Trace metals and animal health: Interplay of the gut microbiota with iron, manganese, zinc, and copper

作     者：Edward Alain B.Pajarillo Eunsook Lee Dae-Kyung Kang Edward Alain B.Pajarillo;Eunsook Lee;Dae-Kyung Kang

作者机构：Department of Pharmacy and Pharmaceutical SciencesFlorida A&M UniversityTallahassee 32307FLUSA Department of Animal Resources ScienceDankook UniversityCheonan 31116Republic of Korea 

出 版 物：《Animal Nutrition》 (动物营养（英文版）)

年 卷 期：2021年第7卷第3期

页      面：750-761页

核心收录：

学科分类：090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 09[农学] 

基　　金：supported by a grant from National Institute of Environmental Health Sciences(R01 ES024756) 

主　　题：Gut microbiota Microbiome Iron Manganese Zinc Copper 

摘      要：Metals such as iron,manganese,copper,and zinc are recognized as essential trace *** trace metals play critical roles in development,growth,and metabolism,participating in various metabolic processes by acting as cofactors of enzymes or providing structural support to *** or toxicity of these metals can impact human and animal health,giving rise to a number of metabolic and neurological *** breakdown,absorption,and elimination of these trace metals is a tightly regulated process that requires crosstalk between the host and these *** gut is a complex system that serves as the interface between these components,but other factors that contribute to this delicate interaction are not well *** gut is home to trillions of microorganisms and microbial genes(the gut microbiome)that can regulate the metabolism and transport of micronutrients and contribute to the bioavailability of trace metals through their assimilation from food sources or by competing with the ***,deficiency or toxicity of these metals can modulate the gut microenvironment,including microbiota,nutrient availability,stress,and ***,understanding the role of the gut microbiota in the metabolism of manganese,iron,copper,and zinc,as well as in heavy metal deficiencies and toxicities,and vice versa,may provide insight into developing improved or alternative therapeutic strategies to address emerging health *** review describes the current understanding of how the gut microbiome and trace metals interact and affect host health,particularly in pigs.