b链半字节 Converter Xilinx 编码方案多帧位字能力构建位分辨率

Identification of serum proteins discriminating colorectal cancer patients and healthy controls using surface-enhanced laser desorption ionisation-time of flight mass spectrometry

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World Journal of Gastroenterology 2006年第10期12卷 1536-1544页

作者： Judith YMN Engwegen Helgi H Helgason Annemieke Cats Nathan harris Johannes MG bonfrer jan HM Schellens Jos H beijnen Department of Pharmacy and Pharmacology The Netherlands Cancer Institute/Slotervaart Hospital AmsterdamThe Netherlands Department of Medical Oncology The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital AmsterdamThe Netherlands Department of Gastroenterology and Hepatology The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital AmsterdamThe Netherlands Ciphergen biosystems Inc. Freemont CaliforniaUnited States Department of Clinical Chemistry The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital AmsterdamThe Netherlands Utrecht University Faculty of Pharmaceutical Sciences Department of Biomedical analysisUtrechtThe Netherlands

AIM： To detect the new serum biomarkers for colorectal cancer （CRC） by serum protein profiling with surfaceenhanced laser desorption ionisation - time of flight mass spectrometry （SELDI-TOF MS）. METHODS： Two independent serum sample sets were analysed separately with the ProteinChip technology （set A： 40 CRC ＋ 49 healthy controls; set b： 37 CRC ＋ 31 healthy controls）, using chips with a weak cation exchange moiety and buffer pH 5. Discriminative power of differentially expressed proteins was assessed with a classification tree algorithm. Sensitivities and specificities of the generated classification trees were obtained by blindly applying data from set A to the generated trees from set b and vice versa. CRC serum protein profiles were also compared with those from breast, ovarian, prostate, and non-small cell lung cancer. ResULTS： Mass-to-charge ratios （m/z） 3.1×10^3, 3.3× 10^3, 4.5×10^3, 6.6×10^3 and 28×10^3 were used as classitiers in the best-performing classification trees. Tree sensitivities and specificities were between 65% and 90%.Host of these discriminative m/z values were also different in the other tumour types investigated. M/z 3.3× 10^3, main classifier in most trees, was a doubly charged form of the 6.6× 10^3-Da protein. The latter was identified as apolipoprotein C-I. M/z 3.1×10^3 was identified as an N-terminal fragment of albumin, and m/z 28× 10^3 as apolipoprotein A-I. CONCLUSION： SELDI-TOF MS followed by classification tree pattern analysis is a suitable technique for finding new serum markers for CRC. biomarkers can be identified and reproducibly detected in independent sample sets with high sensitivities and specificities. Although not specific for CRC, these biomarkers have a potential role in disease and treatment monitoring.

关键词： Proteomics Colorectal cancer biomarker Sensitivity Specificity

Trace metals and animal health: Interplay of the gut microbiota with iron, manganese, zinc, and copper

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Animal Nutrition 2021年第3期7卷 750-761页

作者： Edward Alain b.Pajarillo Eunsook Lee Dae-Kyung Kang Department of Pharmacy and Pharmaceutical Sciences Florida A&M UniversityTallahassee 32307FLUSA Department of Animal Resources Science Dankook UniversityCheonan 31116Republic of Korea

Metals such as iron,manganese,copper,and zinc are recognized as essential trace *** trace metals play critical roles in development,growth,and metabolism,participating in various metabolic processes by acting as cofactors of enzymes or providing structural support to *** or toxicity of these metals can impact human and animal health,giving rise to a number of metabolic and neurological *** breakdown,absorption,and elimination of these trace metals is a tightly regulated process that requires crosstalk between the host and these *** gut is a complex system that serves as the interface between these components,but other factors that contribute to this delicate interaction are not well *** gut is home to trillions of microorganisms and microbial genes(the gut microbiome)that can regulate the metabolism and transport of micronutrients and contribute to the bioavailability of trace metals through their assimilation from food sources or by competing with the ***,deficiency or toxicity of these metals can modulate the gut microenvironment,including microbiota,nutrient availability,stress,and ***,understanding the role of the gut microbiota in the metabolism of manganese,iron,copper,and zinc,as well as in heavy metal deficiencies and toxicities,and vice versa,may provide insight into developing improved or alternative therapeutic strategies to address emerging health *** review describes the current understanding of how the gut microbiome and trace metals interact and affect host health,particularly in pigs.

关键词： Gut microbiota Microbiome Iron Manganese Zinc Copper

Restoring nervous system structure and function using tissue engineered living scaffolds

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Neural Regeneration Research 2015年第5期10卷 679-685页

作者： Laura A.Struzyna ja.es P.harris Kritika S.Katiyar H.Isaac Chen D.Kacy Cullen Center for brain Injury and Repair Department of NeurosurgeryPerelman School of MedicineUniversity of Pennsylvania Center for Neurotrauma Neurodegenerationand RestorationPhiladelphia Veterans Affairs Medical Center School of biomedical Engineering Drexel University

Neural tissue engineering is premised on the integration of engineered living tissue with the host nervous system to directly restore lost function or to augment regenerative capacity following ner- vous system injury or neurodegenerative disease. Disconnection of axon pathways - the long-distance fibers connecting specialized regions of the central nervous system or relaying peripheral signals - is a common feature of many neurological disorders and injury. However, functional axonal regenera- tion rarely occurs due to extreme distances to targets, absence of directed guidance, and the presence of inhibitory factors in the central nervous system, resulting in devastating effects on cognitive and sensorimotor function. To address this need, we are pursuing multiple strategies using tissue engi- neered ＂living scaffolds＂, which are preformed three-dimensional constructs consisting of living neural cells in a defined, often anisotropic architecture. Living scaffolds are designed to restore function by serving as a living labeled pathway for targeted axonal regeneration - mimicking key developmental mechanisms- or by restoring lost neural circuitry via direct replacement of neurons and axonal tracts. We are currently utilizing preformed living scaffolds consisting of neuronal dusters spanned by long axonal tracts as regenerative bridges to facilitate long-distance axonal regeneration and for targeted neurosurgical reconstruction of local circuits in the brain. Although there are formidable challenges in predinical and clinical advancement, these living tissue engineered constructs represent a promising strategy to facilitate nervous system repair and functional recovery.

关键词： living scaffolds neural tissue engineering cell transplant biomaterials regeneration neurotrauma neurodegeneration axon pathfinding cell migration

Investigation of free amino acid, total phenolics,antioxidant activity and purine alkaloids to assess the health properties of non-Camellia tea

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Acta Pharmaceutica Sinica b 2016年第2期6卷 170-181页

作者： Wu bi Chunnian He Yunyun Ma Jie Shen Linghua harris Zhang Yong Peng Peigen Xiao Institute of Medicinal Plant Development Chinese Academy of Medical Science Peking Union Medical College Key Laboratory of bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of Education Phyto Medix Co.

To find novel functional beverages from folk teas, 33 species of frequently used non-Camellia tea(plants other than Camellia) were collected and compared with Camellia tea(green tea, pu-erh tea and black tea) for the first time. Data are reported here on the quantities of 20 free amino acids(FAAs) and three purine alkaloids(measured by UHPLC), total polyphenols(measured by Folin-Ciocalteu assay), and antioxidant activity(DPPH). The total amounts of FAAs in non-Camellia tea(0.62–18.99 mg/g) are generally less than that of Camellia tea(16.55–24.99 mg/g). However, for certain FAAs, the quantities were much higher in some non-Camellia teas, such as γ-aminobutyric acid in teas from Ampelopsis grossedentata, Isodon serra and Hibiscus sabdariffa. Interestingly, theanine was detected in tea from Potentilla fruticosa(1.16±0.81 mg/g). Furthermore, the content of polyphenols in teas from A. grossedentata, Acer tataricum subsp. ginnala are significantly higher than those from Camellia tea;teas from I. serra, Pistacia chinensis and A. tataricum subsp. ginnala have remarkable antioxidant activities similar to the activities from green tea(44.23 μg/m L). Purine alkaloids(caffeine, theobromine and theophylline) were not detected in non-Camellia teas. The investigation suggest some non-Camellia teas may be great functional natural products with potential for prevention of chronic diseases and aging,by providing with abundant polyphenols, antioxidants and specific FAAs.

关键词： Non-Camellia tea Amino acids Polyphenols Purine alkaloids Antioxidant activity

在年龄结构化动物种群的分析过程中常见的几种错误

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兽类学报 1993年第3期13卷 217-222页

作者： Richard b.harris Lee H.Metzgar 美国蒙大那大学蒙大拿合作野生动物研究单位美国蒙大那大学生物系

分析动物各年龄组的种群数据有助于推断影响动物种群发展趋势的诸因素,而且便于设计出种群层次。然而,在研究近期文献资料时,我们发现存在三种错误。这些错误均可导致非正确的解释。即:1)在生命表分析中,将Sx与lx等同(Sx由各死亡年龄组... 详细信息

分析动物各年龄组的种群数据有助于推断影响动物种群发展趋势的诸因素,而且便于设计出种群层次。然而,在研究近期文献资料时,我们发现存在三种错误。这些错误均可导致非正确的解释。即:1)在生命表分析中,将Sx与lx等同(Sx由各死亡年龄组推导而出,lx为存活率);2)在综合跨年龄组的成雌生育率时,不计算该年龄组的成雌死亡数;3)在用Leslie矩阵计算周限增长率时,以mx取代Fx。我们将探讨上述错误的含义及后果,并提出解决方法。

关键词：种群分析生命表动物 Lesile矩阵

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胶原纤维在肉制品中的功能性优势和应用

肉类研究 2006年第1期20卷 17-19页

作者： b.harris 王国杰朱万良荆建设 Novapro添加剂公司大连闻达生物科技有限公司大连116620

胶原纤维是天然的动物源产品,用途广泛的产品。它应用在肉制品中具有独一无二的功能性。本文简单介绍了胶原纤维在肉制品中的应用和特点,阐述其使用效果可直接提高肉制品的质量。并列举了一些具体应用实例。

关键词：胶原纤维保水性组织结构和咀嚼感